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Disclosery

ZYME ZYMEWORKS INC

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COM (common), issuer CIK 1937653

195 managers (203 13F filers) reported a position in ZYME shares at 2026-06-30, 68,362,120 shares in all. 23 filers opened a position and 29 filers sold out during the quarter.

Managers
195
13F filers
203
New
23
Added
61
Reduced
73
Sold out
29
Shares held by filers
68,362,120

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q2 2026

Filers in the available 13F reports with a share position at 2026-06-30, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
EcoR1 Capital, LLC22,970,388$600M29.77%013F-HRTimeline
Rubric Capital Management LP7,000,000$183M1.68%013F-HRTimeline
BlackRock, Inc.in group BlackRock, Inc.4,251,030$111M<0.01%-302,85813F-HRTimelineGroup
PERCEPTIVE ADVISORS LLCin group PERCEPTIVE ADVISORS LLC4,182,953$109M1.7%+672,87513F-HRTimelineGroup
BVF INC/ILin group BVF INC/IL3,649,142$95.4M2.44%-85,00013F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY2,231,260$58.3M<0.01%-249,30813F-HRTimelineGroup
VANGUARD GROUP INCgroup of 6 filers holding2,189,691$57.2M-140,708Timeline
BNP PARIBAS ASSET MANAGEMENT Holding S.…in group BNP PARIBAS ASSET MANAGEMENT …1,781,116$46.6M0.05%-126,92313F-HRTimelineGroup
Assenagon Asset Management S.A.1,252,027$32.7M0.04%+524,04113F-HR/ATimeline
Nextech Invest Ltd.1,113,946$29.1M1.38%013F-HRTimeline
STATE STREET CORPin group STATE STREET CORP1,088,216$28.4M<0.01%+76,43913F-HRTimelineGroup
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP994,955$26M<0.01%-144,18013F-HRTimelineGroup
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC914,136$23.9M0.01%-235,88213F-HRTimelineGroup
NOMURA ASSET MANAGEMENT INTERNATIONAL I…in group NOMURA ASSET MANAGEMENT CO LTD889,802$23.3M0.03%new13F-HRTimelineGroup
FMR LLCin group FMR LLC702,568$18.4M<0.01%+35,41513F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC692,410$18.1M<0.01%+32,47013F-HRTimelineGroup
Prosight Management, LP674,434$17.6M3.04%+135,38513F-HRTimeline
Qube Research & Technologies Ltd593,590$15.5M0.02%+81,65313F-HRTimeline
Redmile Group, LLCin group Redmile Group, LLC491,654$12.9M0.86%013F-HRTimelineGroup
Capricorn Fund Managers Ltd486,529$12.7M1.02%-520,68113F-HRTimeline
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC470,822$12.3M<0.01%-128,66413F-HRTimelineGroup
ARROWSTREET CAPITAL, LIMITED PARTNERSHIPin group ARROWSTREET CAPITAL, LIMITED …418,497$10.9M<0.01%-325,40113F-HRTimelineGroup
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\397,190$10.4M<0.01%-524,06013F-HRTimelineGroup
Hillsdale Investment Management Inc.382,922$10M0.23%+37,30013F-HRTimeline
FIRST TRUST ADVISORS LPin group FIRST TRUST ADVISORS LP340,363$8.9M0.01%new13F-HRTimelineGroup
Granahan Investment Management, LLC336,157$8.79M0.31%+85,38413F-HRTimeline
NORTHERN TRUST CORPin group NORTHERN TRUST CORP321,073$8.39M<0.01%+86313F-HRTimelineGroup
Pictet Asset Management Holding SAin group Pictet Asset Management Holdi…308,187$7.45M0.01%+298,93113F-HRTimelineGroup
PICTON MAHONEY ASSET MANAGEMENT271,343$7.09M0.07%+14,65313F-HRTimeline
