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Disclosery

Opaleye Management Inc.: RYTM position timeline

Available 13F reports, 13D and 13G stakes and each Form 3, 4 and 5 line of Opaleye Management Inc. on RYTM, newest first. How the timeline and the estimate are built.

Opaleye Management Inc. held 122,500 RYTM shares at 2026-06-30 per its 13F-HR filed 2026-08-14.

the latest 13F is the newest step

  1. period ended2026-06-30
    13F 122,500 shares
    Change vs previous 13F -500 shares

    1.23% of the 13F portfolio, value $13,601,175.

    13F-HR 0001420506-26-001803 filed by Opaleye Management Inc.
    Filed (acceptance time not in the bulk data set), ingested

    Acceptance time not in the bulk data set (spec §4.2).

  2. period ended2026-03-31
    13F 123,000 shares
    Change vs previous 13F -207,000 shares

    4.65% of the 13F portfolio, value $35,323,200.

    13F-HR 0001420506-26-001151 filed by Opaleye Management Inc.
    Filed (acceptance time not in the bulk data set), ingested

    Acceptance time not in the bulk data set (spec §4.2).

  3. period ended2025-12-31
    13F/A 330,000 shares
    Change vs previous 13F -131,700 shares

    4.66% of the 13F portfolio, value $35,323,200.

    13F-HR/A 0001493152-26-016299 filed by Opaleye Management Inc.
    Filed (acceptance time not in the bulk data set), ingested

    Acceptance time not in the bulk data set (spec §4.2).

  4. period ended2025-09-30
    13F 461,700 shares
    Change vs previous 13F -13,300 shares

    6.59% of the 13F portfolio, value $46,627,083.

    13F-HR 0001493152-25-023429 filed by Opaleye Management Inc.
    Filed (acceptance time not in the bulk data set), ingested

    Acceptance time not in the bulk data set (spec §4.2).

  5. period ended2025-06-30
    13F/A 475,000 shares
    Change vs previous 13F -15,000 shares

    6.07% of the 13F portfolio, value $30,015,250.

    13F-HR/A 0001641172-25-024301 filed by Opaleye Management Inc.
    Filed (acceptance time not in the bulk data set), ingested

    Acceptance time not in the bulk data set (spec §4.2).

  6. period ended2025-03-31
    13F 490,000 shares
    Change vs previous 13F -10,000 shares

    5.78% of the 13F portfolio, value $25,955,300.

    13F-HR 0001641172-25-010914 filed by Opaleye Management Inc.
    Filed (acceptance time not in the bulk data set), ingested

    Acceptance time not in the bulk data set (spec §4.2).

  7. period ended2024-12-31
    13F 500,000 shares
    Change vs previous 13F 0 shares

    4.9% of the 13F portfolio, value $27,990,000.

    13F-HR 0001493152-25-006852 filed by Opaleye Management Inc.
    Filed (acceptance time not in the bulk data set), ingested

    Acceptance time not in the bulk data set (spec §4.2).

  8. period ended2024-09-30
    13F 500,000 shares
    Change vs previous 13F not available

    4.37% of the 13F portfolio, value $26,195,000.

    13F-HR 0001493152-24-045811 filed by Opaleye Management Inc.
    Filed (acceptance time not in the bulk data set), ingested

    Acceptance time not in the bulk data set (spec §4.2).