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Disclosery

KRYS KRYSTAL BIOTECH INC

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Stock (common), issuer CIK 1711279

281 managers (285 13F filers) reported a position in KRYS shares at 2025-09-30, 28,007,923 shares in all. 43 filers opened a position and 32 filers sold out during the quarter.

Managers
281
13F filers
285
New
43
Added
106
Reduced
86
Sold out
32
Shares held by filers
28,007,923

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q3 2025

Filers in the available 13F reports with a share position at 2025-09-30, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
FMR LLCin group FMR LLC4,341,447$766M0.04%+6,68613F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.3,834,128$677M0.01%-11,02713F-HRTimelineGroup
VANGUARD GROUP INCgroup of 2 filers holding2,794,219$493M-30,364Timeline
Avoro Capital Advisors LLC2,777,777$490M6.34%+117,77713F-HRTimeline
STATE STREET CORPin group STATE STREET CORP1,395,967$246M0.01%+40,62113F-HRTimelineGroup
Soleus Capital Management, L.P.1,018,831$180M9.61%+95,87313F-HRTimeline
Capital World Investors809,240$143M0.02%-133,00913F-HRTimeline
Frazier Life Sciences Management, L.P.688,460$122M3.64%013F-HRTimeline
Redmile Group, LLCin group Redmile Group, LLC661,388$117M11.36%-2,08313F-HRTimelineGroup
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC636,988$112M0.09%+602,42813F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC611,244$108M0.01%-8,30313F-HRTimelineGroup
Hood River Capital Management LLC606,946$107M1.27%+73,92313F-HRTimeline
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP533,964$94.3M0.02%+28,07513F-HRTimelineGroup
BRAIDWELL LP520,401$91.9M2.73%-207,41013F-HRTimeline
PRICE T ROWE ASSOCIATES INC /MD/467,058$82.5M0.01%+205,67513F-HRTimeline
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC348,250$61.5M0.01%-182,11113F-HRTimelineGroup
UBS Group AGgroup of 2 filers holding332,762$58.7M+1,202Timeline
FIRST TRUST ADVISORS LPin group FIRST TRUST ADVISORS LP248,392$43.8M0.03%+26,02213F-HRTimelineGroup
NORTHERN TRUST CORPin group NORTHERN TRUST CORP248,165$43.8M0.01%-3,24313F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co242,863$42.9M0.01%-3,31713F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY234,578$41.4M<0.01%+15713F-HR/ATimelineGroup
Nuveen, LLCin group TIAA197,378$34.8M0.01%+9,35913F-HRTimelineGroup
Pictet Asset Management Holding SAin group Pictet Asset Management Holdi…196,904$34.8M0.03%+66,36713F-HRTimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp155,553$27.5M<0.01%-4,96413F-HRTimelineGroup
Woodline Partners LP150,616$26.6M0.13%013F-HRTimeline
WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC149,302$26.4M0.07%+58,20313F-HRTimeline
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC148,713$26.3M0.02%+136,15113F-HRTimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO146,354$25.8M<0.01%+55,20113F-HR/ATimelineGroup
PRINCIPAL FINANCIAL GROUP INCgroup of 2 filers holding142,860$25.2M+1,967Timeline
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/137,995$24.4M<0.01%+16,18313F-HR/ATimelineGroup
MARSHALL WACE, LLPin group MARSHALL WACE, LLP128,960$22.8M0.03%+16,57813F-HRTimelineGroup
