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Disclosery

RYTM RHYTHM PHARMACEUTICALS INC

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COM (common), issuer CIK 1649904

278 managers (282 13F filers) reported a position in RYTM shares at 2025-12-31, 72,872,286 shares in all. 49 filers opened a position and 39 filers sold out during the quarter.

Managers
278
13F filers
282
New
49
Added
107
Reduced
89
Sold out
39
Shares held by filers
72,872,286

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q4 2025

Filers in the available 13F reports with a share position at 2025-12-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
RA CAPITAL MANAGEMENT, L.P.in group RA CAPITAL MANAGEMENT, L.P.6,666,837$714M7.31%+985,47813F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.6,297,334$674M0.01%-4,88113F-HRTimelineGroup
VANGUARD GROUP INCgroup of 2 filers holding6,213,295$665M+1,214,800Timeline
BAKER BROS. ADVISORS LPin group BAKER BROS. ADVISORS LP5,604,483$600M3.51%013F-HRTimelineGroup
PRIMECAP MANAGEMENT CO/CA/3,478,669$372M0.28%-784,19013F-HRTimeline
NEA Management Company, LLC2,909,956$311M15.88%013F-HRTimeline
PERCEPTIVE ADVISORS LLCin group PERCEPTIVE ADVISORS LLC2,546,391$273M4.99%+107,42213F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP2,198,615$235M0.01%+169,96413F-HRTimelineGroup
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC1,830,866$196M0.03%-62,79713F-HR/ATimelineGroup
FMR LLCin group FMR LLC1,706,317$183M0.01%-438,86613F-HRTimelineGroup
FEDERATED HERMES, INC.in group FEDERATED HERMES, INC.1,623,841$174M0.29%-104,04413F-HRTimelineGroup
PRICE T ROWE ASSOCIATES INC /MD/1,560,847$167M0.02%+160,95013F-HRTimeline
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO1,423,989$152M0.01%+235,92013F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC1,375,729$147M0.01%+12,90013F-HRTimelineGroup
Driehaus Capital Management LLC1,285,222$138M0.93%-98,55313F-HRTimeline
WESTFIELD CAPITAL MANAGEMENT CO LP1,267,158$136M0.57%+198,15413F-HRTimeline
Franklin Resourcesgroup of 2 filers holding1,201,844$129M+149,330Timeline
Polar Capital Holdings Plcin group Polar Capital Holdings Plc1,185,392$127M0.58%-59,54013F-HRTimelineGroup
JANUS HENDERSON GROUP PLCin group Janus Henderson1,126,125$121M0.05%-34,76213F-HRTimelineGroup
Checkpoint Capital L.P.992,200$106M33.65%+228,49313F-HRTimeline
Capital Research Global Investorsin group Capital Research Global Inves…985,086$105M0.02%+386,83913F-HRTimelineGroup
UBS Group AGgroup of 2 filers holding976,256$104M+118,448Timeline
ALLIANCEBERNSTEIN L.P.930,233$99.6M0.03%-49,44913F-HRTimeline
JENNISON ASSOCIATES LLC918,567$98.3M0.06%+507,01713F-HRTimeline
Rock Springs Capital Management LP695,010$74.4M3.82%-22,09213F-HRTimeline
Woodline Partners LP688,779$73.7M0.29%+108,59613F-HRTimeline
MORGAN STANLEYin group MORGAN STANLEY651,402$69.7M<0.01%+186,21213F-HR/ATimelineGroup
ADAGE CAPITAL PARTNERS GP, L.L.C.in group ADAGE CAPITAL PARTNERS GP, L.…621,585$66.5M0.1%+77,58513F-HRTimelineGroup
LORD, ABBETT & CO. LLC619,542$66.3M0.2%+43,55813F-HRTimeline
Pictet Asset Management Holding SAin group Pictet Asset Management Holdi…614,663$66.2M0.06%-68,35413F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co532,447$57M0.01%+4,52513F-HRTimelineGroup
