Skip to content
Disclosery

Sofinnova Investments, Inc.

Follow

13F filer, CIK 1631134, Menlo Park, CA

Sofinnova Investments, Inc. reported $2,319,284,145 across 60 holdings for the quarter ended 2025-12-31, in a 13F-HR filed 2026-02-13. Its ten largest share positions make up 54.22% of the portfolio.

Filed (acceptance time not in the bulk data set), ingested 13F-HR 0001104659-26-015127

Period
2025-12-31
Reported value
$2.32B
Holdings
60
Top 10 weight
54.22%
New
11
Sold out
13

Largest buys vs the previous quarter

SecurityShares changeApprox. value
BMYnew+1,512,994$81.6M
AZNadded+808,401$74.3M
LLYnew+61,652$66.3M
JAZZadded+371,032$63.1M
BMRNnew+697,133$41.4M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
GILDexited-1,252,312-$139M
AXSMreduced-381,233-$69.6M
BSXexited-569,427-$55.6M
ROIVreduced-2,414,688-$52.4M
EXASreduced-263,557-$26.8M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q4 2025

Share positions as resolved from 13F-HR 0001104659-26-015127, largest first. % of portfolio is the value over $2,319,284,145, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
NTRANATERA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,550,280 shares; 2024Q4: 1,550,280 shares; 2025Q1: 1,550,280 shares; 2025Q2: 1,550,280 shares; 2025Q3: 1,550,280 shares; 2025Q4: 1,550,280 shares 1,550,280$355M15.31%0Timeline
JAZZJAZZ PHARMACEUTICALS PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 188,562 shares; 2024Q4: 504,193 shares; 2025Q1: 510,050 shares; 2025Q2: 694,096 shares; 2025Q3: 588,828 shares; 2025Q4: 959,860 shares 959,860$163M7.04%+371,032Timeline
AZNASTRAZENECA PLC-SPONS ADRQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 809,406 shares; 2024Q4: 651,344 shares; 2025Q1: not reported; 2025Q2: 293,661 shares; 2025Q3: 823,933 shares; 2025Q4: 1,632,334 shares 1,632,334$150M6.47%+808,401Timeline
VERAVERA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,793,987 shares; 2024Q4: 2,793,987 shares; 2025Q1: 2,793,987 shares; 2025Q2: 2,793,987 shares; 2025Q3: 2,793,987 shares; 2025Q4: 2,793,987 shares 2,793,987$141M6.1%0Timeline
BMYBRISTOL-MYERS SQUIBB COQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 371,497 shares; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 1,512,994 shares 1,512,994$81.6M3.52%newTimeline
UTHRUNITED THERAPEUTICS CORP DELQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 118,513 shares; 2025Q3: 190,626 shares; 2025Q4: 157,641 shares 157,641$76.8M3.31%-32,985Timeline
VRTXVERTEX PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 117,875 shares; 2025Q4: 164,594 shares 164,594$74.6M3.22%+46,719Timeline
ABBVABBVIE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 359,393 shares; 2025Q1: not reported; 2025Q2: 265,850 shares; 2025Q3: 150,966 shares; 2025Q4: 317,783 shares 317,783$72.6M3.13%+166,817Timeline
ISRGINTUITIVE SURGICAL INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 37,896 shares; 2025Q1: 11,984 shares; 2025Q2: 70,642 shares; 2025Q3: 110,896 shares; 2025Q4: 126,968 shares 126,968$71.9M3.1%+16,072Timeline
COGTCOGENT BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,265,230 shares; 2024Q4: 823,160 shares; 2025Q1: 2,182,121 shares; 2025Q2: 2,355,505 shares; 2025Q3: 2,127,941 shares; 2025Q4: 1,973,625 shares 1,973,625$70.1M3.02%-154,316Timeline
