13F-HR filed by Sofinnova Investments, Inc.
Sofinnova Investments, Inc. filed this 13F-HR for the quarter ended 2026-03-31, filed 2026-05-15, with 74 holding rows worth $2,631,154,214.
- Accession
- 0001104659-26-062256
- Filer
- CIK 1631134
- Filed
- 2026-05-15
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q1 2026
A holdings report, 75 entries on the cover page, a total value of $2,631,154,214 stated on the cover page (in dollars after the unit check, H1), rows summing to $2,631,154,214 with VALUE read as dollars as filed, 13F file number 028-18774. The quarter's positions are built on this report. The resolved quarter.
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| NATERA INC COM | 632307104 | Stock | 1,550,280 | $310,040,497 | dollars as filed | |
| iShares Russell 2000 ETF | 464287655 | SHS | 600,000 | $148,800,000 | dollars as filed | put |
| SPDR SER TR | 78464A870 | S&P BIOTECH | 1,050,000 | $134,116,500 | dollars as filed | put |
| Bristol-Myers Squibb Company | 110122108 | COM | 1,988,721 | $120,615,929 | dollars as filed | |
| JAZZ PHARMACEUTICALS PLC SHS USD | G50871105 | Stock | 598,327 | $113,113,719 | dollars as filed | |
| VERA THERAPEUTICS INC | 92337R101 | COMMON STOCK | 2,793,987 | $112,402,097 | dollars as filed | |
| UNITED THERAPEUTICS CORP DEL COM | 91307C102 | Stock | 160,070 | $94,918,309 | dollars as filed | |
| ASTRAZENECA PLC ORD | G0593M107 | ADR | 456,031 | $89,938,434 | dollars as filed | |
| INVESCO QQQ TR | 46090E103 | COM | 150,000 | $86,577,000 | dollars as filed | put |
| COGENT BIOSCIENCES INC | 19240Q201 | COM | 2,113,551 | $81,350,578 | dollars as filed | |
| ISHARES TR | 464287556 | ISHARES BIOTECH | 475,000 | $80,203,750 | dollars as filed | put |
| ULTRAGENYX PHARMACEUTICAL IN | 90400D108 | COM | 3,145,888 | $65,906,354 | dollars as filed | |
| RAPPORT THERAPEUTICS INC COM | 75383L102 | Stock | 1,904,408 | $59,588,926 | dollars as filed | |
| INSMED INC COM PAR $.01 | 457669307 | Stock | 346,075 | $56,590,184 | dollars as filed | |
| ALCON AG ORD SHS | H01301128 | Stock | 729,972 | $55,003,390 | dollars as filed | |
| SUPERNUS PHARMACEUTICALS | 868459108 | COM | 954,309 | $49,328,232 | dollars as filed | |
| UNITED THERAPEUTICS CORP DEL COM | 91307C102 | Stock | 80,300 | $47,616,294 | dollars as filed | put |
| BIOMARIN PHARMACEUTICAL INC | 09061G101 | COM | 781,982 | $44,174,163 | dollars as filed | |
| BIOGEN INC COM | 09062X103 | Stock | 229,521 | $42,078,085 | dollars as filed | |
| CELCUITY INC | 15102K100 | COM | 366,175 | $41,795,215 | dollars as filed | |
| BIOAGE LABS INC COM | 09077V100 | Stock | 2,293,788 | $40,118,352 | dollars as filed | |
| RHYTHM PHARMACEUTICALS INC | 76243J105 | COM | 450,096 | $39,144,849 | dollars as filed | |
| ARRIVENT BIOPHARMA INC | 04272N102 | COM | 1,696,752 | $39,144,069 | dollars as filed | |
| IDEAYA BIOSCIENCES INC COM | 45166A102 | Stock | 1,131,786 | $37,711,110 | dollars as filed | |
| IMMUNOME INC | 45257U108 | COM | 1,701,904 | $37,220,640 | dollars as filed | |
| NEKTAR THERAPEUTICS | 640268306 | COMMON STOCK | 509,546 | $36,661,835 | dollars as filed | |
| AXSOME THERAPEUTICS INC. COM | 05464T104 | Stock | 212,747 | $35,958,498 | dollars as filed | |
| IMMATICS N.V | N44445109 | SHS | 3,630,454 | $35,723,667 | dollars as filed | |
| CELCUITY INC | 15102K100 | COM | 300,000 | $34,242,000 | dollars as filed | put |
| AXSOME THERAPEUTICS INC. COM | 05464T104 | Stock | 200,000 | $33,804,000 | dollars as filed | put |
| BRIDGEBIO PHARMA INC | 10806X102 | COM | 409,183 | $30,385,930 | dollars as filed | |
| DYNE THERAPEUTICS INC COM | 26818M108 | Stock | 1,633,897 | $29,622,553 | dollars as filed | |
| INHIBRX BIOSCIENCES INC | 45720N103 | COM | 406,029 | $27,297,330 | dollars as filed | |
| DEXCOM INC COM | 252131107 | Stock | 393,576 | $24,716,573 | dollars as filed | |
