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Disclosery

13F-HR filed by Sofinnova Investments, Inc.

Sofinnova Investments, Inc. filed this 13F-HR for the quarter ended 2025-03-31, filed 2025-05-15, with 64 holding rows worth $1,531,129,746.

Accession
0001104659-25-049266
Filer
CIK 1631134
Filed
2025-05-15
Accepted by EDGAR
acceptance time not in the bulk data set
Ingested
Source
SEC quarterly data set

Original filing

13F report for Q1 2025

A holdings report, 65 entries on the cover page, a total value of $1,531,129,746 stated on the cover page (in dollars after the unit check, H1), rows summing to $1,531,129,746 with VALUE read as dollars as filed, 13F file number 028-18774. The quarter's positions are built on this report. The resolved quarter.

The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).

Issuer as filedCUSIPClassAmountValueValue read asType
NATERA INC COM632307104Stock1,550,280$219,225,095dollars as filed
Stryker Corporation863667101COM298,567$111,141,566dollars as filed
INVESCO QQQ TR46090E103COM175,000$82,061,000dollars as filedput
iShares Russell 2000 ETF464287655SHS350,000$69,821,500dollars as filedput
VERA THERAPEUTICS INC92337R101COMMON STOCK2,793,987$67,111,568dollars as filed
JAZZ PHARMACEUTICALS PLC SHS USDG50871105Stock510,050$63,322,708dollars as filed
Medtronic PlcG5960L103COM562,992$50,590,461dollars as filed
ALNYLAM PHARMACEUTICALS INC COM02043Q107Stock176,181$47,572,394dollars as filed
Gilead Sciences,Inc.375558103COM418,900$46,937,745dollars as filed
Eli Lilly and Company532457108COM52,800$43,608,048dollars as filed
IDEAYA BIOSCIENCES INC COM45166A102Stock2,622,192$42,951,505dollars as filed
SOLENO THERAPEUTICS INC834203309COM529,300$37,818,485dollars as filedput
SOLENO THERAPEUTICS INC834203309COM484,471$34,615,453dollars as filed
ARRIVENT BIOPHARMA INC04272N102COM1,696,752$31,372,944dollars as filed
PTC THERAPEUTICS INC69366J200COM579,339$29,523,115dollars as filed
SYNDAX PHARMACEUTICALS INC87164F105COM2,275,223$27,951,115dollars as filed
DEXCOM INC COM252131107Stock395,975$27,041,133dollars as filed
BRIDGEBIO PHARMA INC10806X102COM734,227$25,382,227dollars as filed
REPLIMUNE GROUP INC76029N106COMMON STOCK2,479,939$24,179,405dollars as filed
RHYTHM PHARMACEUTICALS INC76243J105COM446,839$23,669,062dollars as filed
INSMED INC COM PAR $.01457669307Stock304,254$23,211,538dollars as filed
BLUEPRINT MEDICINES CORP09627Y109COM261,039$23,104,562dollars as filed
Bristol-Myers Squibb Company110122108COM371,497$22,657,602dollars as filed
INCYTE CORP COM45337C102Stock357,800$21,664,790dollars as filed
ANAPTYSBIO INC032724106COM1,160,033$21,565,013dollars as filed
SAREPTA THERAPEUTICS INC803607100COM327,618$20,908,581dollars as filed
AKERO THERAPEUTICS INC00973Y108COM510,020$20,645,610dollars as filed
AXSOME THERAPEUTICS INC. COM05464T104Stock175,317$20,447,222dollars as filed
RAPPORT THERAPEUTICS INC COM75383L102Stock1,995,594$20,015,808dollars as filed
SUPERNUS PHARMACEUTICALS868459108COM520,678$17,052,205dollars as filed
SAVARA INC805111101COM5,481,666$15,184,215dollars as filed
COGENT BIOSCIENCES INC19240Q201COM2,182,121$13,070,905dollars as filed
ROIVANT SCIENCES LTDG76279101SHS1,279,510$12,910,256dollars as filed
Danaher Corporation235851102COM58,606$12,014,230dollars as filed
PENUMBRA INC COM70975L107Stock42,936$11,481,516dollars as filed
AVIDITY BIOSCIENCES INC COM05370A108Stock379,931$11,215,563dollars as filed
INHIBRX BIOSCIENCES INC45720N103COM697,916$9,763,845dollars as filed
Y-mAbs Therapeutics Inc984241109Common Stock2,194,278$9,720,652dollars as filed
AEROVATE THERAPEUTICS INC008064107COM3,758,686$9,434,302dollars as filed
PHARVARIS NVN69605108COMMON STOCK593,403$9,316,427dollars as filed
BIOAGE LABS INC COM09077V100Stock2,304,901$8,666,428dollars as filed
ACADIA PHARMACEUTICALS INC004225108COM500,000$8,305,000dollars as filedcall
ARCUS BIOSCIENCES INC03969F109COM1,037,776$8,146,542dollars as filed
EDGEWISE THERAPEUTICS INC28036F105COM342,218$7,528,796dollars as filed
DYNE THERAPEUTICS INC COM26818M108Stock716,896$7,498,732dollars as filed
EDGEWISE THERAPEUTICS INC28036F105COM320,400$7,048,800dollars as filedput
IMMATICS N.VN44445109SHS1,554,304$7,009,911dollars as filed
PRAXIS PRECISION MEDICINES I74006W207COM NEW157,640$5,969,827dollars as filed
Intuitive Surgical,Inc.46120E602COM11,984$5,935,316dollars as filed
UNIQURE NVN90064101SHS545,771$5,785,173dollars as filed
IMMUNOME INC45257U108COM788,666$5,307,722dollars as filed
KURA ONCOLOGY INC COM50127T109Stock791,667$5,225,002dollars as filed
INOZYME PHARMA INC45790W108COM4,280,308$3,895,080dollars as filed
SCHOLAR ROCK HLDG CORP80706P103COM116,117$3,733,162dollars as filed
ERASCA INC COM29479A108Stock1,877,085$2,571,606dollars as filed
NEXTCURE INC65343E108COM2,671,856$1,283,292dollars as filed
ESTABLISHMENT LABS HOLDINGSG31249108COMMON STOCK28,675$1,170,083dollars as filed
BOLT BIOTHERAPEUTICS INC097702104COM2,754,437$1,101,775dollars as filed
METSERA INC59267L107COM36,800$1,001,696dollars as filed
ENLIVEN THERAPEUTICS INC COM29337E102Stock33,547$660,205dollars as filed
STRUCTURE THERAPEUTICS INC COMP86366E106EQUITY34,952$605,019dollars as filed
VIR BIOTECHNOLOGY INC92764N102COM83,010$537,905dollars as filed
IKENA ONCOLOGY INC45175G108COM382,616$489,748dollars as filed
DISC MEDICINE INC COM254604101Stock7,485$371,555dollars as filed

Amendment chain

FilingRoleFiledAcceptedIngested
13F-HR 0001104659-25-049266this filing2025-05-15acceptance time not in the bulk data set