13F-HR filed by HighVista Strategies LLC
HighVista Strategies LLC filed this 13F-HR for the quarter ended 2025-09-30, filed 2025-11-14, with 148 holding rows worth $407,965,963.
- Accession
- 0001172661-25-004799
- Filer
- CIK 1335325
- Filed
- 2025-11-14
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q3 2025
A holdings report, 148 entries on the cover page, a total value of $407,965,963 stated on the cover page (in dollars after the unit check, H1), rows summing to $407,965,963 with VALUE read as dollars as filed, 13F file number 028-14212. The quarter's positions are built on this report. The resolved quarter.
Other managers
- included managerHighVista Private Capital Management LLC
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| DB COMMODITY INDEX TRACKING | 46138B103 | ETF | 1,436,136 | $32,356,144 | dollars as filed | |
| ABIVAX SA- | 00370M103 | SPONSORED ADS | 184,468 | $15,661,333 | dollars as filed | |
| MERUS N V | N5749R100 | COM | 133,321 | $12,552,172 | dollars as filed | |
| VIRIDIAN THERAPEUTICS INC | 92790C104 | COM | 469,335 | $10,128,249 | dollars as filed | |
| REVOLUTION MEDICINES INC COM | 76155X100 | Stock | 175,448 | $8,193,421 | dollars as filed | |
| PROTAGONIST THERAPEUTICS | 74366E102 | COM | 121,682 | $8,083,335 | dollars as filed | |
| NUVALENT INC COM | 670703107 | Stock | 93,294 | $8,068,065 | dollars as filed | |
| MINERALYS THERAPEUTICS INC | 603170101 | COM | 209,829 | $7,956,715 | dollars as filed | |
| ARCELLX INC COMMON STOCK | 03940C100 | Stock | 96,177 | $7,896,131 | dollars as filed | |
| AGIOS PHARMACEUTICALS INC | 00847X104 | COM | 195,298 | $7,839,262 | dollars as filed | |
| CYTOKINETICS INC | 23282W605 | COM NEW | 132,930 | $7,305,833 | dollars as filed | |
| INSMED INC COM PAR $.01 | 457669307 | Stock | 49,949 | $7,193,155 | dollars as filed | |
| CIDARA THERAPEUTICS INC | 171757206 | COM NEW | 70,904 | $6,789,767 | dollars as filed | |
| COGENT BIOSCIENCES INC | 19240Q201 | COM | 462,405 | $6,640,136 | dollars as filed | |
| STRUCTURE THERAPEUTICS INC COMP | 86366E106 | EQUITY | 236,236 | $6,614,608 | dollars as filed | |
| Amazon.com, Inc | 023135106 | COM | 26,393 | $5,795,111 | dollars as filed | |
| SanDisk Corporation | 80004C200 | COM | 47,451 | $5,324,002 | dollars as filed | |
| ENLIVEN THERAPEUTICS INC COM | 29337E102 | Stock | 259,135 | $5,304,493 | dollars as filed | |
| AKERO THERAPEUTICS INC | 00973Y108 | COM | 110,079 | $5,226,551 | dollars as filed | |
| PRAXIS PRECISION MEDICINES I | 74006W207 | COM NEW | 95,002 | $5,035,106 | dollars as filed | |
| Microsoft Corp | 594918104 | COM | 9,458 | $4,898,771 | dollars as filed | |
| OLEMA PHARMACEUTICALS INC | 68062P106 | COM | 437,179 | $4,279,983 | dollars as filed | |
| BRIDGEBIO PHARMA INC | 10806X102 | COM | 81,959 | $4,256,950 | dollars as filed | |
