FMR LLC in group FMR LLC More: the full row for FMR LLC 23,086,967 $820M 0.04% +678,704 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 12,974,591 $461M 0.01% +2,605,056 13F-HR Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 11,514,326 $409M 0.01% +3,756,664 13F-HR Timeline Group DEERFIELD MANAGEMENT COMPANY, L.P. in group DEERFIELD MANAGEMENT COMPANY,… More: the full row for DEERFIELD MANAGEMENT COMPANY, L.P. 9,043,903 $321M 4.12% -9,215 13F-HR Timeline Group Fairmount Funds Management LLC in group Fairmount Funds Management LLC More: the full row for Fairmount Funds Management LLC 9,003,418 $320M 24.34% 0 13F-HR Timeline Group RTW INVESTMENTS, LP More: the full row for RTW INVESTMENTS, LP 7,592,241 $270M 2.7% +4,124,755 13F-HR Timeline Kynam Capital Management, LP More: the full row for Kynam Capital Management, LP 6,165,223 $219M 14.26% -1,720,949 13F-HR Timeline TCG Crossover Management, LLC More: the full row for TCG Crossover Management, LLC 5,868,162 $208M 6.9% -930,000 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 4,940,300 $175M 0.01% +164,881 13F-HR Timeline Group JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 4,537,408 $161M 0.07% +1,359,365 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 3,514,562 $125M 0.01% +240,407 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 2,712,336 $96.3M 0.02% +2,305,437 13F-HR Timeline Group EMERALD ADVISERS, LLC group of 2 filers holding More: the full row for EMERALD ADVISERS, LLC 2,621,840 $93.1M +19,486 Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 2,564,062 $91.1M 0.01% +2,474,346 13F-HR Timeline Vivo Capital, LLC More: the full row for Vivo Capital, LLC 2,398,993 $85.2M 5.51% -390,144 13F-HR Timeline Octagon Capital Advisors LP More: the full row for Octagon Capital Advisors LP 2,350,000 $83.5M 10.45% -524,111 13F-HR Timeline D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 2,247,804 $79.8M 0.06% +716,879 13F-HR Timeline Group Duquesne Family Office LLC More: the full row for Duquesne Family Office LLC 2,214,470 $78.7M 1.86% +1,154,890 13F-HR Timeline Commodore Capital LP in group Commodore Capital LP More: the full row for Commodore Capital LP 2,196,845 $78M 5.19% -5,053,155 13F-HR Timeline Group Venrock Adviser, LLC More: the full row for Venrock Adviser, LLC 2,000,000 $71M 3.51% -2,000,000 13F-HR Timeline Sofinnova Investments, Inc. More: the full row for Sofinnova Investments, Inc. 1,973,625 $70.1M 3.02% -154,316 13F-HR Timeline LORD, ABBETT & CO. LLC More: the full row for LORD, ABBETT & CO. LLC 1,870,537 $66.4M 0.2% new 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 1,705,144 $60.6M 0.01% +45,467 13F-HR/A Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 1,660,735 $59M 0.06% +1,018,256 13F-HR Timeline Group Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 1,629,279 $57.9M 1.73% -95,000 13F-HR Timeline Group Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 1,440,318 $51.2M 0.1% -1,230,168 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 1,438,994 $51.1M 0.03% -228,813 13F-HR Timeline Group Redmile Group, LLC in group Redmile Group, LLC More: the full row for Redmile Group, LLC 1,437,918 $51.1M 3.76% -771,200 13F-HR Timeline Group Candriam S.C.A. More: the full row for Candriam S.C.A. 1,296,475 $46.1M 0.23% +342,266 13F-HR/A Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 1,280,779 $45.5M 0.01% +90,134 13F-HR Timeline Group SILVERARC CAPITAL MANAGEMENT, LLC in group SILVERARC CAPITAL MANAGEMENT,… More: the full row for SILVERARC CAPITAL MANAGEMENT, LLC 1,245,254 $44.2M 6.4% +430,179 13F-HR Timeline Group Saturn V Capital Management LP More: the full row for Saturn V Capital Management LP 1,217,064 $43.2M 7.93% -807,977 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 1,208,228 $42.9M 0.03% +793,262 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 1,199,300 $42.6M 0.01% +17,635 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 1,191,930 $42.3M <0.01% -1,047,325 