| PHARVARIS NV | N69605108 | COMMON STOCK | 818,328 | $23,117,766 | dollars as filed | |
| Pfizer Inc. | 717081103 | COM | 800,000 | $22,464,000 | dollars as filed | call |
| PRAXIS PRECISION MEDICINES I | 74006W207 | COM NEW | 63,680 | $20,517,059 | dollars as filed | |
| GENMAB A/S | 372303206 | Ordinary Shares, nominal value DKK 1 per share | 752,261 | $20,183,163 | dollars as filed | |
| ARCUS BIOSCIENCES INC | 03969F109 | COM | 923,086 | $19,938,658 | dollars as filed | |
| LIQUIDIA CORPORATION COM NEW | 53635D202 | Stock | 500,000 | $18,870,000 | dollars as filed | put |
| XENON PHARMACEUTICALS INC COM | 98420N105 | Stock | 305,216 | $17,748,310 | dollars as filed | |
| Stryker Corporation | 863667101 | COM | 44,480 | $14,615,683 | dollars as filed | |
| ANAPTYSBIO INC | 032724106 | COM | 248,253 | $13,768,111 | dollars as filed | |
| ROIVANT SCIENCES LTD | G76279101 | SHS | 477,995 | $13,240,462 | dollars as filed | |
| EDGEWISE THERAPEUTICS INC | 28036F105 | COM | 386,498 | $12,174,687 | dollars as filed | |
| COMPASS THERAPEUTICS INC | 20454B104 | COM | 2,056,161 | $10,877,092 | dollars as filed | |
| EXELIXIS INC COM | 30161Q104 | Stock | 251,500 | $10,786,835 | dollars as filed | put |
| ORIC PHARMACEUTICALS INC | 68622P109 | COM | 679,578 | $8,610,253 | dollars as filed | |
| TANGO THERAPEUTICS INC | 87583X109 | COM | 395,081 | $8,265,095 | dollars as filed | |
| TYRA BIOSCIENCES INC | 90240B106 | COMMON STOCK | 204,015 | $7,813,775 | dollars as filed | |
| REPLIMUNE GROUP INC | 76029N106 | COMMON STOCK | 1,015,400 | $7,767,810 | dollars as filed | call |
| ULTRAGENYX PHARMACEUTICAL IN | 90400D108 | COM | 350,000 | $7,332,500 | dollars as filed | call |
| AXOGEN INC | 05463X106 | COM | 210,665 | $6,979,331 | dollars as filed | |
| DEFINIUM THERAPEUTICS INC | 24477V105 | COM SHS | 344,166 | $6,504,737 | dollars as filed | |
| CYTOKINETICS INC | 23282W605 | COM NEW | 91,791 | $6,049,945 | dollars as filed | |
| DISC MEDICINE INC COM | 254604101 | Stock | 78,320 | $5,007,781 | dollars as filed | |
| VERADERMICS INC | 922967104 | COMMON STOCK | 73,315 | $4,629,842 | dollars as filed | |
| HARMONY BIOSCIENCES HLDGS IN | 413197104 | COM | 152,695 | $4,276,987 | dollars as filed | |
| VAXCYTE INC COM | 92243G108 | Stock | 50,600 | $2,940,366 | dollars as filed | |
| COMPASS THERAPEUTICS INC | 20454B104 | COM | 500,000 | $2,645,000 | dollars as filed | call |
| MIRUM PHARMACEUTICALS INC | 604749101 | COM | 27,591 | $2,548,857 | dollars as filed | |
| NEXTCURE INC | 65343E207 | COM NEW | 222,654 | $2,377,945 | dollars as filed | |
| SAVARA INC | 805111101 | COM | 364,763 | $1,991,606 | dollars as filed | |
| ESTABLISHMENT LABS HOLDINGS | G31249108 | COMMON STOCK | 33,930 | $1,926,545 | dollars as filed | |
| ACADIA PHARMACEUTICALS INC | 004225108 | COM | 78,551 | $1,748,545 | dollars as filed | |
| TENAX THERAPEUTICS INC | 88032L605 | COM NEW | 104,400 | $1,669,356 | dollars as filed | |
| JADE BIOSCIENCES INC | 008064206 | COM NEW | 107,391 | $1,508,844 | dollars as filed | |
| WAVE LIFE SCIENCES LTD SHS | Y95308105 | Stock | 189,253 | $1,372,084 | dollars as filed | |
| SEPTERNA INC COM | 81734D104 | Stock | 47,506 | $1,141,569 | dollars as filed | |
| ONKURE THERAPEUTICS INC | 68277Q105 | COM CL A | 141,700 | $586,638 | dollars as filed | |
| BOLT BIOTHERAPEUTICS INC | 097702203 | COM NEW | 137,721 | $556,393 | dollars as filed | |
| SOLENO THERAPEUTICS INC | 834203309 | COM | 14,689 | $491,788 | dollars as filed | |
| IMAGENEBIO INC | 45175G207 | CMN | 31,884 | $159,420 | dollars as filed | |
| ZYMEWORKS INC | 98985Y108 | COM | 1,610 | $40,314 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001104659-26-062256 | this filing | 2026-05-15 | acceptance time not in the bulk data set |