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Siren, L.L.C.

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13F filer, CIK 2005245, New York, NY

Siren, L.L.C. reported $1,932,435,966 across 110 holdings for the quarter ended 2025-06-30, in a 13F-HR filed 2025-08-13. Its ten largest share positions make up 48.49% of the portfolio.

Filed (acceptance time not in the bulk data set), ingested 13F-HR 0002005369-25-000014

Period
2025-06-30
Reported value
$1.93B
Holdings
110
Top 10 weight
48.49%
New
15
Sold out
21

Part of the filer group Siren, L.L.C.

How groups are built

Largest buys vs the previous quarter

SecurityShares changeApprox. value
MLTXnew+508,267$24M
DYNadded+2,118,450$20.2M
EWTXadded+1,463,854$19.2M
BCAXadded+1,949,886$18.1M
AKROnew+318,647$17M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
BLUEPRINT MEDICINES CORPexited-726,167-$64.3M
SLNOreduced-259,995-$21.8M
PRTAexited-1,283,555-$15.9M
SMMTexited-695,000-$13.4M
NAMSreduced-717,790-$13M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q2 2025

Share positions as resolved from 13F-HR 0002005369-25-000014, largest first. % of portfolio is the value over $1,932,435,966, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
SRRKSCHOLAR ROCK HLDG CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 11,259,438 shares; 2024Q4: 9,250,005 shares; 2025Q1: 9,250,005 shares; 2025Q2: 9,250,005 shares 9,250,005$328M16.95%0Timeline
KYMRKYMERA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,969,733 shares; 2024Q4: 2,969,733 shares; 2025Q1: 3,240,313 shares; 2025Q2: 3,428,150 shares 3,428,150$150M7.74%+187,837Timeline
ONCBEONE MEDICINES LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 563,314 shares; 2024Q4: 653,721 shares; 2025Q1: 498,689 shares; 2025Q2: 509,990 shares 509,990$123M6.39%+11,301Timeline
IRONDISC MEDICINE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 1,071,865 shares; 2025Q2: 1,099,401 shares 1,099,401$58.2M3.01%+27,536Timeline
CRNXCRINETICS PHARMACEUTICALS INQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,309,652 shares; 2024Q4: 1,609,652 shares; 2025Q1: 1,688,611 shares; 2025Q2: 1,688,611 shares 1,688,611$48.6M2.51%0Timeline
BCAXBICARA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 3,072,827 shares; 2024Q4: 3,272,827 shares; 2025Q1: 3,267,083 shares; 2025Q2: 5,216,969 shares 5,216,969$48.5M2.51%+1,949,886Timeline
DYNDYNE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,134,664 shares; 2024Q4: 1,347,456 shares; 2025Q1: 2,717,987 shares; 2025Q2: 4,836,437 shares 4,836,437$46M2.38%+2,118,450Timeline
CNTACENTESSA PHARMACEUTICALS PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 3,258,677 shares; 2024Q4: 3,004,677 shares; 2025Q1: 2,960,029 shares; 2025Q2: 3,460,029 shares 3,460,029$45.5M2.35%+500,000Timeline
MERUS N VMERUS N VQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 682,201 shares; 2024Q4: 784,412 shares; 2025Q1: 1,043,467 shares; 2025Q2: 853,467 shares 853,467$44.9M2.32%-190,000
APLSAPELLIS PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,167,224 shares; 2024Q4: 2,816,258 shares; 2025Q1: 2,578,396 shares; 2025Q2: 2,578,396 shares 2,578,396$44.6M2.31%0Timeline
ASNDASCENDIS PHARMA A/SQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 347,921 shares; 2024Q4: 297,321 shares; 2025Q1: 287,366 shares; 2025Q2: 245,943 shares 245,943$42.4M2.2%-41,423Timeline
ARWRARROWHEAD PHARMACEUTICALS INQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,458,778 shares; 2024Q4: 2,901,681 shares; 2025Q1: 2,669,880 shares; 2025Q2: 2,669,880 shares 2,669,880$42.2M2.18%0Timeline
EWTXEDGEWISE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 404,113 shares; 2024Q4: 734,343 shares; 2025Q1: 1,696,444 shares; 2025Q2: 3,160,298 shares 3,160,298$41.4M2.14%+1,463,854Timeline
SLNOSOLENO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 351,818 shares; 2025Q1: 727,337 shares; 2025Q2: 467,342 shares 467,342$39.2M2.03%-259,995Timeline
LXRXLEXICON PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 38,918,903 shares; 2024Q4: 38,918,903 shares; 2025Q1: 38,918,903 shares; 2025Q2: 38,918,903 shares 38,918,903$36.8M1.9%0Timeline