13F-HR Timeline Group Holocene Advisors, LP More: the full row for Holocene Advisors, LP 1,178,208 $41.8M 0.09% +1,060,292 13F-HR Timeline Elmind Capital, LP More: the full row for Elmind Capital, LP 1,170,740 $41.6M 12.27% 13F-HR Timeline FRED ALGER MANAGEMENT, LLC in group FRED ALGER MANAGEMENT, LLC More: the full row for FRED ALGER MANAGEMENT, LLC 1,102,181 $39.1M 0.15% new 13F-HR Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 932,621 $33.1M 0.01% -6,999 13F-HR Timeline Group AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 892,920 $31.7M 0.02% new 13F-HR Timeline Group Rock Springs Capital Management LP More: the full row for Rock Springs Capital Management LP 849,030 $30.2M 1.55% -159,278 13F-HR Timeline Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 827,525 $29.4M 0.05% -410,308 13F-HR Timeline Group First Turn Management, LLC More: the full row for First Turn Management, LLC 824,283 $29.3M 3.35% new 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 818,782 $29.1M 0.11% +305,385 13F-HR Timeline Squadron Capital Management LLC More: the full row for Squadron Capital Management LLC 780,000 $27.7M 12.36% 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 726,777 $25.8M <0.01% -561,387 13F-HR/A Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 689,068 $24.5M 0.04% +456,100 13F-HR Timeline VOLORIDGE INVESTMENT MANAGEMENT, LLC More: the full row for VOLORIDGE INVESTMENT MANAGEMENT, LLC 668,970 $23.8M 0.08% new 13F-HR Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 585,765 $20.8M <0.01% +213,495 13F-HR Timeline Group Defilade Capital Management, L.P. More: the full row for Defilade Capital Management, L.P. 568,619 $20.2M 2.74% 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 2 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 513,252 $18.2M +204,874 Timeline Atika Capital Management LLC in group Atika Capital Management LLC More: the full row for Atika Capital Management LLC 506,000 $18M 2.5% new 13F-HR Timeline Group Alyeska Investment Group, L.P. in group Alyeska Investment Group, L.P. More: the full row for Alyeska Investment Group, L.P. 493,934 $17.5M 0.05% +393,934 13F-HR Timeline Group Deep Track Capital, LP More: the full row for Deep Track Capital, LP 453,102 $16.1M 0.37% new 13F-HR Timeline J. Goldman & Co LP More: the full row for J. Goldman & Co LP 439,269 $15.6M 0.61% new 13F-HR Timeline UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 428,187 $15.2M -1,568,439 Timeline FEDERATED HERMES, INC. in group FEDERATED HERMES, INC. More: the full row for FEDERATED HERMES, INC. 426,782 $15.2M 0.03% +333,557 13F-HR Timeline Group Ensign Peak Advisors, Inc More: the full row for Ensign Peak Advisors, Inc 421,540 $15M 0.03% +395,915 13F-HR/A Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 400,931 $14.2M <0.01% +326,119 13F-HR Timeline Group Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 385,457 $13.7M 0.01% +264,512 13F-HR Timeline Group SPHERA FUNDS MANAGEMENT LTD. in group SPHERA FUNDS MANAGEMENT LTD. More: the full row for SPHERA FUNDS MANAGEMENT LTD. 378,500 $13.4M 2.81% +279,974 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 376,296 $13.4M <0.01% +13,280 13F-HR Timeline Group RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 375,919 $13.4M <0.01% +86,522 13F-HR Timeline Group Assenagon Asset Management S.A. More: the full row for Assenagon Asset Management S.A. 375,626 $13.3M 0.02% -201,378 13F-HR Timeline ORBIMED ADVISORS LLC in group ORBIMED ADVISORS LLC More: the full row for ORBIMED ADVISORS LLC 371,000 $13.2M 0.27% new 13F-HR Timeline Group SUPERSTRING CAPITAL MANAGEMENT LP More: the full row for SUPERSTRING CAPITAL MANAGEMENT LP 366,238 $13M 6.96% +4,830 13F-HR Timeline KENNEDY CAPITAL MANAGEMENT LLC More: the full row for KENNEDY CAPITAL MANAGEMENT LLC 352,387 $12.5M 0.27% -231,498 13F-HR Timeline Affinity Asset Advisors, LLC More: the full row for Affinity Asset Advisors, LLC 350,000 $12.4M 0.89% new 13F-HR Timeline Hennion & Walsh Asset Management, Inc. More: the full row for Hennion & Walsh Asset Management, Inc. 338,065 $12M 0.41% +37,938 13F-HR Timeline HighVista Strategies LLC More: the full row for HighVista Strategies LLC 336,667 $12M 3.08% -125,738 13F-HR Timeline Burkehill Global Management, LP More: the full row for Burkehill Global Management, LP 325,000 $11.5M 0.76% +125,000 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 321,606 $11.4M <0.01% -38,224 13F-HR Timeline Group Patient Square Capital LP More: the full row for Patient Square Capital LP 317,372 $11.3M 2.41% new 13F-HR Timeline NOMURA ASSET MANAGEMENT INTERNATIONAL I… in group NOMURA ASSET MANAGEMENT CO LTD More: the full row for NOMURA ASSET MANAGEMENT INTERNATIONAL INC. 305,940 $10.9M 0.02% 13F-HR Timeline Group Exome Asset Management LLC More: the full row for Exome Asset Management LLC 305,568 $10.9M 5.36% -137,979 13F-HR Timeline Man Group plc in group Man Group plc More: the full row for Man Group plc 292,082 $10.4M 0.02% new 13F-HR Timeline Group Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 276,728 $9.83M 0.01% +163,070 13F-HR Timeline SummitTX Capital, L.P. More: the full row for SummitTX Capital, L.P. 257,171 $9.13M 0.28% -38,639 13F-HR Timeline Nantahala Capital Management, LLC in group Nantahala Capital Management,… More: the full row for Nantahala Capital Management, LLC 250,000 $8.88M 0.53% -1,256,989 13F-HR Timeline Group Evergreen Quality Fund GP, Ltd. More: the full row for Evergreen Quality Fund GP, Ltd. 250,000 $8.88M 0.18% new 13F-HR Timeline NWI MANAGEMENT LP More: the full row for NWI MANAGEMENT LP 241,671 $8.58M 0.52% new 13F-HR/A Timeline F/m Investments LLC More: the full row for F/m Investments LLC 235,804 $8.38M 0.32% +15,636 13F-HR Timeline ALGERT GLOBAL LLC More: the full row for ALGERT GLOBAL LLC 227,862 $8.09M 0.13% -39,280 13F-HR/A Timeline Cormorant Asset Management, LP More: the full row for Cormorant Asset Management, LP 225,000 $7.99M 0.45% new 13F-HR Timeline Boxer Capital Management, LLC in group Boxer Capital Management, LLC More: the full row for Boxer Capital Management, LLC 225,000 $7.99M 1.75% new 13F-HR Timeline Group Seven Fleet Capital Management LP More: the full row for Seven Fleet Capital Management LP 214,099 $7.6M 5.15% 13F-HR/A Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 198,969 $7.07M <0.01% -498,995 13F-HR Timeline Group AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 188,349 $6.69M <0.01% new 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 180,176 $6.4M 0.01% +3,464 13F-HR Timeline SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 179,414 $6.37M 0.01% +168,090 13F-HR Timeline Group Connor, Clark & Lunn Investment Managem… More: the full row for Connor, Clark & Lunn Investment Management Ltd. 175,889 $6.25M 0.02% new 13F-HR Timeline Swiss National Bank More: the full row for Swiss National Bank 165,400 $5.88M <0.01% +3,200 13F-HR Timeline Skandinaviska Enskilda Banken AB (publ) More: the full row for Skandinaviska Enskilda Banken AB (publ) 164,437 $5.84M 0.02% new 13F-HR Timeline TUDOR INVESTMENT CORP ET AL More: the full row for TUDOR INVESTMENT CORP ET AL 159,942 $5.68M 0.03% new 13F-HR Timeline Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 155,984 $5.54M 0.01% new 13F-HR Timeline Group ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 155,510 $5.52M <0.01% +30,890 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 153,625 $5.46M <0.01% +72,621 13F-HR Timeline Group Nicholas Investment Partners, LP More: the full row for Nicholas Investment Partners, LP 151,066 $5.37M 0.39% new 13F-HR Timeline Informed Momentum Co LLC More: the full row for Informed Momentum Co LLC 134,295 $4.77M 0.53% new 13F-HR Timeline VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 133,214 $4.73M <0.01% +71,591 13F-HR Timeline Group DIADEMA PARTNERS LP More: the full row for DIADEMA PARTNERS LP 131,852 $4.68M 2.79% +34,039 13F-HR Timeline BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 127,075 $4.51M 0.12% -65,695 13F-HR Timeline LPL Financial LLC More: the full row for LPL Financial LLC 124,238 $4.41M <0.01% +74,036 13F-HR Timeline AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 121,800 $4.33M <0.01% +4,959 13F-HR Timeline Group PLATINUM INVESTMENT MANAGEMENT LTD More: the full row for PLATINUM INVESTMENT MANAGEMENT LTD 121,229 $4.31M 1% -98,275 13F-HR Timeline PERCEPTIVE ADVISORS LLC in group PERCEPTIVE ADVISORS LLC More: the full row for PERCEPTIVE ADVISORS LLC 121,082 $4.3M 0.08% new 13F-HR Timeline Group PRUDENTIAL FINANCIAL INC in group PRUDENTIAL FINANCIAL INC More: the full row for PRUDENTIAL FINANCIAL INC 120,175 $4.27M 0.01% +104,780 13F-HR Timeline Group Soleus Capital Management, L.P. More: the full row for Soleus Capital Management, L.P. 120,000 $4.26M 0.18% new 13F-HR Timeline Pictet Asset Management Holding SA in group Pictet Asset Management Holdi… More: the full row for Pictet Asset Management Holding SA 112,476 $4.23M <0.01% +98,602 13F-HR Timeline Group Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 114,463 $4.07M 0.02% new 13F-HR Timeline Group PRINCIPAL FINANCIAL GROUP INC in group PRINCIPAL FINANCIAL GROUP INC More: the full row for PRINCIPAL FINANCIAL GROUP INC 111,806 $3.97M <0.01% -160,654 13F-HR Timeline Group Rafferty Asset Management, LLC More: the full row for Rafferty Asset Management, LLC 111,094 $3.95M 0.01% -37,707 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 109,128 $3.88M <0.01% +13,001 13F-HR Timeline Group NEOS Investment Management LLC More: the full row for NEOS Investment Management LLC 107,924 $3.83M 0.02% +18,001 13F-HR Timeline Tema ETFs LLC More: the full row for Tema ETFs LLC 106,329 $3.78M 0.29% +16,406 13F-HR Timeline Aquatic Capital Management LLC More: the full row for Aquatic Capital Management LLC 106,246 $3.77M 0.11% +48,889 13F-HR Timeline SONA ASSET MANAGEMENT (US) LLC in group SONA ASSET MANAGEMENT (US) LLC More: the full row for SONA ASSET MANAGEMENT (US) LLC 105,000 $3.73M 0.12% new 13F-HR Timeline Group Knott David M Jr More: the full row for Knott David M Jr 102,000 $3.62M 1.68% new 13F-HR Timeline ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 100,000 $3.55M 0.01% -462,000 13F-HR Timeline Group AIHC Capital Management Ltd More: the full row for AIHC Capital Management Ltd 100,000 $3.55M 3.33% 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 98,475 $3.5M <0.01% -339 13F-HR Timeline Group MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 96,011 $3.46M <0.01% +32,413 13F-HR Timeline Group NEXTBio Capital Management LP More: the full row for NEXTBio Capital Management LP 95,819 $3.4M 2% 13F-HR Timeline Y-Intercept (Hong Kong) Ltd More: the full row for Y-Intercept (Hong Kong) Ltd 94,804 $3.37M 0.08% new 13F-HR Timeline DV Trading LLC More: the full row for DV Trading LLC 92,133 $3.27M 0.28% 13F-HR Timeline Creative Planning in group Creative Planning More: the full row for Creative Planning 89,905 $3.19M <0.01% +22,167 13F-HR Timeline Group JTC Employer Solutions Trustee Ltd More: the full row for JTC Employer Solutions Trustee Ltd 78,400 $3.02M 0.2% new 13F-HR Timeline CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 83,683 $2.97M <0.01% +2,950 13F-HR Timeline Maven Securities LTD in group Maven Securities LTD More: the full row for Maven Securities LTD 82,800 $2.94M 0.37% new 13F-HR Timeline Group HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 81,340 $2.89M 0.01% new 13F-HR Timeline Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 78,543 $2.8M +5,142 Timeline MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 77,476 $2.75M 0.01% +1,775 13F-HR Timeline Group Jefferies Financial Group Inc. in group Jefferies Financial Group Inc. More: the full row for Jefferies Financial Group Inc. 75,112 $2.67M 0.02% new 13F-HR Timeline Group STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 74,226 $2.64M 0.01% -21,667 13F-HR Timeline PRELUDE CAPITAL