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Disclosery

RYTM RHYTHM PHARMACEUTICALS INC

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COM (common), issuer CIK 1649904

203 managers (205 13F filers) reported a position in RYTM shares at 2024-12-31, 64,917,510 shares in all. 38 filers opened a position and 24 filers sold out during the quarter.

Managers
203
13F filers
205
New
38
Added
66
Reduced
53
Sold out
24
Shares held by filers
64,917,510

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q4 2024

Filers in the available 13F reports with a share position at 2024-12-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
BlackRock, Inc.in group BlackRock, Inc.6,950,715$389M0.01%+61,45713F-HRTimelineGroup
PRIMECAP MANAGEMENT CO/CA/6,571,190$368M0.28%-645,72113F-HRTimeline
RA CAPITAL MANAGEMENT, L.P.in group RA CAPITAL MANAGEMENT, L.P.6,084,412$341M4.53%013F-HRTimelineGroup
BAKER BROS. ADVISORS LPin group BAKER BROS. ADVISORS LP6,084,249$341M3.64%-314,11713F-HRTimelineGroup
PERCEPTIVE ADVISORS LLCin group PERCEPTIVE ADVISORS LLC3,680,473$206M5.74%+120,25913F-HRTimelineGroup
VANGUARD GROUP INCin group VANGUARD GROUP INC3,442,600$193M<0.01%-5,31113F-HRTimelineGroup
NEA Management Company, LLC2,909,956$163M9.19%013F-HRTimeline
Frazier Life Sciences Management, L.P.1,869,808$105M4.34%-547,14413F-HRTimeline
STATE STREET CORPin group STATE STREET CORP1,840,870$103M<0.01%-152,29613F-HRTimelineGroup
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC1,812,206$101M0.02%-2,067,59013F-HRTimelineGroup
FEDERATED HERMES, INC.in group FEDERATED HERMES, INC.1,549,635$86.7M0.19%-114,26513F-HRTimelineGroup
Polar Capital Holdings Plcin group Polar Capital Holdings Plc1,500,000$84M0.47%013F-HRTimelineGroup
Driehaus Capital Management LLC1,290,975$72.3M0.6%-8,51513F-HRTimeline
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC1,255,799$70.3M0.01%-38913F-HRTimelineGroup
JANUS HENDERSON GROUP PLCin group Janus Henderson1,219,554$68.3M0.03%+621,43213F-HRTimelineGroup
ALKEON CAPITAL MANAGEMENT LLC1,167,700$65.4M0.38%013F-HRTimeline
Rock Springs Capital Management LP1,162,718$65.1M2.48%-65,37513F-HRTimeline
Checkpoint Capital L.P.727,982$40.8M20.74%+64,60113F-HRTimeline
MARSHALL WACE, LLPin group MARSHALL WACE, LLP692,803$38.8M0.05%+286,18813F-HRTimelineGroup
PRICE T ROWE ASSOCIATES INC /MD/685,152$38.4M<0.01%+134,62213F-HRTimeline
Hood River Capital Management LLC643,691$36M0.53%+29,09313F-HRTimeline
LOOMIS SAYLES & CO L Pin group LOOMIS SAYLES & CO L P618,485$34.6M0.04%-18,14313F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY560,087$31.4M<0.01%+95,48313F-HR/ATimelineGroup
NORTHERN TRUST CORPin group NORTHERN TRUST CORP545,314$30.5M<0.01%+46,84813F-HRTimelineGroup
Opaleye Management Inc.500,000$28M4.9%013F-HRTimeline
UBS Group AGgroup of 2 filers holding472,808$26.5M+170,801Timeline
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co440,250$24.6M<0.01%+6,38413F-HRTimelineGroup
ORBIMED ADVISORS LLCin group ORBIMED ADVISORS LLC400,000$22.4M0.46%-35,90013F-HRTimelineGroup
Cormorant Asset Management, LP400,000$22.4M1.23%013F-HRTimeline
Sofinnova Investments, Inc.397,428$22.2M1.63%+120,75013F-HRTimeline
