MPM BIOIMPACT LLC More: the full row for MPM BIOIMPACT LLC 3,666,284 $60.1M 3.67% -1,547,077 13F-HR Timeline Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 1,857,362 $30.5M 0.62% 0 13F-HR Timeline Group Vivo Capital, LLC More: the full row for Vivo Capital, LLC 1,844,758 $30.3M 2.76% -822,811 13F-HR Timeline PERCEPTIVE ADVISORS LLC in group PERCEPTIVE ADVISORS LLC More: the full row for PERCEPTIVE ADVISORS LLC 1,653,350 $27.1M 0.42% +688,959 13F-HR Timeline Group BAKER BROS. ADVISORS LP in group BAKER BROS. ADVISORS LP More: the full row for BAKER BROS. ADVISORS LP 1,461,425 $24M 0.12% 0 13F-HR Timeline Group Artisan Partners Limited Partnership More: the full row for Artisan Partners Limited Partnership 1,372,851 $22.5M 0.04% -846,535 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 1,313,439 $21.5M <0.01% +1,233,902 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 954,908 $15.7M <0.01% +808,792 13F-HR Timeline Group Logos Global Management LP More: the full row for Logos Global Management LP 915,000 $15M 0.65% new 13F-HR Timeline Patient Square Capital LP More: the full row for Patient Square Capital LP 909,474 $14.9M 2.31% +215,940 13F-HR Timeline Octagon Capital Advisors LP More: the full row for Octagon Capital Advisors LP 574,200 $9.42M 0.86% 0 13F-HR Timeline ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 528,295 $8.66M 0.41% -484,571 13F-HR Timeline Group Redmile Group, LLC in group Redmile Group, LLC More: the full row for Redmile Group, LLC 410,440 $6.73M 0.45% -80,900 13F-HR Timeline Group Duquesne Family Office LLC More: the full row for Duquesne Family Office LLC 383,363 $6.29M 0.14% 0 13F-HR Timeline AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 378,497 $6.21M <0.01% +147,080 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 267,783 $4.39M <0.01% -51,176 13F-HR Timeline Group Elmind Capital, LP More: the full row for Elmind Capital, LP 265,000 $4.35M 1.09% 0 13F-HR Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 223,915 $3.67M <0.01% +212,630 13F-HR Timeline Group Ishara Investments LP More: the full row for Ishara Investments LP 184,500 $3.03M 2.22% +82,000 13F-HR Timeline Yiheng Capital Management, L.P. More: the full row for Yiheng Capital Management, L.P. 170,142 $2.79M 1.19% 0 13F-HR Timeline BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 163,401 $2.68M 0.05% 0 13F-HR Timeline GREAT POINT PARTNERS LLC More: the full row for GREAT POINT PARTNERS LLC 156,906 $2.57M 0.61% new 13F-HR Timeline Diversify Advisory Services, LLC group of 2 filers holding More: the full row for Diversify Advisory Services, LLC 179,384 $2.49M +115,712 Timeline HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 151,197 $2.48M <0.01% +127,112 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 119,335 $1.96M <0.01% -48,845 13F-HR Timeline ENVESTNET ASSET MANAGEMENT INC in group ENVESTNET ASSET MANAGEMENT INC More: the full row for ENVESTNET ASSET MANAGEMENT INC 113,823 $1.87M <0.01% +18,109 13F-HR Timeline Group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 525,000 $1.69M 0.28% 0 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 91,202 $1.5M 0.02% +49,147 13F-HR Timeline Group Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 84,196 $1.38M <0.01% -44,364 13F-HR Timeline Group Dorsey Wright & Associates More: the full row for Dorsey Wright & Associates 73,115 $1.2M 0.2% -29,435 13F-HR Timeline Polymer Capital Management (HK) LTD More: the full row for Polymer Capital Management (HK) LTD 64,500 $1.06M 0.11% 0 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 59,240 $972K <0.01% new 13F-HR Timeline Group LPL Financial LLC More: the full row for LPL Financial LLC 53,751 $882K <0.01% -2,120 13F-HR Timeline AdvisorShares Investments LLC More: the full row for AdvisorShares Investments LLC 43,663 $716K 0.09% -6,677 13F-HR Timeline Cetera Investment Advisers More: the full row for Cetera Investment Advisers 35,257 $578K <0.01% +9,899 13F-HR Timeline Engineers Gate Manager LP More: the full row for Engineers Gate Manager LP 32,439 $532K 0.01% -601 13F-HR Timeline Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 28,805 $472K <0.01% -8,622 13F-HR Timeline STIFEL FINANCIAL CORP in group STIFEL FINANCIAL CORP More: the full row for STIFEL FINANCIAL