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Disclosery

SPTX SEAPORT THERAPEUTICS INC

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COMMON STOCK (common), issuer CIK 2042347

51 managers (54 13F filers) reported a position in SPTX shares at 2026-06-30, 37,408,896 shares in all. 54 filers opened a position and 0 filers sold out during the quarter.

Managers
51
13F filers
54
New
54
Added
0
Reduced
0
Sold out
0
Shares held by filers
37,408,896

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q2 2026

Filers in the available 13F reports with a share position at 2026-06-30, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
ARCH Venture Management, LLC6,294,951$137M12.42%new13F-HRTimeline
GENERAL ATLANTIC, L.P.6,101,582$133M4.56%new13F-HRTimeline
Sofinnova Investments, Inc.3,564,871$77.4M4.14%new13F-HRTimeline
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC2,178,642$47.3M<0.01%new13F-HRTimelineGroup
TRV GP VI, LLC2,061,222$44.8M19.27%new13F-HRTimeline
CANADA PENSION PLAN INVESTMENT BOARD1,975,791$42.9M0.02%new13F-HRTimeline
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO1,815,845$40.9M<0.01%new13F-HRTimelineGroup
Foresite Capital Management VI LLCin group Foresite Capital Management V…1,779,521$38.7M6.02%new13F-HRTimelineGroup
PRICE T ROWE ASSOCIATES INC /MD/1,308,604$28.4M<0.01%new13F-HRTimeline
FMR LLCin group FMR LLC1,185,100$25.7M<0.01%new13F-HRTimelineGroup
Bellevue Group AGin group Bellevue Group AG1,100,000$23.9M0.5%new13F-HRTimelineGroup
Siren, L.L.C.in group Siren, L.L.C.1,095,316$23.8M0.48%new13F-HRTimelineGroup
JENNISON ASSOCIATES LLC1,079,669$23.5M0.01%new13F-HRTimeline
VANGUARD GROUP INCgroup of 4 filers holding703,229$15.3MnewTimeline
RA CAPITAL MANAGEMENT, L.P.in group RA CAPITAL MANAGEMENT, L.P.700,000$15.2M0.13%new13F-HRTimelineGroup
Woodline Partners LP586,345$12.7M0.04%new13F-HRTimeline
PERCEPTIVE ADVISORS LLCin group PERCEPTIVE ADVISORS LLC500,000$10.9M0.17%new13F-HRTimelineGroup
BRAIDWELL LP500,000$10.9M0.4%new13F-HRTimeline
PRINCIPAL FINANCIAL GROUP INCin group PRINCIPAL FINANCIAL GROUP INC414,672$9.01M<0.01%new13F-HRTimelineGroup
Aberdeen Group plcin group Aberdeen Group plc310,355$6.74M0.01%new13F-HRTimelineGroup
UBS Group AGin group UBS Group AG279,184$6.06M<0.01%new13F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.229,863$4.99M<0.01%new13F-HRTimelineGroup
SEVEN GRAND MANAGERS, LLC225,000$4.89M0.2%new13F-HRTimeline
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC191,144$4.15M<0.01%new13F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC175,866$3.82M<0.01%new13F-HRTimelineGroup
Pier Capital, LLC169,985$3.69M0.49%new13F-HRTimeline
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC131,788$2.86M<0.01%new13F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co97,693$2.12M<0.01%new13F-HRTimelineGroup
Pentwater Capital Management LP83,000$1.8M0.01%new13F-HRTimeline
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …82,565$1.79M<0.01%new13F-HRTimelineGroup
Alyeska Investment Group, L.P.in group Alyeska Investment Group, L.P.75,000$1.63M<0.01%new13F-HRTimelineGroup
ALPS ADVISORS INC54,328$1.18M0.01%new13F-HRTimeline
TD Asset Management Inc47,944$1.04M<0.01%new13F-HRTimeline
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC45,337$985K<0.01%new13F-HRTimelineGroup
GSA CAPITAL PARTNERS LLP33,178$721K0.05%new13F-HRTimeline
DAFNA Capital Management LLC32,400$704K0.13%new13F-HRTimeline
NORTHERN TRUST CORPin group NORTHERN TRUST CORP31,802$691K<0.01%new13F-HRTimelineGroup
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC26,000$565K0.03%new13F-HRTimelineGroup
Ghisallo Capital Management LLC25,000$543K0.01%new13F-HRTimeline
Burkehill Global Management, LP25,000$543K0.02%new13F-HRTimeline
Squarepoint Ops LLCin group Squarepoint Ops LLC24,753$538K<0.01%new13F-HRTimelineGroup
HighTower Advisors, LLC16,666$362K<0.01%new13F-HRTimeline
MORGAN STANLEYin group MORGAN STANLEY11,692$254K<0.01%new13F-HRTimelineGroup
XTX Topco Ltdin group XTX Topco Ltd10,983$239K<0.01%new13F-HRTimelineGroup
Weiss Asset Management LPin group Weiss Asset Management LP10,000$217K<0.01%new13F-HRTimelineGroupThe filing omitted confidential holdings, a later amendment may add them.
Zimmer Partners, LP10,000$217K0.01%new13F-HRTimeline
CITIGROUP INCin group CITIGROUP INC2,454$53.3K<0.01%new13F-HRTimelineGroup
JONES FINANCIAL COMPANIES LLLPin group JONES FINANCIAL COMPANIES LLLP2,256$48.3K<0.01%new13F-HRTimelineGroup
ASSETMARK, INCin group ASSETMARK, INC1,431$31.1K<0.01%new13F-HRTimelineGroup
BARCLAYS PLCin group BARCLAYS PLC837$18.2K<0.01%new13F-HRTimelineGroup
Integrated Wealth Concepts LLC32$695<0.01%new13F-HRTimeline