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Disclosery

TSHA TAYSHA GENE THERAPIES INC

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COMMON STOCK (common), issuer CIK 1806310

150 managers (151 13F filers) reported a position in TSHA shares at 2025-06-30, 257,713,389 shares in all. 43 filers opened a position and 20 filers sold out during the quarter.

Managers
150
13F filers
151
New
43
Added
48
Reduced
34
Sold out
20
Shares held by filers
257,713,389

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q2 2025

Filers in the available 13F reports with a share position at 2025-06-30, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
RTW INVESTMENTS, LP25,021,584$57.8M0.82%+6,233,71813F-HRTimeline
RA CAPITAL MANAGEMENT, L.P.in group RA CAPITAL MANAGEMENT, L.P.23,555,648$54.4M0.92%+12,683,14513F-HRTimelineGroup
Avoro Capital Advisors LLC21,700,000$50.1M0.88%+1,700,00113F-HRTimeline
MORGAN STANLEYin group MORGAN STANLEY16,865,082$39M<0.01%+18,70813F-HRTimelineGroup
FMR LLCin group FMR LLC15,627,822$36.1M<0.01%-4,13213F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.13,303,775$30.7M<0.01%-285,40313F-HRTimelineGroup
Octagon Capital Advisors LP12,592,500$29.1M6.38%+1,892,50013F-HRTimeline
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC12,587,700$29.1M<0.01%+12,228,69313F-HRTimelineGroup
Siren, L.L.C.in group Siren, L.L.C.11,014,737$25.4M1.32%+4,500,00013F-HRTimelineGroup
VANGUARD GROUP INCin group VANGUARD GROUP INC10,894,127$25.2M<0.01%+2,123,20613F-HRTimelineGroup
Jefferies Financial Group Inc.in group Jefferies Financial Group Inc.10,313,733$23.8M0.39%+10,068,47913F-HRTimelineGroup
Point72 Asset Management, L.P.in group Point72 Asset Management, L.P.7,317,614$16.9M0.04%+2,747,93613F-HRTimelineGroup
DEERFIELD MANAGEMENT COMPANY, L.P.in group DEERFIELD MANAGEMENT COMPANY,…5,386,000$12.4M0.23%new13F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP5,138,310$11.9M<0.01%+1,904,79813F-HRTimelineGroup
Polar Capital Holdings Plcin group Polar Capital Holdings Plc5,000,000$11.6M0.06%+2,000,00013F-HRTimelineGroup
ADAGE CAPITAL PARTNERS GP, L.L.C.in group ADAGE CAPITAL PARTNERS GP, L.…4,839,000$11.2M0.02%new13F-HRTimelineGroup
TORONTO DOMINION BANKin group TORONTO DOMINION BANK4,728,806$10.9M0.02%new13F-HRTimelineGroup
TYBOURNE CAPITAL MANAGEMENT (HK) LTD4,095,000$9.46M27.39%+395,00013F-HRTimeline
BAKER BROS. ADVISORS LPin group BAKER BROS. ADVISORS LP4,004,756$9.25M0.09%013F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC3,793,572$8.77M<0.01%+128,84013F-HRTimelineGroup
MONTANOVA CAPITAL, LLC3,217,449$7.43M0.28%new13F-HRTimeline
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC3,009,870$6.95M1.13%+1,943,56113F-HRTimelineGroup
Vestal Point Capital, LP3,000,000$6.93M0.36%new13F-HRTimeline
MPM BIOIMPACT LLC2,953,562$6.82M1.18%new13F-HRTimeline
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC2,935,728$6.78M0.01%+1,163,07413F-HRTimelineGroup
B Group, Inc.1,800,556$4.16M3.59%+545,00013F-HRTimeline
GREAT POINT PARTNERS LLC1,500,000$3.46M2.25%new13F-HRTimeline
NORTHERN TRUST CORPin group NORTHERN TRUST CORP1,328,741$3.07M<0.01%-102,92513F-HRTimelineGroup
