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Disclosery

KRYS KRYSTAL BIOTECH INC

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Stock (common), issuer CIK 1711279

329 managers (336 13F filers) reported a position in KRYS shares at 2025-12-31, 28,425,252 shares in all. 63 filers opened a position and 27 filers sold out during the quarter.

Managers
329
13F filers
336
New
63
Added
111
Reduced
105
Sold out
27
Shares held by filers
28,425,252

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q4 2025

Filers in the available 13F reports with a share position at 2025-12-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
FMR LLCin group FMR LLC4,349,628$1.07B0.05%+8,18113F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.3,937,817$971M0.02%+103,68913F-HRTimelineGroup
Avoro Capital Advisors LLC2,888,888$712M7%+111,11113F-HR/ATimeline
VANGUARD GROUP INCgroup of 2 filers holding2,780,972$686M-13,247Timeline
STATE STREET CORPin group STATE STREET CORP1,342,303$331M0.01%-53,66413F-HRTimelineGroup
Soleus Capital Management, L.P.941,059$232M9.84%-77,77213F-HRTimeline
Capital World Investors809,500$200M0.03%+26013F-HRTimeline
Redmile Group, LLCin group Redmile Group, LLC677,705$167M12.3%+16,31713F-HRTimelineGroup
Hood River Capital Management LLC613,302$151M1.66%+6,35613F-HRTimeline
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC611,878$151M0.01%+63413F-HRTimelineGroup
PRICE T ROWE ASSOCIATES INC /MD/529,955$131M0.01%+62,89713F-HRTimeline
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP492,968$122M0.03%-40,99613F-HRTimelineGroup
Frazier Life Sciences Management, L.P.488,460$120M3.23%-200,00013F-HRTimeline
Bellevue Group AGin group Bellevue Group AG410,323$101M1.92%+409,01113F-HRTimelineGroup
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC386,505$95.3M0.06%-250,48313F-HRTimelineGroup
WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC376,340$92.8M0.26%+227,03813F-HRTimeline
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC293,525$72.4M0.01%-54,72513F-HR/ATimelineGroup
NORGES BANK284,573$70.2M0.01%new13F-HRTimeline
NORTHERN TRUST CORPin group NORTHERN TRUST CORP247,443$61M0.01%-72213F-HRTimelineGroup
FIRST TRUST ADVISORS LPin group FIRST TRUST ADVISORS LP245,276$60.5M0.04%-3,11613F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co242,774$59.9M0.01%-8913F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY221,481$54.6M<0.01%-13,09713F-HR/ATimelineGroup
JANUS HENDERSON GROUP PLCin group Janus Henderson219,440$54.1M0.02%+209,36913F-HRTimelineGroup
BRAIDWELL LP202,101$49.8M1.59%-318,30013F-HRTimeline
UBS Group AGgroup of 2 filers holding193,212$47.6M-139,550Timeline
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/190,807$47M<0.01%+52,81213F-HRTimelineGroup
Nuveen, LLCin group TIAA189,094$46.6M0.01%-8,28413F-HRTimelineGroup
MARSHALL WACE, LLPin group MARSHALL WACE, LLP183,754$45.3M0.04%+54,79413F-HRTimelineGroup
PRINCIPAL FINANCIAL GROUP INCgroup of 2 filers holding165,074$40.7M+22,214Timeline
Pictet Asset Management Holding SAin group Pictet Asset Management Holdi…156,568$38.6M0.04%-40,33613F-HRTimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp151,313$37.3M0.01%-4,24013F-HRTimelineGroup
Woodline Partners LP150,616$37.1M0.14%013F-HRTimeline