TimesSquare Capital Management, LLC118,514$20.9M0.3%+4,31013F-HRTimeline
S SQUARED TECHNOLOGY, LLC109,215$19.3M7.33%013F-HRTimeline
ORBIMED ADVISORS LLCin group ORBIMED ADVISORS LLC102,745$18.1M0.43%+93,54513F-HRTimelineGroup
Public Sector Pension Investment Board100,431$17.7M0.07%+13,74313F-HRTimeline
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC93,908$16.6M0.02%+29,91513F-HRTimelineGroup
C WorldWide Group Holding A/Sin group C WorldWide Group Holding A/S85,809$15.1M0.23%013F-HRTimelineGroup
SEGALL BRYANT & HAMILL, LLC85,263$15.1M0.2%-63,35113F-HRTimeline
BARCLAYS PLCin group BARCLAYS PLC75,896$13.4M<0.01%-16,97513F-HR/ATimelineGroup
RHUMBLINE ADVISERS70,552$12.5M0.01%-20113F-HRTimeline
READYSTATE ASSET MANAGEMENT LP70,349$12.4M0.6%-77,63113F-HRTimeline
Invesco Ltd.in group Invesco Ltd.66,880$11.8M<0.01%-4,00813F-HRTimelineGroup
Handelsbanken Fonder AB66,800$11.8M0.04%013F-HRTimeline
Legal & General Group Plcin group Legal & General Group Plc65,815$11.6M<0.01%-2,57813F-HRTimelineGroup
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC64,363$11.4M<0.01%-4,37213F-HRTimelineGroup
Skandinaviska Enskilda Banken AB (publ)59,978$10.6M0.04%013F-HRTimeline
Aberdeen Group plcin group Aberdeen Group plc59,372$10.5M0.02%-49,14613F-HRTimelineGroup
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC55,792$9.85M<0.01%-7,04313F-HRTimelineGroup
VICTORY CAPITAL MANAGEMENT INC54,816$9.68M0.01%-25,30713F-HRTimeline
Biondo Investment Advisors, LLC51,885$9.16M1.15%+30,64513F-HRTimeline
TD Asset Management Inc45,080$7.96M0.01%+25,00013F-HRTimeline
Swiss National Bank42,000$7.41M<0.01%+60013F-HRTimeline
Palisades Investment Partners, LLC41,389$7.31M2.87%+1,18613F-HRTimeline
KENNEDY CAPITAL MANAGEMENT LLC39,291$6.94M0.15%+1,14513F-HRTimeline
Corient Private Wealth LPin group Corient Private Wealth LP39,130$6.92M0.01%-1,40813F-HRTimelineGroup
MUTUAL OF AMERICA CAPITAL MANAGEMENT LLCin group MUTUAL OF AMERICA CAPITAL MAN…37,934$6.7M0.07%-42313F-HRTimelineGroup
PERCEPTIVE ADVISORS LLCin group PERCEPTIVE ADVISORS LLC35,000$6.18M0.18%new13F-HRTimelineGroup
Rafferty Asset Management, LLC34,640$6.11M0.02%-2513F-HRTimeline
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …34,455$6.08M<0.01%+9,77513F-HRTimelineGroup
Decheng Capital LLC32,300$5.7M0.99%-33,70013F-HRTimeline
Verition Fund Management LLC31,333$5.53M0.03%+4,81913F-HRTimeline
ALLIANCEBERNSTEIN L.P.29,920$5.28M<0.01%-1,20013F-HRTimeline
STATE OF WISCONSIN INVESTMENT BOARD29,340$5.18M0.01%-6,74913F-HRTimeline
EFG Asset Management (North America) Co…27,095$4.78M0.62%+4,21713F-HRTimeline
NEW YORK STATE COMMON RETIREMENT FUND26,994$4.77M0.01%+3,61213F-HRTimeline
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…26,549$4.69M0.01%+16,19113F-HRTimelineGroup
PRUDENTIAL FINANCIAL INCin group PRUDENTIAL FINANCIAL INC25,496$4.5M0.01%-65513F-HRTimelineGroup
Ikarian Capital, LLCin group Ikarian Capital, LLC24,421$4.31M0.87%new13F-HRTimelineGroup
FEDERATED HERMES, INC.in group FEDERATED HERMES, INC.23,981$4.23M0.01%-18,76213F-HRTimelineGroup
SEI INVESTMENTS COin group SEI INVESTMENTS CO23,393$4.13M<0.01%+4,09313F-HRTimelineGroup
CANADA LIFE ASSURANCE Coin group CANADA LIFE ASSURANCE Co21,398$3.78M0.01%+55113F-HRTimelineGroup