LLYELI LILLY & COQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 14,364 shares; 2025Q1: 52,800 shares; 2025Q2: 97,018 shares; 2025Q3: not reported; 2025Q4: 61,652 shares 61,652$66.3M2.86%newTimeline
RAPPRAPPORT THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,995,594 shares; 2024Q4: 1,995,594 shares; 2025Q1: 1,995,594 shares; 2025Q2: 1,995,594 shares; 2025Q3: 1,947,579 shares; 2025Q4: 1,904,408 shares 1,904,408$57.8M2.49%-43,171Timeline
BBIOBRIDGEBIO PHARMA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 734,227 shares; 2025Q2: 993,093 shares; 2025Q3: 831,847 shares; 2025Q4: 720,448 shares 720,448$55.1M2.38%-111,399Timeline
RNAMAVIDITY BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 30,472 shares; 2024Q4: 13,789 shares; 2025Q1: 379,931 shares; 2025Q2: 584,801 shares; 2025Q3: 875,925 shares; 2025Q4: 745,116 shares 745,116$53.7M2.32%-130,809Timeline
DYNDYNE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 772,070 shares; 2024Q4: 1,071,498 shares; 2025Q1: 716,896 shares; 2025Q2: 614,865 shares; 2025Q3: 985,828 shares; 2025Q4: 2,254,161 shares 2,254,161$44.1M1.9%+1,268,333Timeline
BMRNBIOMARIN PHARMACEUTICAL INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 697,133 shares 697,133$41.4M1.79%newTimeline
APGEAPOGEE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 76,180 shares; 2025Q3: 565,417 shares; 2025Q4: 534,845 shares 534,845$40.4M1.74%-30,572Timeline
CDTXCIDARA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 251,031 shares; 2025Q3: 54,197 shares; 2025Q4: 180,265 shares 180,265$39.8M1.72%+126,068Timeline
PRAXPRAXIS PRECISION MEDICINES IQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 157,640 shares; 2025Q2: 15,717 shares; 2025Q3: 172,833 shares; 2025Q4: 125,722 shares 125,722$37.1M1.6%-47,111Timeline
IMTXIMMATICS N.VQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 386,100 shares; 2024Q4: 343,206 shares; 2025Q1: 1,554,304 shares; 2025Q2: 2,240,528 shares; 2025Q3: 2,227,837 shares; 2025Q4: 3,435,542 shares 3,435,542$36.1M1.56%+1,207,705Timeline
INBXINHIBRX BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 536,068 shares; 2024Q4: 527,190 shares; 2025Q1: 697,916 shares; 2025Q2: 708,678 shares; 2025Q3: 440,092 shares; 2025Q4: 454,657 shares 454,657$35.9M1.55%+14,565Timeline
IMNMIMMUNOME INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 676,766 shares; 2024Q4: 746,824 shares; 2025Q1: 788,666 shares; 2025Q2: 778,476 shares; 2025Q3: 436,051 shares; 2025Q4: 1,618,477 shares 1,618,477$34.8M1.5%+1,182,426Timeline
AVBPARRIVENT BIOPHARMA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,696,752 shares; 2024Q4: 1,696,752 shares; 2025Q1: 1,696,752 shares; 2025Q2: 1,696,752 shares; 2025Q3: 1,696,752 shares; 2025Q4: 1,696,752 shares 1,696,752$34.1M1.47%0Timeline
GKOSGLAUKOS CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 312,994 shares; 2025Q4: 288,128 shares 288,128$32.5M1.4%-24,866Timeline
IDYAIDEAYA BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,749,455 shares; 2024Q4: 1,069,090 shares; 2025Q1: 2,622,192 shares; 2025Q2: 2,147,795 shares; 2025Q3: 922,695 shares; 2025Q4: 885,121 shares 885,121$30.6M1.32%-37,574Timeline
BIOABIOAGE LABS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,304,901 shares; 2024Q4: 2,304,901 shares; 2025Q1: 2,304,901 shares; 2025Q2: 2,304,901 shares; 2025Q3: 2,293,788 shares; 2025Q4: 2,293,788 shares 2,293,788$30.3M1.31%0Timeline
