VANGUARD GROUP INC group of 2 filers holding More: the full row for VANGUARD GROUP INC 18,225,477 $1.26B +1,075,158 Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 16,032,944 $1.11B 0.02% +1,062,792 13F-HR Timeline Group Darwin Global Management, Ltd. in group Darwin Global Management, Ltd. More: the full row for Darwin Global Management, Ltd. 12,960,538 $895M 84.75% +2,463,261 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 12,704,410 $877M 0.1% +123,429 13F-HR Timeline Capital International Investors in group Capital International Investo… More: the full row for Capital International Investors 7,116,997 $491M 0.09% +593,206 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 6,106,153 $422M 0.02% -72,077 13F-HR Timeline Group BAKER BROS. ADVISORS LP in group BAKER BROS. ADVISORS LP More: the full row for BAKER BROS. ADVISORS LP 5,006,863 $346M 3.69% +590,945 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 4,856,249 $335M 0.02% -2,335,269 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 4,087,143 $282M 0.02% +273,759 13F-HR Timeline Group Franklin Resources group of 2 filers holding More: the full row for Franklin Resources 4,038,553 $279M -491,603 Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 3,286,248 $227M 0.02% -20,098 13F-HR Timeline Group Artisan Partners Limited Partnership More: the full row for Artisan Partners Limited Partnership 3,126,339 $216M 0.33% +242,242 13F-HR Timeline RTW INVESTMENTS, LP More: the full row for RTW INVESTMENTS, LP 3,014,558 $208M 3.15% -257,450 13F-HR Timeline AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 2,850,097 $197M 0.05% +269,678 13F-HR Timeline Group FIL Ltd in group FIL Ltd More: the full row for FIL Ltd 2,638,160 $182M 0.17% +198,412 13F-HR Timeline Group WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC More: the full row for WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC 2,433,443 $168M 0.41% +12,535 13F-HR Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 2,363,561 $163M 0.06% -86,532 13F-HR Timeline MACQUARIE GROUP LTD in group MACQUARIE GROUP LTD More: the full row for MACQUARIE GROUP LTD 2,313,159 $160M 0.19% +27,238 13F-HR Timeline Group T. Rowe Price Investment Management, In… More: the full row for T. Rowe Price Investment Management, Inc. 1,982,707 $137M 0.08% -294,436 13F-HR Timeline Pictet Asset Management Holding SA in group Pictet Asset Management Holdi… More: the full row for Pictet Asset Management Holding SA 1,959,718 $135M 0.15% +96,377 13F-HR Timeline Group NORGES BANK More: the full row for NORGES BANK 1,833,810 $127M 0.02% +177,043 13F-HR Timeline PRINCIPAL FINANCIAL GROUP INC group of 2 filers holding More: the full row for PRINCIPAL FINANCIAL GROUP INC 1,820,782 $126M -53,127 Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 1,750,642 $121M 0.02% +290,678 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 1,720,049 $119M 0.02% +327,000 13F-HR Timeline Group ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 1,647,562 $114M 0.2% +615,000 13F-HR Timeline Group MONTANOVA CAPITAL, LLC More: the full row for MONTANOVA CAPITAL, LLC 1,611,561 $111M 4.12% -24,148 13F-HR Timeline Palo Alto Investors LP More: the full row for Palo Alto Investors LP 1,603,465 $111M 17.15% -337,528 13F-HR Timeline Integral Health Asset Management, LLC More: the full row for Integral Health Asset Management, LLC 1,550,000 $107M 9.46% +100,000 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 1,546,607 $107M 0.02% +102,341 13F-HR Timeline Group Hood River Capital Management LLC More: the full