13F-HR filed by ORBIMED ADVISORS LLC
ORBIMED ADVISORS LLC filed this 13F-HR for the quarter ended 2024-12-31, filed 2025-02-14, with 118 holding rows worth $4,861,409,522.
- Accession
- 0001172661-25-001136
- Filer
- CIK 1055951
- Filed
- 2025-02-14
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q4 2024
A holdings report, 119 entries on the cover page, a total value of $4,861,409,522 stated on the cover page (in dollars after the unit check, H1), rows summing to $4,861,409,522 with VALUE read as dollars as filed, 13F file number 028-06774. The quarter's positions are built on this report. The resolved quarter.
Other managers
- included managerORBIMED CAPITAL LLC028-10410
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| EDGEWISE THERAPEUTICS INC | 28036F105 | COM | 15,021,721 | $401,079,951 | dollars as filed | |
| SINOVAC BIOTECH LTD | P8696W104 | SHS | 2,718,735 | $333,996,595 | dollars as filed | |
| Boston Scientific Corporation | 101137107 | COM | 3,160,300 | $282,277,996 | dollars as filed | |
| Eli Lilly and Company | 532457108 | COM | 337,600 | $260,627,200 | dollars as filed | |
| Intuitive Surgical,Inc. | 46120E602 | COM | 401,700 | $209,671,332 | dollars as filed | |
| ENLIVEN THERAPEUTICS INC COM | 29337E102 | Stock | 7,959,538 | $179,089,605 | dollars as filed | |
| NEUROCRINE BIOSCIENCES INC | 64125C109 | COM | 938,120 | $128,053,380 | dollars as filed | |
| Stryker Corporation | 863667101 | COM | 344,400 | $124,001,220 | dollars as filed | |
| SAREPTA THERAPEUTICS INC | 803607100 | COM | 963,400 | $117,139,806 | dollars as filed | |
| ARGENX SE SPONSORED ADR | 04016X101 | ADR | 189,700 | $116,665,500 | dollars as filed | |
| DISC MEDICINE INC COM | 254604101 | Stock | 1,785,571 | $113,205,201 | dollars as filed | |
| TENET HEALTHCARE CORP COM NEW | 88033G407 | Stock | 792,000 | $99,974,160 | dollars as filed | |
| IONIS PHARMACEUTICALS INC COM | 462222100 | Stock | 2,817,347 | $98,494,451 | dollars as filed | |
| ALNYLAM PHARMACEUTICALS INC COM | 02043Q107 | Stock | 415,600 | $97,794,836 | dollars as filed | |
| UPSTREAM BIO INC | 91678A107 | COMMON STOCK | 5,693,589 | $93,602,603 | dollars as filed | |
| ARS PHARMACEUTICALS INC | 82835W108 | COM | 8,288,510 | $87,443,781 | dollars as filed | |
| EDWARDS LIFESCIENCES CORP COM | 28176E108 | Stock | 1,145,302 | $84,786,707 | dollars as filed | |
| Merck & Co.,Inc. | 58933Y105 | COM | 829,900 | $82,558,452 | dollars as filed | |
| ARRIVENT BIOPHARMA INC | 04272N102 | COM | 3,027,328 | $80,648,018 | dollars as filed | |
| BIOGEN INC COM | 09062X103 | Stock | 509,100 | $77,851,572 | dollars as filed | |
| INTEGER HLDGS CORP | 45826H109 | COM | 575,000 | $76,199,000 | dollars as filed | |
| CYTOKINETICS INC | 23282W605 | COM NEW | 1,584,005 | $74,511,595 | dollars as filed | |
| MBX BIOSCIENCES INC COM | 55287L101 | Stock | 3,812,215 | $70,259,122 | dollars as filed | |