TBLATABOOLA.COM LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 9,969,495 shares; 2024Q4: 9,969,495 shares; 2025Q1: 9,969,495 shares; 2025Q2: 9,969,495 shares 9,969,495$36.5M1.89%0Timeline
SLDBSOLID BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,749,041 shares; 2024Q4: 3,749,041 shares; 2025Q1: 7,415,905 shares; 2025Q2: 7,415,905 shares 7,415,905$36.1M1.87%0Timeline
RVMDREVOLUTION MEDICINES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 753,601 shares; 2024Q4: 571,548 shares; 2025Q1: 563,755 shares; 2025Q2: 938,755 shares 938,755$34.5M1.79%+375,000Timeline
RNAMAVIDITY BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,440,736 shares; 2024Q4: 1,127,295 shares; 2025Q1: 1,110,610 shares; 2025Q2: 1,110,610 shares 1,110,610$31.5M1.63%0Timeline
RYTMRHYTHM PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 277,533 shares; 2025Q2: 409,742 shares 409,742$25.9M1.34%+132,209Timeline
APGEAPOGEE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 747,325 shares; 2025Q1: 594,994 shares; 2025Q2: 594,994 shares 594,994$25.8M1.34%0Timeline
STOKSTOKE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 2,000,000 shares; 2025Q1: 2,247,347 shares; 2025Q2: 2,247,347 shares 2,247,347$25.5M1.32%0Timeline
TSHATAYSHA GENE THERAPIES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 4,879,875 shares; 2024Q4: 6,602,475 shares; 2025Q1: 6,514,737 shares; 2025Q2: 11,014,737 shares 11,014,737$25.4M1.32%+4,500,000Timeline
XENEXENON PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 743,769 shares; 2024Q4: 743,769 shares; 2025Q1: 732,761 shares; 2025Q2: 812,761 shares 812,761$25.4M1.32%+80,000Timeline
WVEWAVE LIFE SCIENCES LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 5,721,172 shares; 2024Q4: 3,750,491 shares; 2025Q1: 3,696,322 shares; 2025Q2: 3,696,322 shares 3,696,322$24M1.24%0Timeline
MLTXMOONLAKE IMMUNOTHERAPEUTICSQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 508,267 shares 508,267$24M1.24%newTimeline
SEPNSEPTERNA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 2,202,514 shares; 2025Q1: 2,202,514 shares; 2025Q2: 2,202,514 shares 2,202,514$23.3M1.2%0Timeline
NAMSNEWAMSTERDAM PHARMA COMPANYQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 920,564 shares; 2024Q4: 2,095,638 shares; 2025Q1: 1,912,030 shares; 2025Q2: 1,194,240 shares 1,194,240$21.6M1.12%-717,790Timeline
TRVITREVI THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 2,906,060 shares; 2025Q1: 2,863,793 shares; 2025Q2: 3,938,793 shares 3,938,793$21.5M1.11%+1,075,000Timeline
TNGXTANGO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,603,897 shares; 2024Q4: 2,603,897 shares; 2025Q1: 2,565,342 shares; 2025Q2: 3,364,814 shares 3,364,814$17.2M0.89%+799,472Timeline
AKROAKERO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 318,647 shares 318,647$17M0.88%newTimeline
SLNSILENCE THERAPEUTICS PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,831,770 shares; 2024Q4: 2,831,770 shares; 2025Q1: 2,789,833 shares; 2025Q2: 2,911,438 shares 2,911,438$16.9M0.87%+121,605Timeline
AVBPARRIVENT BIOPHARMA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 700,000 shares 700,000$15.2M0.79%newTimeline
BCYCBICYCLE THERAPEUTICS PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 1,839,398 shares; 2025Q1: 1,812,752 shares; 2025Q2: 2,012,752 shares 2,012,752$14M0.72%+200,000Timeline
RCUSARCUS BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,612,077 shares; 2024Q4: 1,612,077 shares; 2025Q1: 1,612,077 shares; 2025Q2: 1,612,077 shares 1,612,077$13.1M0.68%0Timeline
IHSIHS HOLDING LIMITEDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,357,520 shares; 2024Q4: 2,357,520 shares; 2025Q1: 2,357,520 shares; 2025Q2: 2,357,520 shares 2,357,520$13.1M0.68%0Timeline
AMZNAMAZON COM INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 34,750 shares; 2024Q4: 36,500 shares; 2025Q1: 56,500 shares; 2025Q2: 56,500 shares 56,500$12.4M0.64%0Timeline
