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Disclosery

KRYS KRYSTAL BIOTECH INC

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Stock (common), issuer CIK 1711279

272 managers (277 13F filers) reported a position in KRYS shares at 2025-06-30, 27,651,525 shares in all. 40 filers opened a position and 63 filers sold out during the quarter.

Managers
272
13F filers
277
New
40
Added
100
Reduced
96
Sold out
63
Shares held by filers
27,651,525

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q2 2025

Filers in the available 13F reports with a share position at 2025-06-30, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
FMR LLCin group FMR LLC4,334,761$596M0.03%+13,92913F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.3,845,155$529M0.01%-98,01013F-HRTimelineGroup
VANGUARD GROUP INCgroup of 2 filers holding2,824,583$388M-2,645Timeline
Avoro Capital Advisors LLC2,660,000$366M6.4%-71,00013F-HRTimeline
STATE STREET CORPin group STATE STREET CORP1,355,346$186M0.01%+128,63913F-HRTimelineGroup
Capital World Investors942,249$130M0.02%-12,21913F-HRTimeline
Soleus Capital Management, L.P.922,958$127M8.76%+481,20013F-HRTimeline
BRAIDWELL LP727,811$100M3.42%+327,06713F-HRTimeline
Frazier Life Sciences Management, L.P.688,460$94.6M3.78%013F-HRTimeline
Redmile Group, LLCin group Redmile Group, LLC663,471$91.2M9.71%-74,20413F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC619,547$85.2M0.01%+7,19413F-HRTimelineGroup
Hood River Capital Management LLC533,023$73.3M1.02%+8,37913F-HRTimeline
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC530,361$72.9M0.01%+296,72113F-HRTimelineGroup
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP505,889$69.5M0.02%-28,03013F-HRTimelineGroup
UBS Group AGgroup of 2 filers holding331,560$45.6M-325,065Timeline
NORGES BANK282,706$38.9M<0.01%+9,49713F-HRTimeline
PRICE T ROWE ASSOCIATES INC /MD/261,383$35.9M<0.01%-149,47813F-HRTimeline
NORTHERN TRUST CORPin group NORTHERN TRUST CORP251,408$34.6M<0.01%-8,58713F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co246,180$33.8M0.01%-4,33413F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY234,421$32.2M<0.01%-63,78413F-HRTimelineGroup
FIRST TRUST ADVISORS LPin group FIRST TRUST ADVISORS LP222,370$30.6M0.02%+189,24513F-HRTimelineGroup
Nuveen, LLCin group TIAA188,019$25.8M0.01%-46,16113F-HRTimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp160,517$22.1M<0.01%-8,66213F-HRTimelineGroup
Woodline Partners LP150,616$20.7M0.11%-71,42713F-HRTimeline
SEGALL BRYANT & HAMILL, LLC148,614$20.4M0.29%+3,27713F-HRTimeline
READYSTATE ASSET MANAGEMENT LP147,980$20.3M0.84%new13F-HRTimeline
PRINCIPAL FINANCIAL GROUP INCgroup of 2 filers holding140,893$19.4M+14,549Timeline
Pictet Asset Management Holding SAin group Pictet Asset Management Holdi…130,537$17.9M0.02%+65,27513F-HRTimelineGroup
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/121,812$16.7M<0.01%+29,25113F-HRTimelineGroup
TimesSquare Capital Management, LLC114,204$15.7M0.23%-27,97913F-HRTimeline
MARSHALL WACE, LLPin group MARSHALL WACE, LLP112,382$15.4M0.02%+95,15813F-HRTimelineGroup
S SQUARED TECHNOLOGY, LLC109,215$15M6.33%+12,00013F-HRTimeline
Aberdeen Group plcin group Aberdeen Group plc108,518$14.9M0.03%+71,21713F-HRTimelineGroup