VOLORIDGE INVESTMENT MANAGEMENT, LLC380,537$21.3M0.08%+27,21413F-HRTimeline
Pictet Asset Management Holding SAin group Pictet Asset Management Holdi…375,349$21M0.02%+46,01013F-HRTimelineGroup
Candriam S.C.A.332,392$18.6M0.11%-62,98513F-HRTimeline
Invesco Ltd.in group Invesco Ltd.302,846$17M<0.01%+38,42913F-HRTimelineGroup
SILVERARC CAPITAL MANAGEMENT, LLCin group SILVERARC CAPITAL MANAGEMENT,…273,896$15.3M3.43%+18,31813F-HRTimelineGroup
Franklin Resourcesgroup of 2 filers holding268,205$15M-78,635Timeline
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO264,585$14.8M<0.01%+182,99313F-HRTimelineGroup
STEMPOINT CAPITAL LP208,016$11.6M2.92%+166,74813F-HRTimeline
NORGES BANK205,649$11.5M<0.01%+139,37313F-HRTimeline
SAMSARA BIOCAPITAL, LLC172,647$9.66M1.33%013F-HRTimeline
LORD, ABBETT & CO. LLC160,651$8.99M0.03%+58,00513F-HRTimeline
Integral Health Asset Management, LLC150,000$8.4M0.74%new13F-HRTimeline
Bank of New York Mellon Corpin group Bank of New York Mellon Corp148,246$8.3M<0.01%-68013F-HRTimelineGroup
Nuveen Asset Management, LLCin group TIAA146,903$8.22M<0.01%-97213F-HRTimelineGroup
Walleye Capital LLCin group Walleye Capital LLC144,342$8.08M0.08%new13F-HRTimelineGroup
Balyasny Asset Management L.P.in group Balyasny Asset Management138,363$7.75M0.02%new13F-HRTimelineGroup
BARCLAYS PLCin group BARCLAYS PLC135,397$7.58M<0.01%+29,00013F-HR/ATimelineGroup
FIRST TRUST ADVISORS LPin group FIRST TRUST ADVISORS LP118,337$6.62M0.01%+47,57513F-HRTimelineGroup
FMR LLCin group FMR LLC113,109$6.33M<0.01%+62,81413F-HRTimelineGroup
LAZARD ASSET MANAGEMENT LLCin group LAZARD ASSET MANAGEMENT LLC106,261$5.95M0.01%new13F-HRTimelineGroup
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/104,488$5.85M<0.01%-1,76213F-HRTimelineGroup
Hennion & Walsh Asset Management, Inc.99,447$5.57M0.25%-1,51413F-HRTimeline
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC97,169$5.44M0.01%-5,66313F-HR/ATimelineGroup
Qube Research & Technologies Ltd95,235$5.33M0.01%new13F-HRTimeline
Swiss National Bank90,200$5.05M<0.01%+90013F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS85,249$4.77M<0.01%+70,82413F-HRTimelineGroup
Cinctive Capital Management LP82,755$4.63M0.25%new13F-HRTimeline
RHUMBLINE ADVISERS82,731$4.63M<0.01%+2,01713F-HR/ATimeline
Aberdeen Group plcin group Aberdeen Group plc80,517$4.51M0.01%-32,28713F-HRTimelineGroup
Universal- Beteiligungs- und Serviceges…in group Universal- Beteiligungs- und …76,084$4.26M0.01%13F-HRTimelineGroup
DIADEMA PARTNERS LP75,000$4.2M4.73%13F-HRTimeline
CITIGROUP INCin group CITIGROUP INC69,777$3.91M<0.01%+28,58013F-HRTimelineGroup
Informed Momentum Co LLC63,078$3.53M0.5%new13F-HRTimeline
ALLIANCEBERNSTEIN L.P.61,470$3.44M<0.01%+1,90013F-HRTimeline
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …59,969$3.36M<0.01%+11,26613F-HRTimelineGroup
Schonfeld Strategic Advisors LLC59,700$3.34M0.02%+29,16513F-HRTimeline
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC58,415$3.27M0.01%-50,77113F-HRTimelineGroup
Global IMC LLC56,936$3.19M0.57%new13F-HRTimeline
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC53,367$2.99M<0.01%+11,48013F-HRTimelineGroup
