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Disclosery

RYTM RHYTHM PHARMACEUTICALS INC

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COM (common), issuer CIK 1649904

226 managers (229 13F filers) reported a position in RYTM shares at 2025-06-30, 66,539,256 shares in all. 31 filers opened a position and 33 filers sold out during the quarter.

Managers
226
13F filers
229
New
31
Added
93
Reduced
74
Sold out
33
Shares held by filers
66,539,256

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q2 2025

Filers in the available 13F reports with a share position at 2025-06-30, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
BlackRock, Inc.in group BlackRock, Inc.6,267,538$396M0.01%-587,21713F-HRTimelineGroup
BAKER BROS. ADVISORS LPin group BAKER BROS. ADVISORS LP5,604,483$354M3.44%013F-HRTimelineGroup
RA CAPITAL MANAGEMENT, L.P.in group RA CAPITAL MANAGEMENT, L.P.5,561,359$351M5.92%-523,05313F-HRTimelineGroup
PRIMECAP MANAGEMENT CO/CA/4,878,037$308M0.24%-909,28513F-HRTimeline
VANGUARD GROUP INCin group VANGUARD GROUP INC3,589,114$227M<0.01%+144,18813F-HRTimelineGroup
NEA Management Company, LLC2,909,956$184M13.84%013F-HRTimeline
PERCEPTIVE ADVISORS LLCin group PERCEPTIVE ADVISORS LLC2,418,299$153M5.73%-130,14613F-HRTimelineGroup
FMR LLCin group FMR LLC1,953,441$123M0.01%+265,06613F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP1,907,601$121M<0.01%-63,13213F-HRTimelineGroup
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC1,733,722$110M0.02%+95,81413F-HRTimelineGroup
FEDERATED HERMES, INC.in group FEDERATED HERMES, INC.1,686,494$107M0.2%+94,62313F-HRTimelineGroup
WESTFIELD CAPITAL MANAGEMENT CO LP1,629,468$103M0.43%+288,37613F-HRTimeline
JANUS HENDERSON GROUP PLCin group Janus Henderson1,411,902$89.3M0.04%-243,44813F-HRTimelineGroup
PRICE T ROWE ASSOCIATES INC /MD/1,341,392$84.8M0.01%+142,33913F-HRTimeline
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC1,311,253$82.9M0.01%+24,08513F-HRTimelineGroup
Driehaus Capital Management LLC1,269,952$80.2M0.64%-188,07013F-HRTimeline
Polar Capital Holdings Plcin group Polar Capital Holdings Plc1,250,870$79M0.41%+750,87013F-HRTimelineGroup
Checkpoint Capital L.P.1,060,000$67M31.21%+152,76013F-HRTimeline
ALKEON CAPITAL MANAGEMENT LLC1,017,700$64.3M0.31%+200,00013F-HRTimeline
Rock Springs Capital Management LP861,153$54.4M3.39%+26,96513F-HRTimeline
Franklin Resourcesgroup of 2 filers holding856,247$54.1M+530,087Timeline
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO783,559$49.5M<0.01%+639,91913F-HRTimelineGroup
LOOMIS SAYLES & CO L Pin group LOOMIS SAYLES & CO L P591,454$37.4M0.05%-14,31013F-HRTimelineGroup
Sofinnova Investments, Inc.586,010$37M2.52%+139,17113F-HRTimeline
Hood River Capital Management LLC543,688$34.4M0.48%-115,74313F-HRTimeline
MORGAN STANLEYin group MORGAN STANLEY524,480$33.1M<0.01%+20,43113F-HRTimelineGroup
Woodline Partners LP514,381$32.5M0.17%new13F-HRTimeline
NORTHERN TRUST CORPin group NORTHERN TRUST CORP510,246$32.2M<0.01%-25,96013F-HRTimelineGroup
UBS Group AGgroup of 2 filers holding480,209$30.3M+82,319Timeline
Opaleye Management Inc.475,000$30M6.07%-15,00013F-HR/ATimeline
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co461,438$29.2M0.01%+16,00913F-HRTimelineGroup
