PERCEPTIVE ADVISORS LLC in group PERCEPTIVE ADVISORS LLC More: the full row for PERCEPTIVE ADVISORS LLC 1,304,846 $43.3M 0.67% +589,539 13F-HR Timeline Group BVF INC/IL in group BVF INC/IL More: the full row for BVF INC/IL 1,251,788 $41.6M 1.06% 0 13F-HR Timeline Group Affinity Asset Advisors, LLC More: the full row for Affinity Asset Advisors, LLC 1,172,487 $38.9M 1.9% +102,968 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 1,122,655 $37.3M <0.01% +889,971 13F-HR Timeline Group SAMSARA BIOCAPITAL, LLC More: the full row for SAMSARA BIOCAPITAL, LLC 1,062,872 $35.3M 2.9% 0 13F-HR Timeline VANGUARD GROUP INC group of 4 filers holding More: the full row for VANGUARD GROUP INC 1,001,458 $33.2M +178,996 Timeline Kynam Capital Management, LP More: the full row for Kynam Capital Management, LP 872,558 $29M 1.6% 0 13F-HR Timeline ORBIMED ADVISORS LLC in group ORBIMED ADVISORS LLC More: the full row for ORBIMED ADVISORS LLC 743,944 $24.7M 0.47% -57,200 13F-HR Timeline Group Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 711,162 $23.6M 0.04% +245,370 13F-HR Timeline Group EVENTIDE ASSET MANAGEMENT, LLC More: the full row for EVENTIDE ASSET MANAGEMENT, LLC 585,262 $19.4M 0.26% -130,045 13F-HR Timeline Velan Capital Investment Management LP More: the full row for Velan Capital Investment Management LP 512,160 $17M 10.42% 0 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 458,029 $15.2M 0.05% +588 13F-HR Timeline ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 404,014 $13.4M 0.63% -120,427 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 389,692 $12.9M <0.01% +218,306 13F-HR Timeline Group ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 373,839 $12.4M 0.01% +38,026 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 365,972 $12.2M 0.01% +155,594 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 305,979 $10.2M <0.01% +253,861 13F-HR Timeline Group Merck & Co., Inc. in group Merck & Co., Inc. More: the full row for Merck & Co., Inc. 272,351 $9.04M 1.72% new 13F-HR Timeline Group ACUTA CAPITAL PARTNERS, LLC More: the full row for ACUTA CAPITAL PARTNERS, LLC 270,251 $8.97M 6.25% +826 13F-HR Timeline AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 244,669 $8.12M <0.01% new 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 237,827 $7.9M 0.01% -454,284 13F-HR Timeline Group KVP Capital Advisors, LP More: the full row for KVP Capital Advisors, LP 226,575 $7.52M 5.52% 0 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 208,512 $6.92M <0.01% -184,359 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 201,688 $6.7M 0.01% +136,512 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 175,246 $5.82M <0.01% -47,388 13F-HR Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 167,997 $5.58M <0.01% new 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 159,627 $5.32M <0.01% new 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 149,216 $4.95M <0.01% +122,029 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 125,933 $4.18M <0.01% +92,767 13F-HR Timeline Group Seven Fleet Capital Management LP More: the full row for Seven Fleet Capital Management LP 159,118 $3.79M 0.63% new 13F-HR Timeline Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 106,610 $3.54M <0.01% new 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 101,965 $3.39M <0.01% -15,572 13F-HR Timeline Group MACKENZIE FINANCIAL CORP More: the full row for MACKENZIE FINANCIAL CORP 94,767 $3.15M <0.01% new 13F-HR Timeline RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 86,324 $2.87M <0.01% -11,500 13F-HR Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 57,305 $1.9M <0.01% +40,140 13F-HR Timeline Group Y-Intercept (Hong Kong) Ltd More: the full row for Y-Intercept (Hong Kong) Ltd 55,879 $1.86M 0.04% new 13F-HR Timeline Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 55,539 $1.84M <0.01% new 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 52,169 $1.73M 0.02% +43,966 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 49,302 $1.64M <0.01% +38,725 13F-HR Timeline Group Sigma Planning Corp More: the full row for Sigma Planning Corp 45,020 $1.49M 0.04% +32,500 13F-HR Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 41,369 $1.37M <0.01% new 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 36,954 $1.23M <0.01% +36,815 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 36,140 $1.2M <0.01% +17,267 13F-HR Timeline Group Fisher Asset Management, LLC More: the full row for Fisher Asset Management, LLC 35,295 $1.17M <0.01% 0 13F-HR Timeline Elmind Capital, LP More: the full row for Elmind Capital, LP 32,037 $1.06M 0.27% new 13F-HR Timeline D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 30,128 $1M <0.01% new 13F-HR Timeline Group Trexquant Investment LP More: the full row for Trexquant Investment LP 27,636 $918K 0.01% -6,707 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 