SILVERCREST ASSET MANAGEMENT GROUP LLC223,766$5.85M0.04%+60,11713F-HRTimeline
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/219,071$5.73M<0.01%-17,68313F-HRTimelineGroup
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN217,199$5.68M<0.01%+27,56313F-HRTimelineGroup
SummitTX Capital, L.P.210,802$5.51M0.15%-110,62513F-HRTimeline
Man Group plcin group Man Group plc210,779$5.51M0.01%+20,88913F-HRTimelineGroup
UBS Group AGgroup of 2 filers holding196,454$5.14M-294,710Timeline
FEDERATED HERMES, INC.in group FEDERATED HERMES, INC.187,995$4.91M0.01%+5,58513F-HRTimelineGroup
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC166,416$4.35M<0.01%-9,99513F-HRTimelineGroup
STATE OF WISCONSIN INVESTMENT BOARD155,579$4.07M0.01%+89,47313F-HRTimeline
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co152,416$3.98M<0.01%-32,70813F-HRTimelineGroup
KENNEDY CAPITAL MANAGEMENT LLC145,386$3.8M0.07%-2,84013F-HRTimeline
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.144,807$3.79M<0.01%-90,81413F-HRTimelineGroup
DIADEMA PARTNERS LP142,132$3.72M1.31%013F-HRTimeline
CITIGROUP INCin group CITIGROUP INC131,441$3.44M<0.01%+17,11413F-HRTimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp131,106$3.43M<0.01%+7,00113F-HRTimelineGroup
XTX Topco Ltdin group XTX Topco Ltd125,877$3.29M0.04%-18,00513F-HRTimelineGroup
Nuveen, LLCin group TIAA119,389$3.12M<0.01%-532,27313F-HRTimelineGroup
PANAGORA ASSET MANAGEMENT INC118,603$3.1M0.01%-88,25113F-HRTimeline
Invesco Ltd.in group Invesco Ltd.112,212$2.93M<0.01%-13,41813F-HRTimelineGroup
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC111,282$2.91M<0.01%+20,61313F-HRTimelineGroup
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…110,014$2.88M<0.01%-28,67613F-HRTimelineGroup
Tidal Investments LLCin group Tidal Investments LLC105,615$2.76M0.01%+68413F-HRTimelineGroup
Tema ETFs LLC105,615$2.76M0.09%+68413F-HRTimeline
PLATINUM INVESTMENT MANAGEMENT LTD105,184$2.75M0.68%013F-HRTimeline
Manatuck Hill Partners, LLC100,000$2.61M0.87%+60,00013F-HRTimeline
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO106,398$2.56M<0.01%-7,67413F-HRTimelineGroup
KORNITZER CAPITAL MANAGEMENT INC /KS88,800$2.32M0.05%013F-HRTimeline
MACKENZIE FINANCIAL CORP87,745$2.29M<0.01%+5,01913F-HRTimeline
PRINCIPAL FINANCIAL GROUP INCin group PRINCIPAL FINANCIAL GROUP INC84,990$2.22M<0.01%+6,44313F-HRTimelineGroup
Y-Intercept (Hong Kong) Ltd83,455$2.18M0.04%new13F-HRTimeline
SUSQUEHANNA INTERNATIONAL GROUP, LLPgroup of 3 filers holding83,433$2.18M-40,783Timeline
LMR Partners LLPin group LMR Partners LLP82,500$2.16M0.02%new13F-HRTimelineGroup
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC82,264$2.15M<0.01%+8,04213F-HRTimelineGroup
STIFEL FINANCIAL CORPin group STIFEL FINANCIAL CORP77,214$2.02M<0.01%+45813F-HRTimelineGroup
FRANKLIN RESOURCES INCin group Franklin Resources76,528$2M<0.01%-1,13113F-HRTimelineGroup
RHUMBLINE ADVISERS75,066$1.96M<0.01%-33313F-HRTimeline
Swiss National Bank74,200$1.94M<0.01%013F-HRTimeline
MARTINGALE ASSET MANAGEMENT L P73,282$1.92M0.05%+40,51813F-HRTimeline
TWO SIGMA INVESTMENTS, LPin group TWO SIGMA INVESTMENTS, LP71,874$1.88M<0.01%new13F-HRTimelineGroup