Pictet Asset Management Holding SAin group Pictet Asset Management Holdi…416,115$26.3M0.03%+156,76913F-HRTimelineGroup
Siren, L.L.C.in group Siren, L.L.C.409,742$25.9M1.34%+132,20913F-HRTimelineGroup
SILVERARC CAPITAL MANAGEMENT, LLCin group SILVERARC CAPITAL MANAGEMENT,…400,772$25.3M5.18%+63,16713F-HRTimelineGroup
MARSHALL WACE, LLPin group MARSHALL WACE, LLP376,242$23.8M0.03%-158,86113F-HRTimelineGroup
BARCLAYS PLCin group BARCLAYS PLC351,198$22.2M0.01%+249,98113F-HR/ATimelineGroup
ADAGE CAPITAL PARTNERS GP, L.L.C.in group ADAGE CAPITAL PARTNERS GP, L.…341,000$21.5M0.04%new13F-HRTimelineGroup
VOLORIDGE INVESTMENT MANAGEMENT, LLC338,804$21.4M0.08%-84,06413F-HRTimeline
RENAISSANCE TECHNOLOGIES LLC314,893$19.9M0.03%+300,78113F-HRTimeline
Candriam S.C.A.312,452$19.7M0.11%+20,98313F-HRTimeline
COMERICA BANK301,661$19.1M0.07%+56,90713F-HRTimeline
ORBIMED ADVISORS LLCin group ORBIMED ADVISORS LLC248,512$15.7M0.39%-131,48813F-HRTimelineGroup
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC244,003$15.4M0.02%+158,15413F-HRTimelineGroup
Qube Research & Technologies Ltd240,345$15.2M0.02%+24,15213F-HRTimeline
Assenagon Asset Management S.A.237,998$15M0.02%+215,80613F-HRTimeline
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/222,152$14M<0.01%+110,40013F-HRTimelineGroup
NORGES BANK207,389$13.1M<0.01%-16,09513F-HRTimeline
LORD, ABBETT & CO. LLC204,275$12.9M0.04%+68,91513F-HRTimeline
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC198,110$12.5M0.01%-19,26913F-HRTimelineGroup
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA196,236$12.4M<0.01%+196,10513F-HR/ATimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp184,109$11.6M<0.01%+37,52413F-HRTimelineGroup
STEMPOINT CAPITAL LP176,752$11.2M3.6%+142,93613F-HRTimeline
Artisan Partners Limited Partnership174,479$11M0.02%new13F-HRTimeline
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC173,069$10.9M<0.01%+74,78813F-HRTimelineGroup
Point72 Asset Management, L.P.in group Point72 Asset Management, L.P.170,832$10.8M0.03%+106,99013F-HRTimelineGroup
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…130,998$8.28M0.01%+16,22013F-HRTimelineGroup
Logos Global Management LP130,000$8.21M1.1%new13F-HRTimeline
Nuveen, LLCin group TIAA121,855$7.7M<0.01%-25,44613F-HRTimelineGroup
Integral Health Asset Management, LLC120,000$7.58M0.71%new13F-HRTimeline
PANAGORA ASSET MANAGEMENT INC119,466$7.55M0.03%-21,69613F-HRTimeline
Connor, Clark & Lunn Investment Managem…115,118$7.27M0.03%+64,56113F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS102,239$6.46M0.01%+16,17313F-HRTimelineGroup
LAZARD ASSET MANAGEMENT LLCin group LAZARD ASSET MANAGEMENT LLC99,445$6.28M0.01%-3,75713F-HRTimelineGroup
PDT Partners, LLC97,638$6.17M0.35%-4,55713F-HRTimeline
Universal- Beteiligungs- und Serviceges…in group Universal- Beteiligungs- und …95,517$6.04M0.01%+2,41213F-HRTimelineGroup
Swiss National Bank90,600$5.73M<0.01%+1,30013F-HRTimeline
RHUMBLINE ADVISERS87,526$5.53M<0.01%+1,80713F-HRTimeline
HARBOR CAPITAL ADVISORS, INC.86,546$5.47M0.23%+9,24913F-HRTimeline
NEUBERGER BERMAN GROUP LLCin group NEUBERGER BERMAN GROUP LLC86,139$5.44M<0.01%+18,20013F-HR/ATimelineGroup
