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Disclosery

XENE XENON PHARMACEUTICALS INC

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Stock (common), issuer CIK 1582313

241 managers (246 13F filers) reported a position in XENE shares at 2025-12-31, 84,431,112 shares in all. 43 filers opened a position and 22 filers sold out during the quarter.

Managers
241
13F filers
246
New
43
Added
81
Reduced
74
Sold out
22
Shares held by filers
84,431,112

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q4 2025

Filers in the available 13F reports with a share position at 2025-12-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
FMR LLCin group FMR LLC8,920,250$400M0.02%+1,34313F-HRTimelineGroup
Avoro Capital Advisors LLC5,424,444$243M2.39%+24,44413F-HR/ATimeline
BlackRock, Inc.in group BlackRock, Inc.5,100,284$229M<0.01%+329,33313F-HRTimelineGroup
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…4,764,779$214M0.04%+1,154,92213F-HRTimelineGroup
Driehaus Capital Management LLC4,538,691$203M1.38%+369,57713F-HRTimeline
JANUS HENDERSON GROUP PLCin group Janus Henderson4,084,034$183M0.08%+140,14913F-HRTimelineGroup
Capital International Investorsin group Capital International Investo…3,414,959$153M0.02%+233,46613F-HRTimelineGroup
Polar Capital Holdings Plcin group Polar Capital Holdings Plc2,465,694$111M0.51%-81,07213F-HRTimelineGroup
BRAIDWELL LP1,825,076$81.8M2.62%-1,779,95313F-HRTimeline
Commodore Capital LPin group Commodore Capital LP1,800,000$80.7M5.37%-900,00013F-HRTimelineGroup
ALLIANCEBERNSTEIN L.P.1,593,814$71.4M0.02%-60,60313F-HRTimeline
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO1,494,032$67M<0.01%+94,99913F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP1,492,550$66.9M<0.01%+26,08313F-HRTimelineGroup
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC1,321,213$59.2M0.04%+362,11513F-HRTimelineGroup
JENNISON ASSOCIATES LLC1,292,055$57.9M0.03%+156,82013F-HRTimeline
Holocene Advisors, LP1,282,081$57.5M0.12%-694,47213F-HRTimeline
Affinity Asset Advisors, LLC1,250,000$56M4.03%-150,00013F-HRTimeline
WESTFIELD CAPITAL MANAGEMENT CO LP1,226,771$55M0.23%+20,70513F-HRTimeline
BNP PARIBAS ASSET MANAGEMENT Holding S.…in group BNP PARIBAS ASSET MANAGEMENT …1,060,221$47.5M0.05%+389,96413F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC952,679$42.7M<0.01%-24,75613F-HRTimelineGroup
PRICE T ROWE ASSOCIATES INC /MD/862,300$38.6M<0.01%+820,60813F-HRTimeline
Siren, L.L.C.in group Siren, L.L.C.812,761$36.4M1.09%013F-HRTimelineGroup
First Turn Management, LLC799,743$35.8M4.1%013F-HRTimeline
Rock Springs Capital Management LP787,788$35.3M1.81%-63,95613F-HRTimeline
FRANKLIN RESOURCES INCin group Franklin Resources758,059$34M0.01%+62,15913F-HRTimelineGroup
Aberdeen Group plcin group Aberdeen Group plc750,291$33.6M0.05%+171,14613F-HRTimelineGroup
TWO SIGMA INVESTMENTS, LPgroup of 2 filers holding696,063$31.2M+677,963Timeline
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC696,047$31.2M<0.01%-24,61213F-HR/ATimelineGroup
Fiera Capital Corpin group Fiera Capital Corp686,056$30.7M0.1%+166,05713F-HRTimelineGroup
ADAGE CAPITAL PARTNERS GP, L.L.C.in group ADAGE CAPITAL PARTNERS GP, L.…685,100$30.7M0.05%-150,00013F-HRTimelineGroup
AMERICAN CENTURY COMPANIES INCin group AMERICAN CENTURY COMPANIES INC680,473$30.5M0.02%+21,21613F-HRTimelineGroup
FEDERATED HERMES, INC.in group FEDERATED HERMES, INC.672,237$30.1M0.05%+439,73713F-HRTimelineGroup
VANGUARD GROUP INCgroup of 2 filers holding669,174$30M-182,212Timeline
