FMR LLC in group FMR LLC More: the full row for FMR LLC 23,122,748 $890M 0.05% +35,781 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 16,045,014 $618M 0.01% +3,070,423 13F-HR Timeline Group VANGUARD GROUP INC group of 7 filers holding More: the full row for VANGUARD GROUP INC 15,472,496 $596M new Timeline VANGUARD PORTFOLIO MANAGEMENT LLC : 7,333,333 (0.01%) 13F-HR VANGUARD CAPITAL MANAGEMENT LLC : 6,894,959 (0.01%) 13F-HR/A VANGUARD FIDUCIARY TRUST CO : 1,058,087 (0.01%) 13F-HR VANGUARD ASSET MANAGEMENT, Ltd : 87,617 (<0.01%) 13F-HR Vanguard Global Advisers, LLC : 69,597 (<0.01%) 13F-HR Vanguard Investments Australia, L… : 20,444 (<0.01%) 13F-HR Vanguard Personalized Indexing Ma… : 8,459 (<0.01%) 13F-HR DEERFIELD MANAGEMENT COMPANY, L.P. in group DEERFIELD MANAGEMENT COMPANY,… More: the full row for DEERFIELD MANAGEMENT COMPANY, L.P. 9,043,903 $348M 4.11% 0 13F-HR Timeline Group JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 5,965,125 $230M 0.11% +1,427,717 13F-HR/A Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 5,663,543 $218M 0.01% +723,243 13F-HR Timeline Group Fairmount Funds Management LLC in group Fairmount Funds Management LLC More: the full row for Fairmount Funds Management LLC 5,503,418 $212M 15.3% -3,500,000 13F-HR Timeline Group RTW INVESTMENTS, LP More: the full row for RTW INVESTMENTS, LP 5,458,675 $210M 2.09% -2,133,566 13F-HR Timeline TCG Crossover Management, LLC More: the full row for TCG Crossover Management, LLC 4,946,894 $190M 5.45% -921,268 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 4,434,054 $171M 0.02% +2,728,910 13F-HR Timeline Group Kynam Capital Management, LP More: the full row for Kynam Capital Management, LP 4,037,331 $155M 9.86% -2,127,892 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 3,699,519 $142M 0.01% +184,957 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 3,578,622 $138M 0.03% +866,286 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 3,212,815 $124M 0.01% +648,753 13F-HR Timeline LORD, ABBETT & CO. LLC More: the full row for LORD, ABBETT & CO. LLC 3,181,270 $122M 0.4% +1,310,733 13F-HR Timeline Commodore Capital LP in group Commodore Capital LP More: the full row for Commodore Capital LP 2,888,007 $111M 6.43% +691,162 13F-HR Timeline Group EMERALD ADVISERS, LLC group of 2 filers holding More: the full row for EMERALD ADVISERS, LLC 2,616,964 $101M -4,876 Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 2,429,629 $93.5M 0.01% +1,843,864 13F-HR Timeline Group Octagon Capital Advisors LP More: the full row for Octagon Capital Advisors LP 2,350,000 $90.5M 10.01% 0 13F-HR Timeline Holocene Advisors, LP More: the full row for Holocene Advisors, LP 2,250,196 $86.6M 0.21% +1,071,988 13F-HR Timeline Sofinnova Investments, Inc. More: the full row for Sofinnova Investments, Inc. 2,113,551 $81.4M 4.08% +139,926 13F-HR Timeline Venrock Adviser, LLC More: the full row for Venrock Adviser, LLC 2,000,000 $77M 2.87% 0 13F-HR Timeline D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 1,868,389 $71.9M 0.06% -379,415 13F-HR Timeline Group Pictet Asset Management Holding SA in group Pictet Asset Management Holdi… More: the full row for Pictet Asset Management Holding SA 1,798,768 $68.8M 0.07% +1,686,292 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 1,714,927 $66M 0.05% +275,933 13F-HR Timeline Group Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 1,709,279 $65.8M 1.82% +80,000 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 1,600,168 $61.6M 0.07% -60,567 13F-HR Timeline Group Candriam S.C.A. More: