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Disclosery

TSHA TAYSHA GENE THERAPIES INC

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COMMON STOCK (common), issuer CIK 1806310

154 managers (155 13F filers) reported a position in TSHA shares at 2025-09-30, 264,620,161 shares in all. 27 filers opened a position and 20 filers sold out during the quarter.

Managers
154
13F filers
155
New
27
Added
61
Reduced
34
Sold out
20
Shares held by filers
264,620,161

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q3 2025

Filers in the available 13F reports with a share position at 2025-09-30, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
RTW INVESTMENTS, LP24,354,291$79.6M0.98%-667,29313F-HRTimeline
RA CAPITAL MANAGEMENT, L.P.in group RA CAPITAL MANAGEMENT, L.P.23,555,648$77M0.95%013F-HRTimelineGroup
Avoro Capital Advisors LLC21,700,000$71M0.92%013F-HRTimeline
MORGAN STANLEYin group MORGAN STANLEY19,307,603$63.1M<0.01%+2,442,52113F-HR/ATimelineGroup
BlackRock, Inc.in group BlackRock, Inc.16,364,861$53.5M<0.01%+3,061,08613F-HRTimelineGroup
FMR LLCin group FMR LLC14,593,412$47.7M<0.01%-1,034,41013F-HRTimelineGroup
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC13,383,708$43.8M0.01%+796,00813F-HRTimelineGroup
VANGUARD GROUP INCin group VANGUARD GROUP INC12,849,613$42M<0.01%+1,955,48613F-HRTimelineGroup
Siren, L.L.C.in group Siren, L.L.C.11,014,737$36M1.41%013F-HRTimelineGroup
Octagon Capital Advisors LP9,067,500$29.7M4.63%-3,525,00013F-HRTimeline
Point72 Asset Management, L.P.in group Point72 Asset Management, L.P.7,331,470$24M0.05%+13,85613F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP7,236,465$23.7M<0.01%+2,098,15513F-HRTimelineGroup
Vestal Point Capital, LP5,500,000$18M0.82%+2,500,00013F-HRTimeline
DEERFIELD MANAGEMENT COMPANY, L.P.in group DEERFIELD MANAGEMENT COMPANY,…5,386,000$17.6M0.27%013F-HRTimelineGroup
Polar Capital Holdings Plcin group Polar Capital Holdings Plc5,293,879$17.3M0.08%+293,87913F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC5,174,516$16.9M<0.01%+1,380,94413F-HRTimelineGroup
BARCLAYS PLCin group BARCLAYS PLC5,148,112$16.8M0.01%+4,697,61113F-HR/ATimelineGroup
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC4,026,122$13.2M0.01%+1,090,39413F-HRTimelineGroup
BAKER BROS. ADVISORS LPin group BAKER BROS. ADVISORS LP4,004,756$13.1M0.09%013F-HRTimelineGroup
TYBOURNE CAPITAL MANAGEMENT (HK) LTD3,700,000$12.1M39.11%-395,00013F-HRTimeline
ADAGE CAPITAL PARTNERS GP, L.L.C.in group ADAGE CAPITAL PARTNERS GP, L.…3,328,000$10.9M0.02%-1,511,00013F-HRTimelineGroup
Affinity Asset Advisors, LLC3,000,000$9.81M0.91%+2,800,00013F-HRTimeline
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC2,835,680$9.27M0.92%-174,19013F-HRTimelineGroup
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.2,706,434$8.85M0.01%+2,304,92513F-HRTimelineGroup
Jefferies Financial Group Inc.in group Jefferies Financial Group Inc.2,156,642$7.05M0.06%-8,157,09113F-HRTimelineGroup
TORONTO DOMINION BANKin group TORONTO DOMINION BANK1,923,962$6.29M0.01%-2,804,84413F-HRTimelineGroup
Ally Bridge Group (NY) LLC1,898,112$6.21M5.2%new13F-HRTimeline
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co1,846,510$6.04M<0.01%+1,354,80113F-HRTimelineGroup