Capital World Investors655,737$29.4M<0.01%013F-HRTimeline
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC635,056$28.5M0.02%-748,95113F-HRTimelineGroup
Pictet Asset Management Holding SAin group Pictet Asset Management Holdi…625,985$28M0.03%-636,59413F-HRTimelineGroup
LOOMIS SAYLES & CO L Pin group LOOMIS SAYLES & CO L P612,032$27.4M0.03%-28,59413F-HRTimelineGroup
BARCLAYS PLCin group BARCLAYS PLC600,964$26.9M0.01%+489,66413F-HRTimelineGroup
Vestal Point Capital, LP600,000$26.9M0.99%-500,00013F-HRTimeline
Trails Edge Capital Partners, LP597,092$26.8M6.61%13F-HRTimeline
Caligan Partners LP549,665$24.6M2.26%+105,10013F-HRTimeline
T. Rowe Price Investment Management, In…547,613$24.5M0.02%-51,50013F-HR/ATimeline
DEERFIELD MANAGEMENT COMPANY, L.P.in group DEERFIELD MANAGEMENT COMPANY,…542,020$24.3M0.31%013F-HRTimelineGroup
TimesSquare Capital Management, LLC532,740$23.9M0.36%-24,06013F-HRTimeline
MPM BIOIMPACT LLC485,620$21.8M2.49%-17,77813F-HRTimeline
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP452,147$20.3M<0.01%-1,87613F-HRTimelineGroup
ORBIMED ADVISORS LLCin group ORBIMED ADVISORS LLC447,200$20M0.41%+27,60013F-HRTimelineGroup
NORTHERN TRUST CORPin group NORTHERN TRUST CORP438,714$19.7M<0.01%-59,43313F-HRTimelineGroup
Candriam S.C.A.417,402$18.7M0.09%+20,76613F-HR/ATimeline
Bank of New York Mellon Corpin group Bank of New York Mellon Corp387,158$17.4M<0.01%-31,25813F-HRTimelineGroup
BAKER BROS. ADVISORS LPin group BAKER BROS. ADVISORS LP370,208$16.6M0.1%013F-HRTimelineGroup
Deep Track Capital, LP366,435$16.4M0.37%-833,56513F-HRTimeline
STEMPOINT CAPITAL LP348,605$15.6M2.68%+156,31013F-HRTimeline
MORGAN STANLEYin group MORGAN STANLEY294,332$13.2M<0.01%-72,24013F-HR/ATimelineGroup
DAFNA Capital Management LLC287,939$12.9M3%013F-HRTimeline
DNB Asset Management ASin group DNB Asset Management AS272,831$12.2M0.04%+23,75013F-HRTimelineGroup
TUDOR INVESTMENT CORP ET AL254,002$11.4M0.06%+177,17813F-HRTimeline
Nicholas Investment Partners, LP242,989$10.9M0.79%+123,89113F-HRTimeline
Iron Triangle Partners LP233,688$10.5M1.2%new13F-HRTimeline
Eversept Partners, LP231,380$10.4M0.58%new13F-HRTimeline
NAN FUNG TRINITY (HK) LTD226,965$10.2M0.81%+68,36013F-HRTimeline
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/221,368$9.92M<0.01%+22,26213F-HRTimelineGroup
Nuveen, LLCin group TIAA216,238$9.69M<0.01%-8,05113F-HRTimelineGroup
STATE OF WISCONSIN INVESTMENT BOARD205,569$9.21M0.02%-2,80313F-HRTimeline
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC203,969$9.14M0.68%+14,87113F-HR/ATimelineGroup
PERCEPTIVE ADVISORS LLCin group PERCEPTIVE ADVISORS LLC200,791$9M0.16%013F-HRTimelineGroup
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\190,233$8.53M<0.01%+77,28213F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co189,059$8.47M<0.01%+31213F-HRTimelineGroup
NEW YORK STATE COMMON RETIREMENT FUND186,705$8.37M0.01%+14,99713F-HRTimeline
NEXTBio Capital Management LP183,704$8.23M4.83%13F-HRTimeline
NEUBERGER BERMAN GROUP LLCin group NEUBERGER BERMAN GROUP LLC178,747$8.01M0.01%+6,39313F-HRTimelineGroup
PEREGRINE CAPITAL MANAGEMENT LLC174,851$7.84M0.24%new13F-HRTimeline
Jain Global LLC173,882$7.79M0.08%-78,49713F-HRTimeline
MARSHALL WACE, LLPin group MARSHALL WACE, LLP162,551$7.29M0.01%-449,43113F-HRTimelineGroup
Foresite Capital Management IV, LLCin group Foresite Capital Management V…160,000$7.17M3.12%013F-HRTimelineGroup
Parkman Healthcare Partners LLC154,184$6.91M0.66%-21,95313F-HRTimeline
