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Disclosery

TSHA TAYSHA GENE THERAPIES INC

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COMMON STOCK (common), issuer CIK 1806310

192 managers (195 13F filers) reported a position in TSHA shares at 2025-12-31, 268,983,634 shares in all. 60 filers opened a position and 22 filers sold out during the quarter.

Managers
192
13F filers
195
New
60
Added
62
Reduced
46
Sold out
22
Shares held by filers
268,983,634

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q4 2025

Filers in the available 13F reports with a share position at 2025-12-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
RA CAPITAL MANAGEMENT, L.P.in group RA CAPITAL MANAGEMENT, L.P.23,555,648$130M1.33%013F-HRTimelineGroup
Avoro Capital Advisors LLC21,700,000$119M1.17%013F-HR/ATimeline
BlackRock, Inc.in group BlackRock, Inc.18,643,129$103M<0.01%+2,278,26813F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY18,078,518$99.4M0.01%-1,229,08513F-HR/ATimelineGroup
RTW INVESTMENTS, LP16,398,297$90.2M0.9%-7,955,99413F-HRTimeline
Vestal Point Capital, LP13,750,000$75.6M2.77%+8,250,00013F-HRTimeline
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC13,692,739$75.3M0.01%+309,03113F-HR/ATimelineGroup
FMR LLCin group FMR LLC13,528,366$74.4M<0.01%-1,065,04613F-HRTimelineGroup
VANGUARD GROUP INCin group VANGUARD GROUP INC13,267,805$73M<0.01%+418,19213F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP10,790,084$59.3M<0.01%+3,553,61913F-HRTimelineGroup
Siren, L.L.C.in group Siren, L.L.C.10,129,913$55.7M1.66%-884,82413F-HRTimelineGroup
Octagon Capital Advisors LP8,859,911$48.7M6.1%-207,58913F-HRTimeline
Polar Capital Holdings Plcin group Polar Capital Holdings Plc7,931,403$43.6M0.2%+2,637,52413F-HRTimelineGroup
BARCLAYS PLCin group BARCLAYS PLC5,539,001$30.5M0.01%+390,88913F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC5,387,026$29.6M<0.01%+212,51013F-HRTimelineGroup
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.4,013,635$22.1M0.02%+1,307,20113F-HRTimelineGroup
BAKER BROS. ADVISORS LPin group BAKER BROS. ADVISORS LP4,004,756$22M0.13%013F-HRTimelineGroup
Point72 Asset Management, L.P.in group Point72 Asset Management, L.P.3,868,682$21.3M0.03%-3,462,78813F-HRTimelineGroup
HEALTHCARE OF ONTARIO PENSION PLAN TRUS…3,722,000$20.5M0.03%new13F-HRTimeline
Affinity Asset Advisors, LLC3,300,000$18.1M1.3%+300,00013F-HRTimeline
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC3,178,863$17.5M0.01%-847,25913F-HRTimelineGroup
DEERFIELD MANAGEMENT COMPANY, L.P.in group DEERFIELD MANAGEMENT COMPANY,…2,722,165$15M0.19%-2,663,83513F-HRTimelineGroup
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC2,495,809$13.7M1.03%-339,87113F-HR/ATimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co1,902,978$10.5M<0.01%+56,46813F-HRTimelineGroup
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC1,854,855$10.2M0.01%+1,487,54613F-HRTimelineGroup
NORGES BANK1,837,800$10.1M<0.01%new13F-HRTimeline
B Group, Inc.1,800,556$9.9M7.34%013F-HRTimeline
Casdin Capital, LLC1,500,000$8.25M0.51%new13F-HRTimeline