Dana Investment Advisors, Inc.71,660$1.87M0.05%+15,55313F-HRTimeline
CREDIT AGRICOLE S Ain group CREDIT AGRICOLE S A71,000$1.86M<0.01%-4,00013F-HRTimelineGroup
Fisher Asset Management, LLC70,775$1.85M<0.01%-30,66413F-HRTimeline
SEGALL BRYANT & HAMILL, LLC66,836$1.75M0.02%+21,11013F-HRTimeline
Verdad Advisers, LP66,688$1.74M1.67%-16,01013F-HRTimeline
Campbell & CO Investment Adviser LLC60,874$1.59M0.08%+5,99113F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA56,278$1.47M<0.01%+8,91813F-HRTimelineGroup
ALLIANCEBERNSTEIN L.P.55,896$1.4M<0.01%013F-HRTimeline
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…50,825$1.33M0.31%+40,12313F-HRTimelineGroup
ENVESTNET ASSET MANAGEMENT INCin group ENVESTNET ASSET MANAGEMENT INC48,675$1.27M<0.01%+8,25613F-HRTimelineGroup
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…47,867$1.25M<0.01%+41713F-HRTimelineGroup
Quantinno Capital Management LP47,642$1.25M<0.01%+8,00213F-HRTimeline
North Growth Management Ltd.46,000$1.2M0.15%013F-HRTimeline
Legal & General Group Plcin group Legal & General Group Plc43,160$1.13M<0.01%+16,95113F-HRTimelineGroup
VICTORY CAPITAL MANAGEMENT INC42,524$1.11M<0.01%+12013F-HRTimeline
MARSHALL WACE, LLPin group MARSHALL WACE, LLP40,948$1.07M<0.01%+8,72513F-HRTimelineGroup
O'SHAUGHNESSY ASSET MANAGEMENT, LLC39,534$1.03M<0.01%+2,40513F-HRTimeline
PRICE T ROWE ASSOCIATES INC /MD/38,486$1.01M<0.01%+2,99913F-HRTimeline
CALIFORNIA STATE TEACHERS RETIREMENT SY…37,744$987K<0.01%+35513F-HR/ATimeline
JACOBS LEVY EQUITY MANAGEMENT, INC36,922$965K<0.01%-5,86413F-HRTimeline
TUDOR INVESTMENT CORP ET AL36,471$953K<0.01%-40413F-HRTimeline
HighTower Advisors, LLC36,100$944K<0.01%-16213F-HRTimeline
Persistent Asset Partners Ltd35,935$939K0.3%013F-HRTimeline
HighVista Strategies LLC34,013$889K0.2%-7213F-HRTimeline
COMMONWEALTH EQUITY SERVICES, LLC32,052$838K<0.01%+6,02113F-HRTimeline
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …30,886$807K<0.01%-70613F-HRTimelineGroup
Creative Planningin group Creative Planning29,731$777K<0.01%-2,66313F-HRTimelineGroup
SBI Okasan Asset Management Co.Ltd.32,000$771K0.03%013F-HRTimeline
MetLife Investment Management, LLCin group MetLife Investment Management…27,884$729K<0.01%-1,76913F-HRTimelineGroup
MASSACHUSETTS FINANCIAL SERVICES CO /MA/in group MASSACHUSETTS FINANCIAL SERVI…27,670$723K<0.01%+31613F-HRTimelineGroup
STRS OHIO26,500$693K<0.01%-3,60013F-HRTimeline
Brevan Howard Capital Management LPin group Brevan Howard Capital Managem…25,956$678K0.01%new13F-HRTimelineGroup
Jump Financial, LLCin group Jump Financial, LLC25,608$669K0.01%new13F-HRTimelineGroup
Zurcher Kantonalbank (Zurich Cantonalba…25,162$658K<0.01%-14,19313F-HRTimeline
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding24,844$649K-2,432Timeline
RITHOLTZ WEALTH MANAGEMENT24,243$634K0.01%013F-HR/ATimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS23,229$607K<0.01%-4,89013F-HRTimelineGroup
Duncan Williams Asset Management, LLC22,095$578K0.13%013F-HRTimeline
BARCLAYS PLCin group BARCLAYS PLC20,603$539K<0.01%+2,22913F-HRTimelineGroup