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN152,297$6.83M<0.01%+37,07613F-HRTimelineGroup
MOORE CAPITAL MANAGEMENT, LP140,000$6.27M0.13%013F-HRTimeline
Rhenman & Partners Asset Management AB139,000$6.23M0.58%+58,00013F-HRTimeline
Patient Square Capital LP136,500$6.12M1.31%new13F-HRTimeline
Redmile Group, LLCin group Redmile Group, LLC133,882$6M0.44%new13F-HRTimelineGroup
ALGERT GLOBAL LLC123,189$5.52M0.09%+68,93413F-HR/ATimeline
Assenagon Asset Management S.A.119,186$5.34M0.01%new13F-HRTimeline
MUTUAL OF AMERICA CAPITAL MANAGEMENT LLCin group MUTUAL OF AMERICA CAPITAL MAN…116,088$5.2M0.05%+21,15313F-HRTimelineGroup
Man Group plcin group Man Group plc114,826$5.15M0.01%+91,70713F-HRTimelineGroup
Swiss National Bank114,000$5.11M<0.01%-12,40013F-HRTimeline
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC109,544$4.91M<0.01%+11,97713F-HRTimelineGroup
Squadron Capital Management LLC105,551$4.73M2.11%13F-HRTimeline
Palo Alto Investors LP96,519$4.33M0.6%new13F-HRTimeline
Verition Fund Management LLC93,756$4.2M0.02%+36,63913F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS93,462$4.19M<0.01%-65,77613F-HRTimelineGroup
Granahan Investment Management, LLC92,778$4.16M0.18%+5,30813F-HRTimeline
Atika Capital Management LLCin group Atika Capital Management LLC92,506$4.15M0.58%+54,50613F-HRTimelineGroup
RHUMBLINE ADVISERS90,143$4.04M<0.01%-16,64813F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA89,757$4.02M<0.01%-30,78813F-HRTimelineGroup
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…86,220$3.86M<0.01%+16,32813F-HRTimelineGroup
Balyasny Asset Management L.P.in group Balyasny Asset Management84,360$3.78M0.01%-238,09613F-HRTimelineGroup
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC83,255$3.73M<0.01%+13,33313F-HRTimelineGroup
SCHRODER INVESTMENT MANAGEMENT GROUP81,156$3.58M<0.01%013F-HRTimeline
LAZARD ASSET MANAGEMENT LLCin group LAZARD ASSET MANAGEMENT LLC78,663$3.53M0.01%new13F-HRTimelineGroup
Y-Intercept (Hong Kong) Ltd72,957$3.27M0.07%new13F-HRTimeline
Legal & General Group Plcin group Legal & General Group Plc70,265$3.15M<0.01%-9,58313F-HRTimelineGroup
ALPS ADVISORS INCin group ALPS ADVISORS INC63,302$2.84M0.02%+26,00213F-HRTimelineGroup
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC60,858$2.73M<0.01%013F-HRTimelineGroup
Sofinnova Investments, Inc.59,900$2.68M0.12%new13F-HRTimeline
CALIFORNIA STATE TEACHERS RETIREMENT SY…56,564$2.54M<0.01%-3,67313F-HRTimeline
UBS Group AGgroup of 2 filers holding52,775$2.37M-53,969Timeline
Invesco Ltd.in group Invesco Ltd.50,947$2.28M<0.01%-5,11713F-HRTimelineGroup
Erste Asset Management GmbHin group Erste Asset Management GmbH50,000$2.22M0.02%013F-HRTimelineGroup
NOMURA ASSET MANAGEMENT CO LTDgroup of 2 filers holding47,957$2.15M+47,957Timeline
SEI INVESTMENTS COin group SEI INVESTMENTS CO43,858$1.97M<0.01%+21,43513F-HRTimelineGroup
MetLife Investment Management, LLCin group MetLife Investment Management…42,025$1.88M0.01%-2,19613F-HRTimelineGroup
DekaBank Deutsche Girozentrale39,000$1.82M<0.01%013F-HRTimeline
Artia Global Partners LP40,000$1.79M0.29%013F-HRTimeline
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding39,065$1.75M+783Timeline
TD Asset Management Inc38,148$1.71M<0.01%+21,91813F-HRTimeline
Legato Capital Management LLC37,038$1.66M0.14%+22,82913F-HRTimeline
ENVESTNET ASSET MANAGEMENT INCin group ENVESTNET ASSET MANAGEMENT INC35,801$1.6M<0.01%-1,64713F-HRTimelineGroup
BOOTHBAY FUND MANAGEMENT, LLC35,681$1.6M0.04%+6,82213F-HRTimeline
DARK FOREST CAPITAL MANAGEMENT LP33,459$1.5M0.07%new13F-HRTimeline
