MONTANOVA CAPITAL, LLC More: the full row for MONTANOVA CAPITAL, LLC 9,443,001 $55.7M 1.17% +376,000 13F-HR Timeline Venrock Adviser, LLC More: the full row for Venrock Adviser, LLC 6,434,990 $38M 1.15% 0 13F-HR Timeline MPM BIOIMPACT LLC More: the full row for MPM BIOIMPACT LLC 4,472,843 $26.4M 1.61% new 13F-HR Timeline GREAT POINT PARTNERS LLC More: the full row for GREAT POINT PARTNERS LLC 4,215,930 $24.9M 5.86% 0 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 4,354,715 $24.5M <0.01% -104,136 13F-HR Timeline Group BRAIDWELL LP More: the full row for BRAIDWELL LP 3,980,295 $23.5M 0.87% -8,694 13F-HR Timeline Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 3,734,866 $22M 0.45% 0 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 3,614,695 $21.3M <0.01% +3,157,336 13F-HR Timeline Group Commodore Capital LP in group Commodore Capital LP More: the full row for Commodore Capital LP 3,250,000 $19.2M 1.14% 0 13F-HR Timeline Group ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 2,750,000 $16.2M 0.02% 0 13F-HR Timeline Group Saturn V Capital Management LP More: the full row for Saturn V Capital Management LP 2,101,119 $12.4M 1.78% +1,361,159 13F-HR Timeline QVT Financial LP More: the full row for QVT Financial LP 1,895,153 $11.2M 0.72% +584,560 13F-HR Timeline ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 1,759,295 $10.4M 0.49% +1,128,892 13F-HR Timeline Group ARMISTICE CAPITAL, LLC More: the full row for ARMISTICE CAPITAL, LLC 1,636,000 $9.65M 0.27% +129,000 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 1,584,209 $9.35M <0.01% +1,056,518 13F-HR Timeline Group VANGUARD GROUP INC group of 4 filers holding More: the full row for VANGUARD GROUP INC 1,578,155 $9.31M +842,622 Timeline Affinity Asset Advisors, LLC More: the full row for Affinity Asset Advisors, LLC 1,464,303 $8.64M 0.42% -1,100,000 13F-HR Timeline STEMPOINT CAPITAL LP More: the full row for STEMPOINT CAPITAL LP 1,368,215 $8.07M 1.4% +614,695 13F-HR Timeline Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 1,218,492 $7.19M 1.18% +25,000 13F-HR Timeline EcoR1 Capital, LLC More: the full row for EcoR1 Capital, LLC 1,179,715 $6.96M 0.35% 0 13F-HR Timeline Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 1,173,956 $6.93M 0.16% +662,956 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 1,001,637 $5.91M <0.01% +806,674 13F-HR Timeline Group Boxer Capital Management, LLC More: the full row for Boxer Capital Management, LLC 900,000 $5.31M 0.4% 0 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 573,946 $3.39M <0.01% +421,031 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 528,284 $3.12M <0.01% -1,062 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 505,953 $2.99M <0.01% -366,997 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 500,086 $2.95M <0.01% +395,956 13F-HR Timeline Group Pfizer Inc More: the full row for Pfizer Inc 538,841 $2.88M 1.69% -2,300,072 13F-HR Timeline Foresite Capital Management VI LLC in group Foresite Capital Management V… More: the full row for Foresite Capital Management VI LLC 450,000 $2.65M 0.41% 0 13F-HR Timeline Group BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 379,177 $2.24M 0.04% +4,671 13F-HR Timeline KVP Capital Advisors, LP More: the full row for KVP Capital Advisors, LP 373,128 $2.2M 1.62% 0 13F-HR Timeline TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 350,902 $2.07M <0.01% +32,716 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 321,702 $1.9M <0.01% +8,402 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 300,719 $1.77M <0.01% +282,821 13F-HR Timeline Group AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 282,207 $1.67M <0.01% 0 13F-HR Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 265,314 $1.57M <0.01% +24,287 13F-HR Timeline Group Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 231,600 $1.37M 0.01% +203,537 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 174,395 $1.03M <0.01% +143,299 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 137,639 $812K <0.01% -1,370,424 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 136,224 $804K 0.01% +16,512 13F-HR Timeline Group Alberta Investment Management Corp More: the full row for Alberta Investment Management Corp 133,200 $786K <0.01% 0 13F-HR Timeline Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 126,204 $745K <0.01% new 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 124,365 $734K <0.01% new 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 105,746 $624K <0.01% -64,087 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 