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO134,624$33.2M<0.01%-11,73013F-HRTimelineGroup
FRANKLIN RESOURCES INCin group Franklin Resources125,675$31M0.01%+105,82513F-HRTimelineGroup
ORBIMED ADVISORS LLCin group ORBIMED ADVISORS LLC119,800$29.5M0.6%+17,05513F-HRTimelineGroup
Handelsbanken Fonder AB105,800$26.1M0.08%+39,00013F-HRTimeline
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC103,261$25.5M0.03%+9,35313F-HRTimelineGroup
TimesSquare Capital Management, LLC97,400$24M0.36%-21,11413F-HRTimeline
S SQUARED TECHNOLOGY, LLC96,215$23.7M9.19%-13,00013F-HRTimeline
Public Sector Pension Investment Board89,362$22M0.07%-11,06913F-HRTimeline
C WorldWide Group Holding A/Sin group C WorldWide Group Holding A/S85,809$21.2M0.37%013F-HRTimelineGroup
SEGALL BRYANT & HAMILL, LLC83,246$20.5M0.28%-2,01713F-HRTimeline
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC76,538$19M0.01%+12,17513F-HRTimelineGroup
Biondo Investment Advisors, LLC68,130$16.8M2.03%+16,24513F-HRTimeline
RHUMBLINE ADVISERS66,436$16.4M0.01%-4,11613F-HRTimeline
Legal & General Group Plcin group Legal & General Group Plc63,361$15.6M<0.01%-2,45413F-HRTimelineGroup
ACT CAPITAL MANAGEMENT, LLC60,500$14.9M12.06%13F-HRTimeline
BARCLAYS PLCin group BARCLAYS PLC60,062$14.8M0.01%-15,83413F-HRTimelineGroup
Invesco Ltd.in group Invesco Ltd.60,008$14.8M<0.01%-6,87213F-HRTimelineGroup
TD Asset Management Inc54,142$13.3M0.01%+9,06213F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS53,911$13.3M0.01%+44,73213F-HRTimelineGroup
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC52,345$12.9M<0.01%-3,44713F-HRTimelineGroup
Skandinaviska Enskilda Banken AB (publ)46,732$11.5M0.05%-13,24613F-HRTimeline
Swiss National Bank42,900$10.6M0.01%+90013F-HRTimeline
Palisades Investment Partners, LLC42,765$10.5M3.98%+1,37613F-HRTimeline
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …40,629$10.1M0.01%+6,17413F-HRTimelineGroup
Aberdeen Group plcin group Aberdeen Group plc39,360$9.7M0.02%-20,01213F-HRTimelineGroup
Corient Private Wealth LPin group Corient Private Wealth LP38,346$9.5M0.01%-78413F-HR/ATimelineGroup
MUTUAL OF AMERICA CAPITAL MANAGEMENT LLCin group MUTUAL OF AMERICA CAPITAL MAN…37,269$9.19M0.1%-66513F-HRTimelineGroup
FEDERATED HERMES, INC.in group FEDERATED HERMES, INC.34,541$8.52M0.01%+10,56013F-HRTimelineGroup
Atle Fund Management AB33,853$8.35M2.66%-8,33813F-HRTimeline
SEI INVESTMENTS COin group SEI INVESTMENTS CO32,310$7.97M0.01%+8,91713F-HRTimelineGroup
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN31,572$7.78M<0.01%+11,91913F-HRTimelineGroup
ALLIANCEBERNSTEIN L.P.31,529$7.77M<0.01%+1,60913F-HRTimeline
NEW YORK STATE COMMON RETIREMENT FUND31,342$7.73M0.01%+4,34813F-HRTimeline
CITIGROUP INCin group CITIGROUP INC29,943$7.38M0.01%+20,29313F-HRTimelineGroup
CASTLEARK MANAGEMENT LLC29,260$7.21M0.21%new13F-HRTimeline
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…28,954$7.14M0.01%+2,40513F-HRTimelineGroup
PRUDENTIAL FINANCIAL INCin group PRUDENTIAL FINANCIAL INC27,015$6.66M0.01%+1,51913F-HRTimelineGroup
VICTORY CAPITAL MANAGEMENT INC26,461$6.52M<0.01%-28,35513F-HRTimeline
Granite Investment Partners, LLC25,760$6.35M0.38%new13F-HRTimeline
Rhenman & Partners Asset Management AB25,000$6.16M0.58%+13,25013F-HRTimeline
