13F-HR filed by RA CAPITAL MANAGEMENT, L.P.
RA CAPITAL MANAGEMENT, L.P. filed this 13F-HR for the quarter ended 2024-12-31, filed 2025-02-14, with 89 holding rows worth $7,514,204,405.
- Accession
- 0001104659-25-014181
- Filer
- CIK 1346824
- Filed
- 2025-02-14
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q4 2024
A holdings report, 90 entries on the cover page, a total value of $7,514,204,405 stated on the cover page (in dollars after the unit check, H1), rows summing to $7,514,204,405 with VALUE read as dollars as filed, 13F file number 028-12884. The quarter's positions are built on this report. The resolved quarter.
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| ASCENDIS PHARMA A/S DKK 1.0 AD | 04351P101 | SPONSORED ADR | 10,112,744 | $1,392,221,466 | dollars as filed | |
| VAXCYTE INC COM | 92243G108 | Stock | 8,689,190 | $711,297,093 | dollars as filed | |
| JANUX THERAPEUTICS INC | 47103J105 | COM | 10,365,652 | $554,977,008 | dollars as filed | |
| RHYTHM PHARMACEUTICALS INC | 76243J105 | COM | 6,084,412 | $340,605,384 | dollars as filed | |
| LEGEND BIOTECH CORP | 52490G102 | SPONSORED ADS | 7,506,934 | $244,275,632 | dollars as filed | |
| EDGEWISE THERAPEUTICS INC | 28036F105 | COM | 8,909,091 | $237,872,730 | dollars as filed | |
| NEWAMSTERDAM PHARMA CO NV | N62509109 | COMMON STOCK | 8,845,000 | $227,316,500 | dollars as filed | |
| WAVE LIFE SCIENCES LTD SHS | Y95308105 | Stock | 18,202,009 | $225,158,851 | dollars as filed | |
| ARCELLX INC COMMON STOCK | 03940C100 | Stock | 2,787,327 | $213,760,108 | dollars as filed | |
| AVIDITY BIOSCIENCES INC COM | 05370A108 | Stock | 6,300,408 | $183,215,865 | dollars as filed | |
| SEPTERNA INC COM | 81734D104 | Stock | 6,995,858 | $160,205,148 | dollars as filed | |
| DYNE THERAPEUTICS INC COM | 26818M108 | Stock | 6,381,144 | $150,339,753 | dollars as filed | |
| TYRA BIOSCIENCES INC | 90240B106 | COMMON STOCK | 10,637,290 | $147,858,331 | dollars as filed | |
| RXSIGHT INC | 78349D107 | COM | 3,743,018 | $128,684,959 | dollars as filed | |
| BICARA THERAPEUTICS INC | 055477103 | COM | 6,955,993 | $121,173,398 | dollars as filed | |
| LENZ THERAPEUTICS INC | 52635N103 | COM | 4,178,823 | $120,642,620 | dollars as filed | |
| ARS PHARMACEUTICALS INC | 82835W108 | COM | 10,860,977 | $114,583,307 | dollars as filed | |
| 89BIO INC | 282559103 | COM | 14,175,398 | $110,851,612 | dollars as filed | |
| SPDR SER TR | 78464A870 | S&P BIOTECH | 1,228,240 | $110,615,294 | dollars as filed | |
| GERON CORP | 374163103 | COM | 30,009,536 | $106,233,757 | dollars as filed | |
| ARTIVA BIOTHERAPEUTICS INC | 04317A107 | COM | 9,853,302 | $99,321,284 | dollars as filed | |
| AXSOME THERAPEUTICS INC. COM | 05464T104 | Stock | 1,000,000 | $84,610,000 | dollars as filed | |
| VERONA PHARMA PLC | 925050106 | SPONSORED ADS | 1,766,830 | $82,051,585 | dollars as filed | |
| Day One Biopharmaceuticals Inc | 23954D109 | Common Stock | 5,755,577 | $72,923,161 | dollars as filed | |
| APOGEE THERAPEUTICS INC COM | 03770N101 | Stock | 1,569,491 | $71,097,942 | dollars as filed | |