Invesco Ltd.in group Invesco Ltd.1,332,780$7.33M<0.01%+1,052,98713F-HRTimelineGroup
GordonMD Global Investments LPin group GordonMD Global Investments LP1,330,901$7.32M5.25%13F-HRTimelineGroup
ADAGE CAPITAL PARTNERS GP, L.L.C.in group ADAGE CAPITAL PARTNERS GP, L.…1,328,000$7.3M0.01%-2,000,00013F-HRTimelineGroup
RICE HALL JAMES & ASSOCIATES, LLC1,270,645$6.99M0.38%+692,52713F-HRTimeline
NORTHERN TRUST CORPin group NORTHERN TRUST CORP1,237,987$6.81M<0.01%-479,19113F-HRTimelineGroup
Palo Alto Investors LP1,183,195$6.51M0.91%-62,83813F-HRTimeline
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/1,152,680$6.34M<0.01%-154,60713F-HRTimelineGroup
Aberdeen Group plcin group Aberdeen Group plc1,021,063$5.62M0.01%new13F-HRTimelineGroup
SUPERSTRING CAPITAL MANAGEMENT LP980,768$5.39M2.89%new13F-HRTimeline
Informed Momentum Co LLC823,758$4.53M0.5%new13F-HRTimeline
Quantum Private Wealth, LLC819,715$4.51M1.32%-2,36113F-HRTimeline
SG Americas Securities, LLC781,474$4.3M0.01%+748,52513F-HRTimeline
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO774,412$4.26M<0.01%+478,16813F-HRTimelineGroup
Sands Capital Alternatives, LLC724,873$3.99M0.77%013F-HRTimeline
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…711,235$3.91M<0.01%+143,22913F-HRTimelineGroup
Granahan Investment Management, LLC703,971$3.87M0.17%-412,65813F-HRTimeline
Bank of New York Mellon Corpin group Bank of New York Mellon Corp624,367$3.43M<0.01%-47213F-HRTimelineGroup
UBS Group AGgroup of 2 filers holding550,543$3.03M-88,813Timeline
Nuveen, LLCin group TIAA545,286$3M<0.01%+38,07613F-HRTimelineGroup
Woodline Partners LP500,000$2.75M0.01%013F-HRTimeline
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP490,472$2.7M<0.01%+145,30913F-HRTimelineGroup
TWO SIGMA INVESTMENTS, LPgroup of 2 filers holding490,707$2.7M+424,602Timeline
Squarepoint Ops LLCin group Squarepoint Ops LLC471,577$2.59M0.01%+273,22513F-HRTimelineGroup
Ally Bridge Group (NY) LLC457,132$2.51M3.99%-1,440,98013F-HRTimeline
ACUTA CAPITAL PARTNERS, LLC454,827$2.5M1.7%013F-HRTimeline
HRT FINANCIAL LP409,254$2.25M0.01%new13F-HRTimeline
SPHERA FUNDS MANAGEMENT LTD.in group SPHERA FUNDS MANAGEMENT LTD.368,146$2.02M0.42%-40,00013F-HRTimelineGroup
Rafferty Asset Management, LLC344,784$1.9M0.01%+104,99913F-HRTimeline
BOOTHBAY FUND MANAGEMENT, LLC309,481$1.7M0.04%-106,12613F-HRTimeline
Hennion & Walsh Asset Management, Inc.308,457$1.7M0.06%new13F-HRTimeline
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN305,086$1.68M<0.01%+159,98813F-HRTimelineGroup
Capricorn Fund Managers Ltd300,000$1.65M0.4%new13F-HRTimeline
Focus Partners Wealthin group Focus Partners Wealth295,516$1.63M<0.01%new13F-HRTimelineGroup
AMERICAN CENTURY COMPANIES INCin group AMERICAN CENTURY COMPANIES INC288,535$1.59M<0.01%+249,97913F-HRTimelineGroup
Ensign Peak Advisors, Inc275,111$1.51M<0.01%new13F-HR/ATimeline
Swiss National Bank268,800$1.48M<0.01%new13F-HRTimeline
ORACLE INVESTMENT MANAGEMENT INC265,000$1.46M0.96%new13F-HRTimeline
NOMURA HOLDINGS INCin group NOMURA ASSET MANAGEMENT CO LTD259,339$1.43M<0.01%new13F-HRTimelineGroup
RHUMBLINE ADVISERS257,440$1.42M<0.01%-31,41913F-HRTimeline
