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Siren, L.L.C.

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13F filer, CIK 2005245, New York, NY

Siren, L.L.C. reported $3,607,379,030 across 100 holdings for the quarter ended 2026-03-31, in a 13F-HR filed 2026-05-14. Its ten largest share positions make up 49.77% of the portfolio.

Filed (acceptance time not in the bulk data set), ingested 13F-HR 0002005245-26-000006

Period
2026-03-31
Reported value
$3.61B
Holdings
100
Top 10 weight
49.77%
New
19
Sold out
32

Part of the filer group Siren, L.L.C.

How groups are built

Largest buys vs the previous quarter

SecurityShares changeApprox. value
MANEnew+1,505,374$95.1M
CYTKnew+613,952$40.5M
ERASadded+2,486,997$40.2M
XENEadded+505,803$29.4M
ELVNnew+746,226$29.3M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
CNTAreduced-2,974,053-$118M
APLSexited-2,578,396-$64.8M
TNGXreduced-2,508,269-$52.5M
ASNDexited-235,862-$50.3M
RAPTexited-1,375,000-$46.6M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q1 2026

Share positions as resolved from 13F-HR 0002005245-26-000006, largest first. % of portfolio is the value over $3,607,379,030, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
SRRKSCHOLAR ROCK HLDG CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 11,259,438 shares; 2024Q4: 9,250,005 shares; 2025Q1: 9,250,005 shares; 2025Q2: 9,250,005 shares; 2025Q3: 9,250,005 shares; 2025Q4: 10,825,013 shares; 2026Q1: 10,825,013 shares 10,825,013$532M14.75%0Timeline
KYMRKYMERA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 2,969,733 shares; 2024Q4: 2,969,733 shares; 2025Q1: 3,240,313 shares; 2025Q2: 3,428,150 shares; 2025Q3: 3,428,150 shares; 2025Q4: 3,286,830 shares; 2026Q1: 3,186,830 shares 3,186,830$265M7.36%-100,000Timeline
ERASERASCA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 8,857,179 shares; 2024Q4: 8,857,179 shares; 2025Q1: 8,757,249 shares; 2025Q2: 8,757,249 shares; 2025Q3: 8,757,249 shares; 2025Q4: 8,757,249 shares; 2026Q1: 11,244,246 shares 11,244,246$182M5.04%+2,486,997Timeline
EWTXEDGEWISE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 404,113 shares; 2024Q4: 734,343 shares; 2025Q1: 1,696,444 shares; 2025Q2: 3,160,298 shares; 2025Q3: 3,897,099 shares; 2025Q4: 4,529,990 shares; 2026Q1: 4,430,263 shares 4,430,263$140M3.87%-99,727Timeline
ONCBEONE MEDICINES LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 563,314 shares; 2024Q4: 653,721 shares; 2025Q1: 498,689 shares; 2025Q2: 509,990 shares; 2025Q3: 492,990 shares; 2025Q4: 500,000 shares; 2026Q1: 465,000 shares 465,000$138M3.83%-35,000Timeline
TNGXTANGO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 2,603,897 shares; 2024Q4: 2,603,897 shares; 2025Q1: 2,565,342 shares; 2025Q2: 3,364,814 shares; 2025Q3: 5,883,188 shares; 2025Q4: 8,165,374 shares; 2026Q1: 5,657,105 shares 5,657,105$118M3.28%-2,508,269Timeline
BCAXBICARA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 3,072,827 shares; 2024Q4: 3,272,827 shares; 2025Q1: 3,267,083 shares; 2025Q2: 5,216,969 shares; 2025Q3: 5,216,969 shares; 2025Q4: 5,216,969 shares; 2026Q1: 5,802,970 shares 5,802,970$115M3.2%+586,001Timeline
RVMDREVOLUTION MEDICINES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 753,601 shares; 2024Q4: 571,548 shares; 2025Q1: 563,755 shares; 2025Q2: 938,755 shares; 2025Q3: 1,043,720 shares; 2025Q4: 1,335,075 shares; 2026Q1: 1,110,980 shares 1,110,980$108M3%-224,095Timeline