row for Hood River Capital Management LLC 1,525,628 $105M 1.56% +53,073 13F-HR Timeline LORD, ABBETT & CO. LLC More: the full row for LORD, ABBETT & CO. LLC 1,457,210 $101M 0.32% -13,751 13F-HR Timeline JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 1,445,696 $99.8M 0.05% -43,208 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 1,438,466 $99.3M 0.02% -31,751 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 1,351,365 $93.3M 0.01% +30,374 13F-HR/A Timeline Group Nuveen Asset Management, LLC in group TIAA More: the full row for Nuveen Asset Management, LLC 1,266,630 $87.4M 0.02% +205,473 13F-HR Timeline Group LOOMIS SAYLES & CO L P in group LOOMIS SAYLES & CO L P More: the full row for LOOMIS SAYLES & CO L P 1,174,791 $81.1M 0.1% -35,396 13F-HR Timeline Group GW&K Investment Management, LLC More: the full row for GW&K Investment Management, LLC 1,135,393 $78.4M 0.67% -18,122 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 1,107,666 $76.5M 0.01% -46,232 13F-HR Timeline Group EVENTIDE ASSET MANAGEMENT, LLC More: the full row for EVENTIDE ASSET MANAGEMENT, LLC 1,100,993 $76M 1.38% +194,598 13F-HR Timeline EMERALD ADVISERS, LLC group of 2 filers holding More: the full row for EMERALD ADVISERS, LLC 1,085,260 $74.9M -92,211 Timeline MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 1,064,215 $73.5M 0.09% +293,004 13F-HR Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 1,016,090 $70.2M 0.01% -46,305 13F-HR Timeline Group WESTFIELD CAPITAL MANAGEMENT CO LP More: the full row for WESTFIELD CAPITAL MANAGEMENT CO LP 938,551 $64.8M 0.28% +686,812 13F-HR Timeline Alyeska Investment Group, L.P. in group Alyeska Investment Group, L.P. More: the full row for Alyeska Investment Group, L.P. 935,779 $64.6M 0.24% +188,377 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 920,496 $63.6M -273,343 Timeline Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 900,000 $62.1M 3.68% -700,000 13F-HR Timeline UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 892,572 $61.6M +159,644 Timeline AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 812,780 $56.1M 0.03% +89,097 13F-HR Timeline Group JENNISON ASSOCIATES LLC More: the full row for JENNISON ASSOCIATES LLC 773,813 $53.4M 0.03% +4,560 13F-HR Timeline WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 752,226 $51.9M 0.01% -210,233 13F-HR Timeline Group Polar Capital Holdings Plc in group Polar Capital Holdings Plc More: the full row for Polar Capital Holdings Plc 730,000 $50.4M 0.28% +50,000 13F-HR Timeline Group NOVO HOLDINGS A/S More: the full row for NOVO HOLDINGS A/S 724,666 $50M 3.03% 0 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 3 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 715,395 $49.4M +442,530 Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 699,006 $48.3M 0.04% +134,150 13F-HR Timeline Group Holocene Advisors, LP More: the full row for Holocene Advisors, LP 687,712 $47.5M 0.15% new 13F-HR Timeline TimesSquare Capital Management, LLC More: the full row for TimesSquare Capital Management, LLC 684,384 $47.2M 0.69% +200,515 13F-HR Timeline BROWN ADVISORY INC in group BROWN ADVISORY INC More: the full row for BROWN ADVISORY INC 662,997 $45.8M 0.06% new 13F-HR Timeline Group BNP PARIBAS ASSET MANAGEMENT Holding S.