ALPS ADVISORS INCin group ALPS ADVISORS INC224,920$1.24M0.01%new13F-HRTimelineGroup
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC218,185$1.2M<0.01%+181,68513F-HRTimelineGroup
GSA CAPITAL PARTNERS LLP208,016$1.14M0.1%-269,73313F-HRTimeline
VICTORY CAPITAL MANAGEMENT INC195,764$1.08M<0.01%+170,16413F-HRTimeline
STEMPOINT CAPITAL LP182,130$1M0.17%-657,53913F-HRTimeline
WEXFORD CAPITAL LP180,853$995K0.26%+177,35313F-HRTimeline
ALLIANCEBERNSTEIN L.P.179,640$988K<0.01%013F-HRTimeline
Palumbo Wealth Management LLC178,007$979K0.24%+20,65413F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS172,482$949K<0.01%+126,44813F-HRTimelineGroup
RENAISSANCE TECHNOLOGIES LLC171,100$941K<0.01%new13F-HRTimeline
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC168,862$929K<0.01%+17,86213F-HRTimelineGroup
Seven Fleet Capital Management LP167,223$920K0.62%13F-HR/ATimeline
Privium Fund Management B.V.164,900$907K0.17%+30,00013F-HRTimeline
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC163,146$897K<0.01%-393,63913F-HRTimelineGroup
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\160,779$884K<0.01%+37,98013F-HRTimelineGroup
POLEN CAPITAL MANAGEMENT LLC156,586$861K<0.01%new13F-HRTimeline
Chicago Partners Investment Group LLC166,541$776K0.02%+2,50413F-HRTimeline
CALIFORNIA STATE TEACHERS RETIREMENT SY…138,580$762K<0.01%+128,20713F-HRTimeline
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding135,950$751K+14,380Timeline
Legal & General Group Plcin group Legal & General Group Plc133,146$732K<0.01%+109,99713F-HRTimelineGroup
PROFUND ADVISORS LLC128,590$707K0.02%+75,22413F-HRTimeline
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…124,975$687K<0.01%+103,23313F-HRTimelineGroup
PRICE T ROWE ASSOCIATES INC /MD/121,814$670K<0.01%+7,97913F-HRTimeline
MetLife Investment Management, LLCin group MetLife Investment Management…113,266$623K<0.01%-13,77813F-HRTimelineGroup
STATE OF WISCONSIN INVESTMENT BOARD113,178$622K<0.01%+70,22913F-HRTimeline
FRANKLIN RESOURCES INCin group Franklin Resources108,399$596K<0.01%013F-HRTimelineGroup
PRUDENTIAL FINANCIAL INCin group PRUDENTIAL FINANCIAL INC86,730$477K<0.01%+58,38513F-HRTimelineGroup
INTECH INVESTMENT MANAGEMENT LLC71,069$391K<0.01%+2,44313F-HRTimeline
CANADA PENSION PLAN INVESTMENT BOARD68,900$379K<0.01%new13F-HRTimeline
JANUS HENDERSON GROUP PLCin group Janus Henderson69,000$378K<0.01%new13F-HRTimelineGroup
NEW YORK STATE COMMON RETIREMENT FUND67,500$371K<0.01%-10013F-HRTimeline
Zurcher Kantonalbank (Zurich Cantonalba…67,477$371K<0.01%new13F-HRTimeline
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …67,085$369K<0.01%-2,77213F-HRTimelineGroup
RED REEF ADVISORS LLC65,950$363K0.37%13F-HRTimeline
Creative Planningin group Creative Planning63,235$348K<0.01%+11,00913F-HRTimelineGroup
CITIGROUP INCin group CITIGROUP INC63,015$347K<0.01%+29,52013F-HRTimelineGroup
Police & Firemen's Retirement System of…57,168$314K<0.01%013F-HRTimeline
SummitTX Capital, L.P.56,595$311K0.01%new13F-HRTimeline
COMMONWEALTH EQUITY SERVICES, LLC55,657$306K<0.01%-2,60013F-HRTimeline
