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Disclosery

RYTM RHYTHM PHARMACEUTICALS INC

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COM (common), issuer CIK 1649904

261 managers (265 13F filers) reported a position in RYTM shares at 2025-09-30, 70,887,182 shares in all. 56 filers opened a position and 17 filers sold out during the quarter.

Managers
261
13F filers
265
New
56
Added
99
Reduced
82
Sold out
17
Shares held by filers
70,887,182

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q3 2025

Filers in the available 13F reports with a share position at 2025-09-30, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
BlackRock, Inc.in group BlackRock, Inc.6,302,215$636M0.01%+34,67713F-HRTimelineGroup
RA CAPITAL MANAGEMENT, L.P.in group RA CAPITAL MANAGEMENT, L.P.5,681,359$574M7.07%+120,00013F-HRTimelineGroup
BAKER BROS. ADVISORS LPin group BAKER BROS. ADVISORS LP5,604,483$566M4.09%013F-HRTimelineGroup
VANGUARD GROUP INCgroup of 2 filers holding4,998,495$505M+1,409,381Timeline
PRIMECAP MANAGEMENT CO/CA/4,262,859$431M0.33%-615,17813F-HRTimeline
NEA Management Company, LLC2,909,956$294M16.13%013F-HRTimeline
PERCEPTIVE ADVISORS LLCin group PERCEPTIVE ADVISORS LLC2,438,969$246M7.12%+20,67013F-HRTimelineGroup
FMR LLCin group FMR LLC2,145,183$217M0.01%+191,74213F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP2,028,651$205M0.01%+121,05013F-HRTimelineGroup
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC1,893,663$191M0.03%+159,94113F-HRTimelineGroup
FEDERATED HERMES, INC.in group FEDERATED HERMES, INC.1,727,885$174M0.31%+41,39113F-HRTimelineGroup
PRICE T ROWE ASSOCIATES INC /MD/1,399,897$141M0.02%+58,50513F-HRTimeline
Driehaus Capital Management LLC1,383,775$140M1%+113,82313F-HRTimeline
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC1,362,829$138M0.01%+51,57613F-HRTimelineGroup
Polar Capital Holdings Plcin group Polar Capital Holdings Plc1,244,932$126M0.61%-5,93813F-HRTimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO1,188,069$120M0.01%+404,51013F-HR/ATimelineGroup
JANUS HENDERSON GROUP PLCin group Janus Henderson1,160,887$117M0.05%-251,01513F-HRTimelineGroup
WESTFIELD CAPITAL MANAGEMENT CO LP1,069,004$108M0.45%-560,46413F-HRTimeline
Franklin Resourcesgroup of 2 filers holding1,052,514$106M+196,267Timeline
ALKEON CAPITAL MANAGEMENT LLC1,017,700$103M0.46%013F-HRTimeline
ALLIANCEBERNSTEIN L.P.979,682$98.9M0.03%+918,21213F-HRTimeline
UBS Group AGgroup of 2 filers holding857,808$86.6M+377,599Timeline
Checkpoint Capital L.P.763,707$77.1M25.84%-296,29313F-HRTimeline
Rock Springs Capital Management LP717,102$72.4M4.23%-144,05113F-HRTimeline
Pictet Asset Management Holding SAin group Pictet Asset Management Holdi…683,017$69M0.07%+266,90213F-HRTimelineGroup
Capital Research Global Investorsin group Capital Research Global Inves…598,247$60.4M0.01%new13F-HRTimelineGroup
Woodline Partners LP580,183$58.6M0.28%+65,80213F-HRTimeline
LORD, ABBETT & CO. LLC575,984$58.2M0.17%+371,70913F-HRTimeline
RENAISSANCE TECHNOLOGIES LLC546,593$55.2M0.07%+231,70013F-HRTimeline
ADAGE CAPITAL PARTNERS GP, L.L.C.in group ADAGE CAPITAL PARTNERS GP, L.…544,000$54.9M0.09%+203,00013F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co527,922$53.3M0.01%+66,48413F-HRTimelineGroup
