13F-HR filed by RA CAPITAL MANAGEMENT, L.P.
RA CAPITAL MANAGEMENT, L.P. filed this 13F-HR for the quarter ended 2025-09-30, filed 2025-11-14, with 67 holding rows worth $8,115,527,458.
- Accession
- 0001104659-25-112469
- Filer
- CIK 1346824
- Filed
- 2025-11-14
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q3 2025
A holdings report, 68 entries on the cover page, a total value of $8,115,527,458 stated on the cover page (in dollars after the unit check, H1), rows summing to $8,115,527,458 with VALUE read as dollars as filed, 13F file number 028-12884. The quarter's positions are built on this report. The resolved quarter.
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| ASCENDIS PHARMA A/S DKK 1.0 AD | 04351P101 | SPONSORED ADR | 10,281,496 | $2,044,064,220 | dollars as filed | |
| RHYTHM PHARMACEUTICALS INC | 76243J105 | COM | 5,681,359 | $573,760,445 | dollars as filed | |
| VAXCYTE INC COM | 92243G108 | Stock | 11,965,991 | $431,014,996 | dollars as filed | |
| AVIDITY BIOSCIENCES INC COM | 05370A108 | Stock | 8,641,031 | $376,489,721 | dollars as filed | |
| CIDARA THERAPEUTICS INC | 171757206 | COM NEW | 3,365,523 | $322,282,482 | dollars as filed | |
| SIONNA THERAPEUTICS INC | 829401108 | COMMON STOCK | 10,445,322 | $307,196,920 | dollars as filed | |
| 89BIO INC | 282559103 | COM | 19,889,683 | $292,378,340 | dollars as filed | |
| NEWAMSTERDAM PHARMA CO NV | N62509109 | COMMON STOCK | 10,138,938 | $288,351,397 | dollars as filed | |
| MINERALYS THERAPEUTICS INC | 603170101 | COM | 7,323,750 | $277,716,600 | dollars as filed | |
| JANUX THERAPEUTICS INC | 47103J105 | COM | 11,189,693 | $273,476,097 | dollars as filed | |
| ARCELLX INC COMMON STOCK | 03940C100 | Stock | 3,036,527 | $249,298,867 | dollars as filed | |
| LENZ THERAPEUTICS INC | 52635N103 | COM | 4,178,823 | $194,649,575 | dollars as filed | |
| TYRA BIOSCIENCES INC | 90240B106 | COMMON STOCK | 12,198,625 | $170,658,764 | dollars as filed | |
| EDGEWISE THERAPEUTICS INC | 28036F105 | COM | 10,428,437 | $169,149,248 | dollars as filed | |
| WAVE LIFE SCIENCES LTD SHS | Y95308105 | Stock | 18,202,009 | $133,238,706 | dollars as filed | |
| SEPTERNA INC COM | 81734D104 | Stock | 6,995,858 | $131,592,089 | dollars as filed | |
| DIANTHUS THERAPEUTICS INC | 252828108 | COM | 2,866,733 | $112,805,944 | dollars as filed | |
| BICARA THERAPEUTICS INC | 055477103 | COM | 6,955,993 | $109,835,129 | dollars as filed | |
| GH RESEARCH PLC ORDINARY SHARES | G3855L106 | Stock | 7,676,697 | $109,776,767 | dollars as filed | |
| ARS PHARMACEUTICALS INC | 82835W108 | COM | 10,860,977 | $109,152,819 | dollars as filed | |
| NUVALENT INC COM | 670703107 | Stock | 1,246,456 | $107,793,515 | dollars as filed | |
| DISC MEDICINE INC COM | 254604101 | Stock | 1,577,106 | $104,215,164 | dollars as filed | |
| VOR BIOPHARMA INC | 929033207 | COMMON STOCK | 1,982,301 | $96,577,705 | dollars as filed | |
| FULCRUM THERAPEUTICS INC | 359616109 | COMMON STOCK | 10,229,099 | $94,107,711 | dollars as filed | |
| PEPGEN INC COM | 713317105 | Stock | 20,064,545 | $92,698,198 | dollars as filed | |
| GERON CORP | 374163103 | COM | 60,379,366 | $82,719,731 | dollars as filed | |
| TAYSHA GENE THERAPIES INC | 877619106 | COMMON STOCK | 23,555,648 | $77,026,969 | dollars as filed | |
| BELITE BIO INC | 07782B104 | CMN | 875,000 | $64,750,000 | dollars as filed | |
| CLIMB BIO INC | 28658R106 | COMMON STOCK | 31,419,267 | $63,152,727 | dollars as filed | |
| SCHOLAR ROCK HLDG CORP | 80706P103 | COM | 1,166,788 | $43,451,185 | dollars as filed | |