… in group BNP PARIBAS ASSET MANAGEMENT … More: the full row for BNP PARIBAS ASSET MANAGEMENT Holding S.A. 654,901 $45.2M 0.11% +145,462 13F-HR Timeline Group Long Focus Capital Management, LLC More: the full row for Long Focus Capital Management, LLC 650,800 $44.9M 3.44% +21,900 13F-HR Timeline Cormorant Asset Management, LP More: the full row for Cormorant Asset Management, LP 650,000 $44.9M 2.46% +150,000 13F-HR Timeline SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT… in group SUMMIT PARTNERS PUBLIC ASSET … More: the full row for SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC 638,848 $44.1M 1.48% +60,492 13F-HR Timeline Group Duquesne Family Office LLC More: the full row for Duquesne Family Office LLC 593,470 $41M 1.15% +573,470 13F-HR Timeline Fiera Capital Corp in group Fiera Capital Corp More: the full row for Fiera Capital Corp 581,854 $40.2M 0.13% -10,561 13F-HR Timeline Group Rock Springs Capital Management LP More: the full row for Rock Springs Capital Management LP 550,000 $38M 1.45% -133,344 13F-HR Timeline VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 548,867 $37.9M 0.04% -196,927 13F-HR/A Timeline Group Ensign Peak Advisors, Inc More: the full row for Ensign Peak Advisors, Inc 529,049 $36.5M 0.06% +44,928 13F-HR Timeline TD Asset Management Inc More: the full row for TD Asset Management Inc 526,890 $36.4M 0.03% +13,808 13F-HR Timeline Assenagon Asset Management S.A. More: the full row for Assenagon Asset Management S.A. 525,193 $36.3M 0.07% -332,167 13F-HR Timeline Eagle Health Investments LP More: the full row for Eagle Health Investments LP 513,700 $35.5M 8.69% 0 13F-HR Timeline D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 508,787 $35.1M 0.04% +442,052 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 488,966 $33.8M 0.01% +212,024 13F-HR/A Timeline Group First Light Asset Management, LLC More: the full row for First Light Asset Management, LLC 470,192 $32.5M 3.11% -218,718 13F-HR Timeline SOROS FUND MANAGEMENT LLC in group SOROS FUND MANAGEMENT LLC More: the full row for SOROS FUND MANAGEMENT LLC 455,089 $31.4M 0.55% -23,512 13F-HR Timeline Group Candriam S.C.A. More: the full row for Candriam S.C.A. 453,520 $31.3M 0.18% -22,974 13F-HR Timeline Logos Global Management LP More: the full row for Logos Global Management LP 450,000 $31.1M 3.64% new 13F-HR Timeline First Turn Management, LLC More: the full row for First Turn Management, LLC 446,980 $30.9M 5.53% +90,529 13F-HR Timeline FRONTIER CAPITAL MANAGEMENT CO LLC More: the full row for FRONTIER CAPITAL MANAGEMENT CO LLC 435,006 $30M 0.29% -159,100 13F-HR Timeline Allspring Global Investments Holdings, … in group Allspring Global Investments … More: the full row for Allspring Global Investments Holdings, LLC 423,094 $29.6M 0.05% +32,960 13F-HR Timeline Group VICTORY CAPITAL MANAGEMENT INC More: the full row for VICTORY CAPITAL MANAGEMENT INC 410,577 $28.3M 0.03% -45,382 13F-HR Timeline MPM BIOIMPACT LLC More: the full row for MPM BIOIMPACT LLC 389,611 $26.9M 3.82% -225,780 13F-HR Timeline Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 389,033 $26.9M 0.04% -100,274 13F-HR Timeline FRED ALGER MANAGEMENT, LLC in group FRED ALGER MANAGEMENT, LLC More: the full row for FRED ALGER MANAGEMENT, LLC 385,460 $26.6M 0.13% -66,856 13F-HR Timeline Group SILVERARC CAPITAL MANAGEMENT, LLC in group SILVERARC CAPITAL MANAGEMENT,… More: the full row for SILVERARC CAPITAL MANAGEMENT, LLC 372,230 $25.7M 5.75% +24,535 13F-HR Timeline Group RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 363,446 $25.1M 0.01% 13F-HR/A Timeline Group SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 362,616 $25M 0.03% +29,019 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 354,436 $24.5M 0.01% +22,373 13F-HR/A Timeline Group DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 350,939 $24.2M 