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …32,622$1.45M<0.01%+8,69013F-HRTimelineGroup
Jump Financial, LLCin group Jump Financial, LLC30,987$1.39M0.02%+24,48713F-HRTimelineGroup
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.30,851$1.38M<0.01%-17,60413F-HRTimelineGroup
BAMCO INC /NY/in group Baron Capital30,000$1.34M<0.01%013F-HRTimelineGroup
Handelsbanken Fonder AB29,800$1.34M<0.01%+7,10013F-HRTimeline
INTECH INVESTMENT MANAGEMENT LLC25,840$1.16M0.01%+2,75413F-HRTimeline
Zurcher Kantonalbank (Zurich Cantonalba…25,589$1.15M<0.01%013F-HRTimeline
Lighthouse Investment Partners, LLCin group Lighthouse Investment Partner…25,000$1.12M0.04%new13F-HRTimelineGroup
Quantinno Capital Management LP24,628$1.1M<0.01%+11,25713F-HRTimeline
Rathbones Group PLC23,666$1.06M<0.01%013F-HR/ATimeline
Cinctive Capital Management LP23,317$1.05M0.06%+26313F-HRTimeline
HighMark Wealth Management LLC23,000$1.03M0.42%-3,10013F-HRTimeline
Vestmark Advisory Solutions, Inc.21,884$981K0.01%new13F-HRTimeline
XTX Topco Ltdin group XTX Topco Ltd21,498$964K0.03%new13F-HRTimelineGroup
ASSETMARK, INCin group ASSETMARK, INC21,269$953K<0.01%-1,29713F-HRTimelineGroup
Birchview Capital, LP21,000$941K0.55%013F-HRTimeline
Police & Firemen's Retirement System of…20,128$902K0.01%-90413F-HRTimeline
State of New Jersey Common Pension Fund…in group State of New Jersey Common Pe…19,738$885K<0.01%-35,97313F-HRTimelineGroup
Walleye Capital LLCin group Walleye Capital LLC19,587$878K0.01%new13F-HRTimelineGroup
Creative Planningin group Creative Planning19,200$861K<0.01%+5,99013F-HRTimelineGroup
STIFEL FINANCIAL CORPin group STIFEL FINANCIAL CORP17,548$787K<0.01%-1,16713F-HRTimelineGroup
ProShare Advisors LLC17,279$774K<0.01%+1,53913F-HRTimeline
Entropy Technologies, LP17,025$763K0.04%new13F-HRTimeline
ARIZONA STATE RETIREMENT SYSTEM16,179$725K<0.01%-3,11113F-HRTimeline
Campbell & CO Investment Adviser LLC16,105$722K0.03%-12,56413F-HRTimeline
Orion Porfolio Solutions, LLC14,407$646K<0.01%-51113F-HRTimeline
SBI Okasan Asset Management Co.Ltd.14,400$638K0.04%13F-HRTimeline
J. Safra Sarasin Holding AGin group J. Safra Sarasin Holding AG13,581$609K0.01%-16,58713F-HRTimelineGroup
CIBC WORLD MARKET INC.13,460$603K<0.01%013F-HRTimeline
China Universal Asset Management Co., L…12,592$564K0.04%-92313F-HRTimeline
KLP KAPITALFORVALTNING AS12,300$551K<0.01%-50013F-HRTimeline
PSP Research LLC11,678$523K0.46%13F-HRTimeline
HIMENSION CAPITAL (SINGAPORE) PTE. LTD.11,279$506K0.03%new13F-HRTimeline
Supplemental Annuity Collective Trust o…11,000$493K0.13%013F-HRTimeline
Knott David M Jr10,962$491K0.23%013F-HRTimeline
Elmwood Wealth Management, Inc.10,757$482K0.15%-15013F-HRTimeline
PUBLIC EMPLOYEES RETIREMENT ASSOCIATION…10,633$477K<0.01%013F-HRTimeline
Marex Group Ltdin group Marex Group Ltd10,557$473K0.01%new13F-HRTimelineGroup
HARBOR CAPITAL ADVISORS, INC.10,053$451K0.04%-1,16513F-HRTimeline
Allianz Asset Management GmbHin group Allianz SE9,400$421K<0.01%013F-HRTimelineGroup
TEACHER RETIREMENT SYSTEM OF TEXAS8,632$387K<0.01%-7,36913F-HRTimeline
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…8,319$373K<0.01%-37,58813F-HRTimelineGroup
ALTFEST L J & CO INC8,232$369K0.04%+50113F-HRTimeline
Advisors Asset Management, Inc.8,012$359K0.01%-3,45213F-HR/ATimeline
Neo Ivy Capital Management7,477$335K0.05%-42,36113F-HRTimeline
OXFORD ASSET MANAGEMENT LLP7,379$331K0.12%-14,78313F-HRTimelineThe filing omitted confidential holdings, a later amendment may add them.