B Group, Inc.1,800,556$5.89M5.63%013F-HRTimeline
NORTHERN TRUST CORPin group NORTHERN TRUST CORP1,717,178$5.62M<0.01%+388,43713F-HRTimelineGroup
GREAT POINT PARTNERS LLC1,500,000$4.91M2.05%013F-HRTimeline
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/1,307,287$4.27M<0.01%+576,55913F-HR/ATimelineGroup
Palo Alto Investors LP1,246,033$4.07M0.75%013F-HRTimeline
Granahan Investment Management, LLC1,116,629$3.65M0.15%+158,13613F-HRTimeline
TANG CAPITAL MANAGEMENT LLCin group TANG CAPITAL MANAGEMENT LLC900,000$2.94M0.11%013F-HRTimelineGroup
STEMPOINT CAPITAL LP839,669$2.75M0.55%-364,27213F-HRTimeline
Quantum Private Wealth, LLC822,076$2.69M0.79%+6,10013F-HRTimeline
Sands Capital Alternatives, LLC724,873$2.37M0.52%013F-HRTimeline
Alphabet Inc.in group Alphabet Inc.640,882$2.1M0.09%013F-HRTimelineGroup
UBS Group AGin group UBS Group AG639,356$2.09M<0.01%+378,11713F-HRTimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp624,839$2.04M<0.01%+166,18013F-HRTimelineGroup
Anson Funds Management LPin group Anson Funds Management LP603,500$1.97M0.22%-200,00013F-HRTimelineGroup
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA583,375$1.91M<0.01%+88,06413F-HRTimelineGroup
RICE HALL JAMES & ASSOCIATES, LLC578,118$1.89M0.1%new13F-HRTimeline
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…568,006$1.86M<0.01%-67,96213F-HRTimelineGroup
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC556,785$1.82M<0.01%+419,79113F-HRTimelineGroup
Nuveen, LLCin group TIAA507,210$1.66M<0.01%+42,06613F-HRTimelineGroup
Woodline Partners LP500,000$1.64M0.01%-500,25413F-HRTimeline
GSA CAPITAL PARTNERS LLP477,749$1.56M0.13%+433,05913F-HRTimeline
MARSHALL WACE, LLPin group MARSHALL WACE, LLP476,865$1.56M<0.01%+397,36713F-HRTimelineGroup
ACUTA CAPITAL PARTNERS, LLC454,827$1.49M1.54%-30,84213F-HRTimeline
BOOTHBAY FUND MANAGEMENT, LLC415,607$1.36M0.03%new13F-HRTimeline
SPHERA FUNDS MANAGEMENT LTD.in group SPHERA FUNDS MANAGEMENT LTD.408,146$1.33M0.32%-11,85413F-HRTimelineGroup
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC367,309$1.2M<0.01%-161,68413F-HRTimelineGroup
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP345,163$1.13M<0.01%new13F-HRTimelineGroup
NorthCoast Asset Management LLC298,667$977K<0.01%013F-HRTimeline
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO296,244$969K<0.01%+73,59513F-HR/ATimelineGroup
RHUMBLINE ADVISERS288,859$945K<0.01%+55,60313F-HRTimeline
Invesco Ltd.in group Invesco Ltd.279,793$915K<0.01%+76,12213F-HRTimelineGroup
Chicago Partners Investment Group LLC164,037$819K0.02%+27113F-HRTimeline
Rafferty Asset Management, LLC239,785$784K<0.01%+121,10213F-HRTimeline
Squarepoint Ops LLCin group Squarepoint Ops LLC198,352$649K<0.01%+98,12613F-HRTimelineGroup
ALLIANCEBERNSTEIN L.P.179,640$587K<0.01%+2013F-HRTimeline
READYSTATE ASSET MANAGEMENT LP161,972$530K0.03%new13F-HRTimeline
Palumbo Wealth Management LLC157,353$515K0.16%new13F-HRTimeline
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC151,000$494K<0.01%+15,23413F-HRTimelineGroup
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN145,098$474K<0.01%+37,86413F-HRTimelineGroup
Privium Fund Management B.V.134,900$441K0.08%013F-HRTimeline
MetLife Investment Management, LLCin group MetLife Investment Management…127,044$415K<0.01%+18,96613F-HRTimelineGroup
