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PERCEPTIVE ADVISORS LLC

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13F filer, CIK 1224962, NEW YORK, NY

PERCEPTIVE ADVISORS LLC reported $5,117,574,591 across 94 holdings for the quarter ended 2026-03-31, in a 13F-HR/A filed 2026-05-29. Its ten largest share positions make up 51.95% of the portfolio.

Filed (acceptance time not in the bulk data set), ingested 13F-HR/A 0001012975-26-000499

Period
2026-03-31
Reported value
$5.12B
Holdings
94
Top 10 weight
51.95%
New
20
Sold out
42

Part of the filer group PERCEPTIVE ADVISORS LLC

  • Joseph Edelman
  • Perceptive Capital Solutions Holdings LP
  • Perceptive Life Sciences Master Fund, Ltd.
How groups are built

Stakes and trades reported after 2026-03-31

13D, 13G and Form 4 filings by this filer's group, dated after the 13F period, on securities the quarter does not hold as shares.

  • KARD KARDIGAN INC: 13D/A 8,254,144 shares, 8.8% of the class, 13D/A filed 2026-10-01, 0001193125-26-410754Timeline
    Accepted , ingested

Largest buys vs the previous quarter

SecurityShares changeApprox. value
ASNDadded+450,000$103M
CNTAadded+2,341,269$93M
RLAYadded+7,847,896$78.1M
BCRXadded+4,271,504$40.7M
IONSnew+504,000$37.8M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
EXASexited-1,200,487-$122M
ACLXexited-1,466,071-$95.6M
BSXexited-979,000-$93.3M
FOLDexited-6,370,851-$90.7M
ASTRIA THERAPEUTICS INCexited-6,485,420-$84.9M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q1 2026