LOOMIS SAYLES & CO L Pin group LOOMIS SAYLES & CO L P503,901$53.9M0.07%-23,53813F-HRTimelineGroup
Siren, L.L.C.in group Siren, L.L.C.499,975$53.5M1.6%013F-HRTimelineGroup
NORTHERN TRUST CORPin group NORTHERN TRUST CORP488,216$52.3M0.01%-22,69013F-HRTimelineGroup
Integral Health Asset Management, LLC475,000$50.8M2.58%+255,00013F-HRTimeline
Point72 Asset Management, L.P.in group Point72 Asset Management, L.P.429,420$46M0.07%new13F-HRTimelineGroup
RENAISSANCE TECHNOLOGIES LLC341,193$36.5M0.06%-205,40013F-HRTimeline
Opaleye Management Inc.330,000$35.3M4.66%-131,70013F-HR/ATimeline
Qube Research & Technologies Ltd310,919$33.3M0.05%+72,10013F-HRTimeline
Bank of New York Mellon Corpin group Bank of New York Mellon Corp301,080$32.2M0.01%+118,71513F-HRTimelineGroup
First Light Asset Management, LLC295,844$31.7M2.42%+115,36013F-HRTimeline
Invesco Ltd.in group Invesco Ltd.291,150$31.2M<0.01%+147,59513F-HRTimelineGroup
Candriam S.C.A.287,907$30.8M0.15%+66,04413F-HR/ATimeline
Sofinnova Investments, Inc.271,394$29.1M1.25%+24,42813F-HRTimeline
Artisan Partners Limited Partnership263,591$28.2M0.04%+26,75013F-HRTimeline
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC261,160$28M0.01%+123,19313F-HRTimelineGroup
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…250,156$26.8M<0.01%+225,67913F-HRTimelineGroup
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC249,874$26.7M0.03%+28,28113F-HRTimelineGroup
ORBIMED ADVISORS LLCin group ORBIMED ADVISORS LLC239,800$25.7M0.53%+24,64813F-HRTimelineGroup
Hood River Capital Management LLC237,043$25.4M0.28%+1,20713F-HRTimeline
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/224,484$24M<0.01%-8,66613F-HRTimelineGroup
Logos Global Management LP190,000$20.3M1.36%-10,00013F-HRTimeline
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC186,709$20M0.01%+53,54813F-HRTimelineGroup
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS164,563$17.6M0.01%-59,11813F-HRTimelineGroup
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC153,322$16.4M0.01%+20,69613F-HRTimelineGroup
Connor, Clark & Lunn Investment Managem…149,373$16M0.04%+28,11313F-HRTimeline
First Turn Management, LLC146,303$15.7M1.79%new13F-HRTimeline
M&G PLCin group M&G PLC137,074$14.7M0.08%new13F-HRTimelineGroup
SILVERARC CAPITAL MANAGEMENT, LLCin group SILVERARC CAPITAL MANAGEMENT,…135,950$14.6M2.11%-234,04613F-HRTimelineGroup
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…134,180$14.4M0.02%-23,49813F-HRTimelineGroup
BARCLAYS PLCin group BARCLAYS PLC131,436$14.1M0.01%-10,94913F-HRTimelineGroup
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\129,123$13.8M<0.01%+12,38113F-HRTimelineGroup
Universal- Beteiligungs- und Serviceges…in group Universal- Beteiligungs- und …123,537$13.2M0.02%+22,16513F-HRTimelineGroup
Nuveen, LLCin group TIAA115,934$12.4M<0.01%-2,03013F-HRTimelineGroup
Capital World Investors115,693$12.4M<0.01%new13F-HRTimeline
Swiss National Bank111,300$11.9M0.01%+9,00013F-HRTimeline
NEW YORK STATE COMMON RETIREMENT FUND93,677$10M0.01%+18,54613F-HRTimeline
FIRST TRUST ADVISORS LPin group FIRST TRUST ADVISORS LP88,505$9.47M0.01%+7,60213F-HRTimelineGroup
ALGERT GLOBAL LLC88,250$9.45M0.15%-52,03413F-HR/ATimeline
AXIOM INVESTORS LLC /DE83,554$8.94M0.08%+52313F-HRTimeline