| UnitedHealth Group Inc | 91324P102 | COM | 130,900 | $66,217,074 | dollars as filed | |
| NATERA INC COM | 632307104 | Stock | 413,000 | $65,377,900 | dollars as filed | |
| Vertex Pharmaceuticals Incorporated | 92532F100 | COM | 151,000 | $60,807,700 | dollars as filed | |
| THIRD HARMONIC BIO INC | 88427A107 | COM | 5,779,071 | $59,466,641 | dollars as filed | |
| CRINETICS PHARMACEUTICALS INC COM | 22663K107 | Stock | 999,000 | $51,078,870 | dollars as filed | |
| UNIVERSAL HLTH SVCS INC CL B | 913903100 | Stock | 269,300 | $48,317,806 | dollars as filed | |
| SI BONE INC | 825704109 | COM | 3,442,853 | $48,268,799 | dollars as filed | |
| SPRINGWORKS THERAPEUTICS INC | 85205L107 | COM | 1,255,031 | $45,344,270 | dollars as filed | |
| Thermo Fisher Scientific Inc. | 883556102 | COM | 84,400 | $43,907,412 | dollars as filed | |
| TERNS PHARMACEUTICALS INC COM | 880881107 | Stock | 7,562,971 | $41,898,859 | dollars as filed | |
| CG ONCOLOGY INC | 156944100 | COMMON STOCK | 1,431,114 | $41,044,350 | dollars as filed | |
| JANUX THERAPEUTICS INC | 47103J105 | COM | 758,566 | $40,613,624 | dollars as filed | |
| EXACT SCIENCES CORP COM | 30063P105 | Stock | 679,816 | $38,198,861 | dollars as filed | |
| NEUROPACE INC | 641288105 | COMMON STOCK | 3,406,335 | $38,116,889 | dollars as filed | |
| XENON PHARMACEUTICALS INC COM | 98420N105 | Stock | 947,877 | $37,156,778 | dollars as filed | |
| CORVUS PHARMACEUTICALS INC | 221015100 | COM | 6,943,654 | $37,148,549 | dollars as filed | |
| SPDR SER TR | 78464A870 | S&P BIOTECH | 372,000 | $33,502,320 | dollars as filed | |
| COMPASS THERAPEUTICS INC | 20454B104 | COM | 22,362,850 | $32,426,133 | dollars as filed | |
| XTANT MED HLDGS INC | 98420P308 | COM NEW | 73,114,592 | $32,389,764 | dollars as filed | |
| AVIDITY BIOSCIENCES INC COM | 05370A108 | Stock | 1,112,886 | $32,362,725 | dollars as filed | |
| VERA THERAPEUTICS INC | 92337R101 | COMMON STOCK | 742,572 | $31,403,370 | dollars as filed | |
| DYNE THERAPEUTICS INC COM | 26818M108 | Stock | 1,227,080 | $28,910,005 | dollars as filed | |
| CULLINAN THERAPEUTICS INC | 230031106 | COM | 1,942,555 | $23,660,320 | dollars as filed | |
| VIR BIOTECHNOLOGY INC | 92764N102 | COM | 3,218,617 | $23,624,649 | dollars as filed | |
| Gilead Sciences,Inc. | 375558103 | COM | 245,600 | $22,686,072 | dollars as filed | |
| RHYTHM PHARMACEUTICALS INC | 76243J105 | COM | 400,000 | $22,392,000 | dollars as filed | |
| IMMATICS N.V | N44445109 | SHS | 3,087,462 | $21,951,855 | dollars as filed | |
| AMICUS THERAPEUTICS INC | 03152W109 | COM | 2,285,400 | $21,528,468 | dollars as filed | |
| SCPHARMACEUTICALS INC | 810648105 | COM | 6,059,528 | $21,450,729 | dollars as filed | |
| RAPT THERAPEUTICS INC | 75382E109 | COM | 13,135,260 | $20,753,711 | dollars as filed | |
| TYRA BIOSCIENCES INC | 90240B106 | COMMON STOCK | 1,470,086 | $20,434,195 | dollars as filed | |
| MINERALYS THERAPEUTICS INC | 603170101 | COM | 1,611,637 | $19,839,251 | dollars as filed | |