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\21,379$3.77M<0.01%+2,24413F-HRTimelineGroup
CALIFORNIA STATE TEACHERS RETIREMENT SY…20,882$3.69M<0.01%+75613F-HRTimeline
SYNOVUS FINANCIAL CORP20,516$3.62M0.04%-12713F-HRTimeline
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC20,133$3.55M<0.01%+8,16513F-HRTimelineGroup
FRANKLIN RESOURCES INCin group Franklin Resources19,850$3.5M<0.01%+1,42513F-HRTimelineGroup
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN19,653$3.47M<0.01%+3,10613F-HRTimelineGroup
Thrivent Financial for Lutheransin group Thrivent Financial for Luther…18,584$3.28M0.01%-11613F-HRTimelineGroup
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC18,523$3.27M0.32%new13F-HRTimelineGroup
Erste Asset Management GmbHin group Erste Asset Management GmbH18,200$3.22M0.03%013F-HRTimelineGroup
NEW YORK STATE TEACHERS RETIREMENT SYST…15,550$2.75M0.01%-10013F-HRTimeline
DekaBank Deutsche Girozentrale15,503$2.72M<0.01%013F-HRTimeline
Fiera Capital Corpin group Fiera Capital Corp15,063$2.66M0.01%-44813F-HRTimelineGroup
Fieldview Capital Management, LLC14,705$2.6M0.42%+15913F-HRTimeline
State of New Jersey Common Pension Fund…in group State of New Jersey Common Pe…14,599$2.58M0.01%-43413F-HRTimelineGroup
MetLife Investment Management, LLCin group MetLife Investment Management…14,430$2.55M0.01%-31613F-HRTimelineGroup
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding14,409$2.54M-1,990Timeline
State of Alaska, Department of Revenue14,274$2.52M0.03%-85613F-HRTimeline
Illinois Municipal Retirement Fund14,245$2.51M0.03%+1,93413F-HRTimeline
Bridge City Capital, LLC14,154$2.5M0.67%new13F-HRTimeline
ALPS ADVISORS INCin group ALPS ADVISORS INC13,367$2.36M0.01%-4,09513F-HRTimelineGroup
ENVESTNET ASSET MANAGEMENT INCin group ENVESTNET ASSET MANAGEMENT INC13,108$2.31M<0.01%-2,00813F-HRTimelineGroup
Evolutionary Tree Capital Management, L…12,461$2.2M2.4%+16513F-HRTimeline
Privium Fund Management B.V.12,170$2.15M0.39%+2,85013F-HRTimeline
Torray Investment Partners LLC11,901$2.1M0.29%+32713F-HRTimeline
Louisiana State Employees Retirement Sy…11,800$2.08M0.03%-10013F-HRTimeline
Rhenman & Partners Asset Management AB11,750$2.07M0.23%-1,00013F-HRTimeline
Creative Planningin group Creative Planning11,609$2.05M<0.01%+3,25313F-HRTimelineGroup
State of Tennessee, Department of Treas…11,118$1.96M0.01%+16713F-HRTimeline
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…10,881$1.92M<0.01%+72813F-HRTimelineGroup
ACUTA CAPITAL PARTNERS, LLC10,573$1.87M1.93%new13F-HRTimeline
GW&K Investment Management, LLC10,492$1.85M0.02%-19,68313F-HRTimeline
SCHRODER INVESTMENT MANAGEMENT GROUP10,170$1.8M<0.01%-5813F-HRTimeline
Main Management ETF Advisors, LLCin group Main Management ETF Advisors,…10,075$1.78M0.07%+4,94413F-HRTimelineGroup
JANUS HENDERSON GROUP PLCin group Janus Henderson10,071$1.78M<0.01%013F-HRTimelineGroup
COMMONWEALTH EQUITY SERVICES, LLC10,006$1.77M<0.01%+1,79113F-HRTimeline
Connor, Clark & Lunn Investment Managem…9,778$1.73M0.01%new13F-HRTimeline
INTECH INVESTMENT MANAGEMENT LLC9,751$1.72M0.02%-1,22713F-HRTimeline
Bridgewater Associates, LP9,723$1.72M0.01%new13F-HRTimeline