| MINERALYS THERAPEUTICS INC | 603170101 | COM | 4,850,984 | $59,715,613 | dollars as filed | |
| PRAXIS PRECISION MEDICINES I | 74006W207 | COM NEW | 761,955 | $58,640,057 | dollars as filed | |
| CLIMB BIO INC | 28658R106 | COMMON STOCK | 31,419,267 | $56,554,681 | dollars as filed | |
| RECURSION PHARMACEUTICALS IN | 75629V104 | CL A | 7,725,096 | $52,221,649 | dollars as filed | |
| Tourmaline Bio Inc | 89157D105 | Common Stock | 2,538,925 | $51,489,399 | dollars as filed | |
| ACRIVON THERAPEUTICS INC | 004890109 | CMN | 8,340,508 | $50,209,858 | dollars as filed | |
| FULCRUM THERAPEUTICS INC | 359616109 | COMMON STOCK | 10,229,099 | $48,076,765 | dollars as filed | |
| 10X GENOMICS INC CL A COM | 88025U109 | Stock | 3,279,401 | $47,092,198 | dollars as filed | |
| GH RESEARCH PLC ORDINARY SHARES | G3855L106 | Stock | 6,686,689 | $46,806,823 | dollars as filed | |
| ASTRIA THERAPEUTICS INC COM | 04635X102 | Stock | 5,105,213 | $45,640,604 | dollars as filed | |
| VOR BIOPHARMA INC | 929033108 | COM | 39,646,039 | $44,007,103 | dollars as filed | |
| STRUCTURE THERAPEUTICS INC COMP | 86366E106 | EQUITY | 1,517,418 | $41,152,376 | dollars as filed | |
| DIANTHUS THERAPEUTICS INC | 252828108 | COM | 1,866,400 | $40,687,520 | dollars as filed | |
| PEPGEN INC COM | 713317105 | Stock | 10,689,545 | $40,513,376 | dollars as filed | |
| EVOLENT HEALTH INC CL A | 30050B101 | Stock | 3,577,197 | $40,243,466 | dollars as filed | |
| KURA ONCOLOGY INC COM | 50127T109 | Stock | 4,451,041 | $38,768,567 | dollars as filed | |
| IDEAYA BIOSCIENCES INC COM | 45166A102 | Stock | 1,347,252 | $34,624,376 | dollars as filed | |
| ZAI LAB LTD ADR | 98887Q104 | ADR | 1,295,040 | $33,917,098 | dollars as filed | |
| CHIMERIX INC COM | 16934W106 | Stock | 8,800,000 | $30,624,000 | dollars as filed | |
| CIDARA THERAPEUTICS INC | 171757206 | COM NEW | 1,092,796 | $29,374,356 | dollars as filed | |
| MBX BIOSCIENCES INC COM | 55287L101 | Stock | 1,511,334 | $27,853,886 | dollars as filed | |
| NKARTA INC | 65487U108 | COMMON STOCK | 10,805,129 | $26,904,771 | dollars as filed | |
| ACUMEN PHARMACEUTICALS INC | 00509G209 | CMN | 14,932,063 | $25,683,148 | dollars as filed | |
| 4D MOLECULAR THERAPEUTICS INC COM | 35104E100 | Stock | 4,563,211 | $25,417,085 | dollars as filed | |
| NURIX THERAPEUTICS INC | 67080M103 | COMMON STOCK | 1,333,333 | $25,119,994 | dollars as filed | |
| SERA PROGNOSTICS INC | 81749D107 | CMN | 3,032,808 | $24,687,057 | dollars as filed | |
| AEROVATE THERAPEUTICS INC | 008064107 | COM | 9,192,092 | $24,359,044 | dollars as filed | |
| EYEPOINT INC COM NEW | 30233G209 | Stock | 3,181,818 | $23,704,544 | dollars as filed | |
| LARIMAR THERAPEUTICS INC | 517125100 | COM | 6,045,351 | $23,395,508 | dollars as filed | |
| CERIBELL INC | 15678C102 | COMMON STOCK | 824,582 | $21,340,182 | dollars as filed | |
| TRAVERE THERAPEUTICS INC | 89422G107 | COM | 1,150,000 | $20,033,000 | dollars as filed | |
| ENLIVEN THERAPEUTICS INC COM | 29337E102 | Stock | 848,986 | $19,102,185 | dollars as filed | |