Schonfeld Strategic Advisors LLC77,983$4.93M0.04%+20,83313F-HRTimeline
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…77,262$4.88M0.01%-5,71813F-HRTimelineGroup
FIRST TRUST ADVISORS LPin group FIRST TRUST ADVISORS LP73,714$4.66M<0.01%-16,06513F-HRTimelineGroup
Cinctive Capital Management LP70,937$4.48M0.25%+66,58113F-HRTimeline
Invesco Ltd.in group Invesco Ltd.68,924$4.36M<0.01%-192,97813F-HRTimelineGroup
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …68,132$4.31M<0.01%+3,74613F-HRTimelineGroup
Aberdeen Group plcin group Aberdeen Group plc67,657$4.28M0.01%-40,47213F-HRTimelineGroup
Cubist Systematic Strategies, LLC64,577$4.08M0.04%-109,24513F-HRTimeline
ALLIANCEBERNSTEIN L.P.61,470$3.88M<0.01%013F-HRTimeline
ALGERT GLOBAL LLC60,219$3.81M0.08%-1,24213F-HR/ATimeline
NEW YORK STATE COMMON RETIREMENT FUND58,618$3.7M<0.01%+41,76813F-HR/ATimeline
KENNEDY CAPITAL MANAGEMENT LLC57,217$3.62M0.09%+2,28713F-HRTimeline
TD Asset Management Inc56,000$3.54M<0.01%+5,80013F-HRTimeline
Balyasny Asset Management L.P.in group Balyasny Asset Management54,088$3.42M0.01%-301,62413F-HRTimelineGroup
Legal & General Group Plcin group Legal & General Group Plc52,681$3.33M<0.01%+1,52313F-HRTimelineGroup
AXIOM INVESTORS LLC /DE52,460$3.31M0.03%new13F-HRTimeline
Rafferty Asset Management, LLC51,611$3.26M0.01%-6,12113F-HRTimeline
Hennion & Walsh Asset Management, Inc.51,079$3.23M0.13%-38,54313F-HRTimeline
SAMSARA BIOCAPITAL, LLC50,476$3.19M0.65%-87,64213F-HRTimeline
Nan Fung Group Holdings Ltd49,120$3.1M4.89%013F-HRTimeline
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC49,040$3.1M<0.01%+9,67713F-HRTimelineGroup
SILVERCREST ASSET MANAGEMENT GROUP LLC48,775$3.08M0.02%new13F-HRTimeline
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC45,390$2.87M0.47%+8,50013F-HRTimelineGroup
CALIFORNIA STATE TEACHERS RETIREMENT SY…42,917$2.71M<0.01%+19613F-HRTimeline
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN42,368$2.68M<0.01%-28,27013F-HRTimelineGroup
Granahan Investment Management, LLC41,172$2.6M0.11%new13F-HRTimeline
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\36,779$2.32M<0.01%-7,00013F-HRTimelineGroup
STATE OF WISCONSIN INVESTMENT BOARD35,708$2.26M0.01%+2,68313F-HRTimeline
DARK FOREST CAPITAL MANAGEMENT LP34,829$2.2M0.09%+9,42013F-HRTimeline
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding34,809$2.2M-2,589Timeline
CITIGROUP INCin group CITIGROUP INC34,324$2.17M<0.01%-51,88213F-HRTimelineGroup
ALPS ADVISORS INCin group ALPS ADVISORS INC34,178$2.16M0.01%-12,02913F-HRTimelineGroup
SEI INVESTMENTS COin group SEI INVESTMENTS CO33,145$2.09M<0.01%+76413F-HRTimelineGroup
MetLife Investment Management, LLCin group MetLife Investment Management…32,395$2.05M0.01%-1913F-HRTimelineGroup
State of New Jersey Common Pension Fund…in group State of New Jersey Common Pe…30,373$1.92M0.01%-5,01913F-HRTimelineGroup
WEDGE CAPITAL MANAGEMENT L L P/NC29,991$1.9M0.03%-6,99313F-HRTimeline
HighVista Strategies LLC28,068$1.77M0.65%-6,97113F-HRTimeline
INTECH INVESTMENT MANAGEMENT LLC27,443$1.73M0.02%-6,45013F-HRTimeline
SummitTX Capital, L.P.25,452$1.61M0.07%+8,10913F-HRTimeline
READYSTATE ASSET MANAGEMENT LP24,666$1.56M0.06%new13F-HRTimeline