Informed Momentum Co LLC24,667$6.08M0.68%new13F-HRTimeline
Rafferty Asset Management, LLC24,268$5.98M0.02%-10,37213F-HRTimeline
EFG International AGin group EFG International AG23,569$5.82M0.11%13F-HRTimelineGroup
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\22,450$5.53M<0.01%+1,07113F-HRTimelineGroup
CANADA LIFE ASSURANCE Coin group CANADA LIFE ASSURANCE Co22,087$5.45M0.01%+68913F-HRTimelineGroup
Elmind Capital, LP22,000$5.42M1.6%13F-HRTimeline
CALIFORNIA STATE TEACHERS RETIREMENT SY…20,583$5.07M0.01%-29913F-HRTimeline
BESSEMER GROUP INCin group BESSEMER GROUP INC20,260$5M0.01%+20,11113F-HRTimelineGroup
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC20,014$4.93M0.37%+1,49113F-HR/ATimelineGroup
GW&K Investment Management, LLC19,581$4.83M0.04%+9,08913F-HRTimeline
SG Americas Securities, LLC18,909$4.66M0.01%+15,59113F-HRTimeline
Fiera Capital Corpin group Fiera Capital Corp18,857$4.65M0.01%+3,79413F-HRTimelineGroup
State of Alaska, Department of Revenue17,902$4.41M0.05%+3,62813F-HRTimeline
Thrivent Financial for Lutheransin group Thrivent Financial for Luther…17,734$4.37M0.01%-85013F-HRTimelineGroup
1832 Asset Management L.P.17,600$4.34M0.01%new13F-HRTimeline
PERCEPTIVE ADVISORS LLCin group PERCEPTIVE ADVISORS LLC17,500$4.31M0.08%-17,50013F-HRTimelineGroup
Decheng Capital LLC17,300$4.27M0.57%-15,00013F-HRTimeline
Pinnacle Financial Partners, Inc.in group Pinnacle Financial Partners, …16,983$4.19M0.03%13F-HR/ATimelineGroup
Verition Fund Management LLC16,969$4.18M0.02%-14,36413F-HRTimeline
Evolutionary Tree Capital Management, L…16,811$4.14M4.81%+4,35013F-HRTimeline
STATE BOARD OF ADMINISTRATION OF FLORID…15,756$3.88M0.01%+9,97113F-HRTimeline
NEW YORK STATE TEACHERS RETIREMENT SYST…15,650$3.86M0.01%+10013F-HRTimeline
Ikarian Capital, LLCin group Ikarian Capital, LLC14,814$3.65M0.47%-9,60713F-HRTimelineGroup
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC14,658$3.61M<0.01%-134,05513F-HRTimelineGroup
Natixis Investment Managersgroup of 2 filers holding14,602$3.6M+14,480Timeline
STATE OF WISCONSIN INVESTMENT BOARD14,466$3.57M0.01%-14,87413F-HRTimeline
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding14,363$3.54M-46Timeline
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC14,157$3.49M<0.01%-5,97613F-HRTimelineGroup
Creative Planningin group Creative Planning13,881$3.42M<0.01%+2,27213F-HRTimelineGroup
MetLife Investment Management, LLCin group MetLife Investment Management…13,844$3.41M0.02%-58613F-HRTimelineGroup
CREDIT AGRICOLE S Ain group CREDIT AGRICOLE S A12,976$3.2M0.01%new13F-HRTimelineGroup
Illinois Municipal Retirement Fund12,699$3.13M0.04%-1,54613F-HRTimeline
Privium Fund Management B.V.12,170$3M0.55%013F-HRTimeline
Bridge City Capital, LLC12,135$2.99M0.88%-2,01913F-HRTimeline
Torray Investment Partners LLC11,985$2.95M0.42%+8413F-HRTimeline
Tetragon Partners GP Ltdin group Tetragon Partners GP Ltd11,814$2.91M0.61%+6,94413F-HRTimelineGroup
Louisiana State Employees Retirement Sy…11,800$2.91M0.05%013F-HRTimeline
State of Tennessee, Department of Treas…10,193$2.85M0.01%-92513F-HRTimeline
DekaBank Deutsche Girozentrale15,503$2.63M<0.01%013F-HRTimeline
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…10,651$2.63M<0.01%-23013F-HRTimelineGroup