Zweig-DiMenna Associates LLC81,600$8.73M0.62%new13F-HRTimeline
SummitTX Capital, L.P.80,729$8.64M0.26%+68,86013F-HRTimeline
ExodusPoint Capital Management, LP75,141$8.04M0.09%new13F-HRTimeline
NEUBERGER BERMAN GROUP LLCin group NEUBERGER BERMAN GROUP LLC73,572$7.88M0.01%-11,54513F-HRTimelineGroup
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN72,617$7.77M<0.01%+25,48313F-HRTimelineGroup
Balyasny Asset Management L.P.in group Balyasny Asset Management72,282$7.74M0.01%-277,72613F-HRTimelineGroup
RHUMBLINE ADVISERS71,212$7.62M0.01%-10,85613F-HRTimeline
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC70,046$7.5M<0.01%-9,73413F-HRTimelineGroup
NEXTBio Capital Management LP67,586$7.23M4.24%13F-HRTimeline
NORGES BANK66,213$7.09M<0.01%new13F-HRTimeline
CASTLEARK MANAGEMENT LLC64,479$6.9M0.2%+21,94013F-HRTimeline
VOLORIDGE INVESTMENT MANAGEMENT, LLC60,575$6.48M0.02%-307,68813F-HRTimeline
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …59,609$6.37M0.01%-1,30813F-HRTimelineGroup
PDT Partners, LLC59,436$6.36M0.41%-26,70013F-HRTimeline
STEMPOINT CAPITAL LP58,915$6.31M1.08%-32,52913F-HRTimeline
Informed Momentum Co LLC57,327$6.14M0.68%-1,15313F-HRTimeline
Rafferty Asset Management, LLC55,526$5.94M0.02%-20813F-HRTimeline
Legal & General Group Plcin group Legal & General Group Plc55,075$5.9M<0.01%-2,30113F-HRTimelineGroup
TD Asset Management Inc55,050$5.89M<0.01%-4,51413F-HRTimeline
CALIFORNIA STATE TEACHERS RETIREMENT SY…53,537$5.73M0.01%+4,60313F-HRTimeline
Granahan Investment Management, LLC53,452$5.72M0.24%+3,72413F-HRTimeline
PRUDENTIAL FINANCIAL INCin group PRUDENTIAL FINANCIAL INC53,145$5.69M0.01%-19,86513F-HRTimelineGroup
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC51,349$5.5M0.41%+1,77813F-HR/ATimelineGroup
Nan Fung Group Holdings Ltd49,120$5.26M4.71%013F-HRTimeline
VICTORY CAPITAL MANAGEMENT INC45,381$4.86M<0.01%+2,49813F-HRTimeline
WCM INVESTMENT MANAGEMENT, LLC44,805$4.78M0.01%-2,92813F-HRTimeline
Harvest Investment Services, LLC43,953$4.7M0.89%-4,18713F-HRTimeline
HighVista Strategies LLC42,867$4.59M1.18%+5,38513F-HRTimeline
Hillsdale Investment Management Inc.42,300$4.53M0.12%-30013F-HRTimeline
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC41,115$4.4M<0.01%-2,97813F-HRTimelineGroup
HARBOR CAPITAL ADVISORS, INC.40,896$4.38M0.34%+3,69113F-HRTimeline
PFM Health Sciences, LP40,210$4.3M0.44%-7,95213F-HRTimeline
KENNEDY CAPITAL MANAGEMENT LLC39,887$4.27M0.09%+31213F-HRTimeline
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding38,144$4.08M+8,454Timeline
SEI INVESTMENTS COin group SEI INVESTMENTS CO37,432$4.01M<0.01%+5,77413F-HRTimelineGroup
STATE OF WISCONSIN INVESTMENT BOARD36,079$3.86M0.01%-4,69713F-HRTimeline
Rhenman & Partners Asset Management AB35,000$3.75M0.35%013F-HRTimeline
Nicholas Investment Partners, LP34,710$3.72M0.27%new13F-HRTimeline
SILVERCREST ASSET MANAGEMENT GROUP LLC34,127$3.65M0.03%+4313F-HRTimeline
Squarepoint Ops LLCin group Squarepoint Ops LLC32,829$3.51M0.01%new13F-HRTimelineGroup
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP32,018$3.43M<0.01%+3,64013F-HRTimelineGroup
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.31,356$3.36M<0.01%+27,77113F-HRTimelineGroup
Magnetar Financial LLCin group Magnetar Financial LLC29,598$3.17M0.03%new13F-HRTimelineGroup