ARWRARROWHEAD PHARMACEUTICALS INQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 2,458,778 shares; 2024Q4: 2,901,681 shares; 2025Q1: 2,669,880 shares; 2025Q2: 2,669,880 shares; 2025Q3: 2,669,880 shares; 2025Q4: 1,500,476 shares; 2026Q1: 1,615,476 shares 1,615,476$101M2.81%+115,000Timeline
MANEVERADERMICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 1,505,374 shares 1,505,374$95.1M2.64%newTimeline
XENEXENON PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 743,769 shares; 2024Q4: 743,769 shares; 2025Q1: 732,761 shares; 2025Q2: 812,761 shares; 2025Q3: 812,761 shares; 2025Q4: 812,761 shares; 2026Q1: 1,318,564 shares 1,318,564$76.7M2.13%+505,803Timeline
OLMAOLEMA PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 3,300,700 shares; 2026Q1: 4,756,949 shares 4,756,949$70.9M1.97%+1,456,249Timeline
CRNXCRINETICS PHARMACEUTICALS INQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 1,309,652 shares; 2024Q4: 1,609,652 shares; 2025Q1: 1,688,611 shares; 2025Q2: 1,688,611 shares; 2025Q3: 1,688,611 shares; 2025Q4: 1,507,636 shares; 2026Q1: 1,903,636 shares 1,903,636$69.1M1.92%+396,000Timeline
LXRXLEXICON PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 38,918,903 shares; 2024Q4: 38,918,903 shares; 2025Q1: 38,918,903 shares; 2025Q2: 38,918,903 shares; 2025Q3: 38,918,903 shares; 2025Q4: 38,918,903 shares; 2026Q1: 44,303,518 shares 44,303,518$69.1M1.92%+5,384,615Timeline
COGTCOGENT BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 854,379 shares; 2025Q3: 1,724,279 shares; 2025Q4: 1,629,279 shares; 2026Q1: 1,709,279 shares 1,709,279$65.8M1.82%+80,000Timeline
STOKSTOKE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 2,000,000 shares; 2025Q1: 2,247,347 shares; 2025Q2: 2,247,347 shares; 2025Q3: 2,247,347 shares; 2025Q4: 2,247,347 shares; 2026Q1: 1,995,347 shares 1,995,347$65M1.8%-252,000Timeline
RCUSARCUS BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 1,612,077 shares; 2024Q4: 1,612,077 shares; 2025Q1: 1,612,077 shares; 2025Q2: 1,612,077 shares; 2025Q3: 2,912,077 shares; 2025Q4: 3,007,077 shares; 2026Q1: 3,007,077 shares 3,007,077$65M1.8%0Timeline
GPCRSTRUCTURE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 1,026,811 shares; 2025Q4: 1,078,698 shares; 2026Q1: 1,328,698 shares 1,328,698$64M1.78%+250,000Timeline
IRONDISC MEDICINE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 1,071,865 shares; 2025Q2: 1,099,401 shares; 2025Q3: 913,401 shares; 2025Q4: 988,401 shares; 2026Q1: 988,401 shares 988,401$63.2M1.75%0Timeline
RYTMRHYTHM PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 277,533 shares; 2025Q2: 409,742 shares; 2025Q3: 499,975 shares; 2025Q4: 499,975 shares; 2026Q1: 725,511 shares 725,511$63.1M1.75%+225,536Timeline
SLDBSOLID BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 2,749,041 shares; 2024Q4: 3,749,041 shares; 2025Q1: 7,415,905 shares; 2025Q2: 7,415,905 shares; 2025Q3: 7,415,905 shares; 2025Q4: 7,690,405 shares; 2026Q1: 7,690,405 shares 7,690,405$55.4M1.53%0Timeline
SEPNSEPTERNA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 2,202,514 shares; 2025Q1: 2,202,514 shares; 2025Q2: 2,202,514 shares; 2025Q3: 2,202,514 shares; 2025Q4: 2,000,000 shares; 2026Q1: 2,000,000 shares 2,000,000$48.1M1.33%0Timeline
CNTACENTESSA PHARMACEUTICALS PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 3,258,677 shares; 2024Q4: 3,004,677 shares; 2025Q1: 2,960,029 shares; 2025Q2: 3,460,029 shares; 2025Q3: 3,227,517 shares; 2025Q4: 4,027,517 shares; 2026Q1: 1,053,464 shares 1,053,464$41.8M1.16%-2,974,053Timeline