0.01% -16,313 13F-HR Timeline Group B Group, Inc. More: the full row for B Group, Inc. 350,000 $24.2M 14.77% 13F-HR Timeline Caption Management, LLC More: the full row for Caption Management, LLC 348,994 $24.1M 0.99% +250,194 13F-HR Timeline C WorldWide Group Holding A/S in group C WorldWide Group Holding A/S More: the full row for C WorldWide Group Holding A/S 343,110 $23.7M 0.29% 0 13F-HR Timeline Group Octagon Capital Advisors LP More: the full row for Octagon Capital Advisors LP 332,000 $22.9M 3.9% -104,820 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 323,735 $22.4M 0.02% -12,827 13F-HR Timeline Group Swiss National Bank More: the full row for Swiss National Bank 321,100 $22.2M 0.01% +18,600 13F-HR Timeline Soleus Capital Management, L.P. More: the full row for Soleus Capital Management, L.P. 320,272 $22.1M 1.67% +290,000 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 317,753 $21.9M 0.03% +24,974 13F-HR/A Timeline PANAGORA ASSET MANAGEMENT INC More: the full row for PANAGORA ASSET MANAGEMENT INC 317,162 $21.9M 0.1% +26,692 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 313,181 $21.6M 0.02% +25,108 13F-HR Timeline Group Patient Square Capital LP More: the full row for Patient Square Capital LP 307,167 $21.2M 7.93% +135,463 13F-HR Timeline Aberdeen Group plc in group Aberdeen Group plc More: the full row for Aberdeen Group plc 289,653 $20M 0.04% +178,041 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 288,337 $19.9M 0.02% +25,292 13F-HR/A Timeline NWI MANAGEMENT LP More: the full row for NWI MANAGEMENT LP 279,000 $19.3M 1.52% +181,460 13F-HR Timeline SCHRODER INVESTMENT MANAGEMENT GROUP More: the full row for SCHRODER INVESTMENT MANAGEMENT GROUP 268,063 $18.5M 0.02% +127,641 13F-HR Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 263,721 $18.2M 0.03% -395,954 13F-HR Timeline Group ENVESTNET ASSET MANAGEMENT INC group of 2 filers holding More: the full row for ENVESTNET ASSET MANAGEMENT INC 262,672 $18.1M +15,452 Timeline Bellevue Group AG in group Bellevue Group AG More: the full row for Bellevue Group AG 258,483 $17.8M 0.34% -266,951 13F-HR Timeline Group California Public Employees Retirement … More: the full row for California Public Employees Retirement System 256,355 $17.7M 0.01% -2,522 13F-HR/A Timeline Sofinnova Investments, Inc. More: the full row for Sofinnova Investments, Inc. 256,281 $17.7M 1.3% -30,026 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 247,443 $17.1M 0.02% +126,177 13F-HR Timeline Group Nationale-Nederlanden Powszechne Towarz… More: the full row for Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. 243,748 $16.8M 2.04% new 13F-HR Timeline FEDERATED HERMES, INC. in group FEDERATED HERMES, INC. More: the full row for FEDERATED HERMES, INC. 235,836 $16.3M 0.04% +192,853 13F-HR Timeline Group Avidity Partners Management LP More: the full row for Avidity Partners Management LP 232,800 $16.1M 1.6% -359,200 13F-HR Timeline AXA S.A. in group AXA S.A. More: the full row for AXA S.A. 226,821 $15.7M 0.05% -360 13F-HR Timeline Group KINGDON CAPITAL MANAGEMENT, L.L.C. More: the full row for KINGDON CAPITAL MANAGEMENT, L.L.C. 225,000 $15.5M 2.65% -175,000 13F-HR Timeline Cutter Capital Management, LP More: the full row for Cutter Capital Management, LP 210,884 $14.6M 5.97% -5,000 13F-HR Timeline Hudson Bay Capital Management LP in group Hudson Bay Capital Management… More: the full row for Hudson Bay Capital Management LP 210,000 $14.5M 0.09% -30,000 13F-HR Timeline Group Granahan Investment Management, LLC More: the full row for Granahan