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Disclosery

RYTM RHYTHM PHARMACEUTICALS INC

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COM (common), issuer CIK 1649904

228 managers (230 13F filers) reported a position in RYTM shares at 2025-03-31, 64,818,874 shares in all. 43 filers opened a position and 19 filers sold out during the quarter.

Managers
228
13F filers
230
New
43
Added
86
Reduced
69
Sold out
19
Shares held by filers
64,818,874

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q1 2025

Filers in the available 13F reports with a share position at 2025-03-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
BlackRock, Inc.in group BlackRock, Inc.6,854,755$363M0.01%-95,96013F-HRTimelineGroup
RA CAPITAL MANAGEMENT, L.P.in group RA CAPITAL MANAGEMENT, L.P.6,084,412$322M5.38%013F-HRTimelineGroup
PRIMECAP MANAGEMENT CO/CA/5,787,322$307M0.25%-783,86813F-HRTimeline
BAKER BROS. ADVISORS LPin group BAKER BROS. ADVISORS LP5,604,483$297M3.29%-479,76613F-HRTimelineGroup
VANGUARD GROUP INCin group VANGUARD GROUP INC3,444,926$182M<0.01%+2,32613F-HRTimelineGroup
NEA Management Company, LLC2,909,956$154M11.87%013F-HRTimeline
PERCEPTIVE ADVISORS LLCin group PERCEPTIVE ADVISORS LLC2,548,445$135M4.79%-1,132,02813F-HR/ATimelineGroup
STATE STREET CORPin group STATE STREET CORP1,970,733$104M<0.01%+129,86313F-HRTimelineGroup
JANUS HENDERSON GROUP PLCin group Janus Henderson1,655,350$90.7M0.05%+435,79613F-HRTimelineGroup
FMR LLCin group FMR LLC1,688,375$89.4M0.01%+1,575,26613F-HRTimelineGroup
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC1,637,908$86.8M0.02%-174,29813F-HR/ATimelineGroup
FEDERATED HERMES, INC.in group FEDERATED HERMES, INC.1,591,871$84.3M0.18%+42,23613F-HRTimelineGroup
Driehaus Capital Management LLC1,458,022$77.2M0.74%+167,04713F-HRTimeline
WESTFIELD CAPITAL MANAGEMENT CO LP1,341,092$71M0.35%new13F-HRTimeline
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC1,287,168$68.2M0.01%+31,36913F-HRTimelineGroup
PRICE T ROWE ASSOCIATES INC /MD/1,199,053$63.5M0.01%+513,90113F-HRTimeline
Checkpoint Capital L.P.907,240$48.1M26.37%+179,25813F-HRTimeline
Rock Springs Capital Management LP834,188$44.2M2.53%-328,53013F-HRTimeline
ALKEON CAPITAL MANAGEMENT LLC817,700$43.3M0.26%-350,00013F-HRTimeline
Frazier Life Sciences Management, L.P.678,760$36M1.64%-1,191,04813F-HRTimeline
Hood River Capital Management LLC659,431$34.9M0.6%+15,74013F-HRTimeline
LOOMIS SAYLES & CO L Pin group LOOMIS SAYLES & CO L P605,764$32.1M0.05%-12,72113F-HRTimelineGroup
NORTHERN TRUST CORPin group NORTHERN TRUST CORP536,206$28.4M<0.01%-9,10813F-HRTimelineGroup
MARSHALL WACE, LLPin group MARSHALL WACE, LLP535,103$28.3M0.04%-157,70013F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY504,049$26.7M<0.01%-56,03813F-HRTimelineGroup
Polar Capital Holdings Plcin group Polar Capital Holdings Plc500,000$26.5M0.16%-1,000,00013F-HRTimelineGroup
Opaleye Management Inc.490,000$26M5.78%-10,00013F-HRTimeline
Sofinnova Investments, Inc.446,839$23.7M1.78%+49,41113F-HRTimeline
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co445,429$23.6M<0.01%+5,17913F-HR/ATimelineGroup
VOLORIDGE INVESTMENT MANAGEMENT, LLC422,868$22.4M0.08%+42,33113F-HRTimeline
