FMR LLC in group FMR LLC More: the full row for FMR LLC 6,565,272 $227M 0.01% +280,800 13F-HR Timeline Group GENERAL ATLANTIC, L.P. More: the full row for GENERAL ATLANTIC, L.P. 6,550,757 $227M 7.79% -1,480,495 13F-HR Timeline Foresite Capital Management VI LLC group of 2 filers holding More: the full row for Foresite Capital Management VI LLC 5,442,723 $188M +470,017 Timeline venBio Partners LLC More: the full row for venBio Partners LLC 4,643,430 $161M 30.92% +4,126 13F-HR Timeline VIKING GLOBAL INVESTORS LP in group VIKING GLOBAL INVESTORS LP More: the full row for VIKING GLOBAL INVESTORS LP 3,653,310 $126M 0.36% 0 13F-HR Timeline Group EQT Fund Management S.a r.l. More: the full row for EQT Fund Management S.a r.l. 3,424,609 $118M 13.73% 0 13F-HR Timeline DEERFIELD MANAGEMENT COMPANY, L.P. in group DEERFIELD MANAGEMENT COMPANY,… More: the full row for DEERFIELD MANAGEMENT COMPANY, L.P. 3,376,042 $117M 1.22% +250,000 13F-HR Timeline Group Bain Capital Life Sciences Investors, L… in group Bain Capital Life Sciences In… More: the full row for Bain Capital Life Sciences Investors, LLC 2,675,509 $92.5M 5.5% 0 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 2,392,934 $82.7M 0.01% +274,034 13F-HR Timeline Group Polar Capital Holdings Plc in group Polar Capital Holdings Plc More: the full row for Polar Capital Holdings Plc 2,326,389 $80.4M 0.23% +1,545,373 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 1,641,200 $56.8M 0.09% +634,184 13F-HR Timeline Group Commodore Capital LP in group Commodore Capital LP More: the full row for Commodore Capital LP 1,425,000 $49.3M 2.93% -493,970 13F-HR Timeline Group NOVO HOLDINGS A/S More: the full row for NOVO HOLDINGS A/S 1,400,000 $48.4M 2.81% -350,000 13F-HR Timeline Saturn V Capital Management LP More: the full row for Saturn V Capital Management LP 1,314,122 $45.4M 6.52% +112,720 13F-HR Timeline TCG Crossover Management, LLC More: the full row for TCG Crossover Management, LLC 1,008,229 $34.9M 0.84% new 13F-HR Timeline Sofinnova Investments, Inc. More: the full row for Sofinnova Investments, Inc. 881,299 $30.5M 1.63% +62,971 13F-HR Timeline 5AM Venture Management, LLC More: the full row for 5AM Venture Management, LLC 797,600 $27.6M 9.58% 0 13F-HR Timeline Seven Fleet Capital Management LP More: the full row for Seven Fleet Capital Management LP 774,501 $26.8M 4.42% +601,770 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 771,454 $26.7M <0.01% +14,241 13F-HR Timeline Group Cormorant Asset Management, LP More: the full row for Cormorant Asset Management, LP 750,000 $25.9M 1.33% -250,000 13F-HR Timeline Soleus Capital Management, L.P. More: the full row for Soleus Capital Management, L.P. 730,907 $25.3M 0.87% +28,855 13F-HR Timeline Jones Hill Capital LP More: the full row for Jones Hill Capital LP 677,879 $23.4M 4.98% +510,865 13F-HR Timeline Patient Square Capital LP More: the full row for Patient Square Capital LP 671,209 $23.2M 3.6% +178,209 13F-HR Timeline Kynam Capital Management, LP More: the full row for Kynam Capital Management, LP 661,795 $22.9M 1.26% +21,400 13F-HR Timeline Rock Springs Capital Management LP More: the full row for Rock Springs Capital Management LP 648,333 $22.4M 1.09% +2,800 13F-HR Timeline Elmind Capital, LP More: the full row for Elmind Capital, LP 525,750 $18.2M 4.57% +50,000 13F-HR Timeline Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 524,302 $18.1M 0.03% +62,051 13F-HR Timeline Group DV EQUITIES, LLC More: the full row for DV EQUITIES, LLC 482,524 $16.7M 2.42% 13F-HR Timeline D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 471,402 $16.3M 0.01% +150,245 13F-HR Timeline Group Octagon Capital Advisors LP More: the full row for Octagon Capital Advisors LP 456,721 $15.8M 1.45% +291,721 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 427,403 $14.8M 0.01% +245,457 13F-HR Timeline Group Alyeska Investment Group, L.P. in group Alyeska Investment Group, L.P. More: the full row for Alyeska Investment Group, L.P. 406,829 $14.1M 0.04% +281,829 13F-HR Timeline Group Eversept Partners, LP More: the full row for Eversept Partners, LP 386,383 $13.4M 0.73% -20,577 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 358,270 $12.4M <0.01% -83,986 13F-HR Timeline Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 308,856 $10.7M 1.75% -178,000 13F-HR Timeline Tetragon Partners GP Ltd in group Tetragon Partners GP Ltd More: the full row for Tetragon Partners GP Ltd 295,627 $10.2M 1.66% +74,016 13F-HR Timeline Group UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 254,790 $8.81M +105,203 Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 241,785 $8.36M <0.01% +73,155 13F-HR Timeline Group EcoR1 Capital, LLC More: the full row for EcoR1 Capital, LLC 235,000 $8.13M 0.4% new 13F-HR Timeline TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 216,640 $7.49M 0.01% +90,564 13F-HR Timeline Group ORBIMED ADVISORS LLC in group ORBIMED ADVISORS LLC More: the full row for ORBIMED ADVISORS LLC 205,400 $7.1M 0.13% 0 13F-HR Timeline Group Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 200,419 $6.93M 0.03% new 13F-HR Timeline Group Kalehua Capital Management LLC More: the full row for Kalehua Capital Management LLC 198,772 $6.87M 3.95% 0 13F-HR/A Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 180,063 $6.23M <0.01% new 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 168,631 $5.83M <0.01% +15,686 13F-HR Timeline Group Cinctive Capital Management LP More: the full row for Cinctive Capital Management LP 161,113 $5.57M 0.22% new 13F-HR Timeline HighVista Strategies LLC More: the full row for HighVista Strategies LLC 160,494 $5.55M 1.27% +62,628 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 149,978 $5.19M <0.01% +7,049 13F-HR Timeline Group Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 139,850 $4.84M 0.01% +68,640 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 138,810 $4.8M <0.01% +123,165 13F-HR Timeline Group Trexquant Investment LP More: the full row for Trexquant Investment LP 136,305 $4.71M 0.03% +70,184 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 109,760 $3.8M 0.05% +54,829 13F-HR Timeline Group NEXTBio Capital Management LP More: the full row for NEXTBio Capital Management LP 108,055 $3.74M 1.72% new 13F-HR Timeline ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 105,528 $3.65M 0.17% 0 13F-HR Timeline Group BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 102,793 $3.55M 0.07% -54,324 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 97,336 $3.37M <0.01% -66,987 13F-HR Timeline Group LAZARD ASSET MANAGEMENT LLC in group LAZARD ASSET MANAGEMENT LLC More: the full row for LAZARD ASSET MANAGEMENT LLC 92,889 $3.21M <0.01% new 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 89,912 $3.11M <0.01% +783 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 82,782 $2.86M <0.01% -686 13F-HR Timeline Group STEMPOINT CAPITAL LP More: the full row for STEMPOINT CAPITAL LP 80,907 $2.8M 0.48% -5,730 13F-HR Timeline HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 61,389 $2.12M <0.01% +33,765 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 53,469 $1.85M <0.01% -253 13F-HR Timeline Group Amundi in group Amundi More: the full row for Amundi 49,944 $1.73M <0.01% +18,992 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 44,629 $1.54M <0.01% -51,755 13F-HR Timeline Group MOORE CAPITAL MANAGEMENT, LP More: the full row for MOORE CAPITAL MANAGEMENT, LP 44,001 $1.52M 0.03% new 13F-HR Timeline Y-Intercept (Hong Kong) Ltd More: the full row for Y-Intercept (Hong Kong) Ltd 39,934 $1.38M 0.03% new 13F-HR Timeline Atom Investors LP More: the full row for Atom Investors LP 39,482 $1.37M 0.12% +30,382 13F-HR Timeline Swiss National Bank More: the full row for Swiss National Bank 39,357 $1.36M <0.01% -5,400 13F-HR Timeline TD Asset Management Inc More: the full row for TD Asset Management Inc 38,458 $1.33M <0.01% -16,368 13F-HR Timeline VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 33,735 $1.17M <0.01% new 13F-HR Timeline Group SummitTX Capital, L.P. More: the full row for SummitTX Capital, L.P. 33,354 $1.15M 0.03% +4,170 13F-HR Timeline Engineers Gate Manager LP More: the full row for Engineers Gate Manager LP 33,059 $1.14M 0.01% new 13F-HR Timeline Aquatic Capital Management LLC More: the full row for Aquatic Capital Management LLC 30,223 $1.05M 0.04% new 13F-HR Timeline Birchview Capital, LP More: the full row for Birchview Capital, LP 29,847 $1.03M 0.48% 0 13F-HR Timeline DIADEMA PARTNERS LP More: the full row for DIADEMA PARTNERS LP 29,321 $1.01M 0.36% 0 13F-HR Timeline ARROWSTREET CAPITAL, LIMITED PARTNERSHIP in group ARROWSTREET CAPITAL, LIMITED … More: the full row for ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 29,313 $1.01M <0.01% new 13F-HR Timeline Group MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 23,646 $818K <0.01% -20,549 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 23,120 $799K <0.01% -1,033 13F-HR/A Timeline VANGUARD GROUP INC group of 2 filers holding More: the full row for VANGUARD GROUP INC 21,149 $731K 0 Timeline Palumbo Wealth