EFG International AGin group EFG International AG29,291$3.14M0.06%13F-HRTimelineGroup
MetLife Investment Management, LLCin group MetLife Investment Management…29,174$3.12M0.02%-1,18813F-HRTimelineGroup
LAZARD ASSET MANAGEMENT LLCin group LAZARD ASSET MANAGEMENT LLC25,571$2.74M<0.01%-4,66813F-HRTimelineGroup
LOS ANGELES CAPITAL MANAGEMENT LLC24,334$2.72M0.01%+7,61313F-HRTimeline
Creative Planningin group Creative Planning25,206$2.7M<0.01%+26113F-HRTimelineGroup
Atom Investors LP22,929$2.45M0.19%new13F-HRTimeline
Penserra Capital Management LLCin group Penserra Capital Management L…21,514$2.3M0.03%-8,92213F-HRTimelineGroup
INTECH INVESTMENT MANAGEMENT LLC21,350$2.29M0.02%-2,96213F-HRTimeline
PROFUND ADVISORS LLC21,046$2.25M0.07%+8,58913F-HRTimeline
State of New Jersey Common Pension Fund…in group State of New Jersey Common Pe…19,270$2.06M0.01%-1,64913F-HRTimelineGroup
WEDGE CAPITAL MANAGEMENT L L P/NC19,247$2.06M0.04%-2,99713F-HRTimeline
Advisors Asset Management, Inc.18,524$1.98M0.03%+4,34613F-HR/ATimeline
CAPTRUST FINANCIAL ADVISORS18,325$1.96M<0.01%+6713F-HRTimeline
Handelsbanken Fonder AB17,521$1.88M0.01%+2,00013F-HRTimeline
ARIZONA STATE RETIREMENT SYSTEM15,762$1.69M0.01%+14813F-HRTimeline
STATE BOARD OF ADMINISTRATION OF FLORID…14,650$1.57M<0.01%013F-HRTimeline
Police & Firemen's Retirement System of…14,183$1.52M0.01%-42313F-HRTimeline
STIFEL FINANCIAL CORPin group STIFEL FINANCIAL CORP13,247$1.42M<0.01%-1,20813F-HRTimelineGroup
NISA INVESTMENT ADVISORS, LLC13,139$1.41M<0.01%-11513F-HRTimeline
CITIGROUP INCin group CITIGROUP INC12,720$1.36M<0.01%-36013F-HRTimelineGroup
ProShare Advisors LLC12,622$1.35M<0.01%+1,32313F-HRTimeline
Zurcher Kantonalbank (Zurich Cantonalba…12,435$1.33M<0.01%+1,70913F-HRTimeline
GUGGENHEIM CAPITAL LLCin group GUGGENHEIM CAPITAL LLC12,401$1.33M0.01%+10,11613F-HRTimelineGroup
STRS OHIO12,000$1.28M<0.01%-2,80013F-HRTimeline
KLP KAPITALFORVALTNING AS12,000$1.28M<0.01%+1,00013F-HRTimeline
Rockefeller Capital Management L.P.in group Rockefeller Capital Managemen…11,771$1.26M<0.01%+2,90313F-HR/ATimelineGroup
SG Americas Securities, LLC11,741$1.26M<0.01%-7,81313F-HRTimeline
DNB Asset Management ASin group DNB Asset Management AS11,163$1.19M<0.01%+5,63513F-HRTimelineGroup
Hennion & Walsh Asset Management, Inc.10,908$1.17M0.04%-33,82313F-HRTimeline
China Universal Asset Management Co., L…10,875$1.16M0.09%-76713F-HRTimeline
XTX Topco Ltdin group XTX Topco Ltd10,433$1.12M0.03%new13F-HRTimelineGroup
Knights of Columbus Asset Advisors LLC10,314$1.1M0.06%new13F-HRTimeline
TOTH FINANCIAL ADVISORY CORP10,000$1.07M0.12%013F-HRTimeline
Cannon Financial Strategists, Inc.10,000$1.07M0.15%013F-HRTimeline
Man Group plcin group Man Group plc9,558$1.02M<0.01%-119,77213F-HRTimelineGroup
FRED ALGER MANAGEMENT, LLCin group FRED ALGER MANAGEMENT, LLC9,301$996K<0.01%-3,03413F-HRTimelineGroup
VIRGINIA RETIREMENT SYSTEMS ET Al9,200$985K0.01%+2,50013F-HRTimeline
Headlands Technologies LLC8,632$924K0.08%new13F-HRTimeline
TEACHER RETIREMENT SYSTEM OF TEXAS8,359$895K<0.01%-4,60113F-HRTimeline
Allianz Asset Management GmbHin group Allianz SE8,000$856K<0.01%-4,10013F-HRTimelineGroup
Bellevue Group AGin group Bellevue Group AG7,504$803K0.02%-1,54913F-HRTimelineGroup
Leo Wealth, LLC6,952$744K0.05%-91513F-HRTimeline