UBS Group AGgroup of 2 filers holding397,890$21.1M-74,918Timeline
ORBIMED ADVISORS LLCin group ORBIMED ADVISORS LLC380,000$20.1M0.48%-20,00013F-HRTimelineGroup
Balyasny Asset Management L.P.in group Balyasny Asset Management355,712$18.8M0.05%+217,34913F-HRTimelineGroup
SILVERARC CAPITAL MANAGEMENT, LLCin group SILVERARC CAPITAL MANAGEMENT,…337,605$17.9M3.74%+63,70913F-HRTimelineGroup
FRANKLIN RESOURCES INCin group Franklin Resources326,160$17.3M0.01%+57,95513F-HRTimelineGroup
Candriam S.C.A.291,469$15.4M0.1%-40,92313F-HRTimeline
Siren, L.L.C.in group Siren, L.L.C.277,533$14.7M0.83%new13F-HR/ATimelineGroup
Invesco Ltd.in group Invesco Ltd.261,902$13.9M<0.01%-40,94413F-HRTimelineGroup
Pictet Asset Management Holding SAin group Pictet Asset Management Holdi…259,346$13.9M0.02%-116,00313F-HRTimelineGroup
COMERICA BANK244,754$13M0.05%+227,64113F-HRTimeline
NORGES BANK223,484$11.8M<0.01%+17,83513F-HR/ATimeline
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC217,379$11.5M0.01%+202,12013F-HRTimelineGroup
Qube Research & Technologies Ltd216,193$11.5M0.02%+120,95813F-HRTimeline
Cubist Systematic Strategies, LLC173,822$9.21M0.12%new13F-HRTimeline
Cormorant Asset Management, LP150,000$7.95M0.6%-250,00013F-HRTimeline
Nuveen, LLCin group TIAA147,301$7.8M<0.01%13F-HRTimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp146,585$7.76M<0.01%-1,66113F-HRTimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO143,640$7.61M<0.01%-120,94513F-HRTimelineGroup
PANAGORA ASSET MANAGEMENT INC141,162$7.48M0.04%new13F-HRTimeline
SAMSARA BIOCAPITAL, LLC138,118$7.32M1.3%-34,52913F-HRTimeline
LORD, ABBETT & CO. LLC135,360$7.17M0.03%-25,29113F-HRTimeline
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…114,778$6.08M0.01%+113,78113F-HRTimelineGroup
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/111,752$5.92M<0.01%+7,26413F-HRTimelineGroup
Aberdeen Group plcin group Aberdeen Group plc108,129$5.73M0.01%+27,61213F-HRTimelineGroup
LAZARD ASSET MANAGEMENT LLCin group LAZARD ASSET MANAGEMENT LLC103,202$5.46M0.01%-3,05913F-HRTimelineGroup
PDT Partners, LLC102,195$5.41M0.38%+58,61213F-HRTimeline
BARCLAYS PLCin group BARCLAYS PLC101,217$5.36M<0.01%-34,18013F-HR/ATimelineGroup
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC98,281$5.21M<0.01%+44,91413F-HRTimelineGroup
Universal- Beteiligungs- und Serviceges…in group Universal- Beteiligungs- und …93,105$4.93M0.01%+17,02113F-HRTimelineGroup
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC91,118$4.83M0.01%+32,70313F-HR/ATimelineGroup
FIRST TRUST ADVISORS LPin group FIRST TRUST ADVISORS LP89,779$4.76M<0.01%-28,55813F-HRTimelineGroup
Hennion & Walsh Asset Management, Inc.89,622$4.75M0.21%-9,82513F-HRTimeline
Swiss National Bank89,300$4.73M<0.01%-90013F-HRTimeline
CITIGROUP INCin group CITIGROUP INC86,206$4.57M<0.01%+16,42913F-HRTimelineGroup
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS86,066$4.56M<0.01%+81713F-HRTimelineGroup
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC85,849$4.55M0.01%-11,32013F-HR/ATimelineGroup
RHUMBLINE ADVISERS85,719$4.54M<0.01%+2,98813F-HR/ATimeline
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.83,869$4.44M0.01%+35,67113F-HRTimelineGroup