DNLIDENALI THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 834,028 shares; 2024Q4: 834,028 shares; 2025Q1: 821,513 shares; 2025Q2: 821,513 shares 821,513$11.5M0.59%0Timeline
ERASERASCA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 8,857,179 shares; 2024Q4: 8,857,179 shares; 2025Q1: 8,757,249 shares; 2025Q2: 8,757,249 shares 8,757,249$11.1M0.58%0Timeline
ORICORIC PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,007,575 shares; 2024Q4: 1,007,575 shares; 2025Q1: 1,007,575 shares; 2025Q2: 1,007,575 shares 1,007,575$10.2M0.53%0Timeline
RELYREMITLY GLOBAL INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 25,000 shares; 2024Q4: 490,449 shares; 2025Q1: 490,449 shares; 2025Q2: 515,449 shares 515,449$9.67M0.5%+25,000Timeline
PCVXVAXCYTE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 299,991 shares; 2024Q4: 299,991 shares; 2025Q1: 295,543 shares; 2025Q2: 295,543 shares 295,543$9.61M0.5%0Timeline
CRWDCROWDSTRIKE HLDGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 25,000 shares; 2024Q4: 24,000 shares; 2025Q1: 25,000 shares; 2025Q2: 18,500 shares 18,500$9.42M0.49%-6,500Timeline
CGEMCULLINAN THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,211,357 shares; 2024Q4: 1,211,357 shares; 2025Q1: 1,193,410 shares; 2025Q2: 1,193,410 shares 1,193,410$8.99M0.47%0Timeline
GOOGLALPHABET INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 11,000 shares; 2024Q4: 7,000 shares; 2025Q1: 50,703 shares; 2025Q2: 50,703 shares 50,703$8.93M0.46%0Timeline
UPBUPSTREAM BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 800,000 shares; 2025Q1: 788,450 shares; 2025Q2: 788,450 shares 788,450$8.66M0.45%0Timeline
SEERSEER INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 4,000,000 shares; 2024Q4: 4,000,000 shares; 2025Q1: 4,000,000 shares; 2025Q2: 4,000,000 shares 4,000,000$8.56M0.44%0Timeline
MSFTMICROSOFT CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 22,000 shares; 2024Q4: 23,000 shares; 2025Q1: 28,500 shares; 2025Q2: 16,150 shares 16,150$8.03M0.42%-12,350Timeline
NVDANVIDIA CORPORATIONQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 48,932 shares; 2024Q4: 48,932 shares; 2025Q1: 44,432 shares; 2025Q2: 49,985 shares 49,985$7.9M0.41%+5,553Timeline
IONQIONQ INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 500,000 shares; 2024Q4: 170,000 shares; 2025Q1: 170,000 shares; 2025Q2: 170,000 shares 170,000$7.3M0.38%0Timeline
TSMTAIWAN SEMICONDUCTOR MANUFACQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 25,000 shares; 2024Q4: 15,000 shares; 2025Q1: 28,500 shares; 2025Q2: 30,500 shares 30,500$6.91M0.36%+2,000Timeline
GOSSGOSSAMER BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 13,281,610 shares; 2024Q4: 5,208,968 shares; 2025Q1: 5,208,968 shares; 2025Q2: 5,208,968 shares 5,208,968$6.41M0.33%0Timeline
CRMSALESFORCE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 14,600 shares; 2025Q2: 22,600 shares 22,600$6.16M0.32%+8,000Timeline
COGTCOGENT BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 854,379 shares 854,379$6.13M0.32%newTimeline
RNACCARTESIAN THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 572,236 shares; 2024Q4: 572,236 shares; 2025Q1: 563,272 shares; 2025Q2: 563,272 shares 563,272$5.85M0.3%0Timeline
VERAVERA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 837,928 shares; 2024Q4: 758,465 shares; 2025Q1: 747,216 shares; 2025Q2: 247,216 shares 247,216$5.82M0.3%-500,000Timeline
ADBEADOBE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,000 shares; 2024Q4: 8,798 shares; 2025Q1: 19,298 shares; 2025Q2: 15,051 shares 15,051$5.82M0.3%-4,247Timeline
SIONSIONNA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 325,000 shares; 2025Q2: 325,000 shares 325,000$5.64M0.29%0Timeline
PDDPDD HOLDINGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 40,401 shares; 2024Q4: 52,901 shares; 2025Q1: 52,901 shares; 2025Q2: 52,901 shares 52,901$5.54M0.29%0Timeline
SGMTSAGIMET BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 724,771 shares; 2024Q4: 724,771 shares; 2025Q1: 724,771 shares; 2025Q2: 724,771 shares 724,771$5.52M0.29%0Timeline