27,383 $909K <0.01% +27,272 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 20,628 $685K <0.01% new 13F-HR Timeline GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 19,749 $656K 0.04% -6,073 13F-HR Timeline SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 16,387 $544K <0.01% new 13F-HR Timeline Group Informed Momentum Co LLC More: the full row for Informed Momentum Co LLC 16,232 $539K 0.05% new 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 15,563 $517K <0.01% new 13F-HR Timeline Group RBF Capital, LLC More: the full row for RBF Capital, LLC 15,272 $507K 0.02% 0 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 13,597 $452K <0.01% new 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 13,544 $450K <0.01% new 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 12,356 $410K <0.01% +1,827 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 10,800 $359K <0.01% new 13F-HR Timeline Group MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 9,401 $312K <0.01% new 13F-HR Timeline Group Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 9,306 $309K <0.01% new 13F-HR Timeline Group Integrated Quantitative Investments LLC More: the full row for Integrated Quantitative Investments LLC 8,939 $297K 0.05% new 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 8,426 $280K <0.01% -76,476 13F-HR Timeline Group Lighthouse Investment Partners, LLC in group Lighthouse Investment Partner… More: the full row for Lighthouse Investment Partners, LLC 8,368 $278K 0.01% new 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 7,456 $248K <0.01% -11,389 13F-HR Timeline Group MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. in group Mirae Asset Global Investment… More: the full row for MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 7,313 $243K <0.01% new 13F-HR Timeline Group ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 7,300 $242K <0.01% new 13F-HR Timeline STATE BOARD OF ADMINISTRATION OF FLORID… More: the full row for STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 7,001 $232K <0.01% new 13F-HR Timeline Persistent Asset Partners Ltd More: the full row for Persistent Asset Partners Ltd 6,569 $218K 0.07% -842 13F-HR Timeline Verdad Advisers, LP More: the full row for Verdad Advisers, LP 6,400 $212K 0.2% new 13F-HR Timeline HSBC HOLDINGS PLC in group HSBC HOLDINGS PLC More: the full row for HSBC HOLDINGS PLC 6,234 $206K <0.01% new 13F-HR Timeline Group NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 5,600 $186K <0.01% new 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 4,704 $156K <0.01% new 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 3,462 $115K <0.01% new 13F-HR Timeline Group State of Wyoming More: the full row for State of Wyoming 1,618 $53.7K 0.01% new 13F-HR Timeline Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 1,448 $48.1K <0.01% new 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 1,339 $44.5K <0.01% +289 13F-HR Timeline Group Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 1,275 $42.3K <0.01% new 13F-HR Timeline Group FNY Investment Advisers, LLC More: the full row for FNY Investment Advisers, LLC 1,000 $33K 0.01% 0 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 866 $28.8K <0.01% new 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 687 $23K <0.01% +675 13F-HR Timeline Group Owl Creek Wealth Partners LLC More: the full row for Owl Creek Wealth Partners LLC 491 $16.3K <0.01% 0 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 281 $9.33K <0.01% new 13F-HR Timeline CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 220 $7.3K <0.01% new 13F-HR/A Timeline Quantbot Technologies LP More: the full row for Quantbot Technologies LP 201 $6.67K <0.01% new 13F-HR Timeline Physician Wealth Advisors, Inc. More: the full row for Physician Wealth Advisors, Inc. 182 $6.04K <0.01% 0 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 100 $3.32K <0.01% -1,180 13F-HR Timeline Group PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 62 $2.06K <0.01% 0 13F-HR Timeline Group NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 44 $1.46K <0.01% 0 13F-HR Timeline Avion Wealth More: the full row for Avion Wealth 46 $1K <0.01% -26 13F-HR Timeline HighMark Wealth Management LLC More: the full row for HighMark Wealth Management LLC 23 $763 <0.01% 0 13F-HR Timeline Arax Advisory Partners More: the full row for Arax Advisory Partners 16 $531 <0.01% -25 13F-HR Timeline FIFTH THIRD BANCORP in group FIFTH THIRD BANK, NATIONAL AS… More: the full row for FIFTH THIRD BANCORP 2 $66 <0.01% 0 13F-HR Timeline Group Steward Partners Investment Advisory, L… More: the full row for Steward Partners Investment Advisory, LLC 2 $66 <0.01% new 13F-HR Timeline Optiver Holding B.V. in group Optiver Holding B.V. More: the full row for Optiver Holding B.V. 2 $66 <0.01% new 13F-HR Timeline Group