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…82,980$4.4M0.01%+32,31613F-HRTimelineGroup
HARBOR CAPITAL ADVISORS, INC.77,297$4.09M0.19%+47,04513F-HRTimeline
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN70,638$3.74M<0.01%+33,31413F-HRTimelineGroup
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC70,068$3.71M<0.01%+29,64913F-HRTimelineGroup
NEUBERGER BERMAN GROUP LLCin group NEUBERGER BERMAN GROUP LLC67,939$3.6M<0.01%new13F-HRTimelineGroup
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …64,386$3.41M<0.01%+4,41713F-HRTimelineGroup
Point72 Asset Management, L.P.in group Point72 Asset Management, L.P.63,842$3.38M0.01%new13F-HR/ATimelineGroup
ALLIANCEBERNSTEIN L.P.61,470$3.26M<0.01%013F-HRTimeline
ALGERT GLOBAL LLC61,461$3.26M0.08%+19,91013F-HR/ATimeline
Rafferty Asset Management, LLC57,732$3.06M0.01%+7,33813F-HRTimeline
Schonfeld Strategic Advisors LLC57,150$3.03M0.02%-2,55013F-HRTimeline
KENNEDY CAPITAL MANAGEMENT LLC54,930$2.91M0.07%new13F-HRTimeline
Legal & General Group Plcin group Legal & General Group Plc51,158$2.71M<0.01%-64513F-HRTimelineGroup
Connor, Clark & Lunn Investment Managem…50,557$2.68M0.01%+44,46813F-HRTimeline
TD Asset Management Inc50,200$2.66M<0.01%+2,40013F-HRTimeline
Artia Global Partners LP50,000$2.65M0.78%013F-HRTimeline
DIADEMA PARTNERS LP50,000$2.65M2.12%-25,00013F-HRTimeline
Nan Fung Group Holdings Ltd49,120$2.6M2.12%013F-HRTimeline
ALPS ADVISORS INCin group ALPS ADVISORS INC46,207$2.45M0.01%-3,49313F-HRTimelineGroup
Informed Momentum Co LLC45,108$2.39M0.41%-17,97013F-HRTimeline
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\43,779$2.32M<0.01%-4,96613F-HRTimelineGroup
CALIFORNIA STATE TEACHERS RETIREMENT SY…42,721$2.26M<0.01%-81213F-HRTimeline
Jump Financial, LLCin group Jump Financial, LLC41,760$2.21M0.03%new13F-HR/ATimelineGroup
Aquatic Capital Management LLC41,476$2.2M0.06%+32,25313F-HRTimeline
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC39,363$2.09M<0.01%+23,50613F-HRTimelineGroup
Trexquant Investment LP38,724$2.05M0.02%+30,92613F-HRTimeline
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding37,398$1.99M+2,194Timeline
PRINCIPAL FINANCIAL GROUP INCin group PRINCIPAL FINANCIAL GROUP INC37,156$1.97M<0.01%+27213F-HRTimelineGroup
WEDGE CAPITAL MANAGEMENT L L P/NC36,984$1.96M0.04%-11,42713F-HRTimeline
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC36,890$1.95M0.38%+5,94913F-HRTimelineGroup
Walleye Capital LLCin group Walleye Capital LLC35,828$1.9M0.02%-108,51413F-HRTimelineGroup
State of New Jersey Common Pension Fund…in group State of New Jersey Common Pe…35,392$1.87M0.01%+38813F-HRTimelineGroup
HighVista Strategies LLC35,039$1.86M0.72%-2,38713F-HRTimeline
INTECH INVESTMENT MANAGEMENT LLC33,893$1.8M0.02%+5,80113F-HRTimeline
STEMPOINT CAPITAL LP33,816$1.79M0.57%-174,20013F-HRTimeline
STATE OF WISCONSIN INVESTMENT BOARD33,025$1.75M<0.01%+76313F-HRTimeline
MetLife Investment Management, LLCin group MetLife Investment Management…32,414$1.72M0.01%-1,08413F-HRTimelineGroup
SEI INVESTMENTS COin group SEI INVESTMENTS CO32,381$1.72M<0.01%-1,14113F-HR/ATimelineGroup
XTX Topco Ltdin group XTX Topco Ltd29,949$1.59M0.08%+22,34413F-HRTimelineGroup
TUDOR INVESTMENT CORP ET AL29,513$1.56M0.01%+14,26813F-HRTimeline