| APOGEE THERAPEUTICS INC COM | 03770N101 | Stock | 107,107 | $4,255,361 | dollars as filed | |
| IMMUNOVANT INC | 45258J102 | COM | 253,127 | $4,080,408 | dollars as filed | |
| XOMA ROYALTY CORPORATION | 98419J206 | COMMON STOCK | 105,714 | $4,074,218 | dollars as filed | |
| GUARDANT HEALTH INC COM | 40131M109 | Stock | 64,583 | $4,035,146 | dollars as filed | |
| LIQUIDIA CORPORATION COM NEW | 53635D202 | Stock | 176,485 | $4,013,269 | dollars as filed | |
| RHYTHM PHARMACEUTICALS INC | 76243J105 | COM | 37,482 | $3,785,307 | dollars as filed | |
| SPYRE THERAPEUTICS INC | 00773J202 | COM NEW | 215,746 | $3,615,903 | dollars as filed | |
| CELLDEX THERAPEUTICS INC NEW | 15117B202 | COM NEW | 135,258 | $3,499,124 | dollars as filed | |
| GH RESEARCH PLC ORDINARY SHARES | G3855L106 | Stock | 241,894 | $3,459,085 | dollars as filed | |
| EDGEWISE THERAPEUTICS INC | 28036F105 | COM | 208,101 | $3,375,398 | dollars as filed | |
| Broadcom Inc. | 11135F101 | COM | 10,200 | $3,365,082 | dollars as filed | |
| META PLATFORMS INC CL A | 30303M102 | COM | 4,500 | $3,304,710 | dollars as filed | |
| XENON PHARMACEUTICALS INC COM | 98420N105 | Stock | 82,190 | $3,299,929 | dollars as filed | |
| APELLIS PHARMACEUTICALS INC | 03753U106 | COM | 145,729 | $3,297,847 | dollars as filed | |
| VAXCYTE INC COM | 92243G108 | Stock | 86,802 | $3,126,608 | dollars as filed | |
| Salesforce.com, Inc | 79466L302 | COM | 12,885 | $3,053,745 | dollars as filed | |
| ARGENX SE SPONSORED ADR | 04016X101 | ADR | 4,068 | $3,000,394 | dollars as filed | |
| AVIDITY BIOSCIENCES INC COM | 05370A108 | Stock | 65,580 | $2,857,321 | dollars as filed | |
| Advanced Micro Devices,Inc. | 007903107 | COM | 17,200 | $2,782,788 | dollars as filed | |
| XPO INC COM | 983793100 | Stock | 21,080 | $2,725,012 | dollars as filed | |
| UNITY SOFTWARE INC COM | 91332U101 | Stock | 67,229 | $2,691,849 | dollars as filed | |
| Visa Inc | 92826C839 | COM | 7,861 | $2,683,588 | dollars as filed | |
| VERA THERAPEUTICS INC | 92337R101 | COMMON STOCK | 91,189 | $2,649,952 | dollars as filed | |
| CONSTELLATION ENERGY CORP COM | 21037T109 | Stock | 7,600 | $2,500,932 | dollars as filed | |
| NVIDIA Corp | 67066G104 | COM | 13,400 | $2,500,172 | dollars as filed | |
| HEWLETT PACKARD ENTERPRISE CO COM | 42824C109 | Stock | 98,700 | $2,424,072 | dollars as filed | |
| MasterCard, Inc | 57636Q104 | COM | 4,205 | $2,391,846 | dollars as filed | |
| Alphabet Inc. Reg. Shares C | 02079K107 | COM | 9,800 | $2,386,790 | dollars as filed | |
| CRH PLC ORD | G25508105 | Stock | 19,439 | $2,330,736 | dollars as filed | |
| SCHOLAR ROCK HLDG CORP | 80706P103 | COM | 59,573 | $2,218,498 | dollars as filed | |
| FERGUSON ENTERPRISES INC COMMON STOCK NEW | 31488V107 | Stock | 9,678 | $2,173,485 | dollars as filed | |