Investment Management, LLC 209,354 $14.5M 0.6% -7,991 13F-HR Timeline RA CAPITAL MANAGEMENT, L.P. in group RA CAPITAL MANAGEMENT, L.P. More: the full row for RA CAPITAL MANAGEMENT, L.P. 200,000 $13.8M 0.18% 0 13F-HR Timeline Group PEREGRINE CAPITAL MANAGEMENT LLC More: the full row for PEREGRINE CAPITAL MANAGEMENT LLC 193,479 $13.4M 0.4% +20,642 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 187,016 $12.9M 0.01% -129,860 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 184,072 $12.7M <0.01% -16,364 13F-HR Timeline Group Nicholas Investment Partners, LP More: the full row for Nicholas Investment Partners, LP 182,743 $12.6M 1.11% +81,598 13F-HR Timeline Rafferty Asset Management, LLC More: the full row for Rafferty Asset Management, LLC 180,913 $12.5M 0.04% -45,887 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 176,014 $12.2M <0.01% +14,246 13F-HR Timeline Group Driehaus Capital Management LLC More: the full row for Driehaus Capital Management LLC 171,289 $11.8M 0.1% +3,859 13F-HR Timeline COMERICA BANK More: the full row for COMERICA BANK 170,780 $11.8M 0.05% +108,686 13F-HR/A Timeline Artia Global Partners LP More: the full row for Artia Global Partners LP 167,939 $11.6M 4.68% +115,000 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 162,230 $11.2M 0.08% -54,149 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 160,709 $11.1M <0.01% +33,214 13F-HR Timeline Group SAMLYN CAPITAL, LLC in group SAMLYN CAPITAL, LLC More: the full row for SAMLYN CAPITAL, LLC 159,064 $11M 0.17% -52,434 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 153,343 $10.6M 0.01% +6,601 13F-HR/A Timeline NEUBERGER BERMAN GROUP LLC in group NEUBERGER BERMAN GROUP LLC More: the full row for NEUBERGER BERMAN GROUP LLC 149,241 $10.3M 0.01% +37,403 13F-HR Timeline Group PRUDENTIAL FINANCIAL INC in group PRUDENTIAL FINANCIAL INC More: the full row for PRUDENTIAL FINANCIAL INC 146,722 $10.1M 0.01% +12,132 13F-HR Timeline Group WCM INVESTMENT MANAGEMENT, LLC More: the full row for WCM INVESTMENT MANAGEMENT, LLC 144,740 $9.97M 0.02% -3,590 13F-HR/A Timeline PERCEPTIVE ADVISORS LLC in group PERCEPTIVE ADVISORS LLC More: the full row for PERCEPTIVE ADVISORS LLC 144,000 $9.94M 0.28% -36,000 13F-HR Timeline Group SEGALL BRYANT & HAMILL, LLC More: the full row for SEGALL BRYANT & HAMILL, LLC 139,045 $9.6M 0.13% -1,870 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 132,154 $9.12M 0.01% +45,395 13F-HR Timeline Group Altium Capital Management LLC More: the full row for Altium Capital Management LLC 132,000 $9.11M 2.84% +2,000 13F-HR Timeline STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 122,111 $8.43M 0.02% +12,786 13F-HR Timeline Senator Investment Group LP More: the full row for Senator Investment Group LP 120,000 $8.28M 0.24% new 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 119,800 $8.27M 2.36% -35,035 13F-HR Timeline Group VAN ECK ASSOCIATES CORP in group VAN ECK ASSOCIATES CORP More: the full row for VAN ECK ASSOCIATES CORP 119,234 $8.23M 0.01% -7,790 13F-HR Timeline Group Ally Bridge Group (NY) LLC More: the full row for Ally Bridge Group (NY) LLC 114,360 $7.9M 6.77% -36,473 13F-HR Timeline Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 111,714 $7.72M +10,538 Timeline EFG Asset Management (North America) Co… More: the full row for EFG Asset Management (North America) Corp. 107,625 $7.43M 1.01% +56,758 13F-HR Timeline STEMPOINT CAPITAL LP More: the full row for STEMPOINT CAPITAL LP 106,610 $7.36M 1.85% new 13F-HR Timeline ACUTA CAPITAL PARTNERS, LLC More: the full row for ACUTA