Palo Alto Investors LP1,246,033$2.88M0.61%-173,43513F-HRTimeline
STEMPOINT CAPITAL LP1,203,941$2.78M0.9%new13F-HRTimeline
Woodline Partners LP1,000,254$2.31M0.01%+142,00013F-HRTimeline
Granahan Investment Management, LLC958,493$2.21M0.09%-682,30013F-HRTimeline
TANG CAPITAL MANAGEMENT LLCin group TANG CAPITAL MANAGEMENT LLC900,000$2.08M0.11%new13F-HRTimelineGroup
Quantum Private Wealth, LLC815,976$1.88M0.61%+24,50013F-HRTimeline
Anson Funds Management LPin group Anson Funds Management LP803,500$1.86M0.34%new13F-HRTimelineGroup
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/730,728$1.69M<0.01%+93,88613F-HRTimelineGroup
Sands Capital Alternatives, LLC724,873$1.67M0.33%013F-HRTimeline
Alphabet Inc.in group Alphabet Inc.640,882$1.48M0.07%013F-HRTimelineGroup
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…635,968$1.47M<0.01%+10,77013F-HRTimelineGroup
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC528,993$1.22M<0.01%+312,38213F-HRTimelineGroup
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA495,311$1.15M<0.01%+493,84913F-HR/ATimelineGroup
SG Americas Securities, LLC493,301$1.14M0.01%new13F-HRTimeline
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co491,709$1.14M<0.01%-55,41913F-HRTimelineGroup
ACUTA CAPITAL PARTNERS, LLC485,669$1.12M1.57%new13F-HRTimeline
Nuveen, LLCin group TIAA465,144$1.07M<0.01%-81,27013F-HRTimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp458,659$1.06M<0.01%+5,23913F-HRTimelineGroup
BARCLAYS PLCin group BARCLAYS PLC450,501$1.04M<0.01%-258,46513F-HR/ATimelineGroup
SPHERA FUNDS MANAGEMENT LTD.in group SPHERA FUNDS MANAGEMENT LTD.420,000$970K0.25%new13F-HRTimelineGroup
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.401,509$927K<0.01%new13F-HRTimelineGroup
XTX Topco Ltdin group XTX Topco Ltd320,737$741K0.03%+117,60813F-HRTimelineGroup
NorthCoast Asset Management LLC298,667$690K<0.01%+5,88913F-HRTimeline
UBS Group AGin group UBS Group AG261,239$603K<0.01%-156,89313F-HRTimelineGroup
RHUMBLINE ADVISERS233,256$539K<0.01%+27,79413F-HRTimeline
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO222,649$514K<0.01%-780,41813F-HRTimelineGroup
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…212,572$491K<0.01%-14,90013F-HRTimelineGroup
Invesco Ltd.in group Invesco Ltd.203,671$470K<0.01%+43,77213F-HRTimelineGroup
Affinity Asset Advisors, LLC200,000$462K0.07%new13F-HRTimeline
Chicago Partners Investment Group LLC163,766$441K0.01%+47,20113F-HRTimeline
ALLIANCEBERNSTEIN L.P.179,620$415K<0.01%+71,37013F-HRTimeline
Quadrature Capital Ltdin group Quadrature Capital Ltd161,940$373K0.01%new13F-HRTimelineGroup
ExodusPoint Capital Management, LP148,357$343K<0.01%new13F-HRTimeline
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC136,994$316K<0.01%new13F-HRTimelineGroup
Privium Fund Management B.V.134,900$316K0.07%013F-HRTimeline
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC135,766$314K<0.01%+27,86713F-HRTimelineGroup
CITIGROUP INCin group CITIGROUP INC130,317$301K<0.01%-2,87713F-HRTimelineGroup
Rafferty Asset Management, LLC118,683$274K<0.01%new13F-HRTimeline
LOS ANGELES CAPITAL MANAGEMENT LLC117,740$272K<0.01%-25,07013F-HRTimeline