the full row for Candriam S.C.A. 1,516,297 $58.4M 0.3% +219,822 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 1,509,557 $58.1M 0.22% +690,775 13F-HR/A Timeline Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 1,410,826 $54.3M 0.09% +583,301 13F-HR Timeline Group SILVERARC CAPITAL MANAGEMENT, LLC in group SILVERARC CAPITAL MANAGEMENT,… More: the full row for SILVERARC CAPITAL MANAGEMENT, LLC 1,314,189 $50.6M 5.96% +68,935 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 1,245,751 $47.9M 0.01% +46,451 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 1,242,322 $47.8M 0.01% -38,457 13F-HR Timeline Group FRED ALGER MANAGEMENT, LLC in group FRED ALGER MANAGEMENT, LLC More: the full row for FRED ALGER MANAGEMENT, LLC 1,239,700 $47.7M 0.21% +137,519 13F-HR Timeline Group Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 1,230,888 $47.4M 1.32% new 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 1,192,406 $45.9M 0.03% -15,822 13F-HR Timeline Group Elmind Capital, LP More: the full row for Elmind Capital, LP 1,170,740 $45.1M 12.79% 0 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 1,043,805 $40.2M <0.01% -148,125 13F-HR Timeline Group Deep Track Capital, LP More: the full row for Deep Track Capital, LP 1,000,000 $38.5M 0.79% +546,898 13F-HR Timeline First Turn Management, LLC More: the full row for First Turn Management, LLC 947,339 $36.5M 4.07% +123,056 13F-HR Timeline AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 890,568 $34.3M 0.02% -2,352 13F-HR Timeline Group Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 856,598 $33M 0.06% -583,720 13F-HR Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 831,602 $32M 0.01% -101,019 13F-HR Timeline Group Squadron Capital Management LLC More: the full row for Squadron Capital Management LLC 787,492 $30.3M 12.13% +7,492 13F-HR Timeline J. Goldman & Co LP More: the full row for J. Goldman & Co LP 779,570 $30M 1.39% +340,301 13F-HR Timeline Affinity Asset Advisors, LLC More: the full row for Affinity Asset Advisors, LLC 750,000 $28.9M 1.69% +400,000 13F-HR Timeline RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 706,268 $27.2M 0.04% +17,200 13F-HR Timeline Redmile Group, LLC in group Redmile Group, LLC More: the full row for Redmile Group, LLC 688,036 $26.5M 1.75% -749,882 13F-HR Timeline Group Burkehill Global Management, LP More: the full row for Burkehill Global Management, LP 675,000 $26M 1.29% +350,000 13F-HR Timeline VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 664,146 $25.6M 0.03% +530,932 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 642,679 $24.7M <0.01% -84,098 13F-HR Timeline Group Saturn V Capital Management LP More: the full row for Saturn V Capital Management LP 626,635 $24.1M 4.37% -590,429 13F-HR Timeline Rock Springs Capital Management LP More: the full row for Rock Springs Capital Management LP 624,155 $24M 1.42% -224,875 13F-HR Timeline Patient Square Capital LP More: the full row for Patient Square Capital LP 596,000 $22.9M 4.07% +278,628 13F-HR Timeline Ensign Peak Advisors, Inc More: the full row for Ensign Peak Advisors, Inc 572,872 $22M 0.04% +151,332 13F-HR/A Timeline Fiera Capital Corp in group Fiera Capital Corp More: the full row for Fiera Capital Corp 558,252 $21.5M 0.07% new 13F-HR Timeline Group UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 456,996 $17.6M +28,809 Timeline MASSACHUSETTS FINANCIAL SERVICES CO /MA/ in group MASSACHUSETTS FINANCIAL SERVI… More: the full row for MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 449,482 $17.3M 