| Gilead Sciences,Inc. | 375558103 | COM | 200,000 | $18,474,000 | dollars as filed | call |
| 0 | 000000000 | 0 | 12,048,773 | $17,686,720 | dollars as filed | |
| STRUCTURE THERAPEUTICS INC COMP | 86366E106 | EQUITY | 652,028 | $17,682,999 | dollars as filed | |
| KEROS THERAPEUTICS INC COM | 492327101 | Stock | 1,018,734 | $16,126,559 | dollars as filed | |
| C4 THERAPEUTICS INC | 12529R107 | COM STK | 4,377,900 | $15,760,440 | dollars as filed | |
| MEDPACE HLDGS INC COM | 58506Q109 | Stock | 44,900 | $14,917,127 | dollars as filed | |
| VERASTEM INC | 92337C203 | COMMON STOCK | 2,862,448 | $14,798,856 | dollars as filed | |
| PRELUDE THERAPEUTICS INC | 74065P101 | CMN | 10,909,256 | $13,909,301 | dollars as filed | |
| CORBUS PHARMACEUTICALS | 21833P301 | COM NEW | 1,172,287 | $13,832,987 | dollars as filed | |
| FORTE BIOSCIENCES INC | 34962G208 | COMMON STOCK | 600,000 | $13,626,000 | dollars as filed | |
| INTRA-CELLULAR THERAPIES INC | 46116X101 | COMMON STOCK | 163,000 | $13,613,760 | dollars as filed | |
| ACELYRIN INC | 00445A100 | COM | 4,001,711 | $12,565,373 | dollars as filed | |
| ABCELLERA BIOLOGICS INC COM | 00288U106 | Stock | 4,180,768 | $12,249,650 | dollars as filed | |
| ADC THERAPEUTICS SA | H0036K147 | COMMON STOCK | 5,968,451 | $11,877,217 | dollars as filed | |
| ADICET BIO INC | 007002108 | COM | 11,447,140 | $11,012,149 | dollars as filed | |
| PMV PHARMACEUTICALS INC | 69353Y103 | COM | 6,475,291 | $9,777,689 | dollars as filed | |
| UNIVERSAL HLTH SVCS INC CL B | 913903100 | Stock | 50,000 | $8,971,000 | dollars as filed | call |
| NEUMORA THERAPEUTICS INC. | 640979100 | COM | 804,996 | $8,532,958 | dollars as filed | |
| Q32 BIO INC | 746964105 | Common Stock | 2,252,987 | $7,750,275 | dollars as filed | |
| GERON CORP | 374163103 | COM | 2,168,000 | $7,674,720 | dollars as filed | |
| AVALO THERAPEUTICS INC | 05338F306 | COMMON STOCK | 967,000 | $7,184,810 | dollars as filed | |
| CARDIFF ONCOLOGY INC | 14147L108 | COM | 1,538,462 | $6,676,925 | dollars as filed | |
| Pfizer Inc. | 717081103 | COM | 250,000 | $6,632,500 | dollars as filed | call |
| SCHOLAR ROCK HLDG CORP | 80706P103 | COM | 151,800 | $6,560,796 | dollars as filed | |
| INSMED INC COM PAR $.01 | 457669307 | Stock | 94,559 | $6,528,353 | dollars as filed | |
| ENGENE HOLDINGS INC | 29286M105 | COM | 920,339 | $6,120,254 | dollars as filed | |
| IKENA ONCOLOGY INC | 45175G108 | COM | 3,539,358 | $5,804,547 | dollars as filed | |
| INSPIREMD INC | 45779A846 | COM | 2,133,405 | $5,610,855 | dollars as filed | |
| TRAWS PHARMA INC | 68232V884 | COM NEW | 605,531 | $5,377,115 | dollars as filed | |
| BIOAGE LABS INC COM | 09077V100 | Stock | 921,959 | $5,338,143 | dollars as filed | |
| X4 Pharmaceuticals, Inc. | 98420X103 | COM | 7,133,515 | $5,233,147 | dollars as filed | |
| BICARA THERAPEUTICS INC | 055477103 | COM | 298,301 | $5,196,403 | dollars as filed | |