SYRESPYRE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 374,000 shares; 2025Q1: 368,598 shares; 2025Q2: 368,598 shares 368,598$5.52M0.29%0Timeline
PCRXPACIRA BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 225,000 shares 225,000$5.38M0.28%newTimeline
NOWSERVICENOW INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 7,500 shares; 2024Q4: 5,605 shares; 2025Q1: 9,126 shares; 2025Q2: 5,126 shares 5,126$5.27M0.27%-4,000Timeline
KRROKORRO BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 418,833 shares; 2024Q4: 418,833 shares; 2025Q1: 418,833 shares; 2025Q2: 418,833 shares 418,833$5.23M0.27%0Timeline
DDOGDATADOG INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 32,925 shares; 2024Q4: 30,425 shares; 2025Q1: 47,425 shares; 2025Q2: 38,425 shares 38,425$5.16M0.27%-9,000Timeline
AGENAGENUS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 775,000 shares; 2024Q4: not reported; 2025Q1: 500,000 shares; 2025Q2: 1,064,250 shares 1,064,250$4.86M0.25%+564,250Timeline
FROGJFROG LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 61,000 shares; 2024Q4: 120,116 shares; 2025Q1: 131,616 shares; 2025Q2: 107,116 shares 107,116$4.7M0.24%-24,500Timeline
RAPPRAPPORT THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 384,197 shares; 2024Q4: 384,197 shares; 2025Q1: 378,469 shares; 2025Q2: 378,469 shares 378,469$4.3M0.22%0Timeline
TILINSTIL BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 192,433 shares; 2024Q4: 192,433 shares; 2025Q1: 203,933 shares; 2025Q2: 203,933 shares 203,933$4.25M0.22%0Timeline
DTDYNATRACE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 82,729 shares; 2024Q4: 82,729 shares; 2025Q1: 87,729 shares; 2025Q2: 75,229 shares 75,229$4.15M0.21%-12,500Timeline
WHWKWHITEHAWK THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 2,082,000 shares; 2025Q2: 2,082,000 shares 2,082,000$3.89M0.2%0Timeline
EDUNEW ORIENTAL ED & TECHNOLOGYQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 38,500 shares; 2024Q4: 68,500 shares; 2025Q1: 79,500 shares; 2025Q2: 72,000 shares 72,000$3.88M0.2%-7,500Timeline
IGM BIOSCIENCES INCIGM BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 3,330,422 shares; 2024Q4: 3,330,422 shares; 2025Q1: 3,255,826 shares; 2025Q2: 3,255,826 shares 3,255,826$3.65M0.19%0
FHTXFOGHORN THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 720,720 shares; 2024Q4: 720,720 shares; 2025Q1: 720,720 shares; 2025Q2: 720,720 shares 720,720$3.39M0.18%0Timeline
VIGIL NEUROSCIENCE INCVIGIL NEUROSCIENCE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,991,038 shares; 2024Q4: 1,991,038 shares; 2025Q1: 1,967,064 shares; 2025Q2: 411,191 shares 411,191$3.27M0.17%-1,555,873
NMRANEUMORA THERAPEUTICS INC.Quarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,606,571 shares; 2024Q4: 4,396,100 shares; 2025Q1: 4,358,283 shares; 2025Q2: 4,358,283 shares 4,358,283$3.2M0.17%0Timeline
PRQRPROQR THRAPEUTICS N VQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 1,575,000 shares; 2025Q1: 1,552,183 shares; 2025Q2: 1,552,183 shares 1,552,183$3.17M0.16%0Timeline
NBISNEBIUS GROUP N.V.Quarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 120,000 shares; 2025Q1: 140,000 shares; 2025Q2: 51,000 shares 51,000$2.82M0.15%-89,000Timeline
BDTXBLACK DIAMOND THERAPEUTICS IQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,046,517 shares; 2024Q4: 1,046,517 shares; 2025Q1: 1,046,517 shares; 2025Q2: 1,046,517 shares 1,046,517$2.6M0.13%0Timeline
LXEOLEXEO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 603,435 shares; 2024Q4: 603,435 shares; 2025Q1: 603,435 shares; 2025Q2: 603,435 shares 603,435$2.43M0.13%0Timeline
PANWPALO ALTO NETWORKS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 4,500 shares; 2024Q4: 6,000 shares; 2025Q1: 11,500 shares; 2025Q2: 11,500 shares 11,500$2.35M0.12%0Timeline
QCOMQUALCOMM INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 15,000 shares; 2024Q4: 15,000 shares; 2025Q1: 14,000 shares; 2025Q2: 14,000 shares 14,000$2.23M0.12%0Timeline
WKWORKIVA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 10,000 shares; 2025Q1: 17,500 shares; 2025Q2: 28,000 shares 28,000$1.92M0.1%+10,500Timeline
