13F-HR filed by PERCEPTIVE ADVISORS LLC
PERCEPTIVE ADVISORS LLC filed this 13F-HR for the quarter ended 2025-09-30, filed 2025-11-14, with 93 holding rows worth $3,463,098,749.
- Accession
- 0001012975-25-000762
- Filer
- CIK 1224962
- Filed
- 2025-11-14
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q3 2025
A holdings report, 93 entries on the cover page, a total value of $3,463,098,749 stated on the cover page (in dollars after the unit check, H1), rows summing to $3,463,098,749 with VALUE read as dollars as filed, 13F file number 028-10438. The quarter's positions are built on this report. The resolved quarter.
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| RHYTHM PHARMACEUTICALS INC | 76243J105 | COM | 2,438,969 | $246,311,479 | dollars as filed | |
| ASCENDIS PHARMA A/S DKK 1.0 AD | 04351P101 | SPONSORED ADR | 1,088,501 | $216,404,884 | dollars as filed | |
| ARCELLX INC COMMON STOCK | 03940C100 | Stock | 2,468,353 | $202,651,781 | dollars as filed | |
| CELCUITY INC | 15102K100 | COM | 2,956,319 | $146,042,159 | dollars as filed | |
| NUVALENT INC COM | 670703107 | Stock | 1,562,336 | $135,110,817 | dollars as filed | |
| MERUS N V | N5749R100 | COM | 1,353,093 | $127,393,706 | dollars as filed | |
| AMYLYX PHARMACEUTICALS INC | 03237H101 | COM | 8,952,365 | $121,662,640 | dollars as filed | |
| ROIVANT SCIENCES LTD | G76279101 | SHS | 7,368,461 | $111,484,815 | dollars as filed | |
| MEIRAGTX HOLDINGS PLC | G59665102 | COMMON STOCK | 12,626,103 | $103,792,540 | dollars as filed | |
| INSMED INC COM PAR $.01 | 457669307 | Stock | 702,130 | $101,113,741 | dollars as filed | |
| TRAVERE THERAPEUTICS INC | 89422G107 | COM | 3,794,615 | $90,691,299 | dollars as filed | |
| ARTIVION INC | 228903100 | COM | 2,020,000 | $85,526,800 | dollars as filed | |
| PRAXIS PRECISION MEDICINES I | 74006W207 | COM NEW | 1,564,554 | $82,921,362 | dollars as filed | |
| IMMATICS N.V | N44445109 | SHS | 9,383,456 | $79,947,045 | dollars as filed | |
| CENTESSA PHARMACEUTICALS PLC | 152309100 | SPONSORED ADS | 3,100,902 | $75,196,874 | dollars as filed | |
| SOLID BIOSCIENCES INC | 83422E204 | COMMON STOCK | 11,833,539 | $73,012,936 | dollars as filed | |
| PROTAGONIST THERAPEUTICS | 74366E102 | COM | 1,030,134 | $68,431,802 | dollars as filed | |
| NEUROCRINE BIOSCIENCES INC | 64125C109 | COM | 450,050 | $63,178,019 | dollars as filed | |
| EDGEWISE THERAPEUTICS INC | 28036F105 | COM | 3,795,894 | $61,569,401 | dollars as filed | |
| VERONA PHARMA PLC | 925050106 | SPONSORED ADS | 524,088 | $55,925,430 | dollars as filed | |
| PENUMBRA INC COM | 70975L107 | Stock | 220,547 | $55,868,966 | dollars as filed | |
| AKERO THERAPEUTICS INC | 00973Y108 | COM | 1,135,766 | $53,926,170 | dollars as filed | |
| APOGEE THERAPEUTICS INC COM | 03770N101 | Stock | 1,351,989 | $53,714,523 | dollars as filed | |
| OMADA HEALTH INC | 68170A108 | COM | 2,396,330 | $52,982,856 | dollars as filed | |
| AMICUS THERAPEUTICS INC | 03152W109 | COM | 6,370,851 | $50,202,306 | dollars as filed | |
| ASTRIA THERAPEUTICS INC COM | 04635X102 | Stock | 6,485,420 | $47,213,857 | dollars as filed | |
| INHIBRX BIOSCIENCES INC | 45720N103 | COM | 1,327,707 | $44,717,171 | dollars as filed | |