CITIGROUP INCin group CITIGROUP INC7,361$330K<0.01%-7,50913F-HRTimelineGroup
SG Americas Securities, LLC7,077$317K<0.01%+14913F-HRTimeline
CANADA LIFE ASSURANCE Coin group CANADA LIFE ASSURANCE Co7,024$315K<0.01%013F-HRTimelineGroup
PenderFund Capital Management Ltd.6,850$307K0.05%013F-HRTimeline
TLS Advisors LLC18,858$307K0.81%-14,09813F-HRTimeline
Abel Hall, LLC6,757$303K0.07%new13F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…6,574$295K<0.01%+67513F-HRTimelineGroup
FIRST TRUST ADVISORS LPin group FIRST TRUST ADVISORS LP6,361$285K<0.01%new13F-HRTimelineGroup
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…6,168$276K0.01%-39013F-HRTimelineGroup
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…6,037$271K0.07%+2,56813F-HRTimelineGroup
LETSON INVESTMENT MANAGEMENT, INC.6,000$269K0.1%new13F-HRTimeline
XPONANCE LLC5,975$268K<0.01%+813F-HRTimeline
Thrivent Financial for Lutheransin group Thrivent Financial for Luther…5,583$250K<0.01%-10,51813F-HRTimelineGroup
Ensign Peak Advisors, Inc5,194$233K<0.01%-10,05013F-HR/ATimeline
Magnetar Financial LLCin group Magnetar Financial LLC5,153$231K<0.01%new13F-HRTimelineGroup
Caprock Group, LLC5,069$227K<0.01%new13F-HRTimeline
EntryPoint Capital, LLC5,028$225K0.09%013F-HRTimeline
CIBC WORLD MARKETS CORPin group CIBC Bancorp USA Inc.5,027$225K<0.01%13F-HRTimelineGroup
CITIZENS FINANCIAL GROUP INC/RIin group CITIZENS FINANCIAL GROUP INC/…5,000$224K<0.01%013F-HRTimelineGroup
NORTHWESTERN MUTUAL WEALTH MANAGEMENT COin group NORTHWESTERN MUTUAL INVESTMEN…5,000$224K<0.01%013F-HR/ATimelineGroup
MACKENZIE FINANCIAL CORP4,772$210K<0.01%new13F-HRTimeline
Whalen Wealth Management Inc.4,641$208K0.11%new13F-HRTimeline
Amundiin group Amundi4,609$207K<0.01%new13F-HRTimelineGroup
PRINCIPAL FINANCIAL GROUP INCgroup of 2 filers holding4,488$201K-1,398Timeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…3,232$145K<0.01%+1,71513F-HRTimelineGroup
KBC Group NVin group KBC Group NV2,780$125K<0.01%+90913F-HRTimelineGroup
AMALGAMATED BANK2,387$107K<0.01%-20813F-HRTimeline
IFP Advisors, Inc1,877$84.1K<0.01%-3113F-HRTimeline
GF FUND MANAGEMENT CO. LTD.1,517$68K<0.01%-14213F-HRTimeline
State of Wyoming1,501$67.3K0.01%+35013F-HRTimeline
STRS OHIO1,300$58.3K<0.01%new13F-HRTimeline
Caitong International Asset Management …1,225$54.9K0.01%new13F-HR/ATimeline
Clearstead Advisors, LLC1,215$54.5K<0.01%+82913F-HRTimeline
Rockefeller Capital Management L.P.in group Rockefeller Capital Managemen…1,100$49.3K<0.01%+90013F-HR/ATimelineGroup