ENVESTNET ASSET MANAGEMENT INCin group ENVESTNET ASSET MANAGEMENT INC10,577$2.61M<0.01%-2,53113F-HRTimelineGroup
Main Management ETF Advisors, LLCin group Main Management ETF Advisors,…10,179$2.51M0.09%+10413F-HRTimelineGroup
Bridgewater Associates, LP10,015$2.47M0.01%+29213F-HRTimeline
PROFUND ADVISORS LLC9,887$2.44M0.07%+1,55713F-HRTimeline
COMMONWEALTH EQUITY SERVICES, LLC9,887$2.44M<0.01%-11913F-HRTimeline
INTECH INVESTMENT MANAGEMENT LLC9,751$2.4M0.02%013F-HRTimeline
NOMURA ASSET MANAGEMENT CO LTDgroup of 2 filers holding9,591$2.37M+9,591Timeline
VIRGINIA RETIREMENT SYSTEMS ET Al9,000$2.22M0.01%+7,00013F-HRTimeline
Perigon Wealth Management, LLC8,970$2.21M0.04%+4113F-HRTimeline
NFJ INVESTMENT GROUP, LLC8,249$2.03M0.07%-36313F-HRTimeline
YOUSIF CAPITAL MANAGEMENT, LLC7,167$1.97M0.02%-1,05013F-HRTimeline
CLOUGH CAPITAL PARTNERS L Pin group CLOUGH CAPITAL PARTNERS L P7,806$1.92M0.17%new13F-HRTimelineGroup
TEALWOOD ASSET MANAGEMENT INC7,713$1.9M0.85%-18913F-HRTimeline
AMALGAMATED BANK7,486$1.85M0.01%+7013F-HRTimeline
State of New Jersey Common Pension Fund…in group State of New Jersey Common Pe…7,409$1.83M0.01%-7,19013F-HRTimelineGroup
GUGGENHEIM CAPITAL LLCin group GUGGENHEIM CAPITAL LLC7,252$1.79M0.01%+3,20013F-HRTimelineGroup
Quantum Private Wealth, LLC7,181$1.77M0.52%-2413F-HRTimeline
Police & Firemen's Retirement System of…6,747$1.66M0.01%-11213F-HRTimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.6,732$1.66M<0.01%+6,34413F-HRTimelineGroup
STRS OHIO6,500$1.6M0.01%-90013F-HRTimeline
TEACHERS RETIREMENT SYSTEM OF THE STATE…6,458$1.59M0.01%-76213F-HRTimeline
COMMONWEALTH OF PENNSYLVANIA PUBLIC SCH…6,389$1.58M0.01%-17113F-HRTimeline
ProShare Advisors LLC6,116$1.51M<0.01%+39913F-HRTimeline
ARIZONA STATE RETIREMENT SYSTEM6,038$1.49M0.01%-35913F-HRTimeline
SUSQUEHANNA INTERNATIONAL GROUP, LLPgroup of 2 filers holding5,971$1.47M+2,192Timeline
COOKSON PEIRCE & CO INC5,954$1.47M0.06%+30013F-HRTimeline
OREGON PUBLIC EMPLOYEES RETIREMENT FUND5,896$1.45M0.02%+5713F-HRTimeline
WINTON GROUP Ltdin group WINTON GROUP Ltd5,874$1.45M0.05%-2,33813F-HRTimelineGroup
Erste Asset Management GmbHin group Erste Asset Management GmbH5,700$1.45M0.01%-12,50013F-HRTimelineGroup
COMERICA BANK5,692$1.4M0.01%-1,45913F-HRTimeline
Universal- Beteiligungs- und Serviceges…in group Universal- Beteiligungs- und …5,086$1.25M<0.01%+6113F-HRTimelineGroup
China Universal Asset Management Co., L…4,725$1.16M0.09%-34813F-HRTimeline
KLP KAPITALFORVALTNING AS4,700$1.16M<0.01%013F-HRTimeline
Cetera Investment Advisers4,616$1.14M<0.01%+11813F-HRTimeline
MARTINGALE ASSET MANAGEMENT L P4,506$1.11M0.03%+113F-HRTimeline
KENNEDY CAPITAL MANAGEMENT LLC4,501$1.11M0.02%-34,79013F-HRTimeline
Regal Investment Advisors LLC4,360$1.07M0.06%+4413F-HRTimeline
Mariner, LLCin group Mariner, LLC4,320$1.07M<0.01%-28513F-HRTimelineGroup
Seven Fleet Capital Management LP4,000$986K0.67%13F-HR/ATimeline
PIER 88 INVESTMENT PARTNERS LLC3,970$979K0.22%+15013F-HRTimeline
Zurcher Kantonalbank (Zurich Cantonalba…3,864$953K<0.01%013F-HRTimeline
Fisher Asset Management, LLC3,786$933K<0.01%new13F-HRTimeline
Maryland State Retirement & Pension Sys…3,774$930K0.02%+6913F-HRTimeline
Amundiin group Amundi3,754$926K<0.01%-80713F-HRTimelineGroup