CITIGROUP INCin group CITIGROUP INC9,650$1.7M<0.01%-42,88313F-HRTimelineGroup
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS9,179$1.62M<0.01%+1,99613F-HRTimelineGroup
Perigon Wealth Management, LLC8,929$1.58M0.03%+3113F-HRTimeline
BOOTHBAY FUND MANAGEMENT, LLC8,889$1.57M0.04%new13F-HRTimeline
NFJ INVESTMENT GROUP, LLC8,612$1.52M0.05%new13F-HRTimeline
PROFUND ADVISORS LLC8,330$1.47M0.05%+16413F-HRTimeline
YOUSIF CAPITAL MANAGEMENT, LLC8,217$1.45M0.02%-1,38313F-HRTimeline
WINTON GROUP Ltdin group WINTON GROUP Ltd8,212$1.45M0.05%new13F-HRTimelineGroup
TEALWOOD ASSET MANAGEMENT INC7,902$1.4M0.56%-28113F-HRTimeline
AMALGAMATED BANK7,416$1.31M0.01%+19013F-HRTimeline
STRS OHIO7,400$1.31M<0.01%013F-HRTimeline
TEACHERS RETIREMENT SYSTEM OF THE STATE…7,220$1.27M0.01%-1,10913F-HRTimeline
Quantum Private Wealth, LLC7,205$1.27M0.37%013F-HRTimeline
COMERICA BANK7,151$1.26M<0.01%-1,55713F-HRTimeline
Police & Firemen's Retirement System of…6,859$1.21M0.01%+1,25913F-HRTimeline
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.6,814$1.2M<0.01%-4,91313F-HRTimelineGroup
LOS ANGELES CAPITAL MANAGEMENT LLC6,757$1.19M<0.01%-19,88113F-HRTimeline
COMMONWEALTH OF PENNSYLVANIA PUBLIC SCH…6,560$1.16M0.01%+3113F-HRTimeline
Summit Trail Advisors, LLC6,464$1.14M0.02%-3613F-HRTimeline
ARIZONA STATE RETIREMENT SYSTEM6,397$1.13M0.01%+8113F-HRTimeline
Cynosure Group, LLC5,918$1.04M0.11%013F-HR/ATimeline
DARK FOREST CAPITAL MANAGEMENT LP5,903$1.04M0.04%+39913F-HR/ATimeline
OREGON PUBLIC EMPLOYEES RETIREMENT FUND5,839$1.03M0.01%+3713F-HRTimeline
STATE BOARD OF ADMINISTRATION OF FLORID…5,785$1.02M<0.01%-2213F-HRTimeline
ProShare Advisors LLC5,717$1.01M<0.01%-90813F-HRTimeline
COOKSON PEIRCE & CO INC5,654$998K0.04%new13F-HRTimeline
TEACHER RETIREMENT SYSTEM OF TEXAS5,331$941K<0.01%-51013F-HRTimeline
China Universal Asset Management Co., L…5,073$896K0.07%-73113F-HRTimeline
Universal- Beteiligungs- und Serviceges…in group Universal- Beteiligungs- und …5,025$887K<0.01%+89113F-HRTimelineGroup
Tetragon Partners GP Ltdin group Tetragon Partners GP Ltd4,870$860K0.12%new13F-HRTimelineGroup
BLAIR WILLIAM & CO/IL4,752$839K<0.01%-10013F-HRTimeline
KLP KAPITALFORVALTNING AS4,700$830K<0.01%+40013F-HRTimeline
Amundiin group Amundi4,561$824K<0.01%+36713F-HRTimelineGroup
Mariner, LLCin group Mariner, LLC4,605$813K<0.01%+35013F-HRTimelineGroup
MARTINGALE ASSET MANAGEMENT L P4,505$795K0.02%013F-HRTimeline
Cetera Investment Advisers4,498$794K<0.01%+15413F-HRTimeline
Atle Fund Management AB42,191$791K2.93%+22,03313F-HRTimeline
Ensign Peak Advisors, Inc4,419$780K<0.01%-2,15013F-HR/ATimeline
Pathstone Holdings, LLCin group Pathstone Holdings, LLC4,347$767K<0.01%+40813F-HRTimelineGroup
Regal Investment Advisors LLC4,316$762K0.05%-11813F-HRTimeline
GUGGENHEIM CAPITAL LLCin group GUGGENHEIM CAPITAL LLC4,052$715K0.01%-2,01013F-HRTimelineGroup
OMERS ADMINISTRATION Corp4,000$706K0.01%new13F-HRTimeline
Zurcher Kantonalbank (Zurich Cantonalba…3,864$682K<0.01%013F-HRTimeline
PIER 88 INVESTMENT PARTNERS LLC3,820$674K0.13%013F-HRTimeline
SUSQUEHANNA INTERNATIONAL GROUP, LLPgroup of 2 filers holding3,779$667K-30,012Timeline
Legato Capital Management LLC3,757$663K0.07%new13F-HRTimeline