| RHYTHM PHARMACEUTICALS INC | 76243J105 | COM | 416,666,000 | $42,079,099 | dollars as filed | principal |
| REPLIGEN CORP COM | 759916109 | Stock | 270,428 | $36,148,111 | dollars as filed | |
| ZYMEWORKS INC | 98985Y108 | COM | 2,090,663 | $35,708,524 | dollars as filed | |
| SIONNA THERAPEUTICS INC | 829401108 | COMMON STOCK | 1,179,098 | $34,677,272 | dollars as filed | |
| CARIS LIFE SCIENCES INC | 142152107 | COMMON STOCK | 1,098,163 | $33,219,430 | dollars as filed | |
| ABIVAX SA- | 00370M103 | SPONSORED ADS | 388,608 | $32,992,819 | dollars as filed | |
| VIRIDIAN THERAPEUTICS INC | 92790C104 | COM | 1,462,400 | $31,558,592 | dollars as filed | |
| CYTOMX THERAPEUTICS INC | 23284F105 | COMMON STOCK | 9,680,185 | $30,879,790 | dollars as filed | |
| Boston Scientific Corporation | 101137107 | COM | 310,000 | $30,265,300 | dollars as filed | |
| ALDEYRA THERAPEUTICS INC | 01438T106 | COM | 5,222,311 | $27,260,463 | dollars as filed | |
| BRIGHT MINDS BIOSCIENCES INC | 10919W405 | COMMON STOCK | 449,290 | $27,253,931 | dollars as filed | |
| IMMUNOVANT INC | 45258J102 | COM | 1,587,890 | $25,596,787 | dollars as filed | |
| EXACT SCIENCES CORP COM | 30063P105 | Stock | 465,487 | $25,466,794 | dollars as filed | |
| PALVELLA THERAPEUTICS INC | 697947109 | COMMON STOCK | 395,093 | $24,768,380 | dollars as filed | |
| ORUKA THERAPEUTICS INC COM | 687604108 | Stock | 1,268,021 | $24,384,044 | dollars as filed | |
| Intuitive Surgical,Inc. | 46120E602 | COM | 52,119 | $23,309,180 | dollars as filed | |
| IRHYTHM HOLDINGS INC COM | 450056106 | Stock | 123,000 | $21,154,770 | dollars as filed | |
| AQUESTIVE THERAPEUTICS INC COM | 03843E104 | Stock | 3,760,099 | $21,018,953 | dollars as filed | |
| SPYRE THERAPEUTICS INC | 00773J202 | COM NEW | 1,229,445 | $20,605,498 | dollars as filed | |
| Adagio Med Hldgs Inc Com | 00534B100 | Common Stock | 9,876,576 | $19,160,576 | dollars as filed | |
| AXSOME THERAPEUTICS INC. COM | 05464T104 | Stock | 148,900 | $18,083,905 | dollars as filed | |
| ADMA BIOLOGICS INC | 000899104 | COM | 1,153,468 | $16,909,841 | dollars as filed | |
| ENGENE HOLDINGS INC | 29286M105 | COM | 2,097,236 | $14,324,122 | dollars as filed | |
| ORCHESTRA BIOMED HOLDINGS IN | 68572M106 | COMMON STOCK | 5,292,556 | $13,125,539 | dollars as filed | |
| NURIX THERAPEUTICS INC | 67080M103 | COMMON STOCK | 1,416,149 | $13,085,217 | dollars as filed | |
| RAPPORT THERAPEUTICS INC COM | 75383L102 | Stock | 403,923 | $11,996,513 | dollars as filed | |
| OUTSET MED INC | 690145206 | COM NEW | 833,333 | $11,766,661 | dollars as filed | |
| NAUTILUS BIOTECHNOLOGY INC | 63909J108 | COM | 12,594,211 | $10,642,108 | dollars as filed | |
| CORVUS PHARMACEUTICALS INC | 221015100 | COM | 1,438,595 | $10,602,445 | dollars as filed | |
| KODIAK SCIENCES INC | 50015M109 | COM | 634,577 | $10,388,025 | dollars as filed | |
| SEPTERNA INC COM | 81734D104 | Stock | 541,450 | $10,184,675 | dollars as filed | |
| GOSSAMER BIO INC COM | 38341P102 | Stock | 3,812,797 | $10,027,656 | dollars as filed | |
| KYMERA THERAPEUTICS INC | 501575104 | COM | 169,796 | $9,610,454 | dollars as filed | |