LOOMIS SAYLES & CO L Pin group LOOMIS SAYLES & CO L P527,439$53.3M0.06%-64,01513F-HRTimelineGroup
NORTHERN TRUST CORPin group NORTHERN TRUST CORP510,906$51.6M0.01%+66013F-HRTimelineGroup
Siren, L.L.C.in group Siren, L.L.C.499,975$50.5M1.98%+90,23313F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY465,190$47M<0.01%-59,29013F-HR/ATimelineGroup
Opaleye Management Inc.461,700$46.6M6.59%-13,30013F-HRTimeline
JENNISON ASSOCIATES LLC411,550$41.6M0.02%new13F-HRTimeline
SILVERARC CAPITAL MANAGEMENT, LLCin group SILVERARC CAPITAL MANAGEMENT,…369,996$37.4M5.41%-30,77613F-HRTimelineGroup
VOLORIDGE INVESTMENT MANAGEMENT, LLC368,263$37.2M0.12%+29,45913F-HRTimeline
Balyasny Asset Management L.P.in group Balyasny Asset Management350,008$35.3M0.07%+295,92013F-HRTimelineGroup
Sofinnova Investments, Inc.246,966$24.9M1.53%-339,04413F-HRTimeline
Qube Research & Technologies Ltd238,819$24.1M0.03%-1,52613F-HRTimeline
Artisan Partners Limited Partnership236,841$23.9M0.03%+62,36213F-HRTimeline
Hood River Capital Management LLC235,836$23.8M0.28%-307,85213F-HRTimeline
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/233,150$23.5M<0.01%+10,99813F-HR/ATimelineGroup
Assenagon Asset Management S.A.224,128$22.6M0.03%-13,87013F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS223,681$22.6M0.02%+121,44213F-HRTimelineGroup
Candriam S.C.A.221,863$22.4M0.12%-90,58913F-HRTimeline
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC221,593$22.4M0.02%-22,41013F-HRTimelineGroup
Integral Health Asset Management, LLC220,000$22.2M1.62%+100,00013F-HRTimeline
ORBIMED ADVISORS LLCin group ORBIMED ADVISORS LLC215,152$21.7M0.52%-33,36013F-HRTimelineGroup
COMERICA BANK209,325$21.1M0.08%-92,33613F-HRTimeline
Logos Global Management LP200,000$20.2M2%+70,00013F-HRTimeline
Bank of New York Mellon Corpin group Bank of New York Mellon Corp182,365$18.4M<0.01%-1,74413F-HRTimelineGroup
First Light Asset Management, LLC180,484$18.2M1.72%new13F-HRTimeline
MARSHALL WACE, LLPin group MARSHALL WACE, LLP171,834$17.4M0.02%-204,40813F-HRTimelineGroup
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…157,678$15.9M0.02%+26,68013F-HRTimelineGroup
Invesco Ltd.in group Invesco Ltd.143,555$14.5M<0.01%+74,63113F-HRTimelineGroup
BARCLAYS PLCin group BARCLAYS PLC142,385$14.4M0.01%-208,81313F-HR/ATimelineGroup
ALGERT GLOBAL LLC140,284$14.2M0.24%+80,06513F-HR/ATimeline
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC137,967$13.9M<0.01%-35,10213F-HRTimelineGroup
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC133,161$13.4M0.01%-64,94913F-HRTimelineGroup
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC132,626$13.4M0.01%new13F-HRTimelineGroup
Man Group plcin group Man Group plc129,330$13.1M0.03%new13F-HRTimelineGroup
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA125,786$12.7M<0.01%-70,45013F-HRTimelineGroup
Connor, Clark & Lunn Investment Managem…121,260$12.2M0.04%+6,14213F-HRTimeline
Nuveen, LLCin group TIAA117,964$11.9M<0.01%-3,89113F-HRTimelineGroup
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\116,742$11.8M<0.01%+79,96313F-HRTimelineGroup
Ensign Peak Advisors, Inc111,544$11.3M0.02%+93,88513F-HR/ATimeline
Swiss National Bank102,300$10.3M0.01%+11,70013F-HRTimeline
Universal- Beteiligungs- und Serviceges…in group Universal- Beteiligungs- und …101,372$10.2M0.02%+5,85513F-HRTimelineGroup