Mitsubishi UFJ Asset Management Co., Lt…in group Mitsubishi UFJ Trust & Bankin…57,975$304K<0.01%-22,75713F-HRTimelineGroup
Abacus Wealth Partners, LLC55,173$303K0.03%new13F-HRTimeline
VOLORIDGE INVESTMENT MANAGEMENT, LLC54,785$301K<0.01%new13F-HRTimeline
LANARK FINANCIAL, INC.52,955$291K0.02%new13F-HRTimeline
ProShare Advisors LLC52,463$289K<0.01%+6,42413F-HRTimeline
SEI INVESTMENTS COin group SEI INVESTMENTS CO47,858$263K<0.01%new13F-HRTimelineGroup
Militia Capital Partners, LPin group Militia Capital Management LLC46,500$256K0.1%-20,30013F-HR/ATimelineGroup
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…45,946$253K0.07%+3,00813F-HRTimelineGroup
Williams & Novak Wealth Management, LLC45,000$248K0.19%013F-HRTimeline
Redwood Wealth Management Group, LLC44,700$246K0.1%new13F-HRTimeline
China Universal Asset Management Co., L…44,635$245K0.02%-3,18213F-HRTimeline
GROUP ONE TRADING LLC44,195$243K0.01%+42,44113F-HRTimeline
FIRST MANHATTAN CO. LLC.43,500$239K<0.01%+15,00013F-HRTimeline
Allianz Asset Management GmbHin group Allianz SE42,400$233K<0.01%new13F-HRTimelineGroup
Balyasny Asset Management L.P.in group Balyasny Asset Management42,070$231K<0.01%new13F-HRTimelineGroup
AXQ CAPITAL, LP37,804$208K0.05%-11,87313F-HRTimeline
ARIZONA STATE RETIREMENT SYSTEM37,677$207K<0.01%new13F-HRTimeline
J. Goldman & Co LP33,750$186K0.01%new13F-HRTimeline
LOS ANGELES CAPITAL MANAGEMENT LLC32,918$162K<0.01%new13F-HRTimeline
KLP KAPITALFORVALTNING AS29,300$161K<0.01%new13F-HRTimeline
Leonteq Securities AG27,999$154K0.01%013F-HRTimeline
Allegheny Financial Group26,350$145K0.02%+11,35013F-HRTimeline
Caitong International Asset Management …25,577$141K0.03%+22,37313F-HR/ATimeline
Jefferies Financial Group Inc.in group Jefferies Financial Group Inc.25,000$138K<0.01%-2,131,64213F-HRTimelineGroup
Ethic Inc.22,735$125K<0.01%-3,04913F-HRTimeline
Cambridge Investment Research Advisors,…22,080$121K<0.01%-1,61013F-HRTimeline
Cetera Investment Advisers21,154$116K<0.01%+4,99213F-HRTimeline
MANGROVE PARTNERS IM, LLC20,546$113K0.01%new13F-HRTimeline
ENVESTNET ASSET MANAGEMENT INCin group ENVESTNET ASSET MANAGEMENT INC20,178$111K<0.01%new13F-HRTimelineGroup
Lee Financial Co20,000$110K0.01%013F-HRTimeline
TEACHER RETIREMENT SYSTEM OF TEXAS19,837$109K<0.01%new13F-HRTimeline
SIMPLEX TRADING, LLC19,782$109K<0.01%+17,06013F-HRTimeline
Pictet Asset Management Holding SAin group Pictet Asset Management Holdi…19,318$106K<0.01%new13F-HRTimelineGroup
Scientech Research LLC18,176$100K0.06%new13F-HRTimeline
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC18,144$99.8K<0.01%new13F-HRTimelineGroup
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…17,672$97.2K<0.01%+2,00013F-HRTimelineGroup
XPONANCE LLC17,218$94.7K<0.01%+64313F-HRTimeline
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…16,929$93.1K<0.01%-1,23613F-HRTimelineGroup
CAPTRUST FINANCIAL ADVISORS15,113$83.1K<0.01%new13F-HRTimeline
Legato Capital Management LLC15,023$82.6K0.01%new13F-HRTimeline
CIBC WORLD MARKETS CORPin group CIBC Bancorp USA Inc.14,612$80.4K<0.01%13F-HRTimelineGroup
BANK OF MONTREAL /CAN/in group BANK OF MONTREAL /CAN/13,708$75.4K<0.01%+4013F-HRTimelineGroup