Legal & General Group Plcin group Legal & General Group Plc51,803$2.9M<0.01%+95113F-HRTimelineGroup
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…50,664$2.84M<0.01%+29,18313F-HRTimelineGroup
Rafferty Asset Management, LLC50,394$2.82M0.01%-14,18213F-HRTimeline
Artia Global Partners LP50,000$2.8M1.13%new13F-HRTimeline
ALPS ADVISORS INCin group ALPS ADVISORS INC49,700$2.78M0.02%new13F-HRTimelineGroup
Nan Fung Group Holdings Ltd49,120$2.75M2.35%013F-HRTimeline
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\48,745$2.73M<0.01%+15,48113F-HR/ATimelineGroup
WEDGE CAPITAL MANAGEMENT L L P/NC48,411$2.71M0.05%-43313F-HRTimeline
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.48,198$2.7M<0.01%+43,90413F-HRTimelineGroup
TD Asset Management Inc47,800$2.68M<0.01%+16,00013F-HRTimeline
PDT Partners, LLC43,583$2.44M0.22%+32,08313F-HRTimeline
CALIFORNIA STATE TEACHERS RETIREMENT SY…43,533$2.44M<0.01%-38313F-HR/ATimeline
ALGERT GLOBAL LLC41,551$2.33M0.05%-12,62013F-HR/ATimeline
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC40,419$2.26M<0.01%-62,35913F-HRTimelineGroup
HighVista Strategies LLC37,426$2.1M0.78%013F-HRTimeline
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN37,324$2.09M<0.01%+7,85013F-HRTimelineGroup
PRINCIPAL FINANCIAL GROUP INCin group PRINCIPAL FINANCIAL GROUP INC36,884$2.06M<0.01%+4,29813F-HRTimelineGroup
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding35,204$1.97M+491Timeline
State of New Jersey Common Pension Fund…in group State of New Jersey Common Pe…35,004$1.96M0.01%new13F-HRTimelineGroup
AMERICAN CENTURY COMPANIES INCin group AMERICAN CENTURY COMPANIES INC33,766$1.89M<0.01%new13F-HRTimelineGroup
SEI INVESTMENTS COin group SEI INVESTMENTS CO33,522$1.88M<0.01%+4,50113F-HRTimelineGroup
MetLife Investment Management, LLCin group MetLife Investment Management…33,498$1.88M0.01%+1,84613F-HRTimelineGroup
STATE OF WISCONSIN INVESTMENT BOARD32,262$1.81M<0.01%-19113F-HRTimeline
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC30,941$1.73M0.36%new13F-HRTimelineGroup
HARBOR CAPITAL ADVISORS, INC.30,252$1.69M0.07%-11,11613F-HRTimeline
INTECH INVESTMENT MANAGEMENT LLC28,092$1.57M0.02%+15,70613F-HRTimeline
Corebridge Financial, Inc.in group Corebridge Financial, Inc.27,220$1.52M0.01%-2,05413F-HRTimelineGroup
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…25,555$1.43M<0.01%-2,16113F-HRTimelineGroup
Crestline Management, L.P.25,062$1.4M0.05%+6,06413F-HRTimeline
Bellevue Group AGin group Bellevue Group AG23,596$1.32M0.03%+7,89613F-HRTimelineGroup
Fiduciary Trust Coin group Fiduciary Trust Co20,000$1.12M0.01%013F-HRTimelineGroup
Bryce Point Capital, LLC19,607$1.1M0.32%13F-HRTimeline
STIFEL FINANCIAL CORPin group STIFEL FINANCIAL CORP19,516$1.09M<0.01%-32613F-HRTimelineGroup
Persistent Asset Partners Ltd18,312$1.09M0.93%13F-HRTimeline
Engineers Gate Manager LP19,183$1.07M0.02%new13F-HRTimeline
CASTLEARK MANAGEMENT LLC18,390$1.03M0.04%-87013F-HRTimeline
ProShare Advisors LLC18,328$1.03M<0.01%+4,37013F-HRTimeline
Ensign Peak Advisors, Inc17,659$989K<0.01%013F-HRTimeline
VICTORY CAPITAL MANAGEMENT INC17,152$960K<0.01%-1,03413F-HRTimeline