SYRESPYRE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 374,000 shares; 2025Q1: 368,598 shares; 2025Q2: 368,598 shares; 2025Q3: 368,598 shares; 2025Q4: 818,598 shares; 2026Q1: 818,598 shares 818,598$41.3M1.14%0Timeline
CYTKCYTOKINETICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 525,971 shares; 2024Q4: 402,323 shares; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 613,952 shares 613,952$40.5M1.12%newTimeline
DYNDYNE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 1,134,664 shares; 2024Q4: 1,347,456 shares; 2025Q1: 2,717,987 shares; 2025Q2: 4,836,437 shares; 2025Q3: 4,729,174 shares; 2025Q4: 3,502,941 shares; 2026Q1: 2,229,125 shares 2,229,125$40.4M1.12%-1,273,816Timeline
TSHATAYSHA GENE THERAPIES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 4,879,875 shares; 2024Q4: 6,602,475 shares; 2025Q1: 6,514,737 shares; 2025Q2: 11,014,737 shares; 2025Q3: 11,014,737 shares; 2025Q4: 10,129,913 shares; 2026Q1: 8,829,913 shares 8,829,913$39.5M1.09%-1,300,000Timeline
DBVTDBV TECHNOLOGIES S AQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 1,857,362 shares; 2026Q1: 1,857,362 shares 1,857,362$38.8M1.08%0Timeline
ORICORIC PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 1,007,575 shares; 2024Q4: 1,007,575 shares; 2025Q1: 1,007,575 shares; 2025Q2: 1,007,575 shares; 2025Q3: 1,007,575 shares; 2025Q4: 1,007,575 shares; 2026Q1: 2,998,192 shares 2,998,192$38M1.05%+1,990,617Timeline
ENGNENGENE HOLDINGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 3,336,264 shares; 2026Q1: 5,253,159 shares 5,253,159$35.8M0.99%+1,916,895Timeline
PVLAPALVELLA THERAPEUTICS INC NEQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 75,000 shares; 2026Q1: 257,485 shares 257,485$32.1M0.89%+182,485Timeline
TBLATABOOLA.COM LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 9,969,495 shares; 2024Q4: 9,969,495 shares; 2025Q1: 9,969,495 shares; 2025Q2: 9,969,495 shares; 2025Q3: 9,969,495 shares; 2025Q4: 9,969,495 shares; 2026Q1: 9,969,495 shares 9,969,495$30.9M0.86%0Timeline
ELVNENLIVEN THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 746,226 shares 746,226$29.3M0.81%newTimeline
DNLIDENALI THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 834,028 shares; 2024Q4: 834,028 shares; 2025Q1: 821,513 shares; 2025Q2: 821,513 shares; 2025Q3: 821,513 shares; 2025Q4: 1,396,513 shares; 2026Q1: 1,396,513 shares 1,396,513$26.8M0.74%0Timeline
RELYREMITLY GLOBAL INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 25,000 shares; 2024Q4: 490,449 shares; 2025Q1: 490,449 shares; 2025Q2: 515,449 shares; 2025Q3: 1,618,271 shares; 2025Q4: 1,618,271 shares; 2026Q1: 1,543,271 shares 1,543,271$24.2M0.67%-75,000Timeline
DMRADAMORA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 900,000 shares 900,000$23.3M0.65%newTimeline
ZURAZURA BIO LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 1,300,000 shares; 2026Q1: 3,734,866 shares 3,734,866$22.2M0.62%+2,434,866Timeline
ANNXANNEXON INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 3,958,646 shares 3,958,646$21.9M0.61%newTimeline
TRVITREVI THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 2,906,060 shares; 2025Q1: 2,863,793 shares; 2025Q2: 3,938,793 shares; 2025Q3: 2,536,867 shares; 2025Q4: 2,286,867 shares; 2026Q1: 1,786,867 shares 1,786,867$21.3M0.59%-500,000Timeline