VIRGINIA RETIREMENT SYSTEMS ET Al19,435$508K<0.01%+7,50013F-HRTimeline
SIMPLEX TRADING, LLC19,431$508K0.01%+18,09513F-HRTimeline
BetterWealth, LLC18,622$487K0.09%new13F-HRTimeline
BANK OF MONTREAL /CAN/in group BANK OF MONTREAL /CAN/18,416$481K<0.01%+94813F-HRTimelineGroup
LOS ANGELES CAPITAL MANAGEMENT LLC18,267$477K<0.01%-21,48313F-HRTimeline
Jupiter Topco LLCin group Janus Henderson18,200$476K<0.01%13F-HRTimelineGroup
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC17,437$456K<0.01%-209,53013F-HRTimelineGroup
NEW YORK STATE COMMON RETIREMENT FUND17,371$454K<0.01%013F-HRTimeline
Universal- Beteiligungs- und Serviceges…in group Universal- Beteiligungs- und …17,310$452K<0.01%-13,12213F-HRTimelineGroup
Squarepoint Ops LLCin group Squarepoint Ops LLC16,200$423K<0.01%-66,94613F-HRTimelineGroup
HSBC HOLDINGS PLCin group HSBC HOLDINGS PLC15,588$421K<0.01%-22,18913F-HRTimelineGroup
Vinva Investment Management Ltd11,983$420K<0.01%-12,10713F-HRTimeline
Jackson Creek Investment Advisors LLC18,648$409K0.14%-4713F-HRTimeline
STATE BOARD OF ADMINISTRATION OF FLORID…15,340$401K<0.01%013F-HRTimeline
AGF MANAGEMENT LTDin group AGF MANAGEMENT LTD15,000$392K<0.01%013F-HRTimelineGroup
Police & Firemen's Retirement System of…13,702$358K<0.01%013F-HRTimeline
INTECH INVESTMENT MANAGEMENT LLC11,935$312K<0.01%-60613F-HRTimeline
State of New Jersey Common Pension Fund…in group State of New Jersey Common Pe…11,923$312K<0.01%-86513F-HRTimelineGroup
Janney Montgomery Scott LLC11,865$310K<0.01%+37813F-HRTimeline
China Universal Asset Management Co., L…11,622$304K0.02%-1,65813F-HRTimeline
JAMES INVESTMENT RESEARCH, INC.10,925$286K0.03%013F-HRTimeline
Ewing Morris & Co. Investment Partners …10,850$284K0.15%013F-HRTimeline
ARIZONA STATE RETIREMENT SYSTEM10,175$266K<0.01%-10213F-HRTimeline
Jain Global LLC10,010$262K<0.01%new13F-HRTimeline
PSP Research LLC10,000$261K0.14%013F-HRTimeline
Mitsubishi UFJ Trust & Banking Corpin group Mitsubishi UFJ Trust & Bankin…9,569$250K<0.01%new13F-HRTimelineGroup
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC9,334$244K<0.01%+34113F-HRTimelineGroup
Allspring Global Investments Holdings, …in group Allspring Global Investments …8,762$225K<0.01%+25513F-HRTimelineGroup
ProShare Advisors LLC8,557$224K<0.01%-2,01713F-HRTimeline
INCEPTIONR LLC8,313$217K0.05%new13F-HRTimeline
Magnetar Financial LLCin group Magnetar Financial LLC8,292$217K<0.01%new13F-HRTimelineGroup
KLP KAPITALFORVALTNING AS8,000$209K<0.01%013F-HRTimeline
PRUDENTIAL FINANCIAL INCin group PRUDENTIAL FINANCIAL INC7,940$208K<0.01%-14,03013F-HRTimelineGroup
SG Americas Securities, LLC6,321$165K<0.01%-4,10813F-HRTimeline
Northwest & Ethical Investments L.P.4,630$112K<0.01%-7,61413F-HRTimeline
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…4,164$109K<0.01%013F-HRTimelineGroup
DekaBank Deutsche Girozentrale3,843$94K<0.01%013F-HRTimeline
Arax Advisory Partners2,998$78.4K<0.01%new13F-HRTimeline
State of Wyoming2,792$73K0.01%-14,35613F-HRTimeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…2,373$62K<0.01%-2,49513F-HRTimelineGroup
Asset Management One Co., Ltd.1,659$43.4K<0.01%new13F-HRTimeline