0.01% new 13F-HR Timeline Group Vivo Capital, LLC More: the full row for Vivo Capital, LLC 422,300 $16.3M 1.35% -1,976,693 13F-HR/A Timeline SPHERA FUNDS MANAGEMENT LTD. in group SPHERA FUNDS MANAGEMENT LTD. More: the full row for SPHERA FUNDS MANAGEMENT LTD. 416,340 $16M 2.76% +37,840 13F-HR Timeline Group Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 394,000 $15.2M 0.02% +117,272 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 374,868 $14.4M 0.02% -10,589 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 372,796 $14.3M <0.01% -3,500 13F-HR Timeline Group ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 372,175 $14.3M 0.14% new 13F-HR Timeline RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 369,715 $14.2M <0.01% -6,204 13F-HR Timeline Group KENNEDY CAPITAL MANAGEMENT LLC More: the full row for KENNEDY CAPITAL MANAGEMENT LLC 360,490 $13.9M 0.29% +8,103 13F-HR Timeline NOMURA ASSET MANAGEMENT CO LTD group of 2 filers holding More: the full row for NOMURA ASSET MANAGEMENT CO LTD 354,240 $13.6M +48,300 Timeline Defilade Capital Management, L.P. More: the full row for Defilade Capital Management, L.P. 352,590 $13.6M 1.91% -216,029 13F-HR/A Timeline Integral Health Asset Management, LLC More: the full row for Integral Health Asset Management, LLC 350,000 $13.5M 0.71% new 13F-HR Timeline Weiss Asset Management LP in group Weiss Asset Management LP More: the full row for Weiss Asset Management LP 346,104 $13.3M 0.24% new 13F-HR Timeline Group The filing omitted confidential holdings, a later amendment may add them. BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 343,082 $13.2M 0.01% +144,113 13F-HR Timeline Group Longaeva Partners L.P. More: the full row for Longaeva Partners L.P. 335,000 $12.9M 0.62% new 13F-HR Timeline Hennion & Walsh Asset Management, Inc. More: the full row for Hennion & Walsh Asset Management, Inc. 326,472 $12.6M 0.42% -11,593 13F-HR Timeline DIADEMA PARTNERS LP More: the full row for DIADEMA PARTNERS LP 322,764 $12.4M 5.13% +190,912 13F-HR Timeline ORBIMED ADVISORS LLC in group ORBIMED ADVISORS LLC More: the full row for ORBIMED ADVISORS LLC 322,100 $12.4M 0.27% -48,900 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 2 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 300,233 $11.6M -213,019 Timeline Assenagon Asset Management S.A. More: the full row for Assenagon Asset Management S.A. 295,650 $11.4M 0.02% -79,976 13F-HR Timeline SummitTX Capital, L.P. More: the full row for SummitTX Capital, L.P. 293,780 $11.3M 0.36% +36,609 13F-HR Timeline Atika Capital Management LLC in group Atika Capital Management LLC More: the full row for Atika Capital Management LLC 293,200 $11.3M 1.78% -212,800 13F-HR Timeline Group FEDERATED HERMES, INC. in group FEDERATED HERMES, INC. More: the full row for FEDERATED HERMES, INC. 285,661 $11M 0.02% -141,121 13F-HR Timeline Group Exome Asset Management LLC More: the full row for Exome Asset Management LLC 278,533 $10.7M 6.31% -27,035 13F-HR Timeline Aberdeen Group plc in group Aberdeen Group plc More: the full row for Aberdeen Group plc 272,707 $10.5M 0.02% new 13F-HR Timeline Group AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 252,114 $9.7M <0.01% +63,765 13F-HR/A Timeline Group Alyeska Investment Group, L.P. in group Alyeska Investment Group, L.P. More: the full row for Alyeska Investment Group, L.P. 250,000 $9.62M 0.03% -243,934 13F-HR Timeline Group Nantahala Capital Management, LLC in group Nantahala Capital Management,… More: the full row for Nantahala Capital Management, LLC 250,000 $9.62M 0.6% 0 13F-HR Timeline Group Evergreen Quality Fund GP, Ltd. More: the full row for Evergreen Quality Fund GP, Ltd. 250,000 $9.62M 0.22% 0 13F-HR Timeline NWI MANAGEMENT LP More: the full row for NWI MANAGEMENT LP 241,671 $9.3M 0.57% 0 13F-HR/A Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 262,704 $9.3M <0.01% -138,227 13F-HR/A Timeline Group Tidal Investments LLC in group Tidal Investments LLC More: the full row for Tidal Investments LLC 231,569 $8.91M 0.03% new 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 226,259 $8.71M 0.02% +70,275 13F-HR Timeline Group F/m Investments LLC More: the full row for F/m Investments LLC 226,142 $8.7M 0.58% -9,662 13F-HR Timeline SUPERSTRING CAPITAL MANAGEMENT LP More: the full row for SUPERSTRING CAPITAL MANAGEMENT LP 225,158 $8.67M 6.19% -141,080 13F-HR Timeline Boxer Capital Management, LLC in group Boxer Capital Management, LLC More: the full row for Boxer Capital Management, LLC 225,000 $8.66M 1.14% 0 13F-HR Timeline Group NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 223,216 $8.59M 0.01% +178,814 13F-HR Timeline Hudson Bay Capital Management LP in group Hudson Bay Capital Management… More: the full row for Hudson Bay Capital Management LP 207,574 $7.99M 0.05% new 13F-HR Timeline Group PEREGRINE CAPITAL MANAGEMENT LLC More: the full row for PEREGRINE CAPITAL MANAGEMENT LLC 201,959 $7.77M 0.29% new 13F-HR Timeline Cormorant Asset Management, LP More: the full row for Cormorant Asset Management, LP 200,000 $7.7M 0.39% -25,000 13F-HR Timeline SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 197,510 $7.6M 0.01% +18,096 13F-HR Timeline Group HighVista Strategies LLC More: the full row for HighVista Strategies LLC 197,051 $7.58M 2.09% -139,616 13F-HR Timeline Man Group plc in group Man Group plc More: the full row for Man Group plc 194,801 $7.5M 0.02% -97,281 13F-HR Timeline Group AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 189,796 $7.31M <0.01% +67,996 13F-HR Timeline Group PRUDENTIAL FINANCIAL INC in group PRUDENTIAL FINANCIAL INC More: the full row for PRUDENTIAL FINANCIAL INC 178,165 $6.86M 0.01% +57,990 13F-HR Timeline Group Tema ETFs LLC More: the full row for Tema ETFs LLC 176,667 $6.8M 0.46% +70,338 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 175,276 $6.75M 0.01% -4,900 13F-HR Timeline Fisher Asset Management, LLC More: the full row for Fisher Asset Management, LLC 167,412 $6.44M <0.01% +119,498 13F-HR Timeline Swiss National Bank More: the full row for Swiss National Bank 165,400 $6.37M <0.01% 0 13F-HR Timeline SEB Asset Management AB More: the full row for SEB Asset Management AB 164,437 $6.33M 0.03% 13F-HR Timeline OSTERWEIS CAPITAL MANAGEMENT INC in group OSTERWEIS CAPITAL MANAGEMENT … More: the full row for OSTERWEIS CAPITAL MANAGEMENT INC 150,810 $5.8M 0.3% new 13F-HR Timeline Group Seven Fleet Capital Management LP More: the full row for Seven Fleet Capital Management LP 149,399 $5.75M 1.81% -64,700 13F-HR/A Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 157,310 $5.59M <0.01% +1,800 13F-HR Timeline Connor, Clark & Lunn Investment Managem… More: the full row for Connor, Clark & Lunn Investment Management Ltd. 136,450 $5.25M 0.01% -39,439 13F-HR Timeline NEXTBio Capital Management LP More: the full row for NEXTBio Capital Management LP 131,188 $5.05M 2.34% +35,369 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 127,469 $4.91M <0.01% +18,341 13F-HR Timeline Group Rafferty Asset Management, LLC More: the full row for Rafferty Asset Management, LLC 125,013 $4.81M 0.02% +13,919 