Jump Financial, LLCin group Jump Financial, LLC6,759$723K0.01%new13F-HRTimelineGroup
E. Ohman J:or Asset Management AB6,589$705K0.02%-1,62413F-HRTimeline
PRINCIPAL FINANCIAL GROUP INCin group PRINCIPAL FINANCIAL GROUP INC6,198$663K<0.01%-6,40013F-HRTimelineGroup
ACADIAN ASSET MANAGEMENT LLCin group ACADIAN ASSET MANAGEMENT LLC6,105$652K<0.01%new13F-HRTimelineGroup
EXCHANGE TRADED CONCEPTS, LLC6,080$651K0.01%-30613F-HRTimeline
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…6,017$644K0.18%-1,03513F-HRTimelineGroup
CANADA LIFE ASSURANCE Coin group CANADA LIFE ASSURANCE Co5,797$621K<0.01%-8,59813F-HRTimelineGroup
Legato Capital Management LLC5,723$613K0.05%new13F-HRTimeline
Jasper Ridge Partners, L.P.5,639$604K0.01%013F-HRTimeline
Quantedge Capital Pte Ltd5,600$599K0.29%-12,20013F-HRTimeline
PUBLIC EMPLOYEES RETIREMENT ASSOCIATION…5,463$585K<0.01%013F-HRTimeline
LPL Financial LLC5,427$581K<0.01%+1,43713F-HRTimeline
AlphaCentric Advisors LLC5,052$541K0.54%13F-HRTimeline
Voleon Capital Management LP5,025$538K0.01%-21,87213F-HRTimeline
TWO SIGMA SECURITIES, LLC4,943$529K0.07%new13F-HRTimeline
Gotham Asset Management, LLC4,851$519K<0.01%-413F-HRTimeline
PSP Research LLC4,738$507K0.44%13F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…4,659$499K<0.01%+44213F-HRTimelineGroup
Caption Management, LLC4,614$494K0.02%new13F-HRTimeline
Vestmark Advisory Solutions, Inc.4,560$488K0.01%new13F-HRTimeline
Verition Fund Management LLC4,504$482K<0.01%new13F-HRTimeline
MACKENZIE FINANCIAL CORP4,398$469K<0.01%013F-HRTimeline
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…4,365$467K0.01%013F-HRTimelineGroup
XPONANCE LLC4,269$457K<0.01%+10713F-HRTimeline
Empowered Funds, LLC4,164$446K0.01%+2,01913F-HR/ATimeline
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…4,097$439K<0.01%+99313F-HRTimelineGroup
COMERICA BANK4,014$430K<0.01%-205,31113F-HRTimeline
Ensign Peak Advisors, Inc3,859$413K<0.01%-107,68513F-HR/ATimeline
Quantinno Capital Management LP3,831$410K<0.01%+1,27313F-HRTimeline
Freestone Capital Holdings, LLCin group Freestone Capital Holdings, L…3,700$396K0.01%013F-HRTimelineGroup
Cerity Partners LLCin group Cerity Partners LLC3,664$392K<0.01%+70013F-HRTimelineGroup
O'SHAUGHNESSY ASSET MANAGEMENT, LLC3,580$383K<0.01%-1,25613F-HRTimeline
Avior Wealth Management, LLC3,572$382K0.01%+3113F-HRTimeline
CIBC WORLD MARKETS CORPin group CIBC Bancorp USA Inc.3,502$375K<0.01%13F-HRTimelineGroup
Tidal Investments LLCin group Tidal Investments LLC3,336$357K<0.01%+67213F-HRTimelineGroup
KEYBANK NATIONAL ASSOCIATION/OHin group KEYBANK NATIONAL ASSOCIATION/…3,271$350K<0.01%new13F-HRTimelineGroup
Cinctive Capital Management LP3,225$345K0.02%-31,93113F-HRTimeline
Yorktown Management & Research Co Inc3,050$326K0.26%new13F-HRTimeline
CIM INVESTMENT MANAGEMENT INC2,993$320K0.08%013F-HRTimeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…2,962$317K0.01%+1,20913F-HRTimelineGroup
TWO SIGMA ADVISERS, LPin group TWO SIGMA INVESTMENTS, LP2,900$310K<0.01%-40013F-HRTimelineGroup
Blueshift Asset Management, LLC2,881$308K0.09%new13F-HRTimeline
JGP Global Gestao de Recursos Ltda.2,866$307K0.18%-38713F-HRTimeline
CIBC Asset Management Inc2,848$305K<0.01%new13F-HRTimeline
CWM, LLCin group CWM, LLC2,767$296K<0.01%-12513F-HRTimelineGroup