COMERICA BANK17,113$958K<0.01%-44713F-HR/ATimeline
Handelsbanken Fonder AB17,021$953K<0.01%-2,30013F-HRTimeline
NEW YORK STATE COMMON RETIREMENT FUND16,850$943K<0.01%013F-HR/ATimeline
HSBC HOLDINGS PLCin group HSBC HOLDINGS PLC16,287$921K<0.01%new13F-HRTimelineGroup
STRS OHIO16,400$918K<0.01%+10,20013F-HRTimeline
Quantinno Capital Management LP16,120$902K0.01%013F-HRTimeline
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC15,857$888K<0.01%-16,95213F-HRTimelineGroup
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC15,259$854K<0.01%-21,71813F-HRTimelineGroup
TUDOR INVESTMENT CORP ET AL15,245$853K0.01%new13F-HRTimeline
STATE BOARD OF ADMINISTRATION OF FLORID…14,670$821K<0.01%013F-HRTimeline
TEACHER RETIREMENT SYSTEM OF TEXAS13,586$761K<0.01%+2,11713F-HRTimeline
ARIZONA STATE RETIREMENT SYSTEM13,287$744K<0.01%+11913F-HRTimeline
TWO SIGMA ADVISERS, LPin group TWO SIGMA INVESTMENTS, LP13,100$733K<0.01%+30013F-HRTimelineGroup
China Universal Asset Management Co., L…13,031$729K0.07%+1,27313F-HRTimeline
EXCHANGE TRADED CONCEPTS, LLC12,375$693K0.01%-2,68213F-HRTimeline
Police & Firemen's Retirement System of…11,655$652K0.01%13F-HRTimeline
Atom Investors LP11,605$650K0.08%new13F-HRTimeline
CANADA LIFE ASSURANCE Coin group CANADA LIFE ASSURANCE Co11,578$648K<0.01%013F-HRTimelineGroup
PROFUND ADVISORS LLC10,481$587K0.02%-2,87713F-HRTimeline
Creative Planningin group Creative Planning10,224$572K<0.01%+1,63013F-HRTimelineGroup
Cannon Financial Strategists, Inc.10,000$560K0.1%new13F-HRTimeline
KLP KAPITALFORVALTNING AS9,300$521K<0.01%13F-HRTimeline
Aquatic Capital Management LLC9,223$516K0.01%new13F-HRTimeline
Zurcher Kantonalbank (Zurich Cantonalba…9,034$506K<0.01%-6713F-HRTimeline
Verition Fund Management LLC8,037$450K<0.01%new13F-HRTimeline
Trexquant Investment LP7,798$437K0.01%new13F-HRTimeline
XTX Topco Ltdin group XTX Topco Ltd7,605$426K0.04%new13F-HRTimelineGroup
OMERS ADMINISTRATION Corp7,600$425K<0.01%new13F-HRTimeline
Advisors Asset Management, Inc.7,074$396K0.01%new13F-HR/ATimeline
Farringdon Capital, Ltd.6,854$384K0.16%13F-HRTimeline
Gotham Asset Management, LLC6,786$380K<0.01%-2,68513F-HRTimeline
Jain Global LLC6,700$375K0.01%13F-HRTimeline
VIRTUS ADVISERS, LLCin group Virtus Investment Advisers, L…6,280$352K0.14%-1,14313F-HRTimelineGroup
Allianz Asset Management GmbHin group Allianz SE6,100$341K<0.01%+2,00013F-HRTimelineGroup
Connor, Clark & Lunn Investment Managem…6,089$341K<0.01%new13F-HRTimeline
Y-Intercept (Hong Kong) Ltd5,866$328K0.02%new13F-HRTimeline
Jasper Ridge Partners, L.P.5,639$316K0.01%013F-HRTimeline
Ameritas Investment Partners, Inc.group of 2 filers holding5,546$310K-4,416Timeline
PUBLIC EMPLOYEES RETIREMENT ASSOCIATION…5,463$306K<0.01%013F-HRTimeline
JGP Global Gestao de Recursos Ltda.5,378$301K0.69%-51,00013F-HRTimeline
DARK FOREST CAPITAL MANAGEMENT LP5,211$292K0.04%new13F-HRTimeline
CIBC WORLD MARKETS CORP5,123$287K<0.01%new13F-HRTimeline
Bridgefront Capital, LLC4,604$258K0.09%new13F-HRTimeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…4,539$254K0.01%+4,16113F-HRTimelineGroup
Mariner, LLCin group Mariner, LLC4,525$254K<0.01%new13F-HRTimelineGroup