| INHIBIKASE THERAPEUTICS INC | 45719W205 | COMMON STOCK | 5,421,568 | $8,782,940 | dollars as filed | |
| CELCUITY INC | 15102KAA8 | NOTE 2.750% 8/0 | 6,500,000 | $8,723,792 | dollars as filed | principal |
| CONTINEUM THERAPEUTICS INC CL A | 21217B100 | Stock | 714,592 | $8,396,456 | dollars as filed | |
| XENON PHARMACEUTICALS INC COM | 98420N105 | Stock | 200,791 | $8,061,759 | dollars as filed | |
| ANTERIS TECHNOLOGIES GLOBAL | 03675P102 | COMMON STOCK | 1,705,130 | $7,673,085 | dollars as filed | |
| JANUX THERAPEUTICS INC | 47103J105 | COM | 292,686 | $7,153,246 | dollars as filed | |
| OPUS GENETICS INC | 67577R102 | COMMON STOCK | 4,325,000 | $7,136,250 | dollars as filed | |
| TEMPUS AI INC CL A | 88023B103 | Stock | 85,000 | $6,860,350 | dollars as filed | |
| DYNE THERAPEUTICS INC COM | 26818M108 | Stock | 540,444 | $6,836,617 | dollars as filed | |
| KRYSTAL BIOTECH INC COM | 501147102 | Stock | 35,000 | $6,178,550 | dollars as filed | |
| BETA BIONICS INC | 08659B102 | COMMON STOCK | 277,944 | $5,522,747 | dollars as filed | |
| CRESCENT BIOPHARMA INC | G2545C104 | COMMON STOCK | 453,686 | $5,394,327 | dollars as filed | |
| HEARTFLOW INC | 42238D107 | COM | 150,000 | $5,049,000 | dollars as filed | |
| RAPT THERAPEUTICS INC | 75382E208 | COM NEW | 183,890 | $4,742,523 | dollars as filed | |
| PEPGEN INC COM | 713317105 | Stock | 829,870 | $3,833,999 | dollars as filed | |
| BELITE BIO INC | 07782B104 | CMN | 49,788 | $3,684,312 | dollars as filed | |
| SCPHARMACEUTICALS INC | 810648105 | COM | 583,142 | $3,306,415 | dollars as filed | |
| VIKING THERAPEUTICS INC | 92686J106 | COM | 105,597 | $2,775,089 | dollars as filed | |
| PYXIS ONCOLOGY INC COMMON STOCK | 747324101 | Stock | 1,178,307 | $2,615,842 | dollars as filed | |
| LeonaBio Inc | 04746L203 | COM | 540,296 | $2,236,825 | dollars as filed | |
| ARS PHARMACEUTICALS INC | 82835W108 | COM | 200,000 | $2,010,000 | dollars as filed | put |
| TRINITY BIOTECH INVT LTD | 896438504 | SPONS ADR NEW | 1,790,000 | $1,861,600 | dollars as filed | |
| AVALO THERAPEUTICS INC | 05338F306 | COMMON STOCK | 139,667 | $1,775,168 | dollars as filed | |
| ENVVENO MEDICAL CORPORATION | 29415J106 | COM | 1,759,035 | $1,593,686 | dollars as filed | |
| LYRA THERAPEUTICS INC | 55234L204 | COM NEW | 229,382 | $1,497,864 | dollars as filed | |
| UNIQURE NV | N90064101 | SHS | 20,000 | $1,167,400 | dollars as filed | |
| LEXEO THERAPEUTICS INC | 52886X107 | COMMON STOCK | 139,835 | $928,504 | dollars as filed | |
| BIODESIX INC COM | 09075X207 | Stock | 108,694 | $820,639 | dollars as filed | |
| ALTO NEUROSCIENCE INC COM SHS | 02157Q109 | Stock | 155,366 | $624,571 | dollars as filed | |
| APYX MEDICAL CORPORATION | 03837C106 | COM | 150,000 | $321,000 | dollars as filed | |
| ENSYSCE BIOSCIENCES INC | 293602504 | COM NEW | 86,666 | $205,398 | dollars as filed | |
| REVOLUTION MEDICINES INC | 76155X118 | *W EXP 12/17/202 | 250,000 | $74,975 | dollars as filed | |
| SURROZEN INC | 86889P117 | *W EXP 08/01/203 | 166,666 | $2,967 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001012975-25-000762 | this filing | 2025-11-14 | acceptance time not in the bulk data set |