Corebridge Financial, Inc.in group Corebridge Financial, Inc.26,821$1.42M0.01%-39913F-HRTimelineGroup
DARK FOREST CAPITAL MANAGEMENT LP25,409$1.35M0.06%+20,19813F-HRTimeline
Squarepoint Ops LLCin group Squarepoint Ops LLC24,413$1.29M<0.01%new13F-HR/ATimelineGroup
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…23,558$1.25M<0.01%-1,99713F-HRTimelineGroup
Assenagon Asset Management S.A.22,192$1.18M<0.01%new13F-HRTimeline
Engineers Gate Manager LP21,883$1.16M0.02%+2,70013F-HRTimeline
SG Americas Securities, LLC19,667$1.04M<0.01%new13F-HRTimeline
FOX RUN MANAGEMENT, L.L.C.19,172$1.02M0.16%new13F-HRTimeline
STRS OHIO18,500$980K<0.01%+2,10013F-HRTimeline
STIFEL FINANCIAL CORPin group STIFEL FINANCIAL CORP18,487$979K<0.01%-1,02913F-HRTimelineGroup
SCHRODER INVESTMENT MANAGEMENT GROUP17,618$965K<0.01%new13F-HRTimeline
Ensign Peak Advisors, Inc17,659$935K<0.01%013F-HRTimeline
CAPTRUST FINANCIAL ADVISORS17,357$919K<0.01%new13F-HRTimeline
SummitTX Capital, L.P.17,343$919K0.04%13F-HRTimeline
VICTORY CAPITAL MANAGEMENT INC17,326$918K<0.01%+17413F-HRTimeline
Jefferies Financial Group Inc.in group Jefferies Financial Group Inc.17,100$906K0.02%new13F-HRTimelineGroup
Quantinno Capital Management LP17,086$905K0.01%+96613F-HRTimeline
Handelsbanken Fonder AB17,021$902K<0.01%013F-HRTimeline
NEW YORK STATE COMMON RETIREMENT FUND16,850$893K<0.01%013F-HR/ATimeline
Leo Wealth, LLC16,000$848K0.12%new13F-HRTimeline
Bellevue Group AGin group Bellevue Group AG15,550$824K0.02%-8,04613F-HRTimelineGroup
HSBC HOLDINGS PLCin group HSBC HOLDINGS PLC15,570$823K<0.01%-71713F-HRTimelineGroup
Fiduciary Trust Coin group Fiduciary Trust Co15,000$795K0.01%-5,00013F-HRTimelineGroup
Atom Investors LP14,962$793K0.1%+3,35713F-HRTimeline
ProShare Advisors LLC14,704$779K<0.01%-3,62413F-HRTimeline
STATE BOARD OF ADMINISTRATION OF FLORID…14,670$777K<0.01%013F-HRTimeline
RENAISSANCE TECHNOLOGIES LLC14,112$748K<0.01%new13F-HRTimeline
Voleon Capital Management LP13,819$732K0.06%new13F-HRTimeline
AMERICAN CENTURY COMPANIES INCin group AMERICAN CENTURY COMPANIES INC13,282$704K<0.01%-20,48413F-HRTimelineGroup
ARIZONA STATE RETIREMENT SYSTEM13,181$698K<0.01%-10613F-HRTimeline
China Universal Asset Management Co., L…12,682$672K0.06%-34913F-HRTimeline
PROFUND ADVISORS LLC12,444$659K0.03%+1,96313F-HRTimeline
TEACHER RETIREMENT SYSTEM OF TEXAS12,404$657K<0.01%-1,18213F-HRTimeline
Creative Planningin group Creative Planning12,333$653K<0.01%+2,10913F-HRTimelineGroup
CIBC WORLD MARKETS CORP12,148$643K0.01%+7,02513F-HRTimeline
TWO SIGMA ADVISERS, LPin group TWO SIGMA INVESTMENTS, LP12,100$641K<0.01%-1,00013F-HRTimelineGroup
EXCHANGE TRADED CONCEPTS, LLC11,912$631K0.01%-46313F-HRTimeline
Police & Firemen's Retirement System of…11,655$617K0.01%013F-HRTimeline
CANADA LIFE ASSURANCE Coin group CANADA LIFE ASSURANCE Co11,578$615K<0.01%013F-HRTimelineGroup
Persistent Asset Partners Ltd11,501$609K0.54%-6,81113F-HRTimeline
Advisors Asset Management, Inc.10,250$543K0.01%+3,17613F-HR/ATimeline
Cannon Financial Strategists, Inc.10,000$530K0.09%013F-HRTimeline
KLP KAPITALFORVALTNING AS9,300$493K<0.01%013F-HRTimeline
Zurcher Kantonalbank (Zurich Cantonalba…8,926$473K<0.01%-10813F-HRTimeline