ELDNELEDON PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 690,170 shares; 2025Q2: 690,170 shares 690,170$1.87M0.1%0Timeline
BEKEKE HLDGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 100,000 shares; 2024Q4: 60,000 shares; 2025Q1: 105,000 shares; 2025Q2: 105,000 shares 105,000$1.86M0.1%0Timeline
HUBSHUBSPOT INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 3,000 shares 3,000$1.67M0.09%newTimeline
UNHUNITEDHEALTH GROUP INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 5,076 shares 5,076$1.58M0.08%newTimeline
BIOABIOAGE LABS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 300,000 shares; 2024Q4: 388,000 shares; 2025Q1: 382,406 shares; 2025Q2: 382,406 shares 382,406$1.58M0.08%0Timeline
GTLBGITLAB INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 35,000 shares 35,000$1.58M0.08%newTimeline
Tourmaline Bio IncTourmaline Bio IncQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 91,426 shares; 2024Q4: 91,426 shares; 2025Q1: 91,426 shares; 2025Q2: 91,426 shares 91,426$1.46M0.08%0
RCKTROCKET PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 600,000 shares; 2025Q1: 591,263 shares; 2025Q2: 591,263 shares 591,263$1.45M0.07%0Timeline
TSLATESLA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 9,000 shares; 2025Q2: 4,000 shares 4,000$1.27M0.07%-5,000Timeline
BIRKBIRKENSTOCK HOLDING PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 25,000 shares 25,000$1.23M0.06%newTimeline
SAILSAILPOINT INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 95,000 shares; 2025Q2: 50,000 shares 50,000$1.14M0.06%-45,000Timeline
SEMRSEMRUSH HLDGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 35,000 shares; 2025Q1: 125,000 shares; 2025Q2: 125,000 shares 125,000$1.13M0.06%0Timeline
PRMBPRIMO BRANDS CORPORATIONQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 37,500 shares 37,500$1.11M0.06%newTimeline
CLBTCELLEBRITE DI LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 60,000 shares 60,000$960K0.05%newTimeline
GENERATION BIO COGENERATION BIO COQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,982,733 shares; 2024Q4: 2,982,733 shares; 2025Q1: 2,968,925 shares; 2025Q2: 2,968,925 shares 2,968,925$950K0.05%0
KLRSKALARIS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 282,586 shares; 2025Q2: 282,586 shares 282,586$755K0.04%0Timeline
HOOKHOOKIPA PHARMA INC COM NEWQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 566,640 shares; 2024Q4: 566,640 shares; 2025Q1: 566,640 shares; 2025Q2: 566,640 shares 566,640$711K0.04%0Timeline
TEAMATLASSIAN CORPORATIONQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 3,500 shares 3,500$711K0.04%newTimeline
PCORPROCORE TECHNOLOGIES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 32,300 shares; 2024Q4: 20,000 shares; 2025Q1: 10,000 shares; 2025Q2: 10,000 shares 10,000$684K0.04%0Timeline
CCCCCC INTELLIGENT SOLUTIONS HLQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 50,000 shares 50,000$470K0.02%newTimeline
PCGPG&E CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 25,000 shares 25,000$348K0.02%newTimeline
CYCNCYCLERION THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 116,155 shares; 2024Q4: 116,155 shares; 2025Q1: 116,155 shares; 2025Q2: 116,155 shares 116,155$338K0.02%0Timeline
RDDTREDDIT INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 23,500 shares; 2025Q2: 2,000 shares 2,000$301K0.02%-21,500Timeline
VRTVERTIV HOLDINGS COQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 2,000 shares 2,000$257K0.01%newTimeline
DECKDECKERS OUTDOOR CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 5,000 shares; 2025Q2: 2,000 shares 2,000$206K0.01%-3,000Timeline
CRBUCARIBOU BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 105,347 shares; 2024Q4: 105,347 shares; 2025Q1: 105,347 shares; 2025Q2: 105,347 shares 105,347$133K0.01%0Timeline
IRWDIRONWOOD PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 110,532 shares; 2024Q4: 110,532 shares; 2025Q1: 110,532 shares; 2025Q2: 110,532 shares 110,532$79.6K<0.01%0Timeline

