13F-HR filed by RTW INVESTMENTS, LP
RTW INVESTMENTS, LP filed this 13F-HR for the quarter ended 2024-12-31, filed 2025-02-14, with 72 holding rows worth $6,612,776,360.
- Accession
- 0001493152-25-006608
- Filer
- CIK 1493215
- Filed
- 2025-02-14
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q4 2024
A holdings report, 72 entries on the cover page, a total value of $6,612,776,360 stated on the cover page (in dollars after the unit check, H1), rows summing to $6,612,776,360 with VALUE read as dollars as filed, 13F file number 028-16670. The quarter's positions are built on this report. The resolved quarter.
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| MADRIGAL PHARMACEUTICALS INC COM | 558868105 | Stock | 1,993,687 | $615,191,998 | dollars as filed | |
| ARGENX SE SPONSORED ADR | 04016X101 | ADR | 673,497 | $414,200,655 | dollars as filed | |
| NATERA INC COM | 632307104 | Stock | 2,593,323 | $410,523,031 | dollars as filed | |
| AXSOME THERAPEUTICS INC. COM | 05464T104 | Stock | 4,051,365 | $342,785,993 | dollars as filed | |
| PTC THERAPEUTICS INC | 69366J200 | COM | 7,393,127 | $333,725,753 | dollars as filed | |
| AVIDITY BIOSCIENCES INC COM | 05370A108 | Stock | 7,932,870 | $230,687,860 | dollars as filed | |
| ROCKET PHARMACEUTICALS INC | 77313F106 | COM | 17,687,772 | $222,335,294 | dollars as filed | |
| ALKERMES PLC | G01767105 | SHS | 7,557,835 | $217,363,335 | dollars as filed | |
| Stryker Corporation | 863667101 | COM | 590,221 | $212,509,071 | dollars as filed | |
| PROTAGONIST THERAPEUTICS | 74366E102 | COM | 5,498,545 | $212,243,837 | dollars as filed | |
| INSMED INC COM PAR $.01 | 457669307 | Stock | 3,014,558 | $208,125,084 | dollars as filed | |
| PENUMBRA INC COM | 70975L107 | Stock | 862,450 | $204,814,626 | dollars as filed | |
| AKERO THERAPEUTICS INC | 00973Y108 | COM | 6,859,823 | $190,840,276 | dollars as filed | |
| TARSUS PHARMACEUTICALS INC | 87650L103 | COMMON STOCK | 3,236,549 | $179,207,718 | dollars as filed | |
| MERUS N V | N5749R100 | COM | 4,169,393 | $175,322,976 | dollars as filed | |
| ACADIA PHARMACEUTICALS INC | 004225108 | COM | 8,705,501 | $159,745,943 | dollars as filed | |
| BRUKER CORP | 116794108 | COM | 2,481,119 | $145,443,196 | dollars as filed | |
| IMMUNOCORE HLDGS PLC ADS | 45258D105 | ADR | 4,869,798 | $143,659,041 | dollars as filed | |
| RADNET INC | 750491102 | COM | 1,978,582 | $138,184,167 | dollars as filed | |
| CYTOKINETICS INC | 23282W605 | COM NEW | 2,721,158 | $128,003,272 | dollars as filed | |
| DYNE THERAPEUTICS INC COM | 26818M108 | Stock | 5,218,641 | $122,951,182 | dollars as filed | |
| APOGEE THERAPEUTICS INC COM | 03770N101 | Stock | 2,712,097 | $122,857,994 | dollars as filed | |
| ESTABLISHMENT LABS HOLDINGS | G31249108 | COMMON STOCK | 2,569,687 | $118,385,480 | dollars as filed | |
| MASIMO CORP COM | 574795100 | Stock | 683,294 | $112,948,498 | dollars as filed | |
| VERONA PHARMA PLC | 925050106 | SPONSORED ADS | 1,821,019 | $84,568,122 | dollars as filed | |
| SPYRE THERAPEUTICS INC | 00773J202 | COM NEW | 3,621,996 | $84,320,067 | dollars as filed | |
| ULTRAGENYX PHARMACEUTICAL IN | 90400D108 | COM | 1,968,002 | $82,793,844 | dollars as filed | |
| GLOBUS MED INC CL A | 379577208 | Stock | 972,000 | $80,394,120 | dollars as filed | |
| ZAI LAB LTD ADR | 98887Q104 | ADR | 2,509,119 | $65,713,827 | dollars as filed | |
| ARVINAS INC | 04335A105 | COM | 3,334,308 | $63,918,684 | dollars as filed | |
| CARGO THERAPEUTICS INC COM | 14179K101 | Stock | 4,124,859 | $59,480,467 | dollars as filed | |
| 89BIO INC | 282559103 | COM | 7,478,061 | $58,478,437 | dollars as filed | |
| STOKE THERAPEUTICS INC | 86150R107 | COM | 5,123,525 | $56,512,481 | dollars as filed | |