MACKENZIE FINANCIAL CORP13,308$75.2K<0.01%+2,09413F-HRTimeline
CWM, LLCin group CWM, LLC13,093$72K<0.01%+20813F-HRTimelineGroup
PRINCIPAL FINANCIAL GROUP INCin group PRINCIPAL FINANCIAL GROUP INC12,823$70.5K<0.01%-3,42813F-HRTimelineGroup
CIBC Asset Management Inc11,959$65.8K<0.01%new13F-HRTimeline
PANAGORA ASSET MANAGEMENT INC11,574$63.7K<0.01%new13F-HRTimeline
GUGGENHEIM CAPITAL LLCin group GUGGENHEIM CAPITAL LLC11,111$61.1K<0.01%new13F-HRTimelineGroup
OPPENHEIMER ASSET MANAGEMENT INC.in group OPPENHEIMER ASSET MANAGEMENT …10,773$59.3K<0.01%new13F-HRTimelineGroup
Capital Investment Advisors, LLC10,000$55K<0.01%013F-HRTimeline
ST GERMAIN D J CO INCin group ST GERMAIN D J CO INC9,633$53K<0.01%013F-HRTimelineGroup
AMALGAMATED BANK6,939$38K<0.01%+1,40513F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA6,302$34K<0.01%-577,07313F-HRTimelineGroup
NISA INVESTMENT ADVISORS, LLC5,512$30.3K<0.01%-36013F-HRTimeline
GF FUND MANAGEMENT CO. LTD.5,383$29.6K<0.01%-48613F-HRTimeline
Rockefeller Capital Management L.P.in group Rockefeller Capital Managemen…5,000$27.5K<0.01%013F-HR/ATimelineGroup
Chung Wu Investment Group, LLC4,000$22K0.02%new13F-HRTimeline
Capital Advisors, Ltd. LLC77$12K<0.01%-213F-HRTimeline
INTERNATIONAL ASSETS INVESTMENT MANAGEM…2,000$11K<0.01%new13F-HRTimeline
Sterling Capital Management LLC1,411$7.76K<0.01%+89613F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…1,054$5.8K<0.01%-25413F-HRTimelineGroup
Optiver Holding B.V.in group Optiver Holding B.V.934$5.14K<0.01%-1,33513F-HRTimelineGroup
US BANCORP \DE\in group US BANCORP \DE\912$5.02K<0.01%013F-HRTimelineGroup
Daiwa Securities Group Inc.in group Daiwa Securities Group Inc.691$4K<0.01%-21,12913F-HRTimelineGroup
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…475$2.61K<0.01%-6,13213F-HRTimelineGroup
Essential Partners LLC327$1.8K<0.01%013F-HRTimeline
Parallel Advisors, LLC280$1.54K<0.01%013F-HRTimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.277$1.53K<0.01%+14313F-HRTimelineGroup
GAMMA Investing LLC276$1.52K<0.01%new13F-HRTimeline
Sound Income Strategies, LLC325$1.48K<0.01%new13F-HRTimeline
Allworth Financial LP223$1.23K<0.01%+813F-HRTimeline
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…91$501<0.01%013F-HRTimelineGroup
Bare Financial Services, Inc85$468<0.01%new13F-HRTimeline
ROTHSCHILD INVESTMENT LLC70$385<0.01%new13F-HRTimeline
SIGNATUREFD, LLC60$330<0.01%new13F-HRTimeline
Farther Finance Advisors, LLC55$303<0.01%013F-HRTimeline
SageView Advisory Group, LLC49$270<0.01%new13F-HRTimeline
True Wealth Design, LLC30$165<0.01%013F-HRTimeline
Arax Advisory Partners21$116<0.01%new13F-HRTimeline
Tradewinds Capital Management, LLC20$110<0.01%new13F-HRTimeline
SBI Securities Co., Ltd.15$83<0.01%-113F-HRTimeline
IFP Advisors, Inc14$77<0.01%013F-HRTimeline
MAI Capital Management8$44<0.01%new13F-HRTimeline
NORTHWESTERN MUTUAL WEALTH MANAGEMENT COin group NORTHWESTERN MUTUAL INVESTMEN…8$44<0.01%new13F-HR/ATimelineGroup
ASSETMARK, INCin group ASSETMARK, INC8$44<0.01%new13F-HRTimelineGroup
Hughes Financial Services, LLC4$22<0.01%new13F-HRTimeline