13F-HR filed by Palo Alto Investors LP
Palo Alto Investors LP filed this 13F-HR for the quarter ended 2025-12-31, filed 2026-02-17, with 49 holding rows worth $718,352,025.
- Accession
- 0001306923-26-000002
- Filer
- CIK 1306923
- Filed
- 2026-02-17
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q4 2025
A holdings report, 49 entries on the cover page, a total value of $718,352,025 stated on the cover page (in dollars after the unit check, H1), rows summing to $718,352,025 with VALUE read as dollars as filed, 13F file number 028-11013. The quarter's positions are built on this report. The resolved quarter.
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| INSMED INC COM PAR $.01 | 457669307 | Stock | 489,482 | $85,189,447 | dollars as filed | |
| AMICUS THERAPEUTICS INC | 03152W109 | COM | 5,205,767 | $74,130,122 | dollars as filed | |
| PTC THERAPEUTICS INC | 69366J200 | COM | 903,916 | $68,661,459 | dollars as filed | |
| ACADIA PHARMACEUTICALS INC | 004225108 | COM | 2,484,031 | $66,348,468 | dollars as filed | |
| BIOMARIN PHARMACEUTICAL INC | 09061G101 | COM | 746,256 | $44,349,994 | dollars as filed | |
| ANAPTYSBIO INC | 032724106 | COM | 690,032 | $33,452,751 | dollars as filed | |
| BIOGEN INC COM | 09062X103 | Stock | 183,571 | $32,306,660 | dollars as filed | |
| DYNE THERAPEUTICS INC COM | 26818M108 | Stock | 1,472,197 | $28,796,173 | dollars as filed | |
| UNITED THERAPEUTICS CORP DEL COM | 91307C102 | Stock | 58,186 | $28,351,129 | dollars as filed | |
| DISC MEDICINE INC COM | 254604101 | Stock | 317,456 | $25,209,181 | dollars as filed | |
| IOVANCE BIOTHERAPEUTICS INC | 462260100 | COM | 7,116,676 | $19,428,525 | dollars as filed | |
| NOVOCURE LTD | G6674U108 | ORD SHS | 1,298,964 | $16,795,605 | dollars as filed | |
| SYNDAX PHARMACEUTICALS INC | 87164F105 | COM | 794,507 | $16,692,592 | dollars as filed | |
| GOSSAMER BIO INC COM | 38341P102 | Stock | 4,471,592 | $13,861,935 | dollars as filed | |
| COMPASS THERAPEUTICS INC | 20454B104 | COM | 2,532,419 | $13,599,090 | dollars as filed | |
| PROTHENA CORP PLC SHS | G72800108 | Stock | 1,320,510 | $12,610,871 | dollars as filed | |
| MIRUM PHARMACEUTICALS INC | 604749101 | COM | 156,421 | $12,355,695 | dollars as filed | |
| ANNEXON INC | 03589W102 | COM | 2,384,192 | $11,968,644 | dollars as filed | |
| ULTRAGENYX PHARMACEUTICAL IN | 90400D108 | COM | 461,294 | $10,609,762 | dollars as filed | |
| DENALI THERAPEUTICS INC COM | 24823R105 | Stock | 641,239 | $10,586,856 | dollars as filed | |
| CAREDX INC | 14167L103 | COM | 478,220 | $9,009,665 | dollars as filed | |
| EHEALTH INC | 28238P109 | COM | 1,531,429 | $7,044,573 | dollars as filed | |
| ALKERMES PLC | G01767105 | SHS | 242,560 | $6,786,829 | dollars as filed | |
| CAPRICOR THERAPEUTICS INC | 14070B309 | COMMON STOCK | 226,304 | $6,531,133 | dollars as filed | |
| TAYSHA GENE THERAPIES INC | 877619106 | COMMON STOCK | 1,183,195 | $6,507,573 | dollars as filed | |
| ALIGN TECHNOLOGY INC COM | 016255101 | Stock | 41,520 | $6,483,348 | dollars as filed | |
| AGIOS PHARMACEUTICALS INC | 00847X104 | COM | 212,499 | $5,784,223 | dollars as filed | |
| BICARA THERAPEUTICS INC | 055477103 | COM | 298,575 | $5,025,017 | dollars as filed | |
| NUVATION BIO INC COM CL A | 67080N101 | Stock | 538,079 | $4,821,188 | dollars as filed | |
| ACLARIS THERAPEUTICS INC COM | 00461U105 | Stock | 1,566,840 | $4,716,188 | dollars as filed | |
| XENON PHARMACEUTICALS INC COM | 98420N105 | Stock | 96,519 | $4,325,982 | dollars as filed | |
| TRAVERE THERAPEUTICS INC | 89422G107 | COM | 110,719 | $4,230,573 | dollars as filed | |
| EDWARDS LIFESCIENCES CORP COM | 28176E108 | Stock | 33,640 | $2,867,810 | dollars as filed | |
| NEUROCRINE BIOSCIENCES INC | 64125C109 | COM | 18,117 | $2,569,534 | dollars as filed | |
| STOKE THERAPEUTICS INC | 86150R107 | COM | 72,022 | $2,285,978 | dollars as filed | |
| CRISPR THERAPEUTICS AG NAMEN AKT | H17182108 | Stock | 41,226 | $2,161,891 | dollars as filed | |
| BIONTECH SE SPONSORED ADS | 09075V102 | ADR | 19,614 | $1,867,253 | dollars as filed | |
| ORUKA THERAPEUTICS INC COM | 687604108 | Stock | 59,985 | $1,818,145 | dollars as filed | |
| BICYCLE THERAPEUTICS PLC-ADR | 088786108 | SPONSORED ADS | 221,071 | $1,565,183 | dollars as filed | |
| PYXIS ONCOLOGY INC COMMON STOCK | 747324101 | Stock | 1,037,421 | $1,193,034 | dollars as filed | |
| ALDEYRA THERAPEUTICS INC | 01438T106 | COM | 225,465 | $1,167,909 | dollars as filed | |
| HUMANA INC COM | 444859102 | Stock | 3,985 | $1,020,678 | dollars as filed | |
| INSPIRE MED SYS INC COM | 457730109 | Stock | 8,772 | $809,042 | dollars as filed | |
| COMPASS PATHWAYS PLC | 20451W101 | SPONSORED ADS | 115,616 | $797,750 | dollars as filed | |
| UROGEN PHARMA LTD | M96088105 | COMMON STOCK | 24,500 | $573,790 | dollars as filed | |
| ABEONA THERAPEUTICS INC | 00289Y206 | COM NEW | 108,865 | $573,719 | dollars as filed | |
| PROQR THERAPEUTICS NV | N71542109 | SHS EURO | 188,807 | $381,390 | dollars as filed | |
| GENERATION BIO CO | 37148K209 | COM NEW | 15,047 | $85,467 | dollars as filed | |
| AKARI THERAPEUTICS PLC | 00972G207 | SPONSORED ADR | 146,024 | $42,201 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001306923-26-000002 | this filing | 2026-02-17 | acceptance time not in the bulk data set |