RAPPRAPPORT THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 384,197 shares; 2024Q4: 384,197 shares; 2025Q1: 378,469 shares; 2025Q2: 378,469 shares; 2025Q3: 1,053,469 shares; 2025Q4: 708,469 shares; 2026Q1: 641,469 shares 641,469$20.1M0.56%-67,000Timeline
GOOGLALPHABET INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 11,000 shares; 2024Q4: 7,000 shares; 2025Q1: 50,703 shares; 2025Q2: 50,703 shares; 2025Q3: 21,203 shares; 2025Q4: 20,703 shares; 2026Q1: 65,703 shares 65,703$18.9M0.52%+45,000Timeline
FULCFULCRUM THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 1,950,000 shares; 2026Q1: 2,350,000 shares 2,350,000$18M0.5%+400,000Timeline
WVEWAVE LIFE SCIENCES LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 5,721,172 shares; 2024Q4: 3,750,491 shares; 2025Q1: 3,696,322 shares; 2025Q2: 3,696,322 shares; 2025Q3: 3,696,322 shares; 2025Q4: 2,450,000 shares; 2026Q1: 2,450,000 shares 2,450,000$17.8M0.49%0Timeline
DFTXDEFINIUM THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 919,493 shares 919,493$17.4M0.48%newTimeline
AMLXAMYLYX PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 1,230,000 shares 1,230,000$17.1M0.47%newTimeline
CGEMCULLINAN THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 1,211,357 shares; 2024Q4: 1,211,357 shares; 2025Q1: 1,193,410 shares; 2025Q2: 1,193,410 shares; 2025Q3: 1,193,410 shares; 2025Q4: 1,193,410 shares; 2026Q1: 1,193,410 shares 1,193,410$17M0.47%0Timeline
NMRANEUMORA THERAPEUTICS INC.Quarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 2,606,571 shares; 2024Q4: 4,396,100 shares; 2025Q1: 4,358,283 shares; 2025Q2: 4,358,283 shares; 2025Q3: 4,358,283 shares; 2025Q4: 6,288,783 shares; 2026Q1: 8,497,822 shares 8,497,822$16.6M0.46%+2,209,039Timeline
QUREUNIQURE NVQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 275,200 shares; 2025Q4: not reported; 2026Q1: 1,000,000 shares 1,000,000$16.4M0.45%newTimeline
CTMXCYTOMX THERAPEUTICS INC.Quarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 3,457,711 shares 3,457,711$16.3M0.45%newTimeline
NVDANVIDIA CORPORATIONQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 48,932 shares; 2024Q4: 48,932 shares; 2025Q1: 44,432 shares; 2025Q2: 49,985 shares; 2025Q3: 37,485 shares; 2025Q4: 37,485 shares; 2026Q1: 89,085 shares 89,085$15.5M0.43%+51,600Timeline
SLNSILENCE THERAPEUTICS PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 2,831,770 shares; 2024Q4: 2,831,770 shares; 2025Q1: 2,789,833 shares; 2025Q2: 2,911,438 shares; 2025Q3: 2,911,438 shares; 2025Q4: 2,911,438 shares; 2026Q1: 2,911,438 shares 2,911,438$15.3M0.43%0Timeline
MSFTMICROSOFT CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 22,000 shares; 2024Q4: 23,000 shares; 2025Q1: 28,500 shares; 2025Q2: 16,150 shares; 2025Q3: 17,150 shares; 2025Q4: 15,000 shares; 2026Q1: 41,380 shares 41,380$15.3M0.42%+26,380Timeline
MNPRMONOPAR THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 212,298 shares; 2026Q1: 270,118 shares 270,118$14.8M0.41%+57,820Timeline
TSMTAIWAN SEMICONDUCTOR MANUFACQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 25,000 shares; 2024Q4: 15,000 shares; 2025Q1: 28,500 shares; 2025Q2: 30,500 shares; 2025Q3: 28,200 shares; 2025Q4: 27,700 shares; 2026Q1: 42,200 shares 42,200$14.3M0.4%+14,500Timeline
SIONSIONNA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 325,000 shares; 2025Q2: 325,000 shares; 2025Q3: 325,000 shares; 2025Q4: 300,000 shares; 2026Q1: 300,000 shares 300,000$12M0.33%0Timeline