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.24,278$1.53M<0.01%-59,59113F-HRTimelineGroup
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…22,425$1.42M<0.01%-1,13313F-HRTimelineGroup
Bellevue Group AGin group Bellevue Group AG20,906$1.32M0.03%+5,35613F-HRTimelineGroup
STIFEL FINANCIAL CORPin group STIFEL FINANCIAL CORP18,177$1.15M<0.01%-31013F-HRTimelineGroup
Engineers Gate Manager LP17,676$1.12M0.01%-4,20713F-HRTimeline
Jump Financial, LLCin group Jump Financial, LLC17,671$1.12M0.01%-24,08913F-HR/ATimelineGroup
Ensign Peak Advisors, Inc17,659$1.12M<0.01%013F-HRTimeline
SCHRODER INVESTMENT MANAGEMENT GROUP17,618$1.11M<0.01%013F-HRTimeline
CAPTRUST FINANCIAL ADVISORS17,471$1.1M<0.01%+11413F-HRTimeline
STRS OHIO17,400$1.1M<0.01%-1,10013F-HRTimeline
Creative Planningin group Creative Planning17,222$1.09M<0.01%+4,88913F-HRTimelineGroup
VICTORY CAPITAL MANAGEMENT INC16,241$1.03M<0.01%-1,08513F-HRTimeline
Handelsbanken Fonder AB15,521$981K<0.01%-1,50013F-HRTimeline
Harvest Investment Services, LLC15,466$977K0.22%new13F-HRTimeline
Atom Investors LP14,866$939K0.08%-9613F-HRTimeline
STATE BOARD OF ADMINISTRATION OF FLORID…14,670$927K<0.01%013F-HRTimeline
ARIZONA STATE RETIREMENT SYSTEM13,834$874K0.01%+65313F-HRTimeline
Advisors Asset Management, Inc.13,596$859K0.02%+3,34613F-HR/ATimeline
ProShare Advisors LLC13,536$855K<0.01%-1,16813F-HRTimeline
Leo Wealth, LLC13,445$850K0.07%-2,55513F-HRTimeline
Point72 (DIFC) Ltd13,149$831K0.07%+6,49613F-HRTimeline
PRINCIPAL FINANCIAL GROUP INCin group PRINCIPAL FINANCIAL GROUP INC13,067$826K<0.01%-24,08913F-HRTimelineGroup
China Universal Asset Management Co., L…12,778$807K0.08%+9613F-HRTimeline
TEACHER RETIREMENT SYSTEM OF TEXAS12,772$807K<0.01%+36813F-HRTimeline
Police & Firemen's Retirement System of…12,359$781K0.01%+70413F-HRTimeline
Allianz Asset Management GmbHin group Allianz SE12,100$765K<0.01%+6,00013F-HRTimelineGroup
CANADA LIFE ASSURANCE Coin group CANADA LIFE ASSURANCE Co11,578$733K<0.01%013F-HRTimelineGroup
PROFUND ADVISORS LLC11,254$711K0.03%-1,19013F-HRTimeline
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC10,546$666K<0.01%new13F-HRTimelineGroup
KLP KAPITALFORVALTNING AS10,200$645K<0.01%+90013F-HRTimeline
Fiduciary Trust Coin group Fiduciary Trust Co10,000$632K0.01%-5,00013F-HRTimelineGroup
TOTH FINANCIAL ADVISORY CORP10,000$632K0.07%new13F-HRTimeline
Cannon Financial Strategists, Inc.10,000$632K0.1%013F-HRTimeline
TWO SIGMA ADVISERS, LPin group TWO SIGMA INVESTMENTS, LP9,700$613K<0.01%-2,40013F-HRTimelineGroup
Zurcher Kantonalbank (Zurich Cantonalba…9,652$610K<0.01%+72613F-HRTimeline
E. Ohman J:or Asset Management AB8,213$519K0.01%new13F-HRTimeline
Caption Management, LLC7,540$476K0.04%new13F-HRTimeline
Trexquant Investment LP7,083$448K0.01%-31,64113F-HRTimeline
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…7,052$446K0.15%+60613F-HRTimelineGroup
CIBC WORLD MARKETS CORP6,706$424K<0.01%-5,44213F-HRTimeline
PRUDENTIAL FINANCIAL INCin group PRUDENTIAL FINANCIAL INC7,095$423K<0.01%+2,74013F-HRTimelineGroup
SG Americas Securities, LLC6,185$391K<0.01%-13,48213F-HRTimeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…6,111$386K0.01%+5,05313F-HRTimelineGroup