MANAGEMENT, LLC More: the full row for PRELUDE CAPITAL MANAGEMENT, LLC 72,378 $2.57M 0.19% -64,903 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 68,653 $2.44M <0.01% +54,245 13F-HR Timeline Group INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 61,590 $2.19M 0.02% +23,311 13F-HR Timeline Verition Fund Management LLC More: the full row for Verition Fund Management LLC 59,456 $2.11M 0.01% +42,342 13F-HR Timeline TD Asset Management Inc More: the full row for TD Asset Management Inc 56,342 $2M <0.01% new 13F-HR Timeline Trexquant Investment LP More: the full row for Trexquant Investment LP 56,106 $1.99M 0.02% -510,266 13F-HR Timeline SCHRODER INVESTMENT MANAGEMENT GROUP More: the full row for SCHRODER INVESTMENT MANAGEMENT GROUP 53,307 $1.98M <0.01% -126,426 13F-HR Timeline LMR Partners LLP in group LMR Partners LLP More: the full row for LMR Partners LLP 54,433 $1.93M 0.02% new 13F-HR Timeline Group GILDER GAGNON HOWE & CO LLC More: the full row for GILDER GAGNON HOWE & CO LLC 53,275 $1.89M 0.02% new 13F-HR Timeline VICTORY CAPITAL MANAGEMENT INC More: the full row for VICTORY CAPITAL MANAGEMENT INC 51,586 $1.83M <0.01% +38,632 13F-HR Timeline Jain Global LLC More: the full row for Jain Global LLC 48,079 $1.71M 0.02% new 13F-HR Timeline Fisher Asset Management, LLC More: the full row for Fisher Asset Management, LLC 47,914 $1.7M <0.01% -55,578 13F-HR Timeline Persistent Asset Partners Ltd More: the full row for Persistent Asset Partners Ltd 47,499 $1.69M 0.81% +25,013 13F-HR Timeline Pier Capital, LLC More: the full row for Pier Capital, LLC 46,260 $1.64M 0.26% new 13F-HR Timeline Cinctive Capital Management LP More: the full row for Cinctive Capital Management LP 44,665 $1.59M 0.09% -66,393 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 44,402 $1.58M <0.01% +10,500 13F-HR Timeline PROFUND ADVISORS LLC More: the full row for PROFUND ADVISORS LLC 42,749 $1.52M 0.05% +9,666 13F-HR Timeline SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 37,634 $1.34M <0.01% +11,729 13F-HR Timeline Virtu Financial LLC in group Virtu Financial LLC More: the full row for Virtu Financial LLC 37,619 $1.34M 0.05% new 13F-HR Timeline Group Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 37,486 $1.33M 0.01% +1,806 13F-HR Timeline TEACHERS RETIREMENT SYSTEM OF THE STATE… More: the full row for TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY 37,445 $1.33M 0.01% new 13F-HR Timeline SEVEN GRAND MANAGERS, LLC More: the full row for SEVEN GRAND MANAGERS, LLC 35,000 $1.24M 0.09% new 13F-HR Timeline OPTIMIZE FINANCIAL INC. More: the full row for OPTIMIZE FINANCIAL INC. 33,024 $1.17M 0.59% +472 13F-HR Timeline Legato Capital Management LLC More: the full row for Legato Capital Management LLC 32,740 $1.16M 0.1% new 13F-HR Timeline SECTORAL ASSET MANAGEMENT INC More: the full row for SECTORAL ASSET MANAGEMENT INC 32,685 $1.16M 0.93% new 13F-HR Timeline Allianz Asset Management GmbH in group Allianz SE More: the full row for Allianz Asset Management GmbH 32,600 $1.16M <0.01% new 13F-HR Timeline Group ProShare Advisors LLC More: the full row for ProShare Advisors LLC 32,045 $1.14M <0.01% +4,842 13F-HR Timeline Harvest Investment Services, LLC More: the full row for Harvest Investment Services, LLC 30,738 $1.09M 0.21% new 13F-HR Timeline STRS OHIO More: the full row for STRS OHIO 30,500 $1.08M <0.01% -11,000 13F-HR Timeline TWINBEECH CAPITAL LP More: the full row for TWINBEECH CAPITAL LP 29,300 $1.04M 0.07% new 13F-HR Timeline State of New Jersey Common Pension Fund… in group State of New Jersey Common Pe… More: the full row for State of New Jersey Common Pension Fund D 28,610 $1.02M <0.01% new 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 26,990 $959K new Timeline Engineers Gate Manager LP More: the full row for Engineers Gate Manager LP 26,367 $937K 0.01% -70,119 13F-HR Timeline BANK OF HAWAII More: the full row for BANK OF HAWAII 26,142 $929K 0.05% new 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 