| TALEN ENERGY CORP COM | 87422Q109 | Stock | 5,100 | $2,169,438 | dollars as filed | |
| QUANTA SVCS INC | 74762E102 | COM | 5,200 | $2,154,984 | dollars as filed | |
| AVANTOR INC COM | 05352A100 | Stock | 172,400 | $2,151,552 | dollars as filed | |
| DIANTHUS THERAPEUTICS INC | 252828108 | COM | 54,225 | $2,133,754 | dollars as filed | |
| CLEAN HARBORS INC COM | 184496107 | Stock | 9,106 | $2,114,595 | dollars as filed | |
| LUMENTUM HLDGS INC COM | 55024U109 | Stock | 12,927 | $2,103,352 | dollars as filed | |
| FLOWSERVE CORP | 34354P105 | COM | 38,975 | $2,071,131 | dollars as filed | |
| CAPITAL ONE FINL CORP | 14040H105 | COM | 9,674 | $2,056,499 | dollars as filed | |
| COMPANIA DE MINAS BUENAVENTU | 204448104 | SPONSORED ADR | 82,931 | $2,017,712 | dollars as filed | |
| WORKDAY INC CL A | 98138H101 | Stock | 8,191 | $1,971,820 | dollars as filed | |
| PTC INC COM | 69370C100 | Stock | 9,522 | $1,933,156 | dollars as filed | |
| ARGAN INC | 04010E109 | COM | 7,100 | $1,917,355 | dollars as filed | |
| DYNAVAX TECHNOLOGIES CORP | 268158201 | COM NEW | 192,849 | $1,914,991 | dollars as filed | |
| AMPHENOL CORP NEW | 032095101 | COM | 15,400 | $1,905,750 | dollars as filed | |
| FABRINET SHS | G3323L100 | Stock | 5,100 | $1,859,562 | dollars as filed | |
| BANCO BRADESCO S A | 059460303 | SP ADR PFD NEW | 520,100 | $1,757,938 | dollars as filed | |
| NU HLDGS LTD | G6683N103 | ORD SHS CL A | 109,337 | $1,750,486 | dollars as filed | |
| QXO INC COM NEW | 82846H405 | Stock | 90,200 | $1,719,212 | dollars as filed | |
| WESTERN DIGITAL CORP | 958102105 | COM | 14,242 | $1,709,894 | dollars as filed | |
| EVERPURE INC CL A | 74624M102 | Stock | 20,400 | $1,709,724 | dollars as filed | |
| KBR INC COM | 48242W106 | Stock | 35,500 | $1,678,795 | dollars as filed | |
| PETROLEO BRASILEIRO S A | 71654V101 | SP ADR NON VTG | 138,200 | $1,633,524 | dollars as filed | |
| SEAGATE TECHNOLOGY HLDNGS | G7997R103 | ORD SHS | 6,898 | $1,628,342 | dollars as filed | |
| API GROUP CORP COM STK | 00187Y100 | Stock | 47,350 | $1,627,419 | dollars as filed | |
| MADRIGAL PHARMACEUTICALS INC COM | 558868105 | Stock | 3,537 | $1,622,280 | dollars as filed | |
| CENTESSA PHARMACEUTICALS PLC | 152309100 | SPONSORED ADS | 63,301 | $1,535,049 | dollars as filed | |
| CORE & MAIN INC CL A | 21874C102 | Stock | 27,900 | $1,501,857 | dollars as filed | |
| ROIVANT SCIENCES LTD | G76279101 | SHS | 98,858 | $1,495,722 | dollars as filed | |
| CORBUS PHARMACEUTICALS | 21833P301 | COM NEW | 118,027 | $1,493,041 | dollars as filed | |
| Cisco Systems,Inc. | 17275R102 | COM | 21,800 | $1,491,556 | dollars as filed | |
| Intuit Inc. | 461202103 | COM | 2,163 | $1,477,135 | dollars as filed | |
| TARSUS PHARMACEUTICALS INC | 87650L103 | COMMON STOCK | 24,854 | $1,477,073 | dollars as filed | |