CELCCELCUITY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 253,375 shares; 2025Q4: 299,417 shares 299,417$29.9M1.29%+46,042Timeline
RYTMRHYTHM PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 276,678 shares; 2024Q4: 397,428 shares; 2025Q1: 446,839 shares; 2025Q2: 586,010 shares; 2025Q3: 246,966 shares; 2025Q4: 271,394 shares 271,394$29.1M1.25%+24,428Timeline
CNTACENTESSA PHARMACEUTICALS PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 1,104,274 shares 1,104,274$27.6M1.19%newTimeline
SUPNSUPERNUS PHARMACEUTICALSQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 520,678 shares; 2025Q2: 799,253 shares; 2025Q3: 377,066 shares; 2025Q4: 553,095 shares 553,095$27.5M1.19%+176,029Timeline
INSMINSMED INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 286,307 shares; 2024Q4: 256,281 shares; 2025Q1: 304,254 shares; 2025Q2: 313,923 shares; 2025Q3: 104,339 shares; 2025Q4: 156,801 shares 156,801$27.3M1.18%+52,462Timeline
ALCALCON AGQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 332,520 shares 332,520$26.2M1.13%newTimeline
RCUSARCUS BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 1,037,776 shares; 2025Q2: 1,216,016 shares; 2025Q3: 1,222,263 shares; 2025Q4: 1,096,705 shares 1,096,705$26.1M1.13%-125,558Timeline
DXCMDEXCOM INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 290,210 shares; 2025Q1: 395,975 shares; 2025Q2: 523,694 shares; 2025Q3: 779,616 shares; 2025Q4: 378,219 shares 378,219$25.1M1.08%-401,397Timeline
PHVSPHARVARIS N VQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 600,302 shares; 2024Q4: 560,723 shares; 2025Q1: 593,403 shares; 2025Q2: 585,532 shares; 2025Q3: 739,876 shares; 2025Q4: 745,169 shares 745,169$20.7M0.89%+5,293Timeline
NKTRNEKTAR THERAPEUTICSQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 118,419 shares; 2025Q4: 438,630 shares 438,630$18.5M0.8%+320,211Timeline
CMPXCOMPASS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 2,028,886 shares; 2025Q4: 3,365,446 shares 3,365,446$18.1M0.78%+1,336,560Timeline
ROIVROIVANT SCIENCES LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 1,279,510 shares; 2025Q2: 3,088,814 shares; 2025Q3: 3,149,270 shares; 2025Q4: 734,582 shares 734,582$15.9M0.69%-2,414,688Timeline
ANABANAPTYSBIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 132,927 shares; 2025Q1: 1,160,033 shares; 2025Q2: 1,032,362 shares; 2025Q3: 254,268 shares; 2025Q4: 287,690 shares 287,690$13.9M0.6%+33,422Timeline
GEHCGE HEALTHCARE TECHNOLOGIES IQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 151,085 shares; 2025Q4: 160,876 shares 160,876$13.2M0.57%+9,791Timeline
EWTXEDGEWISE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 384,767 shares; 2024Q4: 402,773 shares; 2025Q1: 342,218 shares; 2025Q2: 716,873 shares; 2025Q3: 520,240 shares; 2025Q4: 437,819 shares 437,819$10.9M0.47%-82,421Timeline
EXASEXACT SCIENCES CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 37,637 shares; 2024Q4: 52,042 shares; 2025Q1: not reported; 2025Q2: 208,300 shares; 2025Q3: 365,000 shares; 2025Q4: 101,443 shares 101,443$10.3M0.44%-263,557Timeline
IRONDISC MEDICINE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 41,352 shares; 2024Q4: 22,752 shares; 2025Q1: 7,485 shares; 2025Q2: 7,312 shares; 2025Q3: 13,553 shares; 2025Q4: 111,010 shares 111,010$8.82M0.38%+97,457Timeline
AMLXAMYLYX PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 527,099 shares 527,099$6.37M0.27%newTimeline
