Sands Capital Alternatives, LLC More: the full row for Sands Capital Alternatives, LLC 13,018,965 $26.4M 4.31% 0 13F-HR Timeline Soleus Capital Management, L.P. More: the full row for Soleus Capital Management, L.P. 10,875,000 $22.1M 0.76% 0 13F-HR Timeline Trails Edge Capital Partners, LP More: the full row for Trails Edge Capital Partners, LP 9,051,318 $18.4M 2.92% +993,973 13F-HR Timeline Fairmount Funds Management LLC More: the full row for Fairmount Funds Management LLC 8,625,000 $17.5M 1.16% 0 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 7,768,057 $15.8M <0.01% +1,464,624 13F-HR Timeline Group ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 7,387,205 $15M 0.7% +780,633 13F-HR Timeline Group VANGUARD GROUP INC group of 4 filers holding More: the full row for VANGUARD GROUP INC 6,388,650 $13M +716,710 Timeline Blackstone Inc. in group Blackstone Inc. More: the full row for Blackstone Inc. 5,938,276 $12.1M 0.04% 0 13F-HR Timeline Group The filing omitted confidential holdings, a later amendment may add them. Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 5,850,000 $11.9M 0.24% 0 13F-HR Timeline Group Commodore Capital LP in group Commodore Capital LP More: the full row for Commodore Capital LP 5,397,488 $11M 0.65% 0 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 4,028,102 $8.18M 0.01% +1,100,025 13F-HR Timeline Group Saturn V Capital Management LP More: the full row for Saturn V Capital Management LP 3,869,056 $7.85M 1.13% +5,611 13F-HR Timeline Kalehua Capital Management LLC More: the full row for Kalehua Capital Management LLC 3,821,890 $7.76M 4.46% 0 13F-HR/A Timeline Spruce Street Capital LP More: the full row for Spruce Street Capital LP 3,581,603 $7.27M 1.43% 0 13F-HR Timeline Squadron Capital Management LLC More: the full row for Squadron Capital Management LLC 3,000,000 $6.09M 2.08% -500,000 13F-HR Timeline Nantahala Capital Management, LLC More: the full row for Nantahala Capital Management, LLC 2,701,863 $5.48M 0.33% 0 13F-HR/A Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 2,607,129 $5.29M <0.01% +436,943 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 1,909,101 $3.88M <0.01% +223,285 13F-HR Timeline Group SummitTX Capital, L.P. More: the full row for SummitTX Capital, L.P. 1,780,262 $3.61M 0.1% +255,726 13F-HR Timeline Integral Health Asset Management, LLC More: the full row for Integral Health Asset Management, LLC 1,350,000 $2.74M 0.11% 0 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 878,585 $1.78M <0.01% +159,785 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 806,264 $1.64M <0.01% -41,347 13F-HR Timeline Group SPHERA FUNDS MANAGEMENT LTD. in group SPHERA FUNDS MANAGEMENT LTD. More: the full row for SPHERA FUNDS MANAGEMENT LTD. 649,309 $1.32M 0.19% new 13F-HR Timeline Group Kennondale Capital Management LLC More: the full row for Kennondale Capital Management LLC 565,983 $1.15M 0.77% new 13F-HR Timeline Pathstone Holdings, LLC in group Pathstone Holdings, LLC More: the full row for Pathstone Holdings, LLC 510,596 $1.04M <0.01% new 13F-HR Timeline Group AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 468,197 $950K <0.01% +296,184 13F-HR Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 425,492 $864K <0.01% -46,907 13F-HR Timeline Group Stonepine Capital Management, LLC More: the full row for Stonepine Capital Management, LLC 396,179 $804K 0.61% -561,023 13F-HR/A Timeline Seven Fleet Capital Management LP More: the full row for Seven Fleet Capital Management LP 346,900 $704K 0.12% +21,300 13F-HR Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 303,126 $615K <0.01% +89,918 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 316,574 $611K <0.01% -11,944 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 275,041 $558K <0.01% +39,627 13F-HR Timeline Group Rangeley Capital, LLC More: the full row for Rangeley Capital, LLC 220,000 $447K 0.42% 0 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 204,654 $415K <0.01% -23,497 13F-HR Timeline Group BLAIR WILLIAM & CO/IL More: the full row for BLAIR WILLIAM & CO/IL 156,080 $317K <0.01% -1,908 13F-HR Timeline ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 134,002 $272K <0.01% new 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 126,677 $257K <0.01% +4,235 13F-HR Timeline Group JONES FINANCIAL COMPANIES LLLP in group JONES FINANCIAL COMPANIES LLLP More: the full row for JONES FINANCIAL COMPANIES LLLP 128,491 $245K <0.01% +96,291 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 120,014 $244K <0.01% +61,297 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 114,006 $231K <0.01% -50,253 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 108,024 $219K <0.01% -214,680 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 103,727 $211K <0.01% +31,764 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 101,841 $207K <0.01% +61,310 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 99,632 $203K <0.01% +48,758 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 74,349 $151K <0.01% -1,028,236 13F-HR Timeline Group IEQ CAPITAL, LLC More: the full row for IEQ CAPITAL, LLC 68,511 $139K <0.01% +52,664 13F-HR Timeline MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 62,524 $127K <0.01% -389 13F-HR Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 62,103 $126K <0.01% +27,746 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 56,090 $114K <0.01% +51,058 13F-HR Timeline Group MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. in group Mirae Asset Global Investment… More: the full row for MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 55,905 $113K <0.01% +5,621 13F-HR Timeline Group Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 53,625 $109K <0.01% +47,108 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 50,170 $102K <0.01% -99,687 13F-HR Timeline Group AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 48,998 $99.5K <0.01% new 13F-HR Timeline Group Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 48,413 $98.3K <0.01% +12,351 13F-HR Timeline Group SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 47,962 $97.4K <0.01% 0 13F-HR Timeline Group NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 47,900 $97.2K <0.01% 0 13F-HR Timeline Abel Hall, LLC More: the full row for Abel Hall, LLC 46,352 $94.1K 0.02% +31,789 13F-HR Timeline TRANSCEND CAPITAL ADVISORS, LLC More: the full row for TRANSCEND CAPITAL ADVISORS, LLC 45,298 $92K 0.01% +29,191 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 41,594 $84.4K <0.01% +23,956 13F-HR Timeline Cerity Partners LLC in group Cerity Partners LLC More: the full row for Cerity Partners LLC 38,014 $77.2K <0.01% new 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 34,339 $69.7K <0.01% -4,575 13F-HR Timeline Group INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 28,626 $58.1K <0.01% +1,742 13F-HR Timeline CAXTON CORP More: the full row for CAXTON CORP 28,453 $57.8K 3.12% 0 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 27,054 $54.9K <0.01% -1,719 13F-HR Timeline Group VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 25,286 $51.3K <0.01% +8,352 13F-HR Timeline Group Mariner, LLC in group Mariner, LLC More: the full row for Mariner, LLC 23,139 $47K <0.01% new 13F-HR Timeline Group Sanctuary Advisors, LLC More: the full row for Sanctuary Advisors, LLC 22,801 $46.3K <0.01% new 13F-HR Timeline NEUBERGER BERMAN GROUP LLC in group NEUBERGER BERMAN GROUP LLC More: the full row for NEUBERGER BERMAN GROUP LLC 21,293 $43.2K <0.01% new 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 20,578 $41.8K <0.01% -2,166 13F-HR Timeline Group Lynx1 Capital Management LP in group Lynx1 Capital Management LP More: the full row for Lynx1 Capital Management LP 20,000 $40.6K <0.01% new 13F-HR/A Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 19,725 $40K <0.01% -1,623 13F-HR Timeline Group WEALTH ENHANCEMENT ADVISORY SERVICES, L… More: the full row for WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 18,759 $38.3K <0.01% new 13F-HR Timeline PRUDENTIAL FINANCIAL INC in group PRUDENTIAL FINANCIAL INC More: the full row for PRUDENTIAL FINANCIAL INC 18,290 $37.1K <0.01% +3,110 13F-HR Timeline Group MERCER GLOBAL ADVISORS INC /ADV More: the full row for MERCER GLOBAL ADVISORS INC /ADV 16,781 $34.1K <0.01% new 13F-HR/A Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 16,242 $33K <0.01% -18,858 13F-HR Timeline Group ProShare Advisors LLC More: the full row for ProShare Advisors LLC 15,895 $32.3K <0.01% +358 13F-HR Timeline Spark Investment Management LLC More: the full row for Spark Investment Management LLC 15,500 $31.5K 0.06% new 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 15,204 $30.9K <0.01% -2,150 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 12,854 $26.1K <0.01% -18,135 13F-HR Timeline Group ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 15,320 $25.7K <0.01% new 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 12,078 $24.5K <0.01% +2,674 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 12,199 $24K <0.01% +10,585 13F-HR Timeline Group XPONANCE LLC More: the full row for XPONANCE LLC 11,550 $23.4K <0.01% new 13F-HR Timeline VICTORY CAPITAL MANAGEMENT INC More: the full row for VICTORY CAPITAL MANAGEMENT INC 11,504 $23.4K <0.01% +952 13F-HR Timeline Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 11,018 $22.4K <0.01% +4,844 13F-HR Timeline Group Arax Advisory Partners More: the full row for Arax Advisory Partners 7,121 $14.5K <0.01% +7,072 13F-HR Timeline Pinnacle Wealth Planning Services, Inc. More: the full row for Pinnacle Wealth Planning Services, Inc. 5,400 $11K <0.01% 0 13F-HR Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 5,200 $10.6K <0.01% new 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 2,447 $4.97K <0.01% -832 13F-HR Timeline CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 1,501 $3.05K <0.01% -4,382 13F-HR/A Timeline Integrated Wealth Concepts LLC More: the full row for Integrated Wealth Concepts LLC 1,256 $2.55K <0.01% new 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 1,140 $2.31K <0.01% +757 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 857 $1.74K <0.01% +644 13F-HR Timeline Group Essential Partners LLC More: the full row for Essential Partners LLC 646 $1.31K <0.01% -1,956 13F-HR Timeline True Wealth Design, LLC More: the full row for True Wealth Design, LLC 499 $1.01K <0.01% +456 13F-HR Timeline ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 436 $885 <0.01% +408 13F-HR Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 370 $750 <0.01% +301 13F-HR Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 148 $300 <0.01% -113 13F-HR Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 81 $164 <0.01% 0 13F-HR Timeline Group Quarry LP More: the full row for Quarry LP 55 $112 <0.01% new 13F-HR Timeline SJS Investment Consulting Inc. More: the full row for SJS Investment Consulting Inc. 32 $65 <0.01% +23 13F-HR Timeline IFP Advisors, Inc More: the full row for IFP Advisors, Inc 23 $47 <0.01% +20 13F-HR Timeline Clearstead Advisors, LLC More: the full row for Clearstead Advisors, LLC 6 $13 <0.01% new 13F-HR Timeline