Caligan Partners LP More: the full row for Caligan Partners LP 8,163,191 $30.9M 1.49% +3,188,285 13F-HR Timeline SAMSARA BIOCAPITAL, LLC More: the full row for SAMSARA BIOCAPITAL, LLC 6,314,805 $23.9M 1.96% +1,120,000 13F-HR Timeline Paradigm Biocapital Advisors LP in group Paradigm Biocapital Advisors … More: the full row for Paradigm Biocapital Advisors LP 4,000,000 $15.1M 0.28% 0 13F-HR Timeline Group ANDERA PARTNERS More: the full row for ANDERA PARTNERS 3,633,181 $13.7M 6.65% +1,815,000 13F-HR Timeline ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 3,606,656 $13.6M 0.64% +1,432,258 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 3,512,174 $13.3M 0.01% +524,561 13F-HR Timeline Group Nantahala Capital Management, LLC More: the full row for Nantahala Capital Management, LLC 2,686,393 $10.2M 0.61% new 13F-HR/A Timeline Trails Edge Capital Partners, LP More: the full row for Trails Edge Capital Partners, LP 2,657,997 $10M 1.6% 0 13F-HR Timeline FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 2,642,611 $9.99M <0.01% +181,046 13F-HR Timeline Group Squadron Capital Management LLC More: the full row for Squadron Capital Management LLC 2,435,000 $9.2M 3.15% +1,900,000 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 2,323,149 $8.78M 0.03% new 13F-HR Timeline Aberdeen Group plc in group Aberdeen Group plc More: the full row for Aberdeen Group plc 2,307,773 $8.72M 0.01% new 13F-HR Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 2,305,192 $8.71M <0.01% -13,501 13F-HR Timeline Group BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 2,003,782 $7.57M 0.14% +533,375 13F-HR Timeline Patient Square Capital LP More: the full row for Patient Square Capital LP 1,967,171 $7.44M 1.15% new 13F-HR Timeline NEXTBio Capital Management LP More: the full row for NEXTBio Capital Management LP 1,787,984 $6.76M 3.11% +454,500 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 1,784,566 $6.75M <0.01% +1,719,616 13F-HR Timeline Group AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 1,697,148 $6.42M <0.01% +852,933 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 1,683,012 $6.36M 0.01% +726,791 13F-HR Timeline Group Integral Health Asset Management, LLC More: the full row for Integral Health Asset Management, LLC 1,520,000 $5.75M 0.24% +1,120,000 13F-HR Timeline Yu Fan More: the full row for Yu Fan 1,500,000 $5.67M 5.25% 0 13F-HR Timeline NEA Management Company, LLC More: the full row for NEA Management Company, LLC 1,462,586 $5.53M 0.35% 0 13F-HR Timeline STEMPOINT CAPITAL LP More: the full row for STEMPOINT CAPITAL LP 1,426,320 $5.39M 0.93% new 13F-HR Timeline Propel Bio Management, LLC More: the full row for Propel Bio Management, LLC 1,281,212 $4.84M 2.53% +556,534 13F-HR Timeline KINGDON CAPITAL MANAGEMENT, L.L.C. More: the full row for KINGDON CAPITAL MANAGEMENT, L.L.C. 1,270,000 $4.8M 0.65% new 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 1,309,100 $4.65M <0.01% new 13F-HR Timeline Group ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 1,120,000 $4.23M 0.01% new 13F-HR Timeline Group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 1,129,101 $4.15M 0.68% -300,000 13F-HR Timeline Polar Capital Holdings Plc in group Polar Capital Holdings Plc More: the full row for Polar Capital Holdings Plc 1,074,214 $4.06M 0.01% -1,057,924 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 965,907 $3.65M <0.01% +311,696 13F-HR Timeline Group SYQUANT CAPITAL SAS More: the full row for SYQUANT CAPITAL SAS 913,135 $3.45M 0.77% new 13F-HR Timeline Alyeska Investment Group, L.P. in group Alyeska Investment Group, L.P. More: the full row for Alyeska Investment Group, L.P. 909,000 $3.44M 0.01% new 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 901,640 $3.41M <0.01% +288,283 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 901,369 $3.41M <0.01% +831,935 13F-HR Timeline Group HighVista Strategies LLC More: the full row for HighVista Strategies LLC 831,442 $3.14M 0.72% +215,776 13F-HR Timeline Deep Track Capital, LP More: the full row for Deep Track Capital, LP 800,000 $3.02M 0.04% -422,453 13F-HR Timeline TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 728,111 $2.75M <0.01% +501,705 13F-HR Timeline Group DIADEMA PARTNERS LP More: the full row for DIADEMA PARTNERS LP 740,786 $2.73M 0.96% +388,387 13F-HR Timeline BVF INC/IL in group BVF INC/IL More: the full row for BVF INC/IL 686,040 $2.59M 0.07% 0 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 685,400 $2.59M <0.01% new 13F-HR Timeline Group Ally Bridge Group (NY) LLC More: the full row for Ally Bridge Group (NY) LLC 634,800 $2.4M 3.09% -110,500 13F-HR Timeline Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 397,558 $1.5M <0.01% new 13F-HR Timeline J. Goldman & Co LP More: the full row for J. Goldman & Co LP 337,500 $1.28M 0.04% +233,982 13F-HR Timeline Simplify Asset Management Inc. More: the full row for