BOOTHBAY FUND MANAGEMENT, LLC3,527$870K0.02%-5,36213F-HRTimeline
RENAISSANCE TECHNOLOGIES LLC3,300$814K<0.01%new13F-HRTimeline
TEACHER RETIREMENT SYSTEM OF TEXAS3,222$794K<0.01%-2,10913F-HRTimeline
BLAIR WILLIAM & CO/IL3,177$783K<0.01%-1,57513F-HRTimeline
Baader Bank Aktiengesellschaft3,163$769K0.06%new13F-HRTimeline
DNB Asset Management ASin group DNB Asset Management AS3,093$763K<0.01%+73713F-HRTimelineGroup
Resona Asset Management Co.,Ltd.in group Resona Asset Management Co.,L…3,057$754K<0.01%013F-HRTimelineGroup
Odyssean, LLC3,014$743K0.53%13F-HRTimeline
Confluence Wealth Services, Inc.2,922$720K0.03%013F-HRTimeline
Quantinno Capital Management LP2,904$716K<0.01%+74213F-HRTimeline
Brevan Howard Capital Management LPin group Brevan Howard Capital Managem…2,902$715K0.01%new13F-HRTimelineGroup
OPTIMIZE FINANCIAL INC.2,855$704K0.35%+4013F-HRTimeline
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…2,792$688K0.19%-37513F-HRTimelineGroup
Entropy Technologies, LP2,503$617K0.03%new13F-HRTimeline
O'SHAUGHNESSY ASSET MANAGEMENT, LLC2,423$597K<0.01%+93813F-HRTimeline
Cynosure Group, LLC2,406$593K0.06%-3,51213F-HRTimeline
Janney Montgomery Scott LLC2,398$591K<0.01%-18213F-HRTimeline
PUBLIC EMPLOYEES RETIREMENT ASSOCIATION…2,363$583K<0.01%013F-HRTimeline
Pathstone Holdings, LLCin group Pathstone Holdings, LLC2,281$562K<0.01%-2,06613F-HRTimelineGroup
Allspring Global Investments Holdings, …in group Allspring Global Investments …2,234$552K<0.01%+18513F-HRTimelineGroup
BANK OF MONTREAL /CAN/in group BANK OF MONTREAL /CAN/2,231$550K<0.01%-9813F-HRTimelineGroup
AVIVA PLCin group AVIVA PLC2,228$549K<0.01%-1,00313F-HRTimelineGroup
Vontobel Holding Ltd.in group Vontobel Holding Ltd.2,155$531K<0.01%-1,02313F-HRTimelineGroup
Crossmark Global Holdings, Inc.2,124$524K0.01%+5513F-HRTimeline
FORA Capital, LLC2,112$521K0.06%new13F-HRTimeline
Ballentine Partners, LLC2,108$520K0.01%-713F-HRTimeline
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.2,108$520K<0.01%-4,70613F-HRTimelineGroup
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…2,013$496K0.02%-5913F-HRTimelineGroup
FARALLON CAPITAL MANAGEMENT, L.L.C.2,000$493K<0.01%013F-HRTimelineThe filing omitted confidential holdings, a later amendment may add them.
Yorktown Management & Research Co Inc2,000$493K0.39%013F-HRTimeline
XPONANCE LLC1,959$483K<0.01%+813F-HRTimeline
Legato Capital Management LLC1,913$472K0.04%-1,84413F-HRTimeline
Allianz Asset Management GmbHin group Allianz SE1,900$468K<0.01%new13F-HRTimelineGroup
EP Wealth Advisors, LLC1,846$455K<0.01%13F-HRTimeline
AlphaCentric Advisors LLC1,813$447K0.45%13F-HRTimeline
MINDSET WEALTH MANAGEMENT, LLC1,793$442K0.12%+32313F-HRTimeline
Pacer Advisors, Inc.1,712$422K<0.01%+1,10513F-HR/ATimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…1,696$418K<0.01%+213F-HRTimelineGroup
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…1,686$416K0.01%+69313F-HRTimelineGroup
Parallel Advisors, LLC1,680$414K0.01%-18313F-HRTimeline
TRANSCEND CAPITAL ADVISORS, LLC1,680$414K0.03%013F-HRTimeline
LOS ANGELES CAPITAL MANAGEMENT LLC2,171$410K<0.01%-4,58613F-HRTimeline
CIBC Bancorp USA Inc.group of 2 filers holding1,649$407KnewTimeline
City Center Advisors, LLC1,628$401K0.37%-7413F-HRTimeline