Logos Global Management LP100,000$13.7M1.84%new13F-HRTimeline
BARCLAYS PLCin group BARCLAYS PLC92,871$12.8M0.01%+47,87413F-HR/ATimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO91,153$12.5M<0.01%-9,62113F-HRTimelineGroup
WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC91,099$12.5M0.03%new13F-HRTimeline
RENAISSANCE TECHNOLOGIES LLC89,800$12.3M0.02%+78,60013F-HRTimeline
Public Sector Pension Investment Board86,688$11.9M0.05%+6,42413F-HRTimeline
C WorldWide Group Holding A/Sin group C WorldWide Group Holding A/S85,809$11.8M0.16%013F-HRTimelineGroup
VICTORY CAPITAL MANAGEMENT INC80,123$11M0.01%+7,30813F-HRTimeline
Invesco Ltd.in group Invesco Ltd.70,888$9.74M<0.01%-183,59813F-HRTimelineGroup
RHUMBLINE ADVISERS70,753$9.73M0.01%+2,02613F-HRTimeline
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC68,735$9.45M<0.01%+2,77413F-HRTimelineGroup
Legal & General Group Plcin group Legal & General Group Plc68,393$9.4M<0.01%+1,88413F-HRTimelineGroup
Handelsbanken Fonder AB66,800$9.18M0.03%-7,50013F-HRTimeline
Decheng Capital LLC66,000$9.07M2.29%+1,00013F-HRTimeline
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC63,993$8.8M0.01%-60813F-HRTimelineGroup
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC62,835$8.64M<0.01%+2,32713F-HRTimelineGroup
Skandinaviska Enskilda Banken AB (publ)59,978$8.24M0.04%013F-HRTimeline
Alyeska Investment Group, L.P.in group Alyeska Investment Group, L.P.53,934$7.41M0.03%new13F-HRTimelineGroup
CITIGROUP INCin group CITIGROUP INC52,533$7.22M0.01%-20,99213F-HRTimelineGroup
FEDERATED HERMES, INC.in group FEDERATED HERMES, INC.42,743$5.88M0.01%+29,96213F-HRTimelineGroup
Swiss National Bank41,400$5.69M<0.01%-40013F-HRTimeline
Corient Private Wealth LPin group Corient Private Wealth LP40,538$5.57M0.01%-1,58913F-HR/ATimelineGroup
Palisades Investment Partners, LLC40,203$5.53M2.42%-49313F-HRTimeline
MUTUAL OF AMERICA CAPITAL MANAGEMENT LLCin group MUTUAL OF AMERICA CAPITAL MAN…38,357$5.27M0.06%+1,92613F-HRTimelineGroup
KENNEDY CAPITAL MANAGEMENT LLC38,146$5.24M0.13%-3,37213F-HRTimeline
STATE OF WISCONSIN INVESTMENT BOARD36,089$4.96M0.01%+11,90613F-HRTimeline
Rafferty Asset Management, LLC34,665$4.77M0.02%+10,50413F-HRTimeline
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC34,560$4.75M<0.01%+34,46413F-HRTimelineGroup
SUSQUEHANNA INTERNATIONAL GROUP, LLPgroup of 3 filers holding33,791$4.64M-2,280Timeline
PRUDENTIAL FINANCIAL INCin group PRUDENTIAL FINANCIAL INC26,151$4.42M0.01%-1,16013F-HRTimelineGroup
ALLIANCEBERNSTEIN L.P.31,120$4.28M<0.01%013F-HRTimeline
Man Group plcin group Man Group plc30,481$4.19M0.01%new13F-HRTimelineGroup
GW&K Investment Management, LLC30,175$4.15M0.04%-3,92513F-HRTimeline
LOS ANGELES CAPITAL MANAGEMENT LLC26,638$3.66M0.01%+1,70913F-HRTimeline
Verition Fund Management LLC26,514$3.64M0.02%+7,88913F-HRTimeline
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …24,680$3.39M<0.01%-7,68613F-HRTimelineGroup
NEW YORK STATE COMMON RETIREMENT FUND23,382$3.21M<0.01%013F-HR/ATimeline
EFG Asset Management (North America) Co…22,878$3.14M0.44%+5,50713F-HRTimeline
Biondo Investment Advisors, LLC21,240$2.92M0.38%new13F-HRTimeline
CANADA LIFE ASSURANCE Coin group CANADA LIFE ASSURANCE Co20,847$2.86M<0.01%-3,76213F-HRTimelineGroup
