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Sofinnova Investments, Inc.

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13F filer, CIK 1631134, Menlo Park, CA

Sofinnova Investments, Inc. reported $1,828,830,662 across 62 holdings for the quarter ended 2025-09-30, in a 13F-HR filed 2025-11-14. Its ten largest share positions make up 55.58% of the portfolio.

Filed (acceptance time not in the bulk data set), ingested 13F-HR 0001104659-25-111551

Period
2025-09-30
Reported value
$1.83B
Holdings
62
Top 10 weight
55.58%
New
14
Sold out
15

Largest buys vs the previous quarter

SecurityShares changeApprox. value
VRTXnew+117,875$46.2M
AZNadded+530,272$40.7M
AXSMadded+299,889$36.4M
UTHRadded+72,113$30.2M
GKOSnew+312,994$25.5M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
QUREreduced-1,421,494-$83M
LLYexited-97,018-$75.6M
RYTMreduced-339,044-$34.2M
IDYAreduced-1,225,100-$33.3M
INSMreduced-209,584-$30.2M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q3 2025

Share positions as resolved from 13F-HR 0001104659-25-111551, largest first. % of portfolio is the value over $1,630,150,121, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
NTRANATERA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,550,280 shares; 2024Q4: 1,550,280 shares; 2025Q1: 1,550,280 shares; 2025Q2: 1,550,280 shares; 2025Q3: 1,550,280 shares 1,550,280$250M15.31%0Timeline
GILDGILEAD SCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 774,227 shares; 2025Q1: 418,900 shares; 2025Q2: 1,050,308 shares; 2025Q3: 1,252,312 shares 1,252,312$139M8.53%+202,004Timeline
VERAVERA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,793,987 shares; 2024Q4: 2,793,987 shares; 2025Q1: 2,793,987 shares; 2025Q2: 2,793,987 shares; 2025Q3: 2,793,987 shares 2,793,987$81.2M4.98%0Timeline
UTHRUNITED THERAPEUTICS CORP DELQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 118,513 shares; 2025Q3: 190,626 shares 190,626$79.9M4.9%+72,113Timeline
JAZZJAZZ PHARMACEUTICALS PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 188,562 shares; 2024Q4: 504,193 shares; 2025Q1: 510,050 shares; 2025Q2: 694,096 shares; 2025Q3: 588,828 shares 588,828$77.6M4.76%-105,268Timeline
AZNASTRAZENECA PLC-SPONS ADRQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 809,406 shares; 2024Q4: 651,344 shares; 2025Q1: not reported; 2025Q2: 293,661 shares; 2025Q3: 823,933 shares 823,933$63.2M3.88%+530,272Timeline
RAPPRAPPORT THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,995,594 shares; 2024Q4: 1,995,594 shares; 2025Q1: 1,995,594 shares; 2025Q2: 1,995,594 shares; 2025Q3: 1,947,579 shares 1,947,579$57.8M3.55%-48,015Timeline
BSXBOSTON SCIENTIFIC CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 135,819 shares; 2024Q4: 346,571 shares; 2025Q1: not reported; 2025Q2: 431,200 shares; 2025Q3: 569,427 shares 569,427$55.6M3.41%+138,227Timeline
DXCMDEXCOM INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 290,210 shares; 2025Q1: 395,975 shares; 2025Q2: 523,694 shares; 2025Q3: 779,616 shares 779,616$52.5M3.22%+255,922Timeline
ISRGINTUITIVE SURGICAL INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 37,896 shares; 2025Q1: 11,984 shares; 2025Q2: 70,642 shares; 2025Q3: 110,896 shares 110,896$49.6M3.04%+40,254Timeline
AXSMAXSOME THERAPEUTICS INC.Quarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 379,527 shares; 2024Q4: 491,726 shares; 2025Q1: 175,317 shares; 2025Q2: 93,610 shares; 2025Q3: 393,499 shares 393,499$47.8M2.93%+299,889Timeline
ROIVROIVANT SCIENCES LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 1,279,510 shares; 2025Q2: 3,088,814 shares; 2025Q3: 3,149,270 shares 3,149,270$47.6M2.92%+60,456Timeline
VRTXVERTEX PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 117,875 shares 117,875$46.2M2.83%newTimeline
BBIOBRIDGEBIO PHARMA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 734,227 shares; 2025Q2: 993,093 shares; 2025Q3: 831,847 shares 831,847$43.2M2.65%-161,246Timeline
RNAMAVIDITY BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 30,472 shares; 2024Q4: 13,789 shares; 2025Q1: 379,931 shares; 2025Q2: 584,801 shares; 2025Q3: 875,925 shares 875,925$38.2M2.34%+291,124Timeline
ABBVABBVIE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 359,393 shares; 2025Q1: not reported; 2025Q2: 265,850 shares; 2025Q3: 150,966 shares 150,966$35M2.14%-114,884Timeline
AVBPARRIVENT BIOPHARMA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,696,752 shares; 2024Q4: 1,696,752 shares; 2025Q1: 1,696,752 shares; 2025Q2: 1,696,752 shares; 2025Q3: 1,696,752 shares 1,696,752$31.3M1.92%0Timeline
COGTCOGENT BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,265,230 shares; 2024Q4: 823,160 shares; 2025Q1: 2,182,121 shares; 2025Q2: 2,355,505 shares; 2025Q3: 2,127,941 shares 2,127,941$30.6M1.87%-227,564Timeline
GKOSGLAUKOS CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 312,994 shares 312,994$25.5M1.57%newTimeline
IDYAIDEAYA BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,749,455 shares; 2024Q4: 1,069,090 shares; 2025Q1: 2,622,192 shares; 2025Q2: 2,147,795 shares; 2025Q3: 922,695 shares 922,695$25.1M1.54%-1,225,100Timeline
RYTMRHYTHM PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 276,678 shares; 2024Q4: 397,428 shares; 2025Q1: 446,839 shares; 2025Q2: 586,010 shares; 2025Q3: 246,966 shares 246,966$24.9M1.53%-339,044Timeline
AKROAKERO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 510,020 shares; 2025Q2: 548,788 shares; 2025Q3: 473,625 shares 473,625$22.5M1.38%-75,163Timeline
APGEAPOGEE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 76,180 shares; 2025Q3: 565,417 shares 565,417$22.5M1.38%+489,237Timeline