Aigen Investment Management, LP7,701$408K0.07%new13F-HRTimeline
Point72 (DIFC) Ltd6,653$352K0.03%new13F-HRTimeline
AlphaQuest LLC6,607$350K0.04%+6,60613F-HRTimeline
Virtus Investment Advisers, LLCgroup of 2 filers holding6,446$341K+166Timeline
Bridgefront Capital, LLC6,414$340K0.1%+1,81013F-HRTimeline
Springhill Fund Asset Management (HK) C…6,277$332K1.59%new13F-HRTimeline
Allianz Asset Management GmbHin group Allianz SE6,100$323K<0.01%013F-HRTimelineGroup
Fieldview Capital Management, LLC6,037$320K0.05%new13F-HRTimeline
BIT Capital GmbH6,013$319K0.04%new13F-HRTimeline
Y-Intercept (Hong Kong) Ltd5,966$316K0.02%+10013F-HRTimeline
Jasper Ridge Partners, L.P.5,639$299K0.01%013F-HRTimeline
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…5,546$294K0.01%013F-HRTimelineGroup
Entropy Technologies, LP5,502$291K0.03%new13F-HRTimeline
PUBLIC EMPLOYEES RETIREMENT ASSOCIATION…5,463$289K<0.01%013F-HRTimeline
E Fund Management Co., Ltd.5,396$286K0.01%new13F-HRTimeline
Quadrature Capital Ltdin group Quadrature Capital Ltd5,278$280K0.01%new13F-HRTimelineGroup
GSA CAPITAL PARTNERS LLP5,069$269K0.02%new13F-HRTimeline
Gotham Asset Management, LLC4,750$252K<0.01%-2,03613F-HRTimeline
PRUDENTIAL FINANCIAL INCin group PRUDENTIAL FINANCIAL INC4,355$243K<0.01%+20013F-HRTimelineGroup
Avior Wealth Management, LLC4,589$243K0.01%new13F-HRTimeline
Mariner, LLCin group Mariner, LLC4,585$243K<0.01%+6013F-HRTimelineGroup
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…4,518$239K<0.01%+4,21413F-HRTimelineGroup
Verition Fund Management LLC4,424$234K<0.01%-3,61313F-HRTimeline
XPONANCE LLC4,365$231K<0.01%+19713F-HRTimeline
Cinctive Capital Management LP4,356$231K0.02%-78,39913F-HRTimeline
MACKENZIE FINANCIAL CORP4,343$230K<0.01%013F-HRTimeline
Chicago Partners Investment Group LLC3,510$227K0.01%-18613F-HRTimeline
LPL Financial LLC4,214$223K<0.01%+3913F-HRTimeline
SIH Partners, LLLPin group SIH Partners, LLLP3,980$211K0.02%new13F-HRTimelineGroup
JGP Global Gestao de Recursos Ltda.3,824$203K0.15%-1,55413F-HRTimeline
Bayforest Capital Ltd3,134$166K0.07%new13F-HR/ATimeline
CWM, LLCin group CWM, LLC2,584$137K<0.01%+1,24013F-HRTimelineGroup
KBC Group NVin group KBC Group NV2,251$119K<0.01%013F-HRTimelineGroup
ELEVATION WEALTH PARTNERS, LLC1,971$104K0.05%013F-HRTimeline
AMALGAMATED BANK1,881$100K<0.01%+613F-HRTimeline
WHITTIER TRUST CO1,760$93.2K<0.01%013F-HRTimeline
GF FUND MANAGEMENT CO. LTD.1,573$83.3K<0.01%+28313F-HRTimeline
NISA INVESTMENT ADVISORS, LLC1,240$65.7K<0.01%-4513F-HRTimeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…1,058$56K<0.01%-3,48113F-HRTimelineGroup
BI Asset Management Fondsmaeglerselskab…in group BI Asset Management Fondsmaeg…648$34K<0.01%new13F-HRTimelineGroup
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.590$31.3K<0.01%-8313F-HRTimelineGroup
Arax Advisory Partners518$27.4K<0.01%+6413F-HRTimeline
SBI Securities Co., Ltd.466$24.7K<0.01%-20013F-HRTimeline
AMERIFLEX GROUP, INC.360$19.1K0.01%013F-HRTimeline
GAMMA Investing LLC281$14.9K<0.01%+8013F-HR/ATimeline
Smartleaf Asset Management LLC255$14K<0.01%+6213F-HRTimeline
JONES FINANCIAL COMPANIES LLLPin group JONES FINANCIAL COMPANIES LLLP231$12.7K<0.01%013F-HR/ATimelineGroup
SIGNATUREFD, LLC224$11.9K<0.01%+213F-HRTimeline