13F-HR Timeline BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 122,228 $4.7M 0.11% -4,847 13F-HR Timeline Informed Momentum Co LLC More: the full row for Informed Momentum Co LLC 121,928 $4.69M 0.54% -12,367 13F-HR Timeline PERCEPTIVE ADVISORS LLC in group PERCEPTIVE ADVISORS LLC More: the full row for PERCEPTIVE ADVISORS LLC 121,082 $4.66M 0.09% 0 13F-HR/A Timeline Group ALGERT GLOBAL LLC More: the full row for ALGERT GLOBAL LLC 116,054 $4.47M 0.07% -111,808 13F-HR/A Timeline Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 112,463 $4.33M 0.04% new 13F-HR Timeline PLATINUM INVESTMENT MANAGEMENT LTD More: the full row for PLATINUM INVESTMENT MANAGEMENT LTD 112,066 $4.31M 1.09% -9,163 13F-HR Timeline Creative Planning in group Creative Planning More: the full row for Creative Planning 110,758 $4.26M <0.01% +20,853 13F-HR Timeline Group VICTORY CAPITAL MANAGEMENT INC More: the full row for VICTORY CAPITAL MANAGEMENT INC 109,419 $4.21M <0.01% +57,833 13F-HR Timeline Trexquant Investment LP More: the full row for Trexquant Investment LP 107,443 $4.14M 0.03% +51,337 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 106,660 $4.11M <0.01% -46,965 13F-HR/A Timeline Group MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 105,517 $4.06M <0.01% +9,506 13F-HR Timeline Group Knott David M Jr More: the full row for Knott David M Jr 104,000 $4M 2.38% +2,000 13F-HR Timeline Pier Capital, LLC More: the full row for Pier Capital, LLC 101,304 $3.9M 0.64% +55,044 13F-HR Timeline CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 100,980 $3.89M <0.01% +17,297 13F-HR Timeline Parkman Healthcare Partners LLC More: the full row for Parkman Healthcare Partners LLC 100,126 $3.85M 0.4% new 13F-HR Timeline Nicholas Investment Partners, LP More: the full row for Nicholas Investment Partners, LP 95,160 $3.66M 0.26% -55,906 13F-HR Timeline Persistent Asset Partners Ltd More: the full row for Persistent Asset Partners Ltd 92,516 $3.56M 1.38% +45,017 13F-HR Timeline Atom Investors LP More: the full row for Atom Investors LP 87,676 $3.37M 0.24% +69,568 13F-HR Timeline TimesSquare Capital Management, LLC More: the full row for TimesSquare Capital Management, LLC 85,000 $3.27M 0.06% new 13F-HR Timeline PRINCIPAL FINANCIAL GROUP INC in group PRINCIPAL FINANCIAL GROUP INC More: the full row for PRINCIPAL FINANCIAL GROUP INC 83,944 $3.23M <0.01% -27,862 13F-HR Timeline Group Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 84,436 $3.22M +5,893 Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 81,243 $3.13M <0.01% -17,232 13F-HR Timeline Group SECTOR GAMMA AS More: the full row for SECTOR GAMMA AS 80,000 $3.08M 0.73% new 13F-HR Timeline SONA ASSET MANAGEMENT (US) LLC in group SONA ASSET MANAGEMENT (US) LLC More: the full row for SONA ASSET MANAGEMENT (US) LLC 80,000 $3.08M 0.12% -25,000 13F-HR Timeline Group MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 78,621 $3.03M 0.02% +1,145 13F-HR Timeline Group LPL Financial LLC More: the full row for LPL Financial LLC 74,155 $2.85M <0.01% -50,083 13F-HR Timeline STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 70,457 $2.71M 0.01% -3,769 13F-HR Timeline Cinctive Capital Management LP More: the full row for Cinctive Capital Management LP 68,761 $2.65M 0.17% +24,096 13F-HR Timeline PRELUDE CAPITAL MANAGEMENT, LLC More: the full row for PRELUDE CAPITAL MANAGEMENT, LLC 64,222 $2.47M 0.19% -8,156 13F-HR Timeline CASTLEARK MANAGEMENT LLC More: the full row for CASTLEARK MANAGEMENT LLC 63,950 $2.46M 0.08% new 13F-HR Timeline ENVESTNET ASSET MANAGEMENT