MASIMASIMO CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 46,201 shares 46,201$6.01M0.26%newTimeline
QUREUNIQURE NVQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 545,771 shares; 2025Q2: 1,558,356 shares; 2025Q3: 136,862 shares; 2025Q4: 176,513 shares 176,513$4.22M0.18%+39,651Timeline
NXTCNEXTCURE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 222,654 shares; 2025Q4: 222,654 shares 222,654$3.16M0.14%0Timeline
WVEWAVE LIFE SCIENCES LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 117,903 shares; 2025Q3: 170,943 shares; 2025Q4: 158,182 shares 158,182$2.69M0.12%-12,761Timeline
XENEXENON PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 59,900 shares 59,900$2.68M0.12%newTimeline
EVMNEVOMMUNE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 153,320 shares 153,320$2.62M0.11%newTimeline
AXSMAXSOME THERAPEUTICS INC.Quarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 379,527 shares; 2024Q4: 491,726 shares; 2025Q1: 175,317 shares; 2025Q2: 93,610 shares; 2025Q3: 393,499 shares; 2025Q4: 12,266 shares 12,266$2.24M0.1%-381,233Timeline
ESTAESTABLISHMENT LABS HLDGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 181,476 shares; 2024Q4: 95,305 shares; 2025Q1: 28,675 shares; 2025Q2: 28,120 shares; 2025Q3: 10,787 shares; 2025Q4: 28,366 shares 28,366$2.07M0.09%+17,579Timeline
RAREULTRAGENYX PHARMACEUTICAL INQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 83,300 shares 83,300$1.92M0.08%newTimeline
SVRASAVARA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 5,662,550 shares; 2024Q4: 5,471,299 shares; 2025Q1: 5,481,666 shares; 2025Q2: 2,457,352 shares; 2025Q3: 2,427,724 shares; 2025Q4: 304,770 shares 304,770$1.84M0.08%-2,122,954Timeline
MIRMMIRUM PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 23,100 shares 23,100$1.82M0.08%newTimeline
ACADACADIA PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 26,800 shares; 2025Q4: 65,567 shares 65,567$1.75M0.08%+38,767Timeline
JBIOJADE BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 107,391 shares; 2025Q3: 107,391 shares; 2025Q4: 107,391 shares 107,391$1.66M0.07%0Timeline
BOLTBOLT BIOTHERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 137,721 shares; 2025Q3: 137,721 shares; 2025Q4: 137,721 shares 137,721$753K0.03%0Timeline
SLNOSOLENO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 586,344 shares; 2024Q4: 757,248 shares; 2025Q1: 484,471 shares; 2025Q2: 415,219 shares; 2025Q3: 166,281 shares; 2025Q4: 12,414 shares 12,414$575K0.02%-153,867Timeline
IMAIMAGENEBIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 31,884 shares; 2025Q4: 31,884 shares 31,884$220K0.01%0Timeline

Sold out in Q4 2025

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
GILDGILEAD SCIENCES INC1,252,312$139Mshares
BSXBOSTON SCIENTIFIC CORP569,427$55.6Mshares
IBBISHARES TR325,000$46.9Mput
UTHRUNITED THERAPEUTICS CORP DEL97,100$40.7Mput
XBISPDR SERIES TRUST400,000$40.1Mput
QUREUNIQURE NV500,000$29.2Mput
AKROAKERO THERAPEUTICS INC473,625$22.5Mshares
SMMTSUMMIT THERAPEUTICS INC900,000$18.6Mcall
QUREUNIQURE NV300,000$17.5Mcall
MERUS N VMERUS N V166,729$15.7Mshares
PTCTPTC THERAPEUTICS INC186,932$11.5Mshares
LQDALIQUIDIA CORPORATION250,000$5.68Mput
SRRKSCHOLAR ROCK HLDG CORP31,410$1.17Mshares

How Q4 2025 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0001104659-26-015127 base2026-02-13acceptance time not in the bulk data set