SYNOVUS FINANCIAL CORP20,643$2.84M0.03%new13F-HRTimeline
Atle Fund Management AB20,158$2.77M1.19%-3,33313F-HRTimeline
CALIFORNIA STATE TEACHERS RETIREMENT SY…20,126$2.77M<0.01%013F-HRTimeline
TD Asset Management Inc20,080$2.76M<0.01%-20,18813F-HRTimeline
Edgestream Partners, L.P.19,678$2.7M0.08%new13F-HRTimeline
SEI INVESTMENTS COin group SEI INVESTMENTS CO19,300$2.65M<0.01%+60913F-HRTimelineGroup
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\19,135$2.63M<0.01%-2,60213F-HRTimelineGroup
Thrivent Financial for Lutheransin group Thrivent Financial for Luther…18,700$2.57M0.01%+11013F-HR/ATimelineGroup
FRANKLIN RESOURCES INCin group Franklin Resources18,425$2.53M<0.01%-58813F-HRTimelineGroup
Erste Asset Management GmbHin group Erste Asset Management GmbH18,200$2.53M0.02%013F-HRTimelineGroup
ALPS ADVISORS INCin group ALPS ADVISORS INC17,462$2.4M0.01%+15,54213F-HRTimelineGroup
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN16,547$2.27M<0.01%-58813F-HRTimelineGroup
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding16,399$2.26M-458Timeline
NEW YORK STATE TEACHERS RETIREMENT SYST…15,650$2.15M<0.01%-32913F-HRTimeline
DekaBank Deutsche Girozentrale15,503$2.15M<0.01%013F-HRTimeline
Fiera Capital Corpin group Fiera Capital Corp15,511$2.13M0.01%-13413F-HRTimelineGroup
State of Alaska, Department of Revenue15,130$2.08M0.02%+1,10613F-HRTimeline
ENVESTNET ASSET MANAGEMENT INCin group ENVESTNET ASSET MANAGEMENT INC15,116$2.08M<0.01%+2,71713F-HRTimelineGroup
State of New Jersey Common Pension Fund…in group State of New Jersey Common Pe…15,033$2.07M0.01%+4,68213F-HRTimelineGroup
MetLife Investment Management, LLCin group MetLife Investment Management…14,746$2.03M0.01%+22213F-HRTimelineGroup
Fieldview Capital Management, LLC14,546$2M0.3%-1,79613F-HRTimeline
Rhenman & Partners Asset Management AB12,750$1.75M0.22%-5,00013F-HRTimeline
SG Americas Securities, LLC12,607$1.73M0.01%+11,29513F-HRTimeline
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC12,562$1.73M<0.01%-47,82613F-HRTimelineGroup
Illinois Municipal Retirement Fund12,311$1.69M0.02%-45113F-HRTimeline
Evolutionary Tree Capital Management, L…12,296$1.69M1.79%-1,04713F-HRTimeline
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC11,968$1.65M<0.01%-16313F-HRTimelineGroup
Louisiana State Employees Retirement Sy…11,900$1.64M0.03%013F-HRTimeline
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.11,727$1.61M<0.01%-38,16513F-HRTimelineGroup
Torray Investment Partners LLC11,574$1.59M0.23%new13F-HRTimeline
INTECH INVESTMENT MANAGEMENT LLC10,978$1.51M0.01%-1,10013F-HRTimeline
State of Tennessee, Department of Treas…10,951$1.51M0.01%-21113F-HRTimeline
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…10,358$1.42M<0.01%-27,42313F-HRTimelineGroup
SCHRODER INVESTMENT MANAGEMENT GROUP10,228$1.41M<0.01%-2,82013F-HRTimeline
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…10,153$1.4M<0.01%-44613F-HRTimelineGroup
JANUS HENDERSON GROUP PLCin group Janus Henderson10,071$1.38M<0.01%013F-HRTimelineGroup
YOUSIF CAPITAL MANAGEMENT, LLC9,600$1.32M0.01%+3013F-HRTimeline
Privium Fund Management B.V.9,320$1.3M0.28%+1,81013F-HRTimeline
ORBIMED ADVISORS LLCin group ORBIMED ADVISORS LLC9,200$1.26M0.03%-14,30013F-HRTimelineGroup