CAPITAL PARTNERS, LLC 104,800 $7.24M 7.28% -2,700 13F-HR Timeline J. Goldman & Co LP More: the full row for J. Goldman & Co LP 104,179 $7.19M 0.25% +92,953 13F-HR Timeline MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 103,429 $7.14M 0.04% +13,807 13F-HR Timeline Group TANG CAPITAL MANAGEMENT LLC in group TANG CAPITAL MANAGEMENT LLC More: the full row for TANG CAPITAL MANAGEMENT LLC 100,000 $6.9M 0.46% 0 13F-HR Timeline Group Universal- Beteiligungs- und Serviceges… in group Universal- Beteiligungs- und … More: the full row for Universal- Beteiligungs- und Servicegesellschaft mbH 98,460 $6.8M 0.01% 13F-HR Timeline Group ORBIMED ADVISORS LLC in group ORBIMED ADVISORS LLC More: the full row for ORBIMED ADVISORS LLC 94,559 $6.53M 0.14% new 13F-HR Timeline Group Aquatic Capital Management LLC More: the full row for Aquatic Capital Management LLC 91,268 $6.3M 0.17% +68,268 13F-HR Timeline ROYCE & ASSOCIATES LP More: the full row for ROYCE & ASSOCIATES LP 90,027 $6.22M 0.06% -5,000 13F-HR Timeline RICE HALL JAMES & ASSOCIATES, LLC More: the full row for RICE HALL JAMES & ASSOCIATES, LLC 88,860 $6.13M 0.34% -4,632 13F-HR Timeline HAP Trading, LLC More: the full row for HAP Trading, LLC 87,533 $6.04M 2.02% +4,052 13F-HR Timeline Corebridge Financial, Inc. in group Corebridge Financial, Inc. More: the full row for Corebridge Financial, Inc. 85,719 $5.92M 0.03% +1,685 13F-HR Timeline Group AXIOM INVESTORS LLC /DE More: the full row for AXIOM INVESTORS LLC /DE 83,874 $5.79M 0.04% -3,340 13F-HR Timeline MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC in group MUTUAL OF AMERICA CAPITAL MAN… More: the full row for MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC 77,048 $5.32M 0.06% -68 13F-HR Timeline Group ALGERT GLOBAL LLC More: the full row for ALGERT GLOBAL LLC 75,754 $5.23M 0.12% -5,747 13F-HR/A Timeline THORNBURG INVESTMENT MANAGEMENT INC More: the full row for THORNBURG INVESTMENT MANAGEMENT INC 74,749 $5.16M 0.07% -1,120 13F-HR Timeline Informed Momentum Co LLC More: the full row for Informed Momentum Co LLC 71,964 $4.97M 0.7% -36,008 13F-HR Timeline Allianz Asset Management GmbH in group Allianz SE More: the full row for Allianz Asset Management GmbH 71,750 $4.95M 0.01% -33,927 13F-HR Timeline Group INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 71,227 $4.92M 0.05% +24,634 13F-HR Timeline Parallax Volatility Advisers, L.P. More: the full row for Parallax Volatility Advisers, L.P. 70,537 $4.87M 0.11% -62,021 13F-HR Timeline Springhill Fund Asset Management (HK) C… More: the full row for Springhill Fund Asset Management (HK) Co Ltd 69,500 $4.8M 7.79% 13F-HR Timeline ESSEX INVESTMENT MANAGEMENT CO LLC More: the full row for ESSEX INVESTMENT MANAGEMENT CO LLC 67,330 $4.65M 0.84% -9,863 13F-HR Timeline FIRST TRUST ADVISORS LP in group FIRST TRUST ADVISORS LP More: the full row for FIRST TRUST ADVISORS LP 66,690 $4.6M <0.01% -214,129 13F-HR Timeline Group Twin Tree Management, LP More: the full row for Twin Tree Management, LP 65,147 $4.5M 0.11% new 13F-HR Timeline AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 64,171 $4.43M 0.01% +1,291 13F-HR Timeline Group State of New Jersey Common Pension Fund… in group State of New Jersey Common Pe… More: the full row for State of New Jersey Common Pension Fund D 64,061 $4.42M 0.02% +4,438 13F-HR Timeline Group Rhenman & Partners Asset Management AB More: the full row for Rhenman & Partners Asset Management AB 61,500 $4.25M 0.44% -68,013 13F-HR Timeline Global IMC LLC More: the full row for Global IMC LLC 61,489 $4.25M 0.76% -33,353 