Management LLC More: the full row for Palumbo Wealth Management LLC 21,004 $726K 0.15% +396 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 20,702 $716K <0.01% +16,334 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 20,612 $713K <0.01% -6,164 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 19,967 $693K <0.01% -38 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 18,202 $629K <0.01% -26,772 13F-HR Timeline Group GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 16,148 $558K 0.04% new 13F-HR Timeline PSP Research LLC More: the full row for PSP Research LLC 15,000 $519K 0.28% -5,000 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 14,719 $509K 0.03% +3,352 13F-HR Timeline ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 14,369 $497K <0.01% +899 13F-HR Timeline OpenArc Corporate Advisory, LLC More: the full row for OpenArc Corporate Advisory, LLC 13,595 $470K 0.01% new 13F-HR Timeline TUDOR INVESTMENT CORP ET AL More: the full row for TUDOR INVESTMENT CORP ET AL 13,147 $455K <0.01% -17,755 13F-HR Timeline Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 12,654 $438K <0.01% -4,353 13F-HR Timeline Group OCCUDO QUANTITATIVE STRATEGIES LP More: the full row for OCCUDO QUANTITATIVE STRATEGIES LP 11,365 $393K 0.02% +1 13F-HR Timeline Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 10,651 $368K 0.09% -635 13F-HR Timeline Group NANO CAP NEW MILLENNIUM GROWTH FUND L P More: the full row for NANO CAP NEW MILLENNIUM GROWTH FUND L P 9,000 $311K 0.24% -1,000 13F-HR Timeline TEACHER RETIREMENT SYSTEM OF TEXAS More: the full row for TEACHER RETIREMENT SYSTEM OF TEXAS 8,416 $291K <0.01% +240 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 8,239 $285K <0.01% 0 13F-HR Timeline Persistent Asset Partners Ltd More: the full row for Persistent Asset Partners Ltd 7,904 $273K 0.09% 0 13F-HR Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 8,980 $254K <0.01% 0 13F-HR Timeline ALGERT GLOBAL LLC More: the full row for ALGERT GLOBAL LLC 6,880 $238K <0.01% new 13F-HR Timeline KLP KAPITALFORVALTNING AS More: the full row for KLP KAPITALFORVALTNING AS 5,800 $201K <0.01% 0 13F-HR Timeline PUBLIC EMPLOYEES RETIREMENT SYSTEM OF O… More: the full row for PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO 5,669 $196K <0.01% -1,900 13F-HR Timeline BNP PARIBAS ASSET MANAGEMENT Holding S.… in group BNP PARIBAS ASSET MANAGEMENT … More: the full row for BNP PARIBAS ASSET MANAGEMENT Holding S.A. 4,561 $158K <0.01% -1,163 13F-HR Timeline Group Mirae Asset Global Investments Co., Ltd. in group Mirae Asset Global Investment… More: the full row for Mirae Asset Global Investments Co., Ltd. 3,125 $108K <0.01% -216 13F-HR Timeline Group CoreCap Advisors, LLC More: the full row for CoreCap Advisors, LLC 2,700 $93.4K <0.01% new 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 2,304 $79.7K <0.01% -138 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 1,728 $59.8K <0.01% +339 13F-HR Timeline Group GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 1,358 $47K <0.01% -81 13F-HR Timeline Quantbot Technologies LP More: the full row for Quantbot Technologies LP 1,188 $41.1K <0.01% -1,203 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 676 $23.4K <0.01% +438 13F-HR Timeline Group SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 624 $21.6K <0.01% -1,549 13F-HR Timeline 1620 INVESTMENT ADVISORS, INC. More: the full row for 1620 INVESTMENT ADVISORS, INC. 520 $18K 0.01% new 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 450 $15.6K <0.01% 0 13F-HR Timeline Group State of Wyoming More: the full row for State of Wyoming 371 $12.8K <0.01% new 13F-HR Timeline Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 329 $11.4K <0.01% -3,650 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 214 $7K <0.01% +133 13F-HR Timeline Group Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 165 $5.71K <0.01% +147 13F-HR Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 116 $4.01K <0.01% new 13F-HR Timeline Centerpoint Advisors, LLC More: the full row for Centerpoint Advisors, LLC 100 $3K <0.01% 0 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 55 $1.9K <0.01% new 13F-HR Timeline Group Bare Financial Services, Inc More: the full row for Bare Financial Services, Inc 14 $484 <0.01% +8 13F-HR Timeline Quarry LP More: the full row for Quarry LP 7 $242 <0.01% new 13F-HR Timeline Larson Financial Group LLC More: the full row for Larson Financial Group LLC 6 $207 <0.01% new 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 1 $35 <0.01% 0 13F-HR Timeline