Perigon Wealth Management, LLC8,898$1.22M0.03%+40713F-HRTimeline
COMERICA BANK8,708$1.2M<0.01%+713F-HRTimeline
Creative Planningin group Creative Planning8,356$1.15M<0.01%-3,73013F-HRTimelineGroup
TEACHERS RETIREMENT SYSTEM OF THE STATE…8,329$1.15M0.01%-68113F-HRTimeline
COMMONWEALTH EQUITY SERVICES, LLC8,215$1.13M<0.01%+91213F-HRTimeline
TEALWOOD ASSET MANAGEMENT INC8,183$1.12M0.5%new13F-HRTimeline
PROFUND ADVISORS LLC8,166$1.12M0.04%+2,20313F-HRTimeline
VIRGINIA RETIREMENT SYSTEMS ET Al7,800$1.07M0.01%013F-HRTimeline
Maryland State Retirement & Pension Sys…7,474$1.03M0.02%+12313F-HRTimeline
STRS OHIO7,400$1.02M<0.01%+50013F-HRTimeline
SPHERA FUNDS MANAGEMENT LTD.in group SPHERA FUNDS MANAGEMENT LTD.7,335$1.01M0.26%new13F-HRTimelineGroup
AMALGAMATED BANK7,226$993K0.01%+2613F-HRTimeline
Quantum Private Wealth, LLC7,205$990K0.32%013F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS7,183$987K<0.01%+2,74613F-HRTimelineGroup
M&G PLCin group M&G PLC6,748$924K0.01%new13F-HRTimelineGroup
ProShare Advisors LLC6,625$911K<0.01%-52613F-HRTimeline
Ensign Peak Advisors, Inc6,569$903K<0.01%013F-HRTimeline
COMMONWEALTH OF PENNSYLVANIA PUBLIC SCH…6,529$897K<0.01%+47213F-HRTimeline
Summit Trail Advisors, LLC6,500$893K0.02%new13F-HRTimeline
Shay Capital LLC6,500$893K0.2%new13F-HRTimeline
ARIZONA STATE RETIREMENT SYSTEM6,316$868K0.01%+14513F-HRTimeline
GUGGENHEIM CAPITAL LLCin group GUGGENHEIM CAPITAL LLC6,062$833K0.01%+1,90913F-HRTimelineGroup
Cynosure Group, LLC5,918$813K0.09%+2,01613F-HRTimeline
TEACHER RETIREMENT SYSTEM OF TEXAS5,841$803K<0.01%+3613F-HRTimeline
STATE BOARD OF ADMINISTRATION OF FLORID…5,807$798K<0.01%013F-HRTimeline
China Universal Asset Management Co., L…5,804$798K0.08%+2613F-HRTimeline
OREGON PUBLIC EMPLOYEES RETIREMENT FUND5,802$798K0.01%013F-HRTimeline
Police & Firemen's Retirement System of…5,600$770K0.01%+18013F-HRTimeline
DARK FOREST CAPITAL MANAGEMENT LP5,504$757K0.03%-3,93313F-HRTimeline
Main Management ETF Advisors, LLCin group Main Management ETF Advisors,…5,131$705K0.03%+8413F-HRTimelineGroup
CenterBook Partners LP5,051$694K0.04%new13F-HRTimeline
BLAIR WILLIAM & CO/IL4,852$667K<0.01%-4,58113F-HRTimeline
Summit Global Investmentsin group Summit Global Investments4,547$625K0.04%-16413F-HRTimelineGroup
MARTINGALE ASSET MANAGEMENT L P4,505$619K0.02%-63113F-HRTimeline
Regal Investment Advisors LLC4,434$609K0.05%+12713F-HRTimeline
BANK OF MONTREAL /CAN/in group BANK OF MONTREAL /CAN/4,407$606K<0.01%-1113F-HRTimelineGroup
Cetera Investment Advisers4,344$597K<0.01%+2,25513F-HRTimeline
Bryce Point Capital, LLC4,323$594K0.5%+3713F-HRTimeline
Amundiin group Amundi4,194$593K<0.01%new13F-HRTimelineGroup
KLP KAPITALFORVALTNING AS4,300$591K<0.01%013F-HRTimeline
Mariner, LLCin group Mariner, LLC4,255$585K<0.01%+61813F-HRTimelineGroup
Universal- Beteiligungs- und Serviceges…in group Universal- Beteiligungs- und …4,134$568K<0.01%-8,61913F-HRTimelineGroup
Pathstone Holdings, LLCin group Pathstone Holdings, LLC3,939$541K<0.01%-4,17013F-HRTimelineGroup
E Fund Management Co., Ltd.3,870$532K0.03%+1,61213F-HRTimeline
Zurcher Kantonalbank (Zurich Cantonalba…3,864$531K<0.01%-1,87813F-HRTimeline
PIER 88 INVESTMENT PARTNERS LLC3,820$525K0.1%-61013F-HRTimeline