STEMPOINT CAPITAL LP91,444$9.23M1.86%-85,30813F-HRTimeline
PDT Partners, LLC86,136$8.7M0.55%-11,50213F-HRTimeline
NEUBERGER BERMAN GROUP LLCin group NEUBERGER BERMAN GROUP LLC85,117$8.6M0.01%-1,02213F-HRTimelineGroup
AXIOM INVESTORS LLC /DE83,031$8.39M0.06%+30,57113F-HRTimeline
RHUMBLINE ADVISERS82,068$8.29M0.01%-5,45813F-HRTimeline
FIRST TRUST ADVISORS LPin group FIRST TRUST ADVISORS LP80,903$8.17M0.01%+7,18913F-HRTimelineGroup
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC79,780$8.06M0.01%+30,74013F-HRTimelineGroup
NEW YORK STATE COMMON RETIREMENT FUND75,131$7.59M0.01%+16,51313F-HRTimeline
PRUDENTIAL FINANCIAL INCin group PRUDENTIAL FINANCIAL INC73,010$7.37M0.01%+65,91513F-HRTimelineGroup
PANAGORA ASSET MANAGEMENT INC64,614$6.53M0.03%-54,85213F-HRTimeline
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …60,917$6.15M0.01%-7,21513F-HRTimelineGroup
TD Asset Management Inc59,564$6.02M<0.01%+3,56413F-HRTimeline
Informed Momentum Co LLC58,480$5.81M0.67%new13F-HRTimeline
Legal & General Group Plcin group Legal & General Group Plc57,376$5.79M<0.01%+4,69513F-HRTimelineGroup
Rafferty Asset Management, LLC55,734$5.63M0.02%+4,12313F-HRTimeline
Walleye Capital LLCin group Walleye Capital LLC50,181$5.07M0.04%new13F-HRTimelineGroup
Granahan Investment Management, LLC49,728$5.02M0.21%+8,55613F-HRTimeline
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC49,571$5.01M0.5%+4,18113F-HRTimelineGroup
Nan Fung Group Holdings Ltd49,120$4.96M8.32%013F-HRTimeline
CALIFORNIA STATE TEACHERS RETIREMENT SY…48,934$4.94M0.01%+6,01713F-HRTimeline
PFM Health Sciences, LP48,162$4.86M0.41%new13F-HRTimeline
Harvest Investment Services, LLC48,140$4.86M0.98%+32,67413F-HRTimeline
WCM INVESTMENT MANAGEMENT, LLC47,733$4.8M0.01%new13F-HRTimeline
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN47,134$4.76M<0.01%+4,76613F-HRTimelineGroup
Hennion & Walsh Asset Management, Inc.44,731$4.52M0.16%-6,34813F-HRTimeline
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC44,093$4.45M<0.01%+33,54713F-HRTimelineGroup
VICTORY CAPITAL MANAGEMENT INC42,883$4.33M<0.01%+26,64213F-HRTimeline
Hillsdale Investment Management Inc.42,600$4.3M0.13%new13F-HRTimeline
CASTLEARK MANAGEMENT LLC42,539$4.3M0.12%new13F-HRTimeline
Aquatic Capital Management LLC42,490$4.29M0.08%+38,53713F-HRTimeline
STATE OF WISCONSIN INVESTMENT BOARD40,776$4.12M0.01%+5,06813F-HRTimeline
KENNEDY CAPITAL MANAGEMENT LLC39,575$4M0.09%-17,64213F-HRTimeline
HighVista Strategies LLC37,482$3.79M0.93%+9,41413F-HRTimeline
HARBOR CAPITAL ADVISORS, INC.37,205$3.76M0.29%-49,34113F-HRTimeline
Trexquant Investment LP37,161$3.75M0.04%+30,07813F-HRTimeline
CANADA PENSION PLAN INVESTMENT BOARD37,000$3.74M<0.01%new13F-HRTimeline
Cinctive Capital Management LP35,156$3.55M0.18%-35,78113F-HRTimeline
Jain Global LLC35,110$3.55M0.05%+31,20213F-HRTimeline
Rhenman & Partners Asset Management AB35,000$3.53M0.39%new13F-HRTimeline
SILVERCREST ASSET MANAGEMENT GROUP LLC34,084$3.44M0.02%-14,69113F-HRTimeline
ALPS ADVISORS INCin group ALPS ADVISORS INC33,000$3.33M0.02%-1,17813F-HRTimelineGroup
SEI INVESTMENTS COin group SEI INVESTMENTS CO31,658$3.2M<0.01%-1,48713F-HRTimelineGroup
Penserra Capital Management LLCin group Penserra Capital Management L…30,436$3.07M0.04%new13F-HRTimelineGroup