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\122,799$402K<0.01%+15,08313F-HRTimelineGroup
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding121,570$396K+14,924Timeline
PRICE T ROWE ASSOCIATES INC /MD/113,835$373K<0.01%+29,23213F-HRTimeline
FRANKLIN RESOURCES INCin group Franklin Resources108,399$354K<0.01%013F-HRTimelineGroup
Mitsubishi UFJ Asset Management Co., Lt…in group Mitsubishi UFJ Trust & Bankin…80,732$264K<0.01%+16113F-HRTimelineGroup
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …69,857$228K<0.01%+8,85213F-HRTimelineGroup
INTECH INVESTMENT MANAGEMENT LLC68,626$224K<0.01%-13,56913F-HRTimeline
NEW YORK STATE COMMON RETIREMENT FUND67,600$221K<0.01%+46,50013F-HRTimeline
Militia Capital Partners, LPin group Militia Capital Management LLC66,800$218K0.1%013F-HR/ATimelineGroup
TWO SIGMA INVESTMENTS, LPin group TWO SIGMA INVESTMENTS, LP66,105$216K<0.01%+33,42313F-HRTimelineGroup
COMMONWEALTH EQUITY SERVICES, LLC58,257$191K<0.01%-1,77913F-HRTimeline
Police & Firemen's Retirement System of…57,168$187K<0.01%+11,49013F-HRTimeline
Engineers Gate Manager LP53,483$175K<0.01%-11,13413F-HRTimeline
PROFUND ADVISORS LLC53,366$175K0.01%+26,76713F-HRTimeline
Jain Global LLC52,608$172K<0.01%new13F-HRTimeline
Creative Planningin group Creative Planning52,226$171K<0.01%+24513F-HRTimelineGroup
AXQ CAPITAL, LP49,677$162K0.06%-7,32313F-HRTimeline
Virtu Financial LLCin group Virtu Financial LLC48,123$157K0.01%new13F-HRTimelineGroup
China Universal Asset Management Co., L…47,817$156K0.01%-4,71013F-HRTimeline
Quadrature Capital Ltdin group Quadrature Capital Ltd47,328$154K<0.01%-114,61213F-HRTimelineGroup
Brevan Howard Capital Management LPin group Brevan Howard Capital Managem…46,643$153K<0.01%new13F-HRTimelineGroup
ProShare Advisors LLC46,039$151K<0.01%+2,29313F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS46,034$151K<0.01%+27,44313F-HRTimelineGroup
Williams & Novak Wealth Management, LLC45,000$147K0.11%013F-HRTimeline
STATE OF WISCONSIN INVESTMENT BOARD42,949$140K<0.01%new13F-HRTimeline
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…42,938$140K0.04%+7,45413F-HRTimelineGroup
AMERICAN CENTURY COMPANIES INCin group AMERICAN CENTURY COMPANIES INC38,556$126K<0.01%new13F-HRTimelineGroup
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC36,500$119K<0.01%-10,66913F-HRTimelineGroup
CITIGROUP INCin group CITIGROUP INC33,495$110K<0.01%-96,82213F-HRTimelineGroup
SG Americas Securities, LLC32,949$108K<0.01%-460,35213F-HRTimeline
FIRST MANHATTAN CO. LLC.28,500$93.2K<0.01%013F-HRTimeline
PRUDENTIAL FINANCIAL INCin group PRUDENTIAL FINANCIAL INC28,345$92.7K<0.01%+5,55513F-HRTimelineGroup
Leonteq Securities AG27,999$91.6K<0.01%013F-HRTimeline
Sender Co & Partners, Inc.27,121$88.7K0.03%new13F-HRTimeline
Ethic Inc.25,784$84.3K<0.01%-2,19113F-HRTimeline
VICTORY CAPITAL MANAGEMENT INC25,600$83.7K<0.01%+10813F-HRTimeline
Cambridge Investment Research Advisors,…23,690$77K<0.01%013F-HRTimeline
Legal & General Group Plcin group Legal & General Group Plc23,149$75.7K<0.01%+4,75413F-HRTimelineGroup
CIBC Bancorp USA Inc.in group CIBC Bancorp USA Inc.22,643$74K<0.01%13F-HR/ATimelineGroup