M&T Bank Corpin group M&T Bank Corp3,785$520K<0.01%+8513F-HRTimelineGroup
AVIVA PLCin group AVIVA PLC3,575$491K<0.01%+31913F-HRTimelineGroup
Hennion & Walsh Asset Management, Inc.3,253$447K0.02%-6,95213F-HRTimeline
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…3,167$435K0.15%+1,09913F-HRTimelineGroup
Vontobel Holding Ltd.in group Vontobel Holding Ltd.3,075$423K<0.01%+37513F-HRTimelineGroup
CIBC WORLD MARKETS CORP3,055$420K<0.01%-2,44913F-HRTimeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…2,998$412K0.01%+2,26813F-HRTimelineGroup
Confluence Wealth Services, Inc.2,922$402K0.02%+213F-HRTimeline
Resona Asset Management Co.,Ltd.in group Resona Asset Management Co.,L…2,917$401K<0.01%new13F-HRTimelineGroup
Advantage Alpha Capital Partners LP2,894$398K0.11%-67513F-HRTimeline
EP Wealth Advisors, LLC2,726$375K<0.01%+10513F-HRTimeline
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…2,509$345K0.01%013F-HRTimelineGroup
Crossmark Global Holdings, Inc.2,457$338K0.01%+8713F-HRTimeline
Graham Capital Management, L.P.2,435$335K0.01%+25613F-HRTimeline
Tempus Wealth Planning, LLC2,379$327K0.08%new13F-HRTimeline
PUBLIC EMPLOYEES RETIREMENT ASSOCIATION…2,363$325K<0.01%013F-HRTimeline
Nebula Research & Development LLC2,355$324K0.03%-3,86513F-HRTimeline
Janney Montgomery Scott LLC2,340$322K<0.01%-43,59513F-HRTimeline
CAPSTONE INVESTMENT ADVISORS, LLCin group CAPSTONE INVESTMENT ADVISORS,…2,196$302K<0.01%new13F-HRTimelineGroup
Ballentine Partners, LLC2,115$291K<0.01%-2113F-HRTimeline
Allspring Global Investments Holdings, …in group Allspring Global Investments …2,068$287K<0.01%-3,11213F-HRTimelineGroup
FARALLON CAPITAL MANAGEMENT, L.L.C.2,000$275K<0.01%013F-HRTimelineThe filing omitted confidential holdings, a later amendment may add them.
Campbell & CO Investment Adviser LLC1,991$274K0.02%new13F-HRTimeline
Vident Advisory, LLCin group Vident Advisory, LLC1,982$272K<0.01%-80513F-HRTimelineGroup
Sound View Wealth Advisors Group, LLC1,947$268K0.02%+43213F-HRTimeline
Aigen Investment Management, LP1,944$267K0.04%new13F-HRTimeline
XPONANCE LLC1,929$265K<0.01%+5613F-HRTimeline
Freestone Grove Partners LP1,895$260K<0.01%new13F-HRTimeline
OmniStar Financial Group, Inc.1,878$258K0.19%-14813F-HRTimeline
Parallel Advisors, LLC1,863$256K0.01%+13213F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA1,811$249K<0.01%+18313F-HR/ATimelineGroup
Mitsubishi UFJ Asset Management Co., Lt…in group Mitsubishi UFJ Trust & Bankin…1,795$247K<0.01%+30313F-HRTimelineGroup
DNB Asset Management ASin group DNB Asset Management AS1,731$238K<0.01%-4813F-HRTimelineGroup
MACKENZIE FINANCIAL CORP1,597$220K<0.01%+6513F-HRTimeline
CWM, LLCin group CWM, LLC1,583$218K<0.01%+10713F-HRTimelineGroup
ALGERT GLOBAL LLC1,500$206K<0.01%new13F-HR/ATimeline
Hilltop Holdings Inc.in group Hilltop Holdings Inc.1,468$202K0.01%+27213F-HRTimelineGroup
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…1,422$195K<0.01%-71913F-HRTimelineGroup
Covestor Ltd1,373$189K0.11%-12413F-HRTimeline
ELEVATION POINT WEALTH PARTNERS, LLC1,251$172K0.01%+1213F-HR/ATimeline
Bellevue Group AGin group Bellevue Group AG1,250$172K<0.01%-1,40013F-HRTimelineGroup
Financiere des Professionnels - Fonds d…1,182$162K0.01%new13F-HR/ATimeline