Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 3,311,438 $36.4M 0.74% +400,000 13F-HR Timeline Group TCG Crossover Management, LLC More: the full row for TCG Crossover Management, LLC 3,033,560 $33.3M 0.8% 0 13F-HR Timeline Redmile Group, LLC in group Redmile Group, LLC More: the full row for Redmile Group, LLC 2,164,777 $23.8M 1.6% 0 13F-HR Timeline Group Nantahala Capital Management, LLC More: the full row for Nantahala Capital Management, LLC 1,346,731 $14.8M 0.89% -800,000 13F-HR/A Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 1,329,625 $14.6M 0.01% +94,818 13F-HR Timeline Group Nextech Invest Ltd. More: the full row for Nextech Invest Ltd. 952,400 $10.5M 0.5% 0 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 909,279 $9.98M 0.01% -164,912 13F-HR Timeline Group Tetragon Partners GP Ltd in group Tetragon Partners GP Ltd More: the full row for Tetragon Partners GP Ltd 764,256 $8.39M 1.37% +134,095 13F-HR Timeline Group Soleus Capital Management, L.P. More: the full row for Soleus Capital Management, L.P. 630,000 $6.92M 0.24% new 13F-HR Timeline Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 610,980 $6.71M 0.01% new 13F-HR Timeline Group 5AM Venture Management, LLC More: the full row for 5AM Venture Management, LLC 476,200 $5.23M 1.82% 0 13F-HR Timeline GREAT POINT PARTNERS LLC More: the full row for GREAT POINT PARTNERS LLC 450,000 $4.94M 1.16% -570,489 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 403,172 $4.43M <0.01% +337,686 13F-HR Timeline Group AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 370,052 $4.06M <0.01% new 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 369,151 $4.05M <0.01% +268,224 13F-HR Timeline Group ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 338,373 $3.72M 0.17% +166,216 13F-HR Timeline Group SummitTX Capital, L.P. More: the full row for SummitTX Capital, L.P. 326,648 $3.59M 0.09% new 13F-HR Timeline Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 269,348 $2.96M 0.02% new 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 243,152 $2.67M <0.01% -3,785 13F-HR Timeline Group Ishara Investments LP More: the full row for Ishara Investments LP 55,350 $2.43M 1.79% -85,150 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 219,917 $2.41M <0.01% +15,140 13F-HR Timeline Group BANK OF MONTREAL /CAN/ in group BANK OF MONTREAL /CAN/ More: the full row for BANK OF MONTREAL /CAN/ 201,734 $2.22M <0.01% -1,167 13F-HR Timeline Group BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 198,347 $2.18M 0.04% -10,741 13F-HR Timeline Propel Bio Management, LLC More: the full row for Propel Bio Management, LLC 191,733 $2.11M 1.1% new 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 184,519 $2.03M <0.01% +69,238 13F-HR Timeline Group FRED ALGER MANAGEMENT, LLC in group FRED ALGER MANAGEMENT, LLC More: the full row for FRED ALGER MANAGEMENT, LLC 177,000 $1.94M 0.01% new 13F-HR Timeline Group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 830,784 $1.83M 0.3% -35,000 13F-HR Timeline Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 163,945 $1.8M <0.01% +59,390 13F-HR Timeline Caption Management, LLC More: the full row for Caption Management, LLC 162,476 $1.78M 0.06% new 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 158,950 $1.75M <0.01% +11,282 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 155,929 $1.71M <0.01% +103,418 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 121,004 $1.33M <0.01% +104,801 13F-HR Timeline Group HSBC HOLDINGS PLC in group HSBC HOLDINGS PLC More: the full row for HSBC HOLDINGS PLC 122,834 $1.32M <0.01% 0 13F-HR Timeline Group Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 118,129 $1.3M 0.01% new 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 115,918 $1.27M <0.01% +26,449 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 107,579 $1.18M 0.02% +1,577 13F-HR Timeline Group M28 Capital Management LP More: the