| Milestone Pharmaceuticals Inc | 59935V107 | COM | 2,000,000 | $4,720,000 | dollars as filed | |
| REPARE THERAPEUTICS INC | 760273102 | COM | 3,322,488 | $4,352,459 | dollars as filed | |
| PASSAGE BIO INC | 702712100 | COM | 7,404,869 | $4,199,301 | dollars as filed | |
| STRUCTURE THERAPEUTICS INC COMP | 86366E106 | EQUITY | 150,000 | $4,068,000 | dollars as filed | call |
| KRYSTAL BIOTECH INC COM | 501147102 | Stock | 23,500 | $3,681,510 | dollars as filed | |
| ARDENT HEALTH INC | 03980N107 | COM | 206,000 | $3,518,480 | dollars as filed | |
| SI BONE INC | 825704109 | COM | 250,000 | $3,505,000 | dollars as filed | call |
| TENET HEALTHCARE CORP COM NEW | 88033G407 | Stock | 25,000 | $3,155,750 | dollars as filed | call |
| CHEMOMAB THERAPEUTICS LTD | 16385C104 | SPONSORED ADS | 1,741,273 | $3,151,704 | dollars as filed | |
| CERIBELL INC | 15678C102 | COMMON STOCK | 112,500 | $2,911,500 | dollars as filed | |
| FATE THERAPEUTICS INC | 31189P102 | COM | 1,680,580 | $2,772,957 | dollars as filed | |
| PEPGEN INC COM | 713317105 | Stock | 653,016 | $2,474,931 | dollars as filed | |
| Instil Bio Inc | 45783C200 | COM NEW | 116,785 | $2,229,426 | dollars as filed | |
| NKARTA INC | 65487U108 | COMMON STOCK | 821,400 | $2,045,286 | dollars as filed | |
| LYELL IMMUNOPHARMA INC | 55083R104 | COM | 3,103,623 | $1,986,319 | dollars as filed | |
| IMMUNOVANT INC | 45258J102 | COM | 78,500 | $1,944,445 | dollars as filed | |
| AKERO THERAPEUTICS INC | 00973Y108 | COM | 66,000 | $1,836,120 | dollars as filed | |
| TANGO THERAPEUTICS INC | 87583X109 | COM | 550,000 | $1,699,500 | dollars as filed | |
| TURNSTONE BIOLOGICS CORP | 90042W100 | COM | 3,099,265 | $1,540,025 | dollars as filed | |
| AMYLYX PHARMACEUTICALS INC | 03237H101 | COM | 348,000 | $1,315,440 | dollars as filed | |
| BIOMX INC | 09090D301 | COM | 1,787,767 | $1,305,249 | dollars as filed | |
| KEZAR LIFE SCIENCES INC | 49372L209 | COM NEW | 192,700 | $1,294,944 | dollars as filed | |
| KORRO BIO INC | 500946108 | COMMON STOCK | 32,400 | $1,233,468 | dollars as filed | |
| ALTO NEUROSCIENCE INC COM SHS | 02157Q109 | Stock | 250,000 | $1,057,500 | dollars as filed | |
| NEXTCURE INC | 65343E108 | COM | 1,141,200 | $879,865 | dollars as filed | |
| AGIOS PHARMACEUTICALS INC | 00847X104 | COM | 26,700 | $877,362 | dollars as filed | |
| C4 THERAPEUTICS INC | 12529R107 | COM STK | 150,000 | $540,000 | dollars as filed | call |
| ELEVATION ONCOLOGY INC COM | 28623U101 | Stock | 941,275 | $529,561 | dollars as filed | |
| INVIVYD INC | 00534A102 | COMMON STOCK | 1,149,300 | $509,255 | dollars as filed | |
| LAKESHORE BIOPHARMA CO LTD | G9845F208 | COM | 140,428 | $485,881 | dollars as filed | |
| XERIS BIOPHARMA HOLDINGS INC | 98422E103 | COM | 80,420 | $272,624 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001172661-25-001136 | this filing | 2025-02-14 | acceptance time not in the bulk data set |