| TAYSHA GENE THERAPIES INC | 877619106 | COMMON STOCK | 10,872,503 | $18,809,430 | dollars as filed | |
| ALECTOR INC | 014442107 | COMMON STOCK | 9,695,228 | $18,323,981 | dollars as filed | |
| PROTARA THERAPEUTICS INC | 74365U107 | COM STK | 3,400,000 | $17,952,000 | dollars as filed | |
| C4 THERAPEUTICS INC | 12529R107 | COM STK | 4,878,000 | $17,560,800 | dollars as filed | |
| SOLID BIOSCIENCES INC | 83422E204 | COMMON STOCK | 4,330,446 | $17,321,784 | dollars as filed | |
| PLIANT THERAPEUTICS INC | 729139105 | COM | 1,281,000 | $16,870,770 | dollars as filed | |
| BRIGHT MINDS BIOSCIENCES INC | 10919W405 | COMMON STOCK | 460,829 | $16,599,061 | dollars as filed | |
| ITEOS THERAPEUTICS INC | 46565G104 | COM | 2,092,259 | $16,068,549 | dollars as filed | |
| BICYCLE THERAPEUTICS PLC-ADR | 088786108 | SPONSORED ADS | 1,093,477 | $15,308,678 | dollars as filed | |
| ELEDON PHARMACEUTICALS INC | 28617k101 | COM | 3,566,338 | $14,693,313 | dollars as filed | |
| INSMED INC COM PAR $.01 | 457669307 | Stock | 200,000 | $13,808,000 | dollars as filed | |
| XENCOR INC | 98401F105 | COMMON STOCK | 575,000 | $13,213,500 | dollars as filed | |
| IMMATICS N.V | N44445109 | SHS | 1,750,000 | $12,442,500 | dollars as filed | |
| ACLARIS THERAPEUTICS INC COM | 00461U105 | Stock | 4,666,667 | $11,573,334 | dollars as filed | |
| MONOPAR THERAPEUTICS INC | 61023L207 | COMMON STOCK | 511,207 | $11,246,554 | dollars as filed | |
| THIRD HARMONIC BIO INC | 88427A107 | COM | 960,620 | $9,884,780 | dollars as filed | |
| WEREWOLF THERAPEUTICS INC | 95075A107 | CMN | 6,144,881 | $9,094,424 | dollars as filed | |
| ARVINAS INC | 04335A105 | COM | 421,348 | $8,077,241 | dollars as filed | |
| ZURA BIO LTD | G9TY5A101 | COMMON STOCK | 3,217,503 | $8,043,758 | dollars as filed | |
| PERCEPTIVE CAPITAL SOLUTIONS | G70077105 | CL A ORD SHS | 750,000 | $7,635,000 | dollars as filed | |
| BIOAGE LABS INC COM | 09077V100 | Stock | 1,310,589 | $7,588,310 | dollars as filed | |
| ADICET BIO INC | 007002108 | COM | 7,541,000 | $7,254,442 | dollars as filed | |
| AVALO THERAPEUTICS INC | 05338F306 | COMMON STOCK | 967,000 | $7,184,810 | dollars as filed | |
| BOUNDLESS BIO INC | 10170A100 | COM | 2,180,631 | $6,323,830 | dollars as filed | |
| ENANTA PHARMACEUTICALS INC | 29251M106 | COM | 1,038,000 | $5,968,500 | dollars as filed | |
| NEWAMSTERDAM PHARMA CO NV-27 | N62509117 | WTS | 333,333 | $4,749,995 | dollars as filed | |
| SURROZEN INC | 86889P208 | COMMON STOCK | 282,580 | $4,055,023 | dollars as filed | |
| LEXEO THERAPEUTICS INC | 52886X107 | COMMON STOCK | 546,554 | $3,596,325 | dollars as filed | |
| ALLAKOS INC | 01671P100 | COM | 1,129,931 | $1,367,217 | dollars as filed | |
| SCHOLAR ROCK HLDG CORP | 80706P103 | COM | 17,616 | $761,364 | dollars as filed | |
| REGULUS THERAPEUTICS INC | 75915K309 | COM | 336,843 | $532,212 | dollars as filed | |
| SCILEX HOLDING CO | 80880W106 | COM | 1,036,218 | $441,843 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001104659-25-014181 | this filing | 2025-02-14 | acceptance time not in the bulk data set |