INC in group ENVESTNET ASSET MANAGEMENT INC More: the full row for ENVESTNET ASSET MANAGEMENT INC 62,230 $2.4M <0.01% +46,635 13F-HR Timeline Group PROFUND ADVISORS LLC More: the full row for PROFUND ADVISORS LLC 57,051 $2.2M 0.08% +14,302 13F-HR Timeline Natixis Investment Managers group of 2 filers holding More: the full row for Natixis Investment Managers 56,483 $2.17M new Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 56,260 $2.17M <0.01% +39,403 13F-HR Timeline Group Jefferies Financial Group Inc. in group Jefferies Financial Group Inc. More: the full row for Jefferies Financial Group Inc. 55,574 $2.14M 0.03% -19,538 13F-HR Timeline Group LMR Partners LLP in group LMR Partners LLP More: the full row for LMR Partners LLP 55,389 $2.13M 0.02% +956 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 53,090 $2.04M <0.01% +40,490 13F-HR Timeline Group TD Asset Management Inc More: the full row for TD Asset Management Inc 52,590 $2.02M <0.01% -3,752 13F-HR Timeline GILDER GAGNON HOWE & CO LLC More: the full row for GILDER GAGNON HOWE & CO LLC 52,163 $2.01M 0.02% -1,112 13F-HR Timeline AIHC Capital Management Ltd More: the full row for AIHC Capital Management Ltd 51,402 $1.98M 1.65% -48,598 13F-HR Timeline Harvest Investment Services, LLC More: the full row for Harvest Investment Services, LLC 50,889 $1.96M 0.36% +20,151 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 50,470 $1.94M 0.03% new 13F-HR Timeline Group ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 50,000 $1.92M <0.01% -50,000 13F-HR Timeline Group SCHRODER INVESTMENT MANAGEMENT GROUP More: the full row for SCHRODER INVESTMENT MANAGEMENT GROUP 53,307 $1.89M <0.01% 0 13F-HR Timeline Universal- Beteiligungs- und Serviceges… in group Universal- Beteiligungs- und … More: the full row for Universal- Beteiligungs- und Servicegesellschaft mbH 45,233 $1.74M <0.01% +35,665 13F-HR Timeline Group INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 42,330 $1.63M 0.02% -19,260 13F-HR Timeline Engineers Gate Manager LP More: the full row for Engineers Gate Manager LP 41,990 $1.62M 0.02% +15,623 13F-HR Timeline Knights of Columbus Asset Advisors LLC More: the full row for Knights of Columbus Asset Advisors LLC 39,039 $1.5M 0.08% new 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 38,822 $1.49M 0.01% +1,336 13F-HR Timeline GUGGENHEIM CAPITAL LLC in group GUGGENHEIM CAPITAL LLC More: the full row for GUGGENHEIM CAPITAL LLC 38,755 $1.49M 0.01% new 13F-HR Timeline Group BANK OF MONTREAL /CAN/ in group BANK OF MONTREAL /CAN/ More: the full row for BANK OF MONTREAL /CAN/ 38,309 $1.47M <0.01% +28,417 13F-HR Timeline Group TEACHERS RETIREMENT SYSTEM OF THE STATE… More: the full row for TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY 37,445 $1.44M 0.01% 0 13F-HR Timeline SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 36,527 $1.41M <0.01% -1,107 13F-HR Timeline TWINBEECH CAPITAL LP More: the full row for TWINBEECH CAPITAL LP 35,900 $1.38M 0.14% +6,600 13F-HR Timeline SEVEN GRAND MANAGERS, LLC More: the full row for SEVEN GRAND MANAGERS, LLC 35,000 $1.35M 0.09% 0 13F-HR Timeline Y-Intercept (Hong Kong) Ltd More: the full row for Y-Intercept (Hong Kong) Ltd 34,759 $1.34M 0.03% -60,045 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 32,925 $1.27M <0.01% -35,728 13F-HR Timeline Group Allianz Asset Management GmbH in group Allianz SE More: the full row for Allianz Asset Management GmbH 32,600 $1.25M <0.01% 0 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 31,261 $1.2M <0.01% -290,345 13F-HR Timeline