MACKENZIE FINANCIAL CORP4,343$243K<0.01%013F-HR/ATimeline
TEXAS TREASURY SAFEKEEPING TRUST CO4,230$237K0.01%013F-HRTimeline
LPL Financial LLC4,175$234K<0.01%-4,32313F-HRTimeline
PRUDENTIAL FINANCIAL INCin group PRUDENTIAL FINANCIAL INC4,155$234K<0.01%-10413F-HRTimelineGroup
XPONANCE LLC4,168$233K<0.01%new13F-HRTimeline
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC3,892$218K<0.01%13F-HR/ATimelineGroup
Chicago Partners Investment Group LLC3,696$214K0.01%-1,02913F-HRTimeline
Freestone Capital Holdings, LLCin group Freestone Capital Holdings, L…3,700$207K0.01%new13F-HRTimelineGroup
SIMPLEX TRADING, LLC2,475$138K<0.01%new13F-HRTimeline
KBC Group NVin group KBC Group NV2,251$126K<0.01%+98813F-HRTimelineGroup
ELEVATION WEALTH PARTNERS, LLC1,971$110K0.05%013F-HRTimeline
AMALGAMATED BANK1,875$105K<0.01%013F-HRTimeline
WHITTIER TRUST CO1,760$98.5K<0.01%-24013F-HRTimeline
CWM, LLCin group CWM, LLC1,344$75K<0.01%+41713F-HRTimelineGroup
GF FUND MANAGEMENT CO. LTD.1,290$72.2K<0.01%13F-HRTimeline
NISA INVESTMENT ADVISORS, LLC1,285$71.9K<0.01%-64,95513F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA1,214$68K<0.01%-5,07113F-HRTimelineGroup
Ascentis Wealth Management, LLCin group Ascentis Wealth Management, L…1,206$67.5K0.02%013F-HRTimelineGroup
State of Wyoming1,084$60.7K0.01%new13F-HRTimeline
NATIXISin group Natixis Investment Managers997$55.8K<0.01%-10,19013F-HRTimelineGroup
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…997$55.8K<0.01%+313F-HRTimelineGroup
R Squared Ltd780$43.7K0.04%13F-HRTimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.673$37.7K<0.01%+513F-HR/ATimelineGroup
SBI Securities Co., Ltd.666$37.3K<0.01%13F-HRTimeline
Raleigh Capital Management Inc.500$28K0.01%new13F-HRTimeline
Arax Advisory Partners454$25.4K<0.01%+40013F-HRTimeline
AMERIFLEX GROUP, INC.360$21.4K0.01%13F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…304$17K<0.01%+18113F-HRTimelineGroup
JONES FINANCIAL COMPANIES LLLPin group JONES FINANCIAL COMPANIES LLLP231$12.9K<0.01%013F-HRTimelineGroup
SIGNATUREFD, LLC222$12.4K<0.01%+913F-HRTimeline
GAMMA Investing LLC201$11.3K<0.01%+8013F-HRTimeline
Daiwa Securities Group Inc.in group Daiwa Securities Group Inc.203$11K<0.01%-2413F-HRTimelineGroup
Smartleaf Asset Management LLC193$10.9K<0.01%+7313F-HRTimeline
US BANCORP \DE\in group US BANCORP \DE\141$7.89K<0.01%013F-HRTimelineGroup
Truvestments Capital LLC138$7.72K<0.01%013F-HRTimeline
Lindbrook Capital, LLC126$7.05K<0.01%013F-HRTimeline
ROTHSCHILD INVESTMENT LLC65$3.64K<0.01%+5513F-HRTimeline
Sterling Capital Management LLC56$3.13K<0.01%013F-HRTimeline
BESSEMER GROUP INCin group BESSEMER GROUP INC30$2K<0.01%013F-HRTimelineGroup
Parallel Advisors, LLC19$1.06K<0.01%013F-HRTimeline
Covestor Ltd10$1K<0.01%+713F-HRTimeline
Farther Finance Advisors, LLC14$784<0.01%013F-HRTimeline
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…12$672<0.01%new13F-HRTimelineGroup
CVA Family Office, LLC12$672<0.01%013F-HRTimeline
Whipplewood Advisors, LLC11$616<0.01%13F-HRTimeline
Hexagon Capital Partners LLC7$392<0.01%new13F-HRTimeline
IFP Advisors, Inc1$56<0.01%new13F-HRTimeline