Sold out in Q2 2025

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
BLUEPRINT MEDICINES CORPBLUEPRINT MEDICINES CORP726,167$64.3Mshares
PRTAPROTHENA CORP PLC1,283,555$15.9Mshares
SMMTSUMMIT THERAPEUTICS INC695,000$13.4Mshares
MTSRMETSERA INC150,000$4.08Mshares
LPLALPL FINL HLDGS INC7,500$2.45Mshares
MRVLMARVELL TECHNOLOGY INC36,808$2.27Mshares
SAROSTANDARDAERO INC56,855$1.51Mshares
BILLBILL HOLDINGS INC28,500$1.31Mshares
PYPLPAYPAL HLDGS INC20,000$1.3Mshares
PEGAPEGASYSTEMS INC16,500$1.15Mshares
MDBMONGODB INC5,500$965Kshares
NKENIKE INC15,000$952Kshares
INTCINTEL CORP40,000$908Kshares
INFORMATICA INCINFORMATICA INC50,000$872Kshares
BABOEING CO5,000$853Kshares
Couchbase IncCouchbase Inc49,850$785Kshares
KRONOS BIO INCKRONOS BIO INC842,954$695Kshares
RACEFERRARI N V1,500$636Kshares
USBUS BANCORP12,500$528Kshares
OXYOCCIDENTAL PETE CORP10,000$494Kshares
GDSGDS HLDGS LTD12,500$317Kshares

How Q2 2025 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0002005369-25-000014 base2025-08-13acceptance time not in the bulk data set