Maryland State Retirement & Pension Sys…3,705$654K0.01%-3,76913F-HRTimeline
CenterBook Partners LP3,429$605K0.03%-1,62213F-HRTimeline
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC3,381$597K<0.01%new13F-HRTimelineGroup
SG Americas Securities, LLC3,318$586K<0.01%-9,28913F-HRTimeline
AVIVA PLCin group AVIVA PLC3,231$570K<0.01%-34413F-HRTimelineGroup
Vontobel Holding Ltd.in group Vontobel Holding Ltd.3,178$561K<0.01%+10313F-HRTimelineGroup
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…3,167$559K0.16%013F-HRTimelineGroup
Resona Asset Management Co.,Ltd.in group Resona Asset Management Co.,L…3,057$540K<0.01%+14013F-HRTimelineGroup
Confluence Wealth Services, Inc.2,922$516K0.03%013F-HRTimeline
SIG BROKERAGE, LP2,849$503K0.13%new13F-HRTimeline
OPTIMIZE FINANCIAL INC.2,815$497K0.26%new13F-HRTimeline
CIBC Bancorp USA Inc.in group CIBC Bancorp USA Inc.2,643$467K<0.01%13F-HR/ATimelineGroup
Janney Montgomery Scott LLC2,580$455K<0.01%+24013F-HRTimeline
Advantage Alpha Capital Partners LP2,387$421K0.13%-50713F-HRTimeline
PUBLIC EMPLOYEES RETIREMENT ASSOCIATION…2,363$417K<0.01%013F-HRTimeline
DNB Asset Management ASin group DNB Asset Management AS2,356$416K<0.01%+62513F-HRTimelineGroup
BANK OF MONTREAL /CAN/in group BANK OF MONTREAL /CAN/2,329$411K<0.01%-2,07813F-HRTimelineGroup
Quantinno Capital Management LP2,162$382K<0.01%new13F-HRTimeline
WOLVERINE TRADING, LLC2,154$381K0.01%new13F-HRTimeline
Ballentine Partners, LLC2,115$373K0.01%013F-HRTimeline
Man Group plcin group Man Group plc2,088$369K<0.01%-28,39313F-HRTimelineGroup
Allspring Global Investments Holdings, …in group Allspring Global Investments …2,049$368K<0.01%-1913F-HRTimelineGroup
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…2,072$366K0.01%-43713F-HRTimelineGroup
Crossmark Global Holdings, Inc.2,069$365K0.01%-38813F-HRTimeline
Freestone Grove Partners LP2,031$359K<0.01%+13613F-HRTimeline
Sound View Wealth Advisors Group, LLC2,003$354K0.02%+5613F-HRTimeline
FARALLON CAPITAL MANAGEMENT, L.L.C.2,000$353K<0.01%013F-HR/ATimeline
VIRGINIA RETIREMENT SYSTEMS ET Al2,000$353K<0.01%-5,80013F-HRTimeline
Yorktown Management & Research Co Inc2,000$353K0.28%new13F-HRTimeline
XPONANCE LLC1,951$344K<0.01%+2213F-HRTimeline
ALTFEST L J & CO INC1,870$330K0.04%new13F-HRTimeline
Parallel Advisors, LLC1,863$329K0.01%013F-HRTimeline
Mitsubishi UFJ Asset Management Co., Lt…in group Mitsubishi UFJ Trust & Bankin…1,798$317K<0.01%+313F-HRTimelineGroup
Covestor Ltd1,778$314K0.17%+40513F-HRTimeline
Campbell & CO Investment Adviser LLC1,721$304K0.02%-27013F-HRTimeline
City Center Advisors, LLC1,702$300K0.29%new13F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…1,694$299K<0.01%+27213F-HRTimelineGroup
TRANSCEND CAPITAL ADVISORS, LLC1,680$297K0.02%new13F-HRTimeline
MACKENZIE FINANCIAL CORP1,597$282K<0.01%013F-HRTimeline
CWM, LLCin group CWM, LLC1,536$271K<0.01%-4713F-HRTimelineGroup
O'SHAUGHNESSY ASSET MANAGEMENT, LLC1,485$262K<0.01%new13F-HRTimeline
MINDSET WEALTH MANAGEMENT, LLC1,470$259K0.07%new13F-HRTimeline
Vident Advisory, LLCin group Vident Advisory, LLC1,418$250K<0.01%-56413F-HRTimelineGroup
Avanza Fonder AB1,418$250K0.01%+47713F-HRTimeline
Bellevue Group AGin group Bellevue Group AG1,312$232K<0.01%+6213F-HRTimelineGroup