full row for M28 Capital Management LP 101,203 $1.11M 2.36% 0 13F-HR Timeline MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 72,039 $791K <0.01% -97,577 13F-HR Timeline Group Birchview Capital, LP More: the full row for Birchview Capital, LP 71,218 $782K 0.37% new 13F-HR Timeline Seven Fleet Capital Management LP More: the full row for Seven Fleet Capital Management LP 60,107 $660K 0.11% -96,652 13F-HR Timeline HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 30,748 $337K <0.01% +18,754 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 29,538 $324K <0.01% 0 13F-HR Timeline Group Virtu Financial LLC in group Virtu Financial LLC More: the full row for Virtu Financial LLC 25,641 $282K 0.01% new 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 25,280 $278K <0.01% -4,493 13F-HR Timeline Group Trexquant Investment LP More: the full row for Trexquant Investment LP 23,842 $262K <0.01% new 13F-HR Timeline Verdad Advisers, LP More: the full row for Verdad Advisers, LP 20,400 $224K 0.21% new 13F-HR Timeline Scientech Research LLC More: the full row for Scientech Research LLC 19,133 $210K 0.17% new 13F-HR Timeline RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 16,930 $186K <0.01% new 13F-HR Timeline Arrowpoint Investment Partners (Singapo… in group Arrowpoint Investment Partner… More: the full row for Arrowpoint Investment Partners (Singapore) Pte. Ltd. 16,334 $179K 0.05% new 13F-HR Timeline Group Persistent Asset Partners Ltd More: the full row for Persistent Asset Partners Ltd 15,170 $167K 0.05% new 13F-HR Timeline RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 15,000 $165K <0.01% -10,000 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 13,815 $152K <0.01% -120 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 13,217 $145K <0.01% +11,382 13F-HR Timeline Group AXQ CAPITAL, LP More: the full row for AXQ CAPITAL, LP 12,566 $138K 0.02% new 13F-HR Timeline SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 12,056 $132K <0.01% -274,642 13F-HR Timeline ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 11,836 $129K <0.01% +7,018 13F-HR Timeline Group GAMMA Investing LLC More: the full row for GAMMA Investing LLC 11,063 $121K <0.01% +1,698 13F-HR Timeline CenterBook Partners LP More: the full row for CenterBook Partners LP 10,416 $114K 0.01% new 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 7,475 $82.1K <0.01% -860 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 3,863 $41.7K <0.01% -3,773 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 3,418 $37.5K <0.01% +481 13F-HR Timeline Group JONES FINANCIAL COMPANIES LLLP in group JONES FINANCIAL COMPANIES LLLP More: the full row for JONES FINANCIAL COMPANIES LLLP 2,500 $25.4K <0.01% 0 13F-HR Timeline Group Mirae Asset Global Investments Co., Ltd. in group Mirae Asset Global Investment… More: the full row for Mirae Asset Global Investments Co., Ltd. 2,101 $23.1K <0.01% -349 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 1,639 $18K <0.01% -674 13F-HR Timeline Group Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 1,300 $14.3K <0.01% 0 13F-HR Timeline Rialto Wealth Management, LLC More: the full row for Rialto Wealth Management, LLC 1,021 $11.2K <0.01% new 13F-HR Timeline GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 975 $10.7K <0.01% -72 13F-HR Timeline Steward Partners Investment Advisory, L… More: the full row for Steward Partners Investment Advisory, LLC 100 $1.1K <0.01% 0 13F-HR Timeline Rockefeller Capital Management L.P. in group Rockefeller Capital Managemen… More: the full row for Rockefeller Capital Management L.P. 45 $494 <0.01% 0 13F-HR Timeline Group Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 41 $450 <0.01% +38 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 28 $307 <0.01% 0 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 26 $0 0% +10 13F-HR Timeline Group Value filed as zero, left out of ratios.