13F-HR Timeline BAMCO INC /NY/ in group Baron Capital More: the full row for BAMCO INC /NY/ 60,000 $4.14M 0.01% +19,500 13F-HR Timeline Group HARBOR CAPITAL ADVISORS, INC. More: the full row for HARBOR CAPITAL ADVISORS, INC. 59,600 $4.12M 0.18% +41,918 13F-HR Timeline Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 58,970 $4.07M 0.01% +38,155 13F-HR Timeline Group Hillsdale Investment Management Inc. More: the full row for Hillsdale Investment Management Inc. 57,000 $3.94M 0.2% +300 13F-HR Timeline ProShare Advisors LLC More: the full row for ProShare Advisors LLC 56,991 $3.93M 0.01% +17,141 13F-HR Timeline Creative Planning in group Creative Planning More: the full row for Creative Planning 56,710 $3.92M <0.01% +11,796 13F-HR Timeline Group OAK RIDGE INVESTMENTS LLC More: the full row for OAK RIDGE INVESTMENTS LLC 56,636 $3.91M 0.31% -1,718 13F-HR Timeline DIADEMA PARTNERS LP More: the full row for DIADEMA PARTNERS LP 56,337 $3.89M 4.38% 13F-HR Timeline CASTLEARK MANAGEMENT LLC More: the full row for CASTLEARK MANAGEMENT LLC 52,780 $3.64M 0.13% +9,480 13F-HR Timeline Affinity Asset Advisors, LLC More: the full row for Affinity Asset Advisors, LLC 50,000 $3.45M 0.54% 0 13F-HR Timeline DekaBank Deutsche Girozentrale More: the full row for DekaBank Deutsche Girozentrale 50,000 $3.43M 0.01% 0 13F-HR Timeline PICTON MAHONEY ASSET MANAGEMENT More: the full row for PICTON MAHONEY ASSET MANAGEMENT 48,897 $3.37M 0.13% +3,354 13F-HR/A Timeline TEACHER RETIREMENT SYSTEM OF TEXAS More: the full row for TEACHER RETIREMENT SYSTEM OF TEXAS 48,337 $3.34M 0.01% +9,471 13F-HR Timeline Erste Asset Management GmbH in group Erste Asset Management GmbH More: the full row for Erste Asset Management GmbH 47,600 $3.31M 0.04% 0 13F-HR Timeline Group GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 47,874 $3.31M 0.11% -122,836 13F-HR/A Timeline ARIZONA STATE RETIREMENT SYSTEM More: the full row for ARIZONA STATE RETIREMENT SYSTEM 47,342 $3.27M 0.02% +2,722 13F-HR Timeline Handelsbanken Fonder AB More: the full row for Handelsbanken Fonder AB 45,281 $3.13M 0.01% +1,700 13F-HR Timeline Hennion & Walsh Asset Management, Inc. More: the full row for Hennion & Walsh Asset Management, Inc. 43,934 $3.03M 0.14% -43,522 13F-HR Timeline PFM Health Sciences, LP More: the full row for PFM Health Sciences, LP 43,774 $3.02M 0.23% -108,454 13F-HR Timeline Edgestream Partners, L.P. More: the full row for Edgestream Partners, L.P. 43,619 $3.01M 0.13% +40,369 13F-HR Timeline Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 43,476 $3M 0.01% +6,755 13F-HR Timeline F/m Investments LLC More: the full row for F/m Investments LLC 42,793 $2.95M 0.11% new 13F-HR Timeline Treasurer of the State of North Carolina More: the full row for Treasurer of the State of North Carolina 41,770 $2.88M 0.01% -730 13F-HR Timeline VOLORIDGE INVESTMENT MANAGEMENT, LLC More: the full row for VOLORIDGE INVESTMENT MANAGEMENT, LLC 39,377 $2.72M 0.01% -699,574 13F-HR Timeline CANADA LIFE ASSURANCE Co in group CANADA LIFE ASSURANCE Co More: the full row for CANADA LIFE ASSURANCE Co 39,379 $2.72M <0.01% +1,568 13F-HR Timeline Group Lighthouse Investment Partners, LLC in group Lighthouse Investment Partner… More: the full row for Lighthouse Investment Partners, LLC 39,000 $2.69M 0.1% -3,000 13F-HR Timeline Group China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 37,934 $2.62M 0.25% +4,882 13F-HR Timeline BANK OF MONTREAL /CAN/ in group BANK OF MONTREAL /CAN/ More: the full row for BANK OF MONTREAL /CAN/ 37,753 $2.61M <0.01% -225,115 13F-HR Timeline Group