Simplify Asset Management Inc. 313,483 $1.18M 0.02% +85,560 13F-HR Timeline Artisan Partners Limited Partnership More: the full row for Artisan Partners Limited Partnership 263,538 $996K <0.01% -59,468 13F-HR Timeline Ghisallo Capital Management LLC More: the full row for Ghisallo Capital Management LLC 250,000 $945K 0.02% new 13F-HR Timeline Burkehill Global Management, LP More: the full row for Burkehill Global Management, LP 225,000 $850K 0.03% new 13F-HR Timeline SEVEN GRAND MANAGERS, LLC More: the full row for SEVEN GRAND MANAGERS, LLC 225,000 $850K 0.03% new 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 224,499 $849K <0.01% +39,592 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 214,282 $810K 0.01% +148,161 13F-HR Timeline Group Persistent Asset Partners Ltd More: the full row for Persistent Asset Partners Ltd 209,182 $791K 0.25% +81,083 13F-HR Timeline Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 207,182 $783K 0.01% +122,859 13F-HR Timeline Group Seven Fleet Capital Management LP More: the full row for Seven Fleet Capital Management LP 200,141 $757K 0.12% 0 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 151,917 $574K <0.01% new 13F-HR Timeline Group Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 144,181 $545K <0.01% new 13F-HR Timeline Group Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 135,648 $513K <0.01% new 13F-HR Timeline Group HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 123,953 $468K <0.01% +105,099 13F-HR Timeline Hudson Bay Capital Management LP in group Hudson Bay Capital Management… More: the full row for Hudson Bay Capital Management LP 115,000 $435K <0.01% -30,459 13F-HR Timeline Group Rathbones Group PLC More: the full row for Rathbones Group PLC 100,000 $378K <0.01% new 13F-HR Timeline COMMONWEALTH EQUITY SERVICES, LLC More: the full row for COMMONWEALTH EQUITY SERVICES, LLC 83,996 $318K <0.01% +6,435 13F-HR Timeline Engineers Gate Manager LP More: the full row for Engineers Gate Manager LP 71,116 $269K <0.01% +43,280 13F-HR Timeline WEALTH ENHANCEMENT ADVISORY SERVICES, L… More: the full row for WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 36,726 $158K <0.01% +10,041 13F-HR Timeline Jefferies Financial Group Inc. in group Jefferies Financial Group Inc. More: the full row for Jefferies Financial Group Inc. 40,000 $151K <0.01% new 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 34,355 $130K <0.01% +2,873 13F-HR Timeline Group R Squared Ltd More: the full row for R Squared Ltd 29,918 $113K 0.06% new 13F-HR Timeline Quaker Wealth Management, LLC More: the full row for Quaker Wealth Management, LLC 24,960 $94.3K 0.03% 0 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 24,467 $92.5K <0.01% 0 13F-HR Timeline Shay Capital LLC More: the full row for Shay Capital LLC 21,871 $82.7K 0.01% new 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 21,600 $81.6K <0.01% +5,600 13F-HR Timeline NewEdge Advisors, LLC More: the full row for NewEdge Advisors, LLC 20,078 $75.9K <0.01% +78 13F-HR Timeline Cerity Partners LLC in group Cerity Partners LLC More: the full row for Cerity Partners LLC 20,000 $75.6K <0.01% 0 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 15,741 $60K <0.01% new 13F-HR Timeline Group Ground Swell Capital, LLC More: the full row for Ground Swell Capital, LLC 12,803 $48.4K 0.05% new 13F-HR Timeline BLAIR WILLIAM & CO/IL More: the full row for BLAIR WILLIAM & CO/IL 10,000 $37.8K <0.01% 0 13F-HR Timeline Frec Markets, Inc. in group Frec Markets, Inc. More: the full row for Frec Markets, Inc. 10,000 $37.8K <0.01% 0 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 6,612 $25K <0.01% new 13F-HR Timeline Group GAMMA Investing LLC More: the full row for GAMMA Investing LLC 5,020 $19K <0.01% +505 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 4,672 $17.7K <0.01% +1,810 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 1,800 $6.8K <0.01% new 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 1,781 $6.73K <0.01% new 13F-HR Timeline Group Stone House Investment Management, LLC More: the full row for Stone House Investment Management, LLC 1,463 $5.53K <0.01% new 13F-HR Timeline Covestor Ltd More: the full row for Covestor Ltd 402 $2K <0.01% 0 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 308 $1.16K <0.01% new 13F-HR Timeline Group Atlantic Union Bankshares Corp in group Atlantic Union Bankshares Corp More: the full row for Atlantic Union Bankshares Corp 300 $1.13K <0.01% 0 13F-HR Timeline Group Larson Financial Group LLC More: the full row for Larson Financial Group LLC 225 $851 <0.01% new 13F-HR Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 155 $586 <0.01% +153 13F-HR Timeline Bell Investment Advisors, Inc More: the full row for Bell Investment Advisors, Inc 76 $288 <0.01% 0 13F-HR Timeline Arax Advisory Partners More: the full row for Arax Advisory Partners 51 $193 <0.01% new 13F-HR Timeline