25,014 $888K 0.07% +527 13F-HR Timeline DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD. in group DYMON ASIA CAPITAL (SINGAPORE… More: the full row for DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD. 24,200 $860K 0.19% new 13F-HR Timeline Group ARIZONA STATE RETIREMENT SYSTEM More: the full row for ARIZONA STATE RETIREMENT SYSTEM 23,344 $829K <0.01% -1,358 13F-HR Timeline STATE BOARD OF ADMINISTRATION OF FLORID… More: the full row for STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 23,142 $822K <0.01% 0 13F-HR Timeline Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 22,438 $797K <0.01% -22,281 13F-HR Timeline Campbell & CO Investment Adviser LLC More: the full row for Campbell & CO Investment Adviser LLC 18,940 $673K 0.03% -42,694 13F-HR Timeline Atom Investors LP More: the full row for Atom Investors LP 18,108 $643K 0.05% new 13F-HR Timeline KLP KAPITALFORVALTNING AS More: the full row for KLP KAPITALFORVALTNING AS 17,800 $632K <0.01% -1,100 13F-HR Timeline FARALLON CAPITAL MANAGEMENT, L.L.C. More: the full row for FARALLON CAPITAL MANAGEMENT, L.L.C. 17,000 $604K <0.01% 0 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 16,857 $599K <0.01% -162,861 13F-HR Timeline Group Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 16,326 $580K 0.01% new 13F-HR Timeline Group ENVESTNET ASSET MANAGEMENT INC in group ENVESTNET ASSET MANAGEMENT INC More: the full row for ENVESTNET ASSET MANAGEMENT INC 15,595 $554K <0.01% new 13F-HR Timeline Group ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 15,317 $543K <0.01% new 13F-HR Timeline Group WINTON GROUP Ltd in group WINTON GROUP Ltd More: the full row for WINTON GROUP Ltd 14,382 $511K 0.02% new 13F-HR Timeline Group OmniStar Financial Group, Inc. More: the full row for OmniStar Financial Group, Inc. 14,303 $508K 0.3% new 13F-HR Timeline Bridgefront Capital, LLC More: the full row for Bridgefront Capital, LLC 14,186 $504K 0.13% new 13F-HR Timeline PSP Research LLC More: the full row for PSP Research LLC 13,233 $470K 0.41% 13F-HR Timeline TEACHER RETIREMENT SYSTEM OF TEXAS More: the full row for TEACHER RETIREMENT SYSTEM OF TEXAS 12,442 $442K <0.01% -7,941 13F-HR Timeline Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 11,284 $401K 0.01% +445 13F-HR Timeline Group XPONANCE LLC More: the full row for XPONANCE LLC 10,944 $389K <0.01% +802 13F-HR Timeline Allspring Global Investments Holdings, … in group Allspring Global Investments … More: the full row for Allspring Global Investments Holdings, LLC 10,525 $366K <0.01% new 13F-HR Timeline Group BANK OF MONTREAL /CAN/ in group BANK OF MONTREAL /CAN/ More: the full row for BANK OF MONTREAL /CAN/ 9,892 $351K <0.01% -13,632 13F-HR Timeline Group Universal- Beteiligungs- und Serviceges… in group Universal- Beteiligungs- und … More: the full row for Universal- Beteiligungs- und Servicegesellschaft mbH 9,568 $340K <0.01% new 13F-HR Timeline Group CIBC Bancorp USA Inc. group of 2 filers holding More: the full row for CIBC Bancorp USA Inc. 9,232 $328K new Timeline MACKENZIE FINANCIAL CORP More: the full row for MACKENZIE FINANCIAL CORP 8,593 $318K <0.01% new 13F-HR Timeline GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 8,827 $314K 0.03% new 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 8,487 $301K <0.01% +4,496 13F-HR Timeline Group O'SHAUGHNESSY ASSET MANAGEMENT, LLC More: the full row for O'SHAUGHNESSY ASSET MANAGEMENT, LLC 8,283 $294K <0.01% new 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 7,563 $269K 0.01% +182 13F-HR Timeline Group OPAL CAPITAL LLC More: the full row for OPAL CAPITAL LLC 6,961 $264K 0.07% 13F-HR Timeline Graham Capital Management, L.P. More: the full row for Graham Capital Management, L.P. 7,418 $263K 0.01% -17,062 13F-HR Timeline Arrowpoint Investment Partners (Singapo… in group Arrowpoint Investment Partner… More: the full row for Arrowpoint Investment Partners (Singapore) Pte. Ltd. 7,353 $261K 0.04% -8,745 13F-HR Timeline Group