FRANKLIN RESOURCES INCin group Franklin Resources108,399$250K<0.01%-7,83913F-HRTimelineGroup
MetLife Investment Management, LLCin group MetLife Investment Management…108,078$250K<0.01%+36713F-HRTimelineGroup
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\107,716$249K<0.01%-26,70213F-HRTimelineGroup
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN107,234$248K<0.01%-1,81413F-HRTimelineGroup
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding106,646$247K-2,800Timeline
Squarepoint Ops LLCin group Squarepoint Ops LLC100,226$232K<0.01%new13F-HR/ATimelineGroup
PRICE T ROWE ASSOCIATES INC /MD/84,603$196K<0.01%+10,57813F-HRTimeline
INTECH INVESTMENT MANAGEMENT LLC82,195$190K<0.01%-17,71713F-HRTimeline
Mitsubishi UFJ Asset Management Co., Lt…in group Mitsubishi UFJ Trust & Bankin…80,571$186K<0.01%new13F-HRTimelineGroup
MARSHALL WACE, LLPin group MARSHALL WACE, LLP79,498$184K<0.01%new13F-HRTimelineGroup
OMERS ADMINISTRATION Corp72,900$168K<0.01%new13F-HRTimeline
EntryPoint Capital, LLC69,109$160K0.08%-66,78813F-HRTimeline
Militia Capital Partners, LPin group Militia Capital Management LLC66,800$154K0.07%new13F-HR/ATimelineGroup
Engineers Gate Manager LP64,617$149K<0.01%new13F-HRTimeline
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …61,005$141K<0.01%-2,79213F-HRTimelineGroup
COMMONWEALTH EQUITY SERVICES, LLC60,036$139K<0.01%-3313F-HRTimeline
AXQ CAPITAL, LP57,000$132K0.04%new13F-HRTimeline
RENAISSANCE TECHNOLOGIES LLC54,900$127K<0.01%new13F-HRTimeline
China Universal Asset Management Co., L…52,527$121K0.01%+11,40713F-HRTimeline
Creative Planningin group Creative Planning51,981$120K<0.01%-26,35413F-HRTimelineGroup
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC47,169$109K<0.01%-1,44713F-HRTimelineGroup
Police & Firemen's Retirement System of…45,678$106K<0.01%013F-HRTimeline
Williams & Novak Wealth Management, LLC45,000$104K0.09%013F-HRTimeline
GSA CAPITAL PARTNERS LLP44,690$103K0.01%new13F-HRTimeline
ProShare Advisors LLC43,746$101K<0.01%-3,44913F-HRTimeline
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…35,484$82K0.03%-37,47313F-HRTimelineGroup
TWO SIGMA INVESTMENTS, LPin group TWO SIGMA INVESTMENTS, LP32,682$75.5K<0.01%new13F-HRTimelineGroup
Ethic Inc.27,975$66.6K<0.01%new13F-HRTimeline
FIRST MANHATTAN CO. LLC.28,500$65.8K<0.01%013F-HRTimeline
Leonteq Securities AG27,999$64.7K<0.01%-52,00013F-HRTimeline
PROFUND ADVISORS LLC26,599$61.4K<0.01%new13F-HRTimeline
VICTORY CAPITAL MANAGEMENT INC25,492$58.9K<0.01%+6,47513F-HRTimeline
Point72 Asia (Singapore) Pte. Ltd.25,252$58.3K0.01%new13F-HRTimeline
Daiwa Securities Group Inc.in group Daiwa Securities Group Inc.23,841$55K<0.01%+23,15013F-HRTimelineGroup
Cambridge Investment Research Advisors,…23,690$55K<0.01%+20013F-HRTimeline
PRUDENTIAL FINANCIAL INCin group PRUDENTIAL FINANCIAL INC22,790$52.6K<0.01%+7,65013F-HRTimelineGroup
STATE BOARD OF ADMINISTRATION OF FLORID…22,700$52.4K<0.01%013F-HRTimeline
NEW YORK STATE COMMON RETIREMENT FUND21,100$48.7K<0.01%013F-HR/ATimeline
CIBC WORLD MARKETS CORP20,417$47.2K<0.01%-18,48013F-HRTimeline