NBISNEBIUS GROUP N.V.Quarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 120,000 shares; 2025Q1: 140,000 shares; 2025Q2: 51,000 shares; 2025Q3: 72,600 shares; 2025Q4: 76,218 shares; 2026Q1: 113,614 shares 113,614$11.8M0.33%+37,396Timeline
RZLTREZOLUTE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 4,870,000 shares; 2025Q4: not reported; 2026Q1: 3,328,287 shares 3,328,287$10.2M0.28%newTimeline
IKTINHIBIKASE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 5,850,000 shares; 2026Q1: 5,850,000 shares 5,850,000$9.83M0.27%0Timeline
AMZNAMAZON COM INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 34,750 shares; 2024Q4: 36,500 shares; 2025Q1: 56,500 shares; 2025Q2: 56,500 shares; 2025Q3: 58,500 shares; 2025Q4: 51,500 shares; 2026Q1: 46,641 shares 46,641$9.71M0.27%-4,859Timeline
GENBGENERATE BIOMEDICINES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 736,104 shares 736,104$9.2M0.26%newTimeline
MPLTMAPLIGHT THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 450,000 shares; 2026Q1: 450,000 shares 450,000$9.15M0.25%0Timeline
NOWSERVICENOW INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 7,500 shares; 2024Q4: 5,605 shares; 2025Q1: 9,126 shares; 2025Q2: 5,126 shares; 2025Q3: 7,126 shares; 2025Q4: 35,630 shares; 2026Q1: 87,090 shares 87,090$9.11M0.25%+51,460Timeline
CRWDCROWDSTRIKE HLDGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 25,000 shares; 2024Q4: 24,000 shares; 2025Q1: 25,000 shares; 2025Q2: 18,500 shares; 2025Q3: 18,500 shares; 2025Q4: 16,500 shares; 2026Q1: 23,070 shares 23,070$9.01M0.25%+6,570Timeline
PDDPDD HOLDINGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 40,401 shares; 2024Q4: 52,901 shares; 2025Q1: 52,901 shares; 2025Q2: 52,901 shares; 2025Q3: 43,401 shares; 2025Q4: 63,401 shares; 2026Q1: 83,401 shares 83,401$8.52M0.24%+20,000Timeline
TSLATESLA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 9,000 shares; 2025Q2: 4,000 shares; 2025Q3: 1,500 shares; 2025Q4: 1,500 shares; 2026Q1: 21,500 shares 21,500$7.99M0.22%+20,000Timeline
NBPNOVABRIDGE BIOSCIENCESQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 1,165,957 shares; 2025Q4: 3,000,000 shares; 2026Q1: 3,000,000 shares 3,000,000$7.38M0.2%0Timeline
BCYCBICYCLE THERAPEUTICS PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 1,839,398 shares; 2025Q1: 1,812,752 shares; 2025Q2: 2,012,752 shares; 2025Q3: 2,012,752 shares; 2025Q4: 2,012,752 shares; 2026Q1: 1,560,882 shares 1,560,882$7.24M0.2%-451,870Timeline
WHWKWHITEHAWK THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 2,082,000 shares; 2025Q2: 2,082,000 shares; 2025Q3: 2,082,000 shares; 2025Q4: 2,082,000 shares; 2026Q1: 2,082,000 shares 2,082,000$7.18M0.2%0Timeline
TENXTENAX THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 352,441 shares; 2025Q4: 427,141 shares; 2026Q1: 427,141 shares 427,141$6.83M0.19%0Timeline
VTVTVTV THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 163,000 shares; 2025Q4: 163,000 shares; 2026Q1: 163,000 shares 163,000$6.46M0.18%0Timeline
DDOGDATADOG INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 32,925 shares; 2024Q4: 30,425 shares; 2025Q1: 47,425 shares; 2025Q2: 38,425 shares; 2025Q3: 32,925 shares; 2025Q4: 36,425 shares; 2026Q1: 54,300 shares 54,300$6.41M0.18%+17,875Timeline
FROGJFROG LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 61,000 shares; 2024Q4: 120,116 shares; 2025Q1: 131,616 shares; 2025Q2: 107,116 shares; 2025Q3: 107,116 shares; 2025Q4: 93,616 shares; 2026Q1: 128,816 shares 128,816$6.05M0.17%+35,200Timeline