MetLife Investment Management, LLCin group MetLife Investment Management…30,362$3.07M0.01%-2,03313F-HRTimelineGroup
SAMSARA BIOCAPITAL, LLC30,285$3.06M0.4%-20,19113F-HRTimeline
LAZARD ASSET MANAGEMENT LLCin group LAZARD ASSET MANAGEMENT LLC30,239$3.05M<0.01%-69,20613F-HRTimelineGroup
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding29,690$3M-5,119Timeline
DARK FOREST CAPITAL MANAGEMENT LP28,639$2.89M0.11%-6,19013F-HR/ATimeline
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP28,378$2.87M<0.01%new13F-HRTimelineGroup
Voleon Capital Management LP26,897$2.72M0.07%new13F-HRTimeline
Aberdeen Group plcin group Aberdeen Group plc26,740$2.7M<0.01%-40,91713F-HRTimelineGroup
Creative Planningin group Creative Planning24,945$2.52M<0.01%+7,72313F-HRTimelineGroup
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…24,477$2.47M<0.01%+2,05213F-HRTimelineGroup
INTECH INVESTMENT MANAGEMENT LLC24,312$2.46M0.02%-3,13113F-HRTimeline
WEDGE CAPITAL MANAGEMENT L L P/NC22,244$2.25M0.04%-7,74713F-HRTimeline
State of New Jersey Common Pension Fund…in group State of New Jersey Common Pe…20,919$2.11M0.01%-9,45413F-HRTimelineGroup
EFG Asset Management (North America) Co…20,269$2.05M0.26%new13F-HRTimeline
Burkehill Global Management, LP20,000$2.02M0.11%new13F-HRTimeline
SG Americas Securities, LLC19,554$1.98M0.01%+13,36913F-HRTimeline
CAPTRUST FINANCIAL ADVISORS18,258$1.84M<0.01%+78713F-HRTimeline
SCHRODER INVESTMENT MANAGEMENT GROUP18,042$1.82M<0.01%+42413F-HRTimeline
Quantedge Capital Pte Ltd17,800$1.8M0.98%new13F-HRTimeline
LOS ANGELES CAPITAL MANAGEMENT LLC16,721$1.69M0.01%+12,84913F-HRTimeline
ARIZONA STATE RETIREMENT SYSTEM15,614$1.58M0.01%+1,78013F-HRTimeline
Handelsbanken Fonder AB15,521$1.57M<0.01%013F-HRTimeline
STRS OHIO14,800$1.49M0.01%-2,60013F-HRTimeline
STATE BOARD OF ADMINISTRATION OF FLORID…14,650$1.48M<0.01%-2013F-HRTimeline
Police & Firemen's Retirement System of…14,606$1.48M0.01%+2,24713F-HRTimeline
STIFEL FINANCIAL CORPin group STIFEL FINANCIAL CORP14,455$1.46M<0.01%-3,72213F-HRTimelineGroup
CANADA LIFE ASSURANCE Coin group CANADA LIFE ASSURANCE Co14,395$1.45M<0.01%+2,81713F-HRTimelineGroup
Advisors Asset Management, Inc.14,178$1.43M0.02%+58213F-HR/ATimeline
Engineers Gate Manager LP13,775$1.39M0.02%-3,90113F-HRTimeline
NISA INVESTMENT ADVISORS, LLC13,254$1.34M0.01%+12,00013F-HRTimeline
CITIGROUP INCin group CITIGROUP INC13,080$1.32M<0.01%-21,24413F-HRTimelineGroup
TEACHER RETIREMENT SYSTEM OF TEXAS12,960$1.31M0.01%+18813F-HRTimeline
PRINCIPAL FINANCIAL GROUP INCin group PRINCIPAL FINANCIAL GROUP INC12,598$1.27M<0.01%-46913F-HRTimelineGroup
PROFUND ADVISORS LLC12,457$1.26M0.04%+1,20313F-HRTimeline
FRED ALGER MANAGEMENT, LLCin group FRED ALGER MANAGEMENT, LLC12,335$1.25M<0.01%new13F-HRTimelineGroup
Allianz Asset Management GmbHin group Allianz SE12,100$1.22M<0.01%013F-HRTimelineGroup
SummitTX Capital, L.P.11,869$1.2M0.05%-13,58313F-HRTimeline
China Universal Asset Management Co., L…11,642$1.18M0.1%-1,13613F-HRTimeline
ProShare Advisors LLC11,299$1.14M<0.01%-2,23713F-HRTimeline
KLP KAPITALFORVALTNING AS11,000$1.11M<0.01%+80013F-HRTimeline
Zurcher Kantonalbank (Zurich Cantonalba…10,726$1.08M<0.01%+1,07413F-HRTimeline
Fiduciary Trust Coin group Fiduciary Trust Co10,000$1.01M0.01%013F-HRTimelineGroup
TOTH FINANCIAL ADVISORY CORP10,000$1.01M0.11%013F-HRTimeline