| STRUCTURE THERAPEUTICS INC COMP | 86366E106 | EQUITY | 1,517,418 | $42,487,704 | dollars as filed | |
| MONOPAR THERAPEUTICS INC | 61023L207 | COMMON STOCK | 511,207 | $41,750,276 | dollars as filed | |
| 4D MOLECULAR THERAPEUTICS INC COM | 35104E100 | Stock | 4,563,211 | $39,654,304 | dollars as filed | |
| SOLID BIOSCIENCES INC | 83422E204 | COMMON STOCK | 5,811,423 | $35,856,480 | dollars as filed | |
| METSERA INC | 59267L107 | COM | 675,525 | $35,350,223 | dollars as filed | |
| ARTIVA BIOTHERAPEUTICS INC | 04317A107 | COM | 9,853,302 | $28,278,977 | dollars as filed | |
| LB PHARMACEUTICALS INC | 50180M108 | COMMON STOCK | 1,776,958 | $28,058,167 | dollars as filed | |
| TRAVERE THERAPEUTICS INC | 89422G107 | COM | 1,150,000 | $27,485,000 | dollars as filed | |
| ASSEMBLY BIOSCIENCES INC | 045396207 | COMMON STOCK | 1,020,410 | $26,122,496 | dollars as filed | |
| ACUMEN PHARMACEUTICALS INC | 00509G209 | CMN | 14,932,063 | $25,533,828 | dollars as filed | |
| CONTINEUM THERAPEUTICS INC CL A | 21217B100 | Stock | 2,122,000 | $24,933,500 | dollars as filed | |
| NKARTA INC | 65487U108 | COMMON STOCK | 10,805,129 | $22,366,617 | dollars as filed | |
| LARIMAR THERAPEUTICS INC | 517125100 | COM | 6,045,351 | $19,526,484 | dollars as filed | |
| INVIVYD INC | 00534A102 | COMMON STOCK | 17,119,096 | $18,831,006 | dollars as filed | |
| TANGO THERAPEUTICS INC | 87583X109 | COM | 2,000,000 | $16,800,000 | dollars as filed | |
| PRIME MEDICINE INC | 74168J101 | COM | 3,000,000 | $16,620,000 | dollars as filed | |
| ARCUS BIOSCIENCES INC | 03969F109 | COM | 1,136,364 | $15,454,550 | dollars as filed | |
| ACRIVON THERAPEUTICS INC | 004890109 | CMN | 8,340,508 | $15,096,319 | dollars as filed | |
| WEREWOLF THERAPEUTICS INC | 95075A107 | CMN | 6,681,307 | $13,162,175 | dollars as filed | |
| UNIQURE NV | N90064101 | SHS | 200,000 | $11,674,000 | dollars as filed | |
| ELEDON PHARMACEUTICALS INC | 28617k101 | COM | 3,566,338 | $9,236,815 | dollars as filed | |
| JADE BIOSCIENCES INC | 008064206 | COM NEW | 1,062,326 | $9,167,873 | dollars as filed | |
| SAB BIOTHERAPEUTICS INC | 78397T202 | COMMON STOCK | 4,401,500 | $8,847,015 | dollars as filed | |
| INSPIRE MED SYS INC COM | 457730109 | Stock | 114,901 | $8,525,654 | dollars as filed | |
| CYTOMX THERAPEUTICS INC | 23284F105 | COMMON STOCK | 2,661,331 | $8,489,646 | dollars as filed | |
| AVALO THERAPEUTICS INC | 05338F306 | COMMON STOCK | 662,968 | $8,426,323 | dollars as filed | |
| PERCEPTIVE CAPITAL SOLUTIONS | G70077105 | CL A ORD SHS | 750,000 | $7,950,000 | dollars as filed | |
| SURROZEN INC | 86889P208 | COMMON STOCK | 602,626 | $7,764,836 | dollars as filed | |
| GENEDX HOLDINGS CORP | 81663L200 | COM CL A | 58,044 | $6,253,661 | dollars as filed | |
| ADICET BIO INC | 007002108 | COM | 7,541,000 | $6,109,718 | dollars as filed | |
| NEWAMSTERDAM PHARMA CO NV-27 | N62509117 | WTS | 333,333 | $5,703,328 | dollars as filed | |
| EVOLENT HEALTH INC CL A | 30050B101 | Stock | 579,052 | $4,898,780 | dollars as filed | |
| GLAUKOS CORP COM | 377322102 | Stock | 54,180 | $4,418,379 | dollars as filed | |
| DESIGN THERAPEUTICS INC | 25056L103 | COM | 475,699 | $3,582,013 | dollars as filed | |
| EXACT SCIENCES CORP COM | 30063P105 | Stock | 54,939 | $3,005,713 | dollars as filed | |
| Inflarx Nv | N44821101 | COM | 1,973,233 | $2,644,132 | dollars as filed | |
| PROGYNY INC COM | 74340E103 | Stock | 96,628 | $2,079,435 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001104659-25-112469 | this filing | 2025-11-14 | acceptance time not in the bulk data set |