97,033 $572K <0.01% -39,490 13F-HR Timeline Group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 96,414 $569K <0.01% +26,222 13F-HR Timeline BRIDGEWAY CAPITAL MANAGEMENT, LLC More: the full row for BRIDGEWAY CAPITAL MANAGEMENT, LLC 85,348 $504K 0.01% 0 13F-HR Timeline Verdad Advisers, LP More: the full row for Verdad Advisers, LP 66,919 $395K 0.38% -30,183 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 65,888 $389K <0.01% new 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 59,437 $351K <0.01% +52,102 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 58,648 $346K <0.01% new 13F-HR Timeline Group RBF Capital, LLC More: the full row for RBF Capital, LLC 58,193 $343K 0.01% 0 13F-HR Timeline DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 55,129 $325K <0.01% +11,994 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 53,776 $317K <0.01% new 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 48,385 $286K <0.01% new 13F-HR Timeline AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 40,461 $239K <0.01% +6,728 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 38,800 $229K <0.01% -77,886 13F-HR Timeline Group MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 36,749 $217K <0.01% new 13F-HR Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 32,029 $189K <0.01% new 13F-HR Timeline Group ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 31,740 $189K <0.01% new 13F-HR Timeline RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 28,820 $170K <0.01% +1,928 13F-HR Timeline Group EntryPoint Capital, LLC More: the full row for EntryPoint Capital, LLC 28,806 $170K 0.04% new 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 27,763 $164K <0.01% +18,354 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 27,164 $160K <0.01% -17,775 13F-HR Timeline Group MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. in group Mirae Asset Global Investment… More: the full row for MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 27,030 $159K <0.01% new 13F-HR Timeline Group Forefront Analytics, LLC More: the full row for Forefront Analytics, LLC 26,968 $159K 0.17% +12,067 13F-HR Timeline Mariner, LLC in group Mariner, LLC More: the full row for Mariner, LLC 23,102 $136K <0.01% -1,632 13F-HR Timeline Group INSIGNEO ADVISORY SERVICES, LLC More: the full row for INSIGNEO ADVISORY SERVICES, LLC 20,650 $122K <0.01% -5,000 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 17,387 $103K <0.01% new 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 17,042 $101K <0.01% new 13F-HR Timeline Group LOS ANGELES CAPITAL MANAGEMENT LLC More: the full row for LOS ANGELES CAPITAL MANAGEMENT LLC 16,916 $99.8K <0.01% new 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 16,000 $94.4K 0.01% -5,600 13F-HR Timeline Abel Hall, LLC More: the full row for Abel Hall, LLC 13,229 $78.1K 0.01% +40 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 13,200 $77.9K <0.01% new 13F-HR Timeline VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 11,616 $68.5K <0.01% new 13F-HR Timeline Group State of Wyoming More: the full row for State of Wyoming 9,878 $58.3K 0.01% +9,823 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 5,788 $34.1K <0.01% -7,528 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 5,726 $33.8K <0.01% new 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 5,350 $31.6K <0.01% new 13F-HR Timeline Group Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 4,714 $27.8K <0.01% new 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 3,383 $20K <0.01% new 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 2,819 $17K <0.01% new 13F-HR Timeline Group SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 2,640 $15.6K <0.01% -15,851 13F-HR Timeline Steward Partners Investment Advisory, L… More: the full row for Steward Partners Investment Advisory, LLC 1,000 $5.9K <0.01% 0 13F-HR Timeline CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 812 $4.79K <0.01% new 13F-HR/A Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 702 $4.14K <0.01% 0 13F-HR Timeline Quarry LP More: the full row for Quarry LP 323 $1.91K <0.01% new 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 318 $1.88K <0.01% 0 13F-HR Timeline Group Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 207 $1.22K <0.01% new 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 77 $454 <0.01% -29 13F-HR Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 50 $295 <0.01% +49 13F-HR Timeline Arax Advisory Partners More: the full row for Arax Advisory Partners 24 $142 <0.01% 0 13F-HR Timeline