DTDYNATRACE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 82,729 shares; 2024Q4: 82,729 shares; 2025Q1: 87,729 shares; 2025Q2: 75,229 shares; 2025Q3: 100,229 shares; 2025Q4: 115,229 shares; 2026Q1: 150,000 shares 150,000$5.55M0.15%+34,771Timeline
WKWORKIVA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 10,000 shares; 2025Q1: 17,500 shares; 2025Q2: 28,000 shares; 2025Q3: 30,000 shares; 2025Q4: 79,123 shares; 2026Q1: 92,500 shares 92,500$5.52M0.15%+13,377Timeline
ABSIABSCI CORPORATIONQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 1,800,000 shares 1,800,000$5.4M0.15%newTimeline
IVVDINVIVYD INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 4,000,000 shares; 2026Q1: 4,000,000 shares 4,000,000$5.2M0.14%0Timeline
MSLESATELLOS BIOSCIENCE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 892,074 shares 892,074$5.02M0.14%newTimeline
IONQIONQ INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 500,000 shares; 2024Q4: 170,000 shares; 2025Q1: 170,000 shares; 2025Q2: 170,000 shares; 2025Q3: 170,000 shares; 2025Q4: 170,000 shares; 2026Q1: 170,000 shares 170,000$4.9M0.14%0Timeline
AVGOBROADCOM INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 7,000 shares; 2026Q1: 15,000 shares 15,000$4.64M0.13%+8,000Timeline
AGMBAGOMAB THERAPEUTICS NVQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 411,250 shares 411,250$4.31M0.12%newTimeline
CLBTCELLEBRITE DI LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 60,000 shares; 2025Q3: 90,000 shares; 2025Q4: 150,000 shares; 2026Q1: 311,544 shares 311,544$4.29M0.12%+161,544Timeline
SEERSEER INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 4,000,000 shares; 2024Q4: 4,000,000 shares; 2025Q1: 4,000,000 shares; 2025Q2: 4,000,000 shares; 2025Q3: 4,000,000 shares; 2025Q4: 4,000,000 shares; 2026Q1: 2,458,673 shares 2,458,673$4.13M0.11%-1,541,327Timeline
KRROKORRO BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 418,833 shares; 2024Q4: 418,833 shares; 2025Q1: 418,833 shares; 2025Q2: 418,833 shares; 2025Q3: 418,833 shares; 2025Q4: 347,718 shares; 2026Q1: 347,718 shares 347,718$3.94M0.11%0Timeline
AGENAGENUS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 775,000 shares; 2024Q4: not reported; 2025Q1: 500,000 shares; 2025Q2: 1,064,250 shares; 2025Q3: 1,064,250 shares; 2025Q4: 1,064,250 shares; 2026Q1: 1,064,250 shares 1,064,250$3.55M0.1%0Timeline
FHTXFOGHORN THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 720,720 shares; 2024Q4: 720,720 shares; 2025Q1: 720,720 shares; 2025Q2: 720,720 shares; 2025Q3: 720,720 shares; 2025Q4: 720,720 shares; 2026Q1: 720,720 shares 720,720$3.45M0.1%0Timeline
FPSFORGENT POWER SOLUTIONS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 100,000 shares 100,000$2.93M0.08%newTimeline
KLRSKALARIS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 282,586 shares; 2025Q2: 282,586 shares; 2025Q3: 318,264 shares; 2025Q4: 435,798 shares; 2026Q1: 435,798 shares 435,798$2.51M0.07%0Timeline
GTLBGITLAB INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 35,000 shares; 2025Q3: 64,000 shares; 2025Q4: 99,000 shares; 2026Q1: 100,000 shares 100,000$2.16M0.06%+1,000Timeline
MUMICRON TECHNOLOGY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 6,000 shares 6,000$2.03M0.06%newTimeline
MNDYMONDAY COM LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 2,000 shares; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 7,000 shares; 2025Q4: 17,000 shares; 2026Q1: 25,000 shares 25,000$1.73M0.05%+8,000Timeline