EXASEXACT SCIENCES CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 37,637 shares; 2024Q4: 52,042 shares; 2025Q1: not reported; 2025Q2: 208,300 shares; 2025Q3: 365,000 shares 365,000$20M1.22%+156,700Timeline
IMTXIMMATICS N.VQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 386,100 shares; 2024Q4: 343,206 shares; 2025Q1: 1,554,304 shares; 2025Q2: 2,240,528 shares; 2025Q3: 2,227,837 shares 2,227,837$19M1.16%-12,691Timeline
PHVSPHARVARIS N VQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 600,302 shares; 2024Q4: 560,723 shares; 2025Q1: 593,403 shares; 2025Q2: 585,532 shares; 2025Q3: 739,876 shares 739,876$18.5M1.13%+154,344Timeline
SUPNSUPERNUS PHARMACEUTICALSQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 520,678 shares; 2025Q2: 799,253 shares; 2025Q3: 377,066 shares 377,066$18M1.11%-422,187Timeline
RCUSARCUS BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 1,037,776 shares; 2025Q2: 1,216,016 shares; 2025Q3: 1,222,263 shares 1,222,263$16.6M1.02%+6,247Timeline
MERUS N VMERUS N VQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 404,562 shares; 2025Q3: 166,729 shares 166,729$15.7M0.96%-237,833
INSMINSMED INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 286,307 shares; 2024Q4: 256,281 shares; 2025Q1: 304,254 shares; 2025Q2: 313,923 shares; 2025Q3: 104,339 shares 104,339$15M0.92%-209,584Timeline
INBXINHIBRX BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 536,068 shares; 2024Q4: 527,190 shares; 2025Q1: 697,916 shares; 2025Q2: 708,678 shares; 2025Q3: 440,092 shares 440,092$14.8M0.91%-268,586Timeline
BIOABIOAGE LABS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,304,901 shares; 2024Q4: 2,304,901 shares; 2025Q1: 2,304,901 shares; 2025Q2: 2,304,901 shares; 2025Q3: 2,293,788 shares 2,293,788$13.5M0.83%-11,113Timeline
CELCCELCUITY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 253,375 shares 253,375$12.5M0.77%newTimeline
DYNDYNE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 772,070 shares; 2024Q4: 1,071,498 shares; 2025Q1: 716,896 shares; 2025Q2: 614,865 shares; 2025Q3: 985,828 shares 985,828$12.5M0.77%+370,963Timeline
PTCTPTC THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 579,339 shares; 2025Q2: 375,939 shares; 2025Q3: 186,932 shares 186,932$11.5M0.7%-189,007Timeline
GEHCGE HEALTHCARE TECHNOLOGIES IQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 151,085 shares 151,085$11.3M0.7%newTimeline
SLNOSOLENO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 586,344 shares; 2024Q4: 757,248 shares; 2025Q1: 484,471 shares; 2025Q2: 415,219 shares; 2025Q3: 166,281 shares 166,281$11.2M0.69%-248,938Timeline
PRAXPRAXIS PRECISION MEDICINES IQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 157,640 shares; 2025Q2: 15,717 shares; 2025Q3: 172,833 shares 172,833$9.16M0.56%+157,116Timeline
SVRASAVARA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 5,662,550 shares; 2024Q4: 5,471,299 shares; 2025Q1: 5,481,666 shares; 2025Q2: 2,457,352 shares; 2025Q3: 2,427,724 shares 2,427,724$8.67M0.53%-29,628Timeline
EWTXEDGEWISE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 384,767 shares; 2024Q4: 402,773 shares; 2025Q1: 342,218 shares; 2025Q2: 716,873 shares; 2025Q3: 520,240 shares 520,240$8.44M0.52%-196,633Timeline
QUREUNIQURE NVQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 545,771 shares; 2025Q2: 1,558,356 shares; 2025Q3: 136,862 shares 136,862$7.99M0.49%-1,421,494Timeline
ANABANAPTYSBIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 132,927 shares; 2025Q1: 1,160,033 shares; 2025Q2: 1,032,362 shares; 2025Q3: 254,268 shares 254,268$7.79M0.48%-778,094Timeline
CMPXCOMPASS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 2,028,886 shares 2,028,886$7.1M0.44%newTimeline
NKTRNEKTAR THERAPEUTICSQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 118,419 shares 118,419$6.74M0.41%newTimeline
CDTXCIDARA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 251,031 shares; 2025Q3: 54,197 shares 54,197$5.19M0.32%-196,834Timeline
IMNMIMMUNOME INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 676,766 shares; 2024Q4: 746,824 shares; 2025Q1: 788,666 shares; 2025Q2: 778,476 shares; 2025Q3: 436,051 shares 436,051$5.11M0.31%-342,425Timeline
NXTCNEXTCURE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 222,654 shares 222,654$1.3M0.08%newTimeline
WVEWAVE LIFE SCIENCES LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 117,903 shares; 2025Q3: 170,943 shares 170,943$1.25M0.08%+53,040Timeline
SRRKSCHOLAR ROCK HLDG CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 116,117 shares; 2025Q2: 26,440 shares; 2025Q3: 31,410 shares 31,410$1.17M0.07%+4,970Timeline
JBIOJADE BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 107,391 shares; 2025Q3: 107,391 shares 107,391$927K0.06%0Timeline
IRONDISC MEDICINE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 41,352 shares; 2024Q4: 22,752 shares; 2025Q1: 7,485 shares; 2025Q2: 7,312 shares; 2025Q3: 13,553 shares 13,553$896K0.05%+6,241Timeline
BOLTBOLT BIOTHERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 137,721 shares; 2025Q3: 137,721 shares 137,721$733K0.04%0Timeline
ACADACADIA PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 26,800 shares 26,800$572K0.04%newTimeline
ESTAESTABLISHMENT LABS HLDGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 181,476 shares; 2024Q4: 95,305 shares; 2025Q1: 28,675 shares; 2025Q2: 28,120 shares; 2025Q3: 10,787 shares 10,787$442K0.03%-17,333Timeline
IMAIMAGENEBIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 31,884 shares 31,884$260K0.02%newTimeline