GF FUND MANAGEMENT CO. LTD.1,585$41.4K<0.01%-9613F-HRTimeline
TD Waterhouse Canada Inc.1,439$37K<0.01%013F-HRTimeline
Caitong International Asset Management …1,309$34.2K<0.01%+1,09313F-HRTimeline
Eurizon Capital SGR S.p.A.1,321$31.9K<0.01%new13F-HRTimeline
GAMMA Investing LLC1,114$29.1K<0.01%+1713F-HRTimeline
Optiver Holding B.V.in group Optiver Holding B.V.1,039$27.2K<0.01%+8113F-HRTimelineGroup
Steward Partners Investment Advisory, L…971$25.4K<0.01%013F-HRTimeline
Nykredit A/Sin group Nykredit A/S966$25.3K<0.01%13F-HRTimelineGroup
LANARK FINANCIAL, INC.962$25.1K<0.01%+33913F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…898$23.5K<0.01%-8913F-HRTimelineGroup
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.882$23.1K<0.01%013F-HRTimelineGroup
JONES FINANCIAL COMPANIES LLLPin group JONES FINANCIAL COMPANIES LLLP837$20.2K<0.01%+37213F-HRTimelineGroup
Freestone Grove Partners LP648$16.9K<0.01%-12,29713F-HRTimeline
NATIONAL BANK OF CANADA /FI/in group NATIONAL BANK OF CANADA /FI/581$15.2K<0.01%+2713F-HRTimelineGroup
Federation des caisses Desjardins du Qu…570$14.9K<0.01%013F-HRTimeline
NISA INVESTMENT ADVISORS, LLC481$12.6K<0.01%-49013F-HRTimeline
UMB Bank, n.a.464$12.1K<0.01%-213F-HRTimelineThe filing omitted confidential holdings, a later amendment may add them.
HUNTINGTON NATIONAL BANKin group HUNTINGTON NATIONAL BANK460$12K<0.01%+11713F-HRTimelineGroup
Inspire Investing, LLCin group Inspire Investing, LLC332$8.68K<0.01%new13F-HRTimelineGroup
Parallel Advisors, LLC329$8.6K<0.01%-2313F-HRTimeline
US BANCORP \DE\in group US BANCORP \DE\315$8.23K<0.01%-3713F-HRTimelineGroup
SBI Securities Co., Ltd.312$8.16K<0.01%+30113F-HRTimeline
Integrated Wealth Concepts LLC295$7.71K<0.01%new13F-HRTimeline
Quarry LP210$5.49K<0.01%new13F-HRTimeline
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…187$4.89K<0.01%-3113F-HRTimelineGroup
Sterling Capital Management LLC165$4.31K<0.01%-15913F-HRTimeline
Fortitude Family Office, LLC116$3.03K<0.01%new13F-HRTimeline
Allworth Financial LP108$2.82K<0.01%-113F-HRTimeline
IFP Advisors, Inc96$2.51K<0.01%013F-HRTimeline
ROTHSCHILD INVESTMENT LLC80$2.09K<0.01%013F-HRTimeline
HighMark Wealth Management LLC80$2.09K<0.01%013F-HRTimeline
SJS Investment Consulting Inc.77$2.01K<0.01%new13F-HRTimeline
Kilter Group LLC66$1.73K<0.01%013F-HRTimeline
Bare Financial Services, Inc64$1.67K<0.01%013F-HRTimeline
Rockefeller Capital Management L.P.in group Rockefeller Capital Managemen…61$1.59K<0.01%013F-HRTimelineGroup
True Wealth Design, LLC58$1.52K<0.01%013F-HRTimeline
Physician Wealth Advisors, Inc.51$1.33K<0.01%013F-HRTimeline
Versant Capital Management, Inc45$1.18K<0.01%013F-HRTimeline
Covestor Ltd40$1K<0.01%+1213F-HRTimeline
Farther Finance Advisors, LLC30$784<0.01%-2713F-HRTimeline
INTERNATIONAL ASSETS INVESTMENT MANAGEM…25$643<0.01%013F-HRTimeline
Essential Partners LLC12$314<0.01%013F-HRTimeline
Smartleaf Asset Management LLC12$289<0.01%013F-HRTimeline
Clearstead Advisors, LLC6$157<0.01%new13F-HRTimeline
Larson Financial Group LLC6$157<0.01%013F-HRTimeline
Silver Grove Financial Group, Inc.4$105<0.01%new13F-HRTimeline
Hughes Financial Services, LLC3$78<0.01%-113F-HRTimeline