| ENTEGRIS INC COM | 29362U104 | Stock | 15,700 | $1,451,622 | dollars as filed | |
| REDDIT INC CL A | 75734B100 | Stock | 6,300 | $1,448,937 | dollars as filed | |
| MASTEC INC COM | 576323109 | Stock | 6,700 | $1,425,827 | dollars as filed | |
| Bank of America Corp | 060505104 | COM | 27,500 | $1,418,725 | dollars as filed | |
| ASCENDIS PHARMA A/S DKK 1.0 AD | 04351P101 | SPONSORED ADR | 7,082 | $1,407,972 | dollars as filed | |
| ADMA BIOLOGICS INC | 000899104 | COM | 95,112 | $1,394,342 | dollars as filed | |
| EVOLUS INC | 30052C107 | COM | 226,025 | $1,387,793 | dollars as filed | |
| RBC BEARINGS INC COM | 75524B104 | Stock | 3,500 | $1,366,015 | dollars as filed | |
| ORTHOFIX MED INC | 68752M108 | COM | 93,200 | $1,364,448 | dollars as filed | |
| Progressive Corporation | 743315103 | COM | 5,500 | $1,358,225 | dollars as filed | |
| JANUX THERAPEUTICS INC | 47103J105 | COM | 55,250 | $1,350,310 | dollars as filed | |
| CORE SCIENTIFIC INC NEW | 21874A106 | COM | 75,163 | $1,348,425 | dollars as filed | |
| Charles Schwab Corp | 808513105 | COM | 14,100 | $1,346,127 | dollars as filed | |
| ALKERMES PLC | G01767105 | SHS | 44,081 | $1,322,430 | dollars as filed | |
| KEROS THERAPEUTICS INC COM | 492327101 | Stock | 83,050 | $1,313,851 | dollars as filed | |
| CORPORACION AMER ARPTS S A | L1995B107 | COM | 71,400 | $1,293,768 | dollars as filed | |
| SOLENO THERAPEUTICS INC | 834203309 | COM | 18,700 | $1,264,120 | dollars as filed | |
| RELAY THERAPEUTICS INC COM | 75943R102 | Stock | 240,459 | $1,255,196 | dollars as filed | |
| OCULAR THERAPEUTIX INC | 67576A100 | COM | 106,611 | $1,246,283 | dollars as filed | |
| RXO, Inc. | 74982T103 | Common Stock, $0.01 par value | 80,900 | $1,244,242 | dollars as filed | |
| JOHNSON CTLS INTL PLC SHS | G51502105 | Stock | 11,100 | $1,220,445 | dollars as filed | |
| ROBLOX CORP CL A | 771049103 | Stock | 8,700 | $1,205,124 | dollars as filed | |
| NextEra Energy,Inc. | 65339F101 | COM | 15,752 | $1,189,119 | dollars as filed | |
| 3M CO COM | 88579Y101 | Stock | 7,600 | $1,179,368 | dollars as filed | |
| MERCADOLIBREINC | 58733R102 | STOK | 500 | $1,168,470 | dollars as filed | |
| CAESARS ENTERTAINMENT INC NE | 12769G100 | COM | 43,000 | $1,162,075 | dollars as filed | |
| AXSOME THERAPEUTICS INC. COM | 05464T104 | Stock | 9,348 | $1,135,314 | dollars as filed | |
| ICICI BANK LIMITED ADR | 45104G104 | ADR | 37,047 | $1,119,931 | dollars as filed | |
| HDFC BANK LTD SPONSORED ADS | 40415F101 | ADR | 32,682 | $1,116,417 | dollars as filed | |
| AUTOLIV INC | 052800109 | COM | 8,700 | $1,074,450 | dollars as filed | |
| NATERA INC COM | 632307104 | Stock | 6,580 | $1,059,182 | dollars as filed | |
| CG ONCOLOGY INC | 156944100 | COMMON STOCK | 26,040 | $1,048,891 | dollars as filed | |