Options

Puts and calls, as filed. The amount and value describe the underlying shares, not the option premium, so they stay out of % of portfolio (H5).

SecurityTypeAmountValueChange
IBBISHARES TR ISHARES BIOTECHput325,000$46.9M-50,000
UTHRUNITED THERAPEUTICS CORP DEL Stockput97,100$40.7Mnew
XBISPDR SERIES TRUST S&P BIOTECHput400,000$40.1Mnew
QUREUNIQURE NV SHSput500,000$29.2Mnew
SMMTSUMMIT THERAPEUTICS INC COMcall900,000$18.6M+200,000
QUREUNIQURE NV SHScall300,000$17.5Mnew
LQDALIQUIDIA CORPORATION Stockput250,000$5.68Mnew

Sold out in Q3 2025

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
LLYELI LILLY & CO97,018$75.6Mshares
IWMISHARES TR250,000$53.9Mput
INOZYME PHARMA INCINOZYME PHARMA INC4,280,308$17.1Mshares
REPLREPLIMUNE GROUP INC1,806,529$16.8Mshares
SNDXSYNDAX PHARMACEUTICALS INC1,524,440$14.3Mshares
RYTMRHYTHM PHARMACEUTICALS INC225,000$14.2Mput
REPLREPLIMUNE GROUP INC1,500,000$13.9Mput
ROIVROIVANT SCIENCES LTD1,000,000$11.3Mcall
Y-mAbs Therapeutics IncY-mAbs Therapeutics Inc2,194,278$9.9Mshares
CDTXCIDARA THERAPEUTICS INC100,000$4.87Mcall
COGTCOGENT BIOSCIENCES INC660,000$4.74Mcall
NEXTCURE INCNEXTCURE INC2,671,856$1.23Mshares
MTSRMETSERA INC36,191$1.03Mshares
GPCRSTRUCTURE THERAPEUTICS INC34,353$712Kshares
IKENA ONCOLOGY INCIKENA ONCOLOGY INC382,616$513Kshares

How Q3 2025 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0001104659-25-111551 base2025-11-14acceptance time not in the bulk data set