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…21,742$71.1K<0.01%-190,83013F-HRTimelineGroup
Daiwa Securities Group Inc.in group Daiwa Securities Group Inc.21,820$71K<0.01%-2,02113F-HRTimelineGroup
Lee Financial Co20,000$65.4K0.01%013F-HRTimeline
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…18,165$59.4K<0.01%new13F-HRTimelineGroup
XPONANCE LLC16,575$54.2K<0.01%+3,73813F-HRTimeline
DRW Securities, LLC16,389$53.3K<0.01%new13F-HRTimeline
PRINCIPAL FINANCIAL GROUP INCin group PRINCIPAL FINANCIAL GROUP INC16,251$53.1K<0.01%+4,09113F-HRTimelineGroup
Cetera Investment Advisers16,162$52.9K<0.01%new13F-HRTimeline
R Squared Ltd16,094$52.6K0.02%new13F-HRTimeline
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…15,672$51.2K<0.01%013F-HRTimelineGroup
Allegheny Financial Group15,000$49K0.01%new13F-HRTimeline
BANK OF MONTREAL /CAN/in group BANK OF MONTREAL /CAN/13,668$44.7K<0.01%new13F-HRTimelineGroup
CWM, LLCin group CWM, LLC12,885$42K<0.01%-6113F-HRTimelineGroup
Arrowpoint Investment Partners (Singapo…in group Arrowpoint Investment Partner…12,200$39.9K0.06%new13F-HRTimelineGroup
MACKENZIE FINANCIAL CORP11,214$36.7K<0.01%013F-HRTimeline
CALIFORNIA STATE TEACHERS RETIREMENT SY…10,373$33.9K<0.01%-2,26213F-HRTimeline
Aigen Investment Management, LP10,367$33.9K0.01%new13F-HRTimeline
Capital Investment Advisors, LLC10,000$32.7K<0.01%013F-HRTimeline
ST GERMAIN D J CO INCin group ST GERMAIN D J CO INC9,633$31.5K<0.01%+4,33313F-HRTimelineGroup
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…6,607$21.6K<0.01%-10,99913F-HRTimelineGroup
NISA INVESTMENT ADVISORS, LLC5,872$19.2K<0.01%+2,12513F-HRTimeline
GF FUND MANAGEMENT CO. LTD.5,869$19.2K<0.01%+62113F-HRTimeline
AMALGAMATED BANK5,534$18K<0.01%013F-HRTimeline
Rockefeller Capital Management L.P.in group Rockefeller Capital Managemen…5,000$16.4K<0.01%new13F-HRTimelineGroup
FNY Investment Advisers, LLC4,289$14K<0.01%new13F-HRTimeline
WEXFORD CAPITAL LP3,500$11.4K<0.01%new13F-HRTimeline
Caitong International Asset Management …3,204$10.5K0.01%+1,05713F-HRTimeline
SIMPLEX TRADING, LLC2,722$8K<0.01%-54113F-HRTimeline
Optiver Holding B.V.in group Optiver Holding B.V.2,269$7.42K<0.01%+20413F-HRTimelineGroup
GROUP ONE TRADING LLC1,754$5.74K<0.01%new13F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…1,308$4.28K<0.01%+30813F-HRTimelineGroup
Aster Capital Management (DIFC) Ltd1,280$4.19K<0.01%new13F-HRTimeline
US BANCORP \DE\in group US BANCORP \DE\912$2.98K<0.01%-6313F-HRTimelineGroup
Clearstead Advisors, LLC690$2.26K<0.01%013F-HRTimeline
Sterling Capital Management LLC515$1.68K<0.01%+10713F-HRTimeline
Essential Partners LLC327$1.07K<0.01%013F-HRTimeline
Parallel Advisors, LLC280$916<0.01%013F-HRTimeline
Morton Brown Family Wealth, LLC260$850<0.01%013F-HRTimeline
Allworth Financial LP215$704<0.01%new13F-HRTimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.134$426<0.01%013F-HRTimelineGroup
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…91$298<0.01%-11413F-HRTimelineGroup
Farther Finance Advisors, LLC55$180<0.01%new13F-HRTimeline
True Wealth Design, LLC30$99<0.01%013F-HRTimeline
SBI Securities Co., Ltd.16$52<0.01%-6413F-HRTimeline
IFP Advisors, Inc14$46<0.01%013F-HR/ATimeline
Capital Advisors, Ltd. LLC79$00%013F-HRTimelineValue filed as zero, left out of ratios.