CORP 27,608 $453K <0.01% -3,128 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 22,782 $374K <0.01% new 13F-HR Timeline Group Burns Matteson Capital Management, LLC More: the full row for Burns Matteson Capital Management, LLC 21,818 $358K 0.11% -813 13F-HR Timeline Atria Investments, Inc More: the full row for Atria Investments, Inc 18,902 $310K <0.01% -2,233 13F-HR Timeline Persistent Asset Partners Ltd More: the full row for Persistent Asset Partners Ltd 15,630 $256K 0.08% +4,238 13F-HR Timeline PERSONAL CFO SOLUTIONS, LLC More: the full row for PERSONAL CFO SOLUTIONS, LLC 12,940 $212K 0.03% +297 13F-HR Timeline Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 12,148 $199K <0.01% new 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 11,630 $191K <0.01% new 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 11,574 $190K <0.01% new 13F-HR Timeline Group SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 10,809 $177K <0.01% -5,955 13F-HR Timeline Group Integrated Wealth Concepts LLC More: the full row for Integrated Wealth Concepts LLC 10,369 $170K <0.01% -213 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 8,000 $131K 0.01% +3,000 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 7,198 $118K <0.01% -881 13F-HR Timeline Group Optiver Holding B.V. in group Optiver Holding B.V. More: the full row for Optiver Holding B.V. 6,455 $106K <0.01% -12,592 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 5,611 $92K <0.01% -488 13F-HR Timeline Truvestments Capital LLC More: the full row for Truvestments Capital LLC 3,892 $63.8K 0.01% 0 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 2,832 $46.4K <0.01% -67 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 1,683 $27.6K <0.01% 0 13F-HR Timeline State of Wyoming More: the full row for State of Wyoming 1,445 $23.7K <0.01% new 13F-HR Timeline Rockefeller Capital Management L.P. in group Rockefeller Capital Managemen… More: the full row for Rockefeller Capital Management L.P. 1,246 $20.4K <0.01% new 13F-HR Timeline Group HM PAYSON & CO More: the full row for HM PAYSON & CO 420 $6.89K <0.01% 0 13F-HR Timeline Continuum Advisory, LLC More: the full row for Continuum Advisory, LLC 400 $6.56K <0.01% new 13F-HR Timeline HARBOUR INVESTMENTS, INC. More: the full row for HARBOUR INVESTMENTS, INC. 362 $5.94K <0.01% +103 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 300 $4.92K <0.01% 0 13F-HR Timeline Group OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 277 $4.54K <0.01% -844 13F-HR Timeline Group Wilmington Savings Fund Society, FSB More: the full row for Wilmington Savings Fund Society, FSB 276 $4.53K <0.01% new 13F-HR Timeline Ascentis Wealth Management, LLC in group Ascentis Wealth Management, L… More: the full row for Ascentis Wealth Management, LLC 259 $4.25K <0.01% 0 13F-HR/A Timeline Group NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 200 $3.28K <0.01% new 13F-HR Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 164 $2.69K <0.01% 0 13F-HR Timeline Federation des caisses Desjardins du Qu… More: the full row for Federation des caisses Desjardins du Quebec 145 $2.38K <0.01% 0 13F-HR Timeline Silver Grove Financial Group, Inc. More: the full row for Silver Grove Financial Group, Inc. 81 $1.33K <0.01% new 13F-HR Timeline Larson Financial Group LLC More: the full row for Larson Financial Group LLC 66 $1.08K <0.01% new 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 53 $848 <0.01% +33 13F-HR Timeline Group Pinnacle Wealth Planning Services, Inc. More: the full row for Pinnacle Wealth Planning Services, Inc. 40 $656 <0.01% 0 13F-HR Timeline NATIONAL BANK OF CANADA /FI/ in group NATIONAL BANK OF CANADA /FI/ More: the full row for NATIONAL BANK OF CANADA /FI/ 23 $371 <0.01% new 13F-HR Timeline Group Bell Investment Advisors, Inc More: the full row for Bell Investment Advisors, Inc 21 $345 <0.01% 0 13F-HR Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 13 $213 <0.01% -54 13F-HR Timeline TRUST CO OF TOLEDO NA /OH/ More: the full row for TRUST CO OF TOLEDO NA /OH/ 10 $164 <0.01% 0 13F-HR Timeline Stone House Investment Management, LLC More: the full row for Stone House Investment Management, LLC 9 $148 <0.01% new 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 2 $33 <0.01% 0 13F-HR Timeline Group