GSA CAPITAL PARTNERS LLP6,097$385K0.03%+1,02813F-HRTimeline
E Fund Management Co., Ltd.5,761$364K0.02%+36513F-HRTimeline
Jasper Ridge Partners, L.P.5,639$356K0.01%013F-HRTimeline
Avior Wealth Management, LLC5,635$356K0.01%+1,04613F-HRTimeline
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…5,546$350K0.01%013F-HRTimelineGroup
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…5,543$350K<0.01%+1,02513F-HRTimelineGroup
PUBLIC EMPLOYEES RETIREMENT ASSOCIATION…5,463$345K<0.01%013F-HRTimeline
Gotham Asset Management, LLC4,851$307K<0.01%+10113F-HRTimeline
LPL Financial LLC4,805$304K<0.01%+59113F-HRTimeline
AXQ CAPITAL, LP4,560$288K0.09%new13F-HRTimeline
MACKENZIE FINANCIAL CORP4,411$279K<0.01%+6813F-HRTimeline
Chicago Partners Investment Group LLC3,115$274K0.01%-39513F-HRTimeline
Mariner, LLCin group Mariner, LLC4,321$273K<0.01%-26413F-HRTimelineGroup
TUDOR INVESTMENT CORP ET AL4,272$270K<0.01%-25,24113F-HRTimeline
XPONANCE LLC4,272$270K<0.01%-9313F-HRTimeline
Aigen Investment Management, LP4,214$266K0.04%-3,48713F-HRTimeline
Aquatic Capital Management LLC3,953$250K0.01%-37,52313F-HRTimeline
Jain Global LLC3,908$247K<0.01%new13F-HRTimeline
LOS ANGELES CAPITAL MANAGEMENT LLC3,872$245K<0.01%new13F-HRTimeline
JGP Global Gestao de Recursos Ltda.3,824$242K0.12%013F-HRTimeline
Freestone Capital Holdings, LLCin group Freestone Capital Holdings, L…3,700$234K0.01%new13F-HRTimelineGroup
O'SHAUGHNESSY ASSET MANAGEMENT, LLC3,476$220K<0.01%new13F-HRTimeline
CWM, LLCin group CWM, LLC3,091$195K<0.01%+50713F-HRTimelineGroup
ELEVATION WEALTH PARTNERS, LLC1,971$125K0.05%013F-HRTimeline
AMALGAMATED BANK1,881$119K<0.01%013F-HRTimeline
WHITTIER TRUST CO1,760$111K<0.01%013F-HRTimeline
KBC Group NVin group KBC Group NV1,707$108K<0.01%-54413F-HRTimelineGroup
GF FUND MANAGEMENT CO. LTD.1,573$99.4K<0.01%013F-HRTimeline
AlphaQuest LLC1,470$92.9K0.01%-5,13713F-HRTimeline
NISA INVESTMENT ADVISORS, LLC1,254$79.2K<0.01%+1413F-HRTimeline
State of Wyoming1,065$67.3K0.01%new13F-HRTimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.979$61.9K<0.01%+38913F-HR/ATimelineGroup
Clearstead Advisors, LLC590$37.3K<0.01%new13F-HRTimeline
Arax Advisory Partners558$35.3K<0.01%+4013F-HRTimeline
BNP PARIBAS ASSET MANAGEMENT Holding S.…in group BNP PARIBAS ASSET MANAGEMENT …421$27K<0.01%new13F-HRTimelineGroup
Global Retirement Partners, LLC400$25.3K<0.01%13F-HRTimeline
AMERIFLEX GROUP, INC.360$22.1K0.01%013F-HRTimeline
Compagnie Lombard Odier SCmA250$15.8K<0.01%new13F-HRTimeline
JONES FINANCIAL COMPANIES LLLPin group JONES FINANCIAL COMPANIES LLLP231$14.5K<0.01%013F-HRTimelineGroup
SIGNATUREFD, LLC224$14.2K<0.01%013F-HRTimeline
Daiwa Securities Group Inc.in group Daiwa Securities Group Inc.229$14K<0.01%+2613F-HRTimelineGroup
Optiver Holding B.V.in group Optiver Holding B.V.221$14K<0.01%+6613F-HRTimelineGroup
GAMMA Investing LLC211$13.3K<0.01%-7013F-HRTimeline
First Horizon Advisors, Inc.200$12.6K<0.01%new13F-HRTimeline
SBI Securities Co., Ltd.168$10.6K<0.01%-29813F-HRTimeline
True Wealth Design, LLC147$9.29K<0.01%+9013F-HRTimeline
US BANCORP \DE\in group US BANCORP \DE\146$9.23K<0.01%013F-HRTimelineGroup
Smartleaf Asset Management LLC145$9.1K<0.01%-11013F-HRTimeline