T. Rowe Price Investment Management, In… More: the full row for T. Rowe Price Investment Management, Inc. 22,365,046 $227M 0.15% +712,884 13F-HR Timeline RTW INVESTMENTS, LP More: the full row for RTW INVESTMENTS, LP 12,946,176 $131M 1.12% +76,836 13F-HR Timeline MONTANOVA CAPITAL, LLC More: the full row for MONTANOVA CAPITAL, LLC 11,190,129 $113M 2.38% 0 13F-HR Timeline PERCEPTIVE ADVISORS LLC in group PERCEPTIVE ADVISORS LLC More: the full row for PERCEPTIVE ADVISORS LLC 10,383,456 $105M 1.63% 0 13F-HR Timeline Group BAKER BROS. ADVISORS LP in group BAKER BROS. ADVISORS LP More: the full row for BAKER BROS. ADVISORS LP 9,508,565 $96.3M 0.48% -1,408,128 13F-HR Timeline Group Jefferies Financial Group Inc. in group Jefferies Financial Group Inc. More: the full row for Jefferies Financial Group Inc. 6,506,802 $65.9M 0.61% +1,447,251 13F-HR Timeline Group Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 6,175,000 $62.6M 1.46% 0 13F-HR Timeline Sofinnova Investments, Inc. More: the full row for Sofinnova Investments, Inc. 3,669,346 $37.2M 1.99% +38,892 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 2,186,494 $22.1M <0.01% +37,412 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 1,814,657 $18.4M 0.01% -37,306 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 1,647,852 $16.7M <0.01% +85,960 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 1,449,597 $14.7M 0.02% -44,203 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 900,736 $9.12M 0.03% -99,861 13F-HR Timeline SPHERA FUNDS MANAGEMENT LTD. in group SPHERA FUNDS MANAGEMENT LTD. More: the full row for SPHERA FUNDS MANAGEMENT LTD. 720,057 $7.29M 1.04% +23,952 13F-HR Timeline Group UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT… More: the full row for UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO 697,431 $7.06M 0.82% 0 13F-HR Timeline Aberdeen Group plc in group Aberdeen Group plc More: the full row for Aberdeen Group plc 653,604 $6.62M 0.01% -167,113 13F-HR Timeline Group Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 523,217 $5.3M 0.01% +156,445 13F-HR Timeline Boxer Capital Management, LLC More: the full row for Boxer Capital Management, LLC 475,000 $4.81M 0.36% new 13F-HR Timeline TD Asset Management Inc More: the full row for TD Asset Management Inc 449,348 $4.55M <0.01% -21,096 13F-HR Timeline WASATCH ADVISORS LP More: the full row for WASATCH ADVISORS LP 441,510 $4.47M 0.03% -23,313 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 419,698 $4.25M <0.01% -37,300 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 410,712 $4.16M <0.01% -241,458 13F-HR Timeline Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 401,643 $4.07M 0.01% -581,221 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 384,171 $3.89M <0.01% +168,193 13F-HR Timeline Group SECTORAL ASSET MANAGEMENT INC More: the full row for SECTORAL ASSET MANAGEMENT INC 224,928 $2.28M 1.59% +158,098 13F-HR Timeline Atom Investors LP More: the full row for Atom Investors LP 216,365 $2.19M 0.19% -37,775 13F-HR Timeline MOORE CAPITAL MANAGEMENT, LP More: the full row for MOORE CAPITAL MANAGEMENT, LP 192,770 $1.95M 0.04% new 13F-HR Timeline SCHRODER INVESTMENT MANAGEMENT GROUP More: the full row for SCHRODER INVESTMENT MANAGEMENT GROUP 197,300 $1.89M <0.01% -205,052 13F-HR Timeline Tidal Investments LLC in group Tidal Investments LLC More: the full row for Tidal Investments LLC 171,499 $1.74M <0.01% +1,110 13F-HR Timeline Group Burkehill Global Management, LP More: the full row for Burkehill Global Management, LP 150,000 $1.52M 0.05% 0 13F-HR Timeline SummitTX Capital, L.P. More: the full row for SummitTX Capital, L.P. 146,351 $1.48M 0.04% -4,761 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 141,400 $1.43M <0.01% +7,123 13F-HR Timeline Group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 135,599 $1.37M 0.01% +26,461 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 137,074 $1.31M <0.01% -3,391 13F-HR Timeline Group MYDA Advisors LLC More: the full row for MYDA Advisors LLC 120,000 $1.22M 0.3% 0 13F-HR Timeline DAFNA Capital Management LLC More: the full row for DAFNA Capital Management LLC 116,960 $1.18M 0.23% -108,900 13F-HR Timeline Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 106,046 $1.07M 0.01% +57,707 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 104,710 $1.06M <0.01% -111,011 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 104,548 $1.06M <0.01% +85,605 13F-HR Timeline Group SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 87,277 $884K <0.01% -12,164 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 66,933 $678K <0.01% +6,019 13F-HR Timeline Group TUDOR INVESTMENT CORP ET AL More: the full row for TUDOR INVESTMENT CORP ET AL 66,434 $673K <0.01% -614 13F-HR Timeline D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 59,161 $599K <0.01% new 13F-HR Timeline Group MACQUARIE GROUP LTD in group MACQUARIE GROUP LTD More: the full row for MACQUARIE GROUP LTD 53,500 $542K <0.01% new 13F-HR Timeline Group Engineers Gate Manager LP More: the full row for Engineers Gate Manager LP 50,886 $515K 0.01% +10,638 13F-HR Timeline Vanguard Personalized Indexing Manageme… in group VANGUARD GROUP INC More: the full row for Vanguard Personalized Indexing Management, LLC 49,365 $500K <0.01% +4,475 13F-HR Timeline Group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 48,569 $492K 0.08% 0 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 46,265 $469K <0.01% -18,389 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 43,657 $442K <0.01% +18,263 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 43,297 $439K <0.01% -60,726 13F-HR Timeline Group Prime Capital Investment Advisors, LLC More: the full row for Prime Capital Investment Advisors, LLC 40,000 $405K <0.01% +10,000 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 36,128 $366K <0.01% -314 13F-HR Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 35,433 $359K <0.01% -225,574 13F-HR Timeline Group ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 34,937 $354K <0.01% -15,228 13F-HR Timeline Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 34,882 $353K 0.08% +7,723 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 33,914 $344K <0.01% +7,314 13F-HR Timeline Group HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 31,724 $321K <0.01% new 13F-HR Timeline Ishara Investments LP More: the full row for Ishara Investments LP 30,750 $311K 0.23% -123,000 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 30,020 $304K <0.01% +15,727 13F-HR Timeline Group MERCER GLOBAL ADVISORS INC /ADV More: the full row for MERCER GLOBAL ADVISORS INC /ADV 29,987 $304K <0.01% 0 13F-HR/A Timeline BRANDYWINE MANAGERS, LLC in group BRANDYWINE MANAGERS, LLC More: the full row for BRANDYWINE MANAGERS, LLC 25,227 $256K 0.13% new 13F-HR Timeline Group FOX RUN MANAGEMENT, L.L.C. More: the full row for FOX RUN MANAGEMENT, L.L.C. 23,694 $240K 0.04% +6,737 13F-HR Timeline Lynx1 Capital Management LP in group Lynx1 Capital Management LP More: the full row for Lynx1 Capital Management LP 23,236 $235K 0.03% -193,737 13F-HR/A Timeline Group J. Goldman & Co LP More: the full row for J. Goldman & Co LP 22,788 $231K 0.01% 0 13F-HR Timeline Graham Capital Management, L.P. More: the full row for Graham Capital Management, L.P. 22,725 $230K 0.01% -2,444 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 21,977 $223K <0.01% -33,323 13F-HR Timeline Group GUGGENHEIM CAPITAL LLC in group GUGGENHEIM CAPITAL LLC More: the full row for GUGGENHEIM CAPITAL LLC 16,434 $166K <0.01% -149 13F-HR Timeline Group Mitsubishi UFJ Asset Management Co., Lt… in group Mitsubishi UFJ Trust & Bankin… More: the full row for Mitsubishi UFJ Asset Management Co., Ltd. 15,299 $155K <0.01% -1,247 13F-HR Timeline Group Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 14,726 $149K <0.01% new 13F-HR Timeline Group Aquatic Capital Management LLC More: the full row for Aquatic Capital Management LLC 14,097 $143K <0.01% -7,076 13F-HR Timeline Mariner, LLC in group Mariner, LLC More: the full row for Mariner, LLC 13,100 $133K <0.01% -353 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 11,469 $116K <0.01% new 13F-HR Timeline Group State of Wyoming More: the full row for State of Wyoming 10,791 $109K 0.01% new 13F-HR Timeline Verdad Advisers, LP More: the full row for Verdad Advisers, LP 10,483 $106K 0.1% new 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 5,255 $53.2K <0.01% +80 13F-HR Timeline Group Quarry LP More: the full row for Quarry LP 3,926 $39.8K 0.01% -14,824 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 2,232 $22.6K <0.01% 0 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 1,110 $11K <0.01% new 13F-HR Timeline Group Integrated Wealth Concepts LLC More: the full row for Integrated Wealth Concepts LLC 600 $6.08K <0.01% new 13F-HR Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 335 $3.39K <0.01% 0 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 258 $2.61K <0.01% -608 13F-HR Timeline Group SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 25 $253 <0.01% 0 13F-HR Timeline HUNTINGTON NATIONAL BANK in group HUNTINGTON NATIONAL BANK More: the full row for HUNTINGTON NATIONAL BANK 1 $10 <0.01% 0 13F-HR Timeline Group