| XENCOR INC | 98401F105 | COMMON STOCK | 2,402,883 | $55,218,251 | dollars as filed | |
| CG ONCOLOGY INC | 156944100 | COMMON STOCK | 1,701,216 | $48,790,875 | dollars as filed | |
| IMMATICS N.V | N44445109 | SHS | 6,540,540 | $46,503,239 | dollars as filed | |
| UROGEN PHARMA LTD | M96088105 | COMMON STOCK | 3,834,794 | $40,840,556 | dollars as filed | |
| ORUKA THERAPEUTICS INC COM | 687604108 | Stock | 1,945,649 | $37,726,134 | dollars as filed | |
| ORCHESTRA BIOMED HOLDINGS IN | 68572M106 | COMMON STOCK | 8,206,162 | $32,824,648 | dollars as filed | |
| NEUROGENE INC | 64135M105 | COMMON STOCK | 1,350,256 | $30,866,852 | dollars as filed | |
| REPLIMUNE GROUP INC | 76029N106 | COMMON STOCK | 2,065,010 | $25,007,271 | dollars as filed | |
| LENZ THERAPEUTICS INC | 52635N103 | COM | 863,389 | $24,926,040 | dollars as filed | |
| GH RESEARCH PLC ORDINARY SHARES | G3855L106 | Stock | 3,327,129 | $23,289,903 | dollars as filed | |
| CULLINAN THERAPEUTICS INC | 230031106 | COM | 1,705,960 | $20,778,593 | dollars as filed | |
| RAPT THERAPEUTICS INC | 75382E109 | COM | 11,764,000 | $18,587,120 | dollars as filed | |
| ROIVANT SCIENCES LTD | G76279101 | SHS | 1,454,273 | $17,204,050 | dollars as filed | |
| SAGE THERAPEUTICS INC | 78667J108 | COM | 3,002,370 | $16,302,869 | dollars as filed | |
| UNIQURE NV | N90064101 | SHS | 903,625 | $15,958,018 | dollars as filed | |
| TAYSHA GENE THERAPIES INC | 877619106 | COMMON STOCK | 8,672,630 | $15,003,650 | dollars as filed | |
| Tourmaline Bio Inc | 89157D105 | Common Stock | 736,681 | $14,939,891 | dollars as filed | |
| DIANTHUS THERAPEUTICS INC | 252828108 | COM | 666,667 | $14,533,341 | dollars as filed | |
| CORVUS PHARMACEUTICALS INC | 221015100 | COM | 2,679,479 | $14,335,213 | dollars as filed | |
| IMMUNOVANT INC | 45258J102 | COM | 530,614 | $13,143,309 | dollars as filed | |
| PEPGEN INC COM | 713317105 | Stock | 3,193,097 | $12,101,838 | dollars as filed | |
| COMPASS PATHWAYS PLC | 20451W101 | SPONSORED ADS | 3,098,987 | $11,714,171 | dollars as filed | |
| WAVE LIFE SCIENCES LTD SHS | Y95308105 | Stock | 900,000 | $11,133,000 | dollars as filed | |
| PERCEPTIVE CAPITAL SOLUTIONS | G70077105 | CL A ORD SHS | 742,500 | $7,558,650 | dollars as filed | |
| EXAGEN INC | 30068X103 | COM | 1,511,866 | $6,198,651 | dollars as filed | |
| Milestone Pharmaceuticals Inc | 59935V107 | COM | 2,506,102 | $5,914,401 | dollars as filed | |
| IDEAYA BIOSCIENCES INC COM | 45166A102 | Stock | 200,000 | $5,140,000 | dollars as filed | |
| IMMUNIC INC | 4525EP101 | COM | 4,567,717 | $4,567,717 | dollars as filed | |
| BIOAGE LABS INC COM | 09077V100 | Stock | 786,353 | $4,552,984 | dollars as filed | |
| CERIBELL INC | 15678C102 | COMMON STOCK | 150,000 | $3,882,000 | dollars as filed | |
| STRUCTURE THERAPEUTICS INC COMP | 86366E106 | EQUITY | 125,000 | $3,390,000 | dollars as filed | |
| ACELYRIN INC | 00445A100 | COM | 978,310 | $3,071,893 | dollars as filed | |
| REGENXBIO INC | 75901B107 | COM | 350,000 | $2,705,500 | dollars as filed | |
| ESSA PHARMA INC | 29668H708 | COM NEW | 1,113,002 | $1,992,274 | dollars as filed | |
| ARTIVA BIOTHERAPEUTICS INC | 04317A107 | COM | 148,844 | $1,500,348 | dollars as filed | |
| NULL | 02008G102 | NULL | 2,947,551 | $1,267,447 | dollars as filed | |
| CENTESSA PHARMACEUTICALS PLC | 152309100 | SPONSORED ADS | 50,000 | $837,500 | dollars as filed | |
| Adagio Med Hldgs Inc Com | 00534B100 | Common Stock | 209,361 | $219,829 | dollars as filed | |
| Rocket Pharmaceuticals Inc W Exp 09/02/202 | 77313F114 | Warrant | 350,000 | $12,005 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001493152-25-006608 | this filing | 2025-02-14 | acceptance time not in the bulk data set |