Group LOS ANGELES CAPITAL MANAGEMENT LLC More: the full row for LOS ANGELES CAPITAL MANAGEMENT LLC 29,086 $1.12M <0.01% +28,743 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 28,803 $1.11M 0.08% +3,789 13F-HR Timeline State of New Jersey Common Pension Fund… in group State of New Jersey Common Pe… More: the full row for State of New Jersey Common Pension Fund D 28,646 $1.1M <0.01% +36 13F-HR Timeline Group ProShare Advisors LLC More: the full row for ProShare Advisors LLC 28,006 $1.08M <0.01% -4,039 13F-HR Timeline STATE BOARD OF ADMINISTRATION OF FLORID… More: the full row for STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 27,707 $1.07M <0.01% +4,565 13F-HR Timeline FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 24,353 $937K <0.01% new 13F-HR Timeline Group SECTORAL ASSET MANAGEMENT INC More: the full row for SECTORAL ASSET MANAGEMENT INC 22,140 $902K 0.75% -10,545 13F-HR Timeline ARIZONA STATE RETIREMENT SYSTEM More: the full row for ARIZONA STATE RETIREMENT SYSTEM 23,023 $886K 0.01% -321 13F-HR Timeline Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 22,857 $880K <0.01% +419 13F-HR Timeline DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD. in group DYMON ASIA CAPITAL (SINGAPORE… More: the full row for DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD. 22,700 $874K 0.19% -1,500 13F-HR Timeline Group Caption Management, LLC More: the full row for Caption Management, LLC 20,000 $770K 0.04% new 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 19,397 $747K 0.02% +11,834 13F-HR Timeline Group ASSETMARK, INC in group ASSETMARK, INC More: the full row for ASSETMARK, INC 18,987 $731K <0.01% new 13F-HR Timeline Group KLP KAPITALFORVALTNING AS More: the full row for KLP KAPITALFORVALTNING AS 18,500 $712K <0.01% +700 13F-HR Timeline STRS OHIO More: the full row for STRS OHIO 17,900 $689K <0.01% -12,600 13F-HR Timeline Virtu Financial LLC in group Virtu Financial LLC More: the full row for Virtu Financial LLC 17,446 $671K 0.03% -20,173 13F-HR Timeline Group Orion Porfolio Solutions, LLC More: the full row for Orion Porfolio Solutions, LLC 17,341 $667K 0.01% new 13F-HR Timeline FARALLON CAPITAL MANAGEMENT, L.L.C. More: the full row for FARALLON CAPITAL MANAGEMENT, L.L.C. 17,000 $654K <0.01% 0 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. Legato Capital Management LLC More: the full row for Legato Capital Management LLC 16,198 $623K 0.06% -16,542 13F-HR Timeline E Fund Management Co., Ltd. More: the full row for E Fund Management Co., Ltd. 16,104 $620K 0.02% 13F-HR Timeline PUBLIC EMPLOYEES RETIREMENT ASSOCIATION… More: the full row for PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO 15,939 $613K <0.01% +13,741 13F-HR Timeline DARK FOREST CAPITAL MANAGEMENT LP More: the full row for DARK FOREST CAPITAL MANAGEMENT LP 15,391 $592K 0.05% new 13F-HR Timeline OmniStar Financial Group, Inc. More: the full row for OmniStar Financial Group, Inc. 14,303 $551K 0.29% 0 13F-HR Timeline JONES FINANCIAL COMPANIES LLLP in group JONES FINANCIAL COMPANIES LLLP More: the full row for JONES FINANCIAL COMPANIES LLLP 14,832 $535K <0.01% +14,565 13F-HR Timeline Group Arrowpoint Investment Partners (Singapo… in group Arrowpoint Investment Partner… More: the full row for Arrowpoint Investment Partners (Singapore) Pte. Ltd. 13,784 $531K 0.77% +6,431 13F-HR Timeline Group ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 13,814 $530K <0.01% -1,503 13F-HR Timeline Group XPONANCE LLC More: the full row for XPONANCE LLC 13,289 $511K <0.01% +2,345 13F-HR Timeline