Cannon Financial Strategists, Inc.10,000$1.01M0.14%013F-HRTimeline
Bellevue Group AGin group Bellevue Group AG9,053$914K0.02%-11,85313F-HRTimelineGroup
Rockefeller Capital Management L.P.in group Rockefeller Capital Managemen…8,868$896K<0.01%new13F-HRTimelineGroup
Entropy Technologies, LP8,502$859K0.06%new13F-HRTimeline
READYSTATE ASSET MANAGEMENT LP8,365$845K0.04%-16,30113F-HRTimeline
Aigen Investment Management, LP8,225$831K0.13%+4,01113F-HRTimeline
E. Ohman J:or Asset Management AB8,213$829K0.02%013F-HRTimeline
Leo Wealth, LLC7,867$794K0.1%-5,57813F-HRTimeline
INCEPTIONR LLC7,482$756K0.18%new13F-HRTimeline
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…7,052$712K0.2%013F-HRTimelineGroup
VIRGINIA RETIREMENT SYSTEMS ET Al6,700$677K<0.01%new13F-HRTimeline
EXCHANGE TRADED CONCEPTS, LLC6,386$645K0.01%new13F-HRTimeline
ARROWSTREET CAPITAL, LIMITED PARTNERSHIPin group ARROWSTREET CAPITAL, LIMITED …6,307$637K<0.01%new13F-HRTimelineGroup
Jasper Ridge Partners, L.P.5,639$569K0.01%013F-HRTimeline
CIBC Bancorp USA Inc.in group CIBC Bancorp USA Inc.5,569$562K<0.01%13F-HR/ATimelineGroup
OXFORD ASSET MANAGEMENT LLP5,538$559K0.18%new13F-HRTimelineThe filing omitted confidential holdings, a later amendment may add them.
DNB Asset Management ASin group DNB Asset Management AS5,528$558K<0.01%new13F-HRTimelineGroup
PUBLIC EMPLOYEES RETIREMENT ASSOCIATION…5,463$552K<0.01%013F-HRTimeline
Quantbot Technologies LP4,981$503K0.01%new13F-HRTimeline
Gotham Asset Management, LLC4,855$490K<0.01%+413F-HRTimeline
O'SHAUGHNESSY ASSET MANAGEMENT, LLC4,836$488K<0.01%+1,36013F-HRTimeline
MACKENZIE FINANCIAL CORP4,398$444K<0.01%-1313F-HRTimeline
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…4,365$441K0.01%-1,18113F-HRTimelineGroup
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…4,217$426K<0.01%-1,32613F-HRTimelineGroup
XPONANCE LLC4,162$420K<0.01%-11013F-HRTimeline
LPL Financial LLC3,990$403K<0.01%-81513F-HRTimeline
GSA CAPITAL PARTNERS LLP3,897$394K0.03%-2,20013F-HRTimeline
Freestone Capital Holdings, LLCin group Freestone Capital Holdings, L…3,700$374K0.01%013F-HRTimelineGroup
FORA Capital, LLC3,599$363K0.06%new13F-HRTimeline
Mariner, LLCin group Mariner, LLC3,597$363K<0.01%-72413F-HRTimelineGroup
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.3,585$362K<0.01%-20,69313F-HRTimelineGroup
Avior Wealth Management, LLC3,541$358K0.01%-2,09413F-HRTimeline
CAPSTONE INVESTMENT ADVISORS, LLCin group CAPSTONE INVESTMENT ADVISORS,…3,497$353K<0.01%new13F-HRTimelineGroup
TWO SIGMA ADVISERS, LPin group TWO SIGMA INVESTMENTS, LP3,300$333K<0.01%-6,40013F-HRTimelineGroup
JGP Global Gestao de Recursos Ltda.3,253$329K0.19%-57113F-HRTimeline
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…3,104$313K<0.01%-74,15813F-HRTimelineGroup
CIM INVESTMENT MANAGEMENT INC2,993$302K0.08%new13F-HRTimeline
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC2,968$300K<0.01%new13F-HRTimelineGroup
Cerity Partners LLCin group Cerity Partners LLC2,964$299K<0.01%new13F-HRTimelineGroup
CWM, LLCin group CWM, LLC2,892$292K<0.01%-19913F-HRTimelineGroup
Chicago Partners Investment Group LLC2,455$279K0.01%-66013F-HRTimeline
B. Riley Wealth Advisors, Inc.2,675$270K0.01%new13F-HRTimeline
Tidal Investments LLCin group Tidal Investments LLC2,664$269K<0.01%new13F-HRTimelineGroup