Lee Financial Co20,000$46.2K0.01%013F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS18,591$42.9K<0.01%+6,35013F-HRTimelineGroup
Legal & General Group Plcin group Legal & General Group Plc18,395$42.5K<0.01%-1,56313F-HRTimelineGroup
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…17,606$40.7K<0.01%+10,74213F-HRTimelineGroup
May Hill Capital, LLC16,051$37.1K0.01%new13F-HRTimeline
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…15,672$36.2K<0.01%013F-HRTimelineGroup
Howard Capital Management, LLC14,165$32.7K<0.01%013F-HRTimeline
E Fund Management Co., Ltd.13,214$30.5K<0.01%new13F-HRTimeline
CWM, LLCin group CWM, LLC12,946$30K<0.01%+2,41913F-HRTimelineGroup
XPONANCE LLC12,837$29.7K<0.01%+19813F-HRTimeline
CALIFORNIA STATE TEACHERS RETIREMENT SY…12,635$29.2K<0.01%013F-HRTimeline
Marex Group Ltdin group Marex Group Ltd12,500$28.9K<0.01%013F-HRTimelineGroup
PRINCIPAL FINANCIAL GROUP INCin group PRINCIPAL FINANCIAL GROUP INC12,160$28.1K<0.01%-1,82913F-HRTimelineGroup
MACKENZIE FINANCIAL CORP11,214$25.9K<0.01%+1,21413F-HRTimeline
IEQ CAPITAL, LLC10,063$23.2K<0.01%new13F-HRTimeline
Bordeaux Wealth Advisors LLC10,058$23.2K<0.01%-5113F-HRTimeline
Capital Investment Advisors, LLC10,000$23.1K<0.01%013F-HR/ATimeline
ATTICUS WEALTH MANAGEMENT, LLC7,425$17.2K<0.01%013F-HRTimeline
AMALGAMATED BANK5,534$13K<0.01%013F-HRTimeline
ST GERMAIN D J CO INCin group ST GERMAIN D J CO INC5,300$12.2K<0.01%new13F-HRTimelineGroup
GF FUND MANAGEMENT CO. LTD.5,248$12.1K<0.01%013F-HRTimeline
Point72 (DIFC) Ltd4,441$10.3K<0.01%-11,08713F-HRTimeline
NISA INVESTMENT ADVISORS, LLC3,747$8.66K<0.01%-48313F-HRTimeline
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC3,605$8.33K<0.01%new13F-HRTimelineGroup
Headlands Technologies LLC3,037$7.01K<0.01%new13F-HRTimeline
SIMPLEX TRADING, LLC3,263$7K<0.01%new13F-HRTimeline
Caitong International Asset Management …2,147$4.96K<0.01%+1,33313F-HRTimeline
Optiver Holding B.V.in group Optiver Holding B.V.2,065$4.77K<0.01%+1,26013F-HRTimelineGroup
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…1,000$2.31K<0.01%013F-HRTimelineGroup
US BANCORP \DE\in group US BANCORP \DE\975$2.25K<0.01%+4413F-HRTimelineGroup
Clearstead Advisors, LLC690$1.59K<0.01%new13F-HRTimeline
Sterling Capital Management LLC408$942<0.01%+24313F-HR/ATimeline
Essential Partners LLC327$755<0.01%13F-HRTimeline
Parallel Advisors, LLC280$647<0.01%013F-HRTimeline
Morton Brown Family Wealth, LLC260$601<0.01%013F-HRTimeline
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…205$473<0.01%-16713F-HRTimelineGroup
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.134$311<0.01%013F-HR/ATimelineGroup
ROTHSCHILD INVESTMENT LLC105$243<0.01%new13F-HRTimeline
SBI Securities Co., Ltd.80$185<0.01%013F-HRTimeline
NATIONAL BANK OF CANADA /FI/in group NATIONAL BANK OF CANADA /FI/48$110<0.01%new13F-HR/ATimelineGroup
True Wealth Design, LLC30$70<0.01%-10213F-HRTimeline
IFP Advisors, Inc14$32<0.01%new13F-HRTimeline
Capital Advisors, Ltd. LLC79$00%013F-HRTimelineValue filed as zero, left out of ratios.
CONCOURSE FINANCIAL GROUP SECURITIES, I…0$0013F-HRTimelineValue filed as zero, left out of ratios. Amount filed as zero, left out of ratios.