GOSSGOSSAMER BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 13,281,610 shares; 2024Q4: 5,208,968 shares; 2025Q1: 5,208,968 shares; 2025Q2: 5,208,968 shares; 2025Q3: 5,208,968 shares; 2025Q4: 5,208,968 shares; 2026Q1: 5,208,968 shares 5,208,968$1.71M0.05%0Timeline
ASAMER SPORTS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 25,000 shares; 2025Q4: not reported; 2026Q1: 50,000 shares 50,000$1.65M0.05%newTimeline
BEKEKE HLDGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 100,000 shares; 2024Q4: 60,000 shares; 2025Q1: 105,000 shares; 2025Q2: 105,000 shares; 2025Q3: 145,000 shares; 2025Q4: 145,000 shares; 2026Q1: 100,000 shares 100,000$1.5M0.04%-45,000Timeline
IRENIREN LIMITEDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 20,000 shares; 2025Q4: 43,100 shares; 2026Q1: 43,100 shares 43,100$1.48M0.04%0Timeline
RANIRANI THERAPEUTICS HLDGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 2,000,000 shares; 2026Q1: 2,000,000 shares 2,000,000$1.47M0.04%0Timeline
AEVAAEVA TECHNOLOGIES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 110,000 shares 110,000$1.45M0.04%newTimeline
MDLNMEDLINE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 75,000 shares; 2026Q1: 25,000 shares 25,000$1.11M0.03%-50,000Timeline
FIGFIGMA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 15,000 shares; 2025Q4: 25,000 shares; 2026Q1: 50,000 shares 50,000$1.06M0.03%+25,000Timeline
PRMBPRIMO BRANDS CORPORATIONQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 37,500 shares; 2025Q3: 75,000 shares; 2025Q4: 75,000 shares; 2026Q1: 50,000 shares 50,000$942K0.03%-25,000Timeline
NUNU HLDGS LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 50,000 shares; 2024Q4: 50,000 shares; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 25,000 shares 25,000$359K0.01%newTimeline

Sold out in Q1 2026

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
APLSAPELLIS PHARMACEUTICALS INC2,578,396$64.8Mshares
ASNDASCENDIS PHARMA A/S235,862$50.3Mshares
RAPTRAPT THERAPEUTICS INC1,375,000$46.6Mshares
ZYMEZYMEWORKS INC1,680,121$44.2Mshares
MLYSMINERALYS THERAPEUTICS INC699,999$25.4Mshares
IHSIHS HOLDING LIMITED2,357,520$17.6Mshares
UPBUPSTREAM BIO INC588,450$16Mshares
MIND MEDICINE MINDMED INCMIND MEDICINE MINDMED INC800,000$10.7Mshares
BNTCBENITEC BIOPHARMA INC775,000$10.4Mshares
LXEOLEXEO THERAPEUTICS INC720,622$7.16Mshares
CRMSALESFORCE INC26,100$6.91Mshares
CMPSCOMPASS PATHWAYS PLC1,000,000$6.9Mshares
BLLNBILLIONTOONE INC83,833$6.86Mshares
SVRASAVARA INC1,000,000$6.03Mshares
XFORX4 PHARMACEUTICALS INC1,500,000$6Mshares
ALMSALUMIS INC500,000$4.88Mshares
METAMETA PLATFORMS INC7,169$4.73Mshares
PEPGPEPGEN INC700,000$4.56Mshares
SGMTSAGIMET BIOSCIENCES INC724,771$4.29Mshares
ADBEADOBE INC12,051$4.22Mshares
EDUNEW ORIENTAL ED & TECHNOLOGY62,000$3.41Mshares
ZSZSCALER INC12,000$2.7Mshares
BDTXBLACK DIAMOND THERAPEUTICS I1,046,517$2.54Mshares
QCOMQUALCOMM INC14,000$2.39Mshares
ARMARM HOLDINGS PLC21,500$2.35Mshares
TILINSTIL BIO INC203,933$2.24Mshares
PANWPALO ALTO NETWORKS INC11,450$2.11Mshares
CRWVCOREWEAVE INC27,500$1.97Mshares
VRNSVARONIS SYS INC37,500$1.23Mshares
GENERATION BIO COGENERATION BIO CO201,419$1.14Mshares
CRBUCARIBOU BIOSCIENCES INC105,347$168Kshares
CYCNCYCLERION THERAPEUTICS INC115,603$147Kshares

How Q1 2026 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0002005245-26-000006 base2026-05-14acceptance time not in the bulk data set