| PENNYMAC FINL SVCS INC NEW | 70932M107 | COM | 8,337 | $1,032,787 | dollars as filed | |
| MAGNERA CORP | 55939A107 | COMMON STOCK | 87,100 | $1,020,812 | dollars as filed | |
| GE Vernova Inc. | 36828A101 | COM | 1,650 | $1,014,585 | dollars as filed | |
| CNX RES CORP COM | 12653C108 | Stock | 31,300 | $1,005,356 | dollars as filed | |
| SHIFT4 PMTS INC CL A | 82452J109 | Stock | 12,500 | $967,500 | dollars as filed | |
| TYRA BIOSCIENCES INC | 90240B106 | COMMON STOCK | 65,812 | $920,710 | dollars as filed | |
| SEA LTD | 81141R100 | SPONSORD ADS | 5,141 | $918,851 | dollars as filed | |
| AFFIRM HLDGS INC COM CL A | 00827B106 | Stock | 12,500 | $913,500 | dollars as filed | |
| NEWAMSTERDAM PHARMA CO NV | N62509109 | COMMON STOCK | 31,831 | $905,274 | dollars as filed | |
| ENTERGY CORP NEW COM | 29364G103 | Stock | 9,600 | $894,624 | dollars as filed | |
| KYMERA THERAPEUTICS INC | 501575104 | COM | 15,728 | $890,204 | dollars as filed | |
| Booking Holdings Inc. | 09857L108 | COM | 157 | $847,686 | dollars as filed | |
| CYTOMX THERAPEUTICS INC | 23284F105 | COMMON STOCK | 257,148 | $820,302 | dollars as filed | |
| JD.COM INC SPON ADS CL A | 47215P106 | ADR | 23,383 | $817,937 | dollars as filed | |
| COUPANG INC | 22266T109 | CL A | 24,050 | $774,410 | dollars as filed | |
| TRIP COM GROUP LTD ADS | 89677Q107 | ADR | 9,756 | $733,651 | dollars as filed | |
| CELCUITY INC | 15102K100 | COM | 13,680 | $675,792 | dollars as filed | |
| ALIBABA GROUP HLDG LTD | 01609W102 | SPONSORED ADS | 3,757 | $671,488 | dollars as filed | |
| UROGEN PHARMA LTD | M96088105 | COMMON STOCK | 31,886 | $636,125 | dollars as filed | |
| NEBIUS GROUP N.V. | N97284108 | SHS CLASS A | 5,200 | $583,804 | dollars as filed | |
| ALCON AG ORD SHS | H01301128 | Stock | 7,862 | $465,902 | dollars as filed | |
| KANZHUN LIMITED | 48553T106 | SPONSORED ADS | 18,900 | $441,504 | dollars as filed | |
| WAVE LIFE SCIENCES LTD SHS | Y95308105 | Stock | 59,261 | $433,790 | dollars as filed | |
| NOKIA CORP | 654902204 | SPONSORED ADR | 82,900 | $398,749 | dollars as filed | |
| AVALO THERAPEUTICS INC | 05338F306 | COMMON STOCK | 27,778 | $353,058 | dollars as filed | |
| INHIBRX BIOSCIENCES INC | 45720N103 | COM | 7,626 | $256,844 | dollars as filed | |
| TAL ED GROUP SPONSORED ADS | 874080104 | ADR | 19,600 | $219,520 | dollars as filed | |
| KE HLDGS INC SPONSORED ADS | 482497104 | ADR | 11,400 | $216,600 | dollars as filed | |
| AURA BIOSCIENCES INC | 05153U107 | COMMON STOCK | 27,174 | $167,935 | dollars as filed | |
| MOONLAKE IMMUNOTHERAPEUTICS CLASS A ORD | 61559X104 | Stock | 19,059 | $136,653 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001172661-25-004799 | this filing | 2025-11-14 | acceptance time not in the bulk data set |