Share positions as resolved from 13F-HR/A 0001012975-26-000499, largest first. % of portfolio is the value over $5,062,539,591, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
PRAXPRAXIS PRECISION MEDICINES IQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 1,164,035 shares; 2024Q4: 1,329,735 shares; 2025Q1: 980,894 shares; 2025Q2: 752,921 shares; 2025Q3: 1,564,554 shares; 2025Q4: 1,995,986 shares; 2026Q1: 2,035,986 shares 2,035,986$656M12.96%+40,000Timeline
CELCCELCUITY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 2,362,279 shares; 2024Q4: 2,362,279 shares; 2025Q1: 2,362,279 shares; 2025Q2: 1,633,208 shares; 2025Q3: 2,956,319 shares; 2025Q4: 3,160,200 shares; 2026Q1: 3,127,200 shares 3,127,200$357M7.05%-33,000Timeline
ASNDASCENDIS PHARMA A/SQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 963,886 shares; 2025Q3: 1,088,501 shares; 2025Q4: 1,081,421 shares; 2026Q1: 1,531,421 shares 1,531,421$350M6.92%+450,000Timeline
ROIVROIVANT SCIENCES LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 847,745 shares; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 3,331,465 shares; 2025Q3: 7,368,461 shares; 2025Q4: 7,985,461 shares; 2026Q1: 8,285,461 shares 8,285,461$230M4.53%+300,000Timeline
CNTACENTESSA PHARMACEUTICALS PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 6,282,290 shares; 2024Q4: 6,349,220 shares; 2025Q1: 3,040,395 shares; 2025Q2: 1,146,935 shares; 2025Q3: 3,100,902 shares; 2025Q4: 2,917,634 shares; 2026Q1: 5,258,903 shares 5,258,903$209M4.13%+2,341,269Timeline
RYTMRHYTHM PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 3,560,214 shares; 2024Q4: 3,680,473 shares; 2025Q1: 2,548,445 shares; 2025Q2: 2,418,299 shares; 2025Q3: 2,438,969 shares; 2025Q4: 2,546,391 shares; 2026Q1: 2,373,795 shares 2,373,795$206M4.08%-172,596Timeline
SYRESPYRE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 2,872,547 shares; 2024Q4: 2,574,723 shares; 2025Q1: 2,313,272 shares; 2025Q2: 1,529,445 shares; 2025Q3: 1,229,445 shares; 2025Q4: 3,069,225 shares; 2026Q1: 3,783,225 shares 3,783,225$191M3.77%+714,000Timeline
NUVLNUVALENT INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 2,979,235 shares; 2024Q4: 2,619,977 shares; 2025Q1: 1,633,968 shares; 2025Q2: 1,375,180 shares; 2025Q3: 1,562,336 shares; 2025Q4: 1,665,105 shares; 2026Q1: 1,580,505 shares 1,580,505$162M3.2%-84,600Timeline
EWTXEDGEWISE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 2,330,294 shares; 2024Q4: 2,685,537 shares; 2025Q1: 6,547,328 shares; 2025Q2: 4,639,949 shares; 2025Q3: 3,795,894 shares; 2025Q4: 4,457,974 shares; 2026Q1: 4,423,974 shares 4,423,974$139M2.75%-34,000Timeline
PTGXPROTAGONIST THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 1,374,563 shares; 2024Q4: 1,271,662 shares; 2025Q1: 1,091,271 shares; 2025Q2: 1,074,448 shares; 2025Q3: 1,030,134 shares; 2025Q4: 1,350,425 shares; 2026Q1: 1,230,879 shares 1,230,879$130M2.56%-119,546Timeline
APGEAPOGEE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 2,015,007 shares; 2024Q4: 1,047,232 shares; 2025Q1: 1,122,767 shares; 2025Q2: 1,182,148 shares; 2025Q3: 1,351,989 shares; 2025Q4: 2,330,651 shares; 2026Q1: 1,540,384 shares 1,540,384$130M2.56%-790,267Timeline
TVTXTRAVERE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 834,252 shares; 2025Q3: 3,794,615 shares; 2025Q4: 4,278,180 shares; 2026Q1: 4,142,551 shares 4,142,551$123M2.43%-135,629Timeline
AMLXAMYLYX PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 2,125,649 shares; 2024Q4: 6,774,348 shares; 2025Q1: 7,874,348 shares; 2025Q2: 7,902,365 shares; 2025Q3: 8,952,365 shares; 2025Q4: 8,284,882 shares; 2026Q1: 8,284,882 shares 8,284,882$115M2.27%0Timeline
IMTXIMMATICS N.VQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 8,086,159 shares; 2024Q4: 9,383,456 shares; 2025Q1: 9,383,456 shares; 2025Q2: 9,383,456 shares; 2025Q3: 9,383,456 shares; 2025Q4: 10,383,456 shares; 2026Q1: 10,383,456 shares 10,383,456$102M2.02%0Timeline
RLAYRELAY THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 1,903,245 shares; 2026Q1: 9,751,141 shares 9,751,141$97M1.92%+7,847,896Timeline
INBXINHIBRX BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 1,064,026 shares; 2024Q4: 1,064,026 shares; 2025Q1: 1,064,026 shares; 2025Q2: 977,892 shares; 2025Q3: 1,327,707 shares; 2025Q4: 1,452,707 shares; 2026Q1: 1,442,707 shares 1,442,707$97M1.92%-10,000Timeline
MGTXMEIRAGTX HLDGS PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 12,581,103 shares; 2024Q4: 12,581,103 shares; 2025Q1: 12,581,103 shares; 2025Q2: 12,626,103 shares; 2025Q3: 12,626,103 shares; 2025Q4: 10,326,103 shares; 2026Q1: 10,326,103 shares 10,326,103$89.3M1.76%0Timeline
ZYMEZYMEWORKS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 2,180,020 shares; 2024Q4: 2,130,020 shares; 2025Q1: 1,864,672 shares; 2025Q2: 1,275,274 shares; 2025Q3: 2,090,663 shares; 2025Q4: 3,261,850 shares; 2026Q1: 3,510,078 shares 3,510,078$87.9M1.74%+248,228Timeline
SLDBSOLID BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 6,906,646 shares; 2024Q4: 6,906,646 shares; 2025Q1: 11,906,646 shares; 2025Q2: 11,906,646 shares; 2025Q3: 11,833,539 shares; 2025Q4: 11,833,539 shares; 2026Q1: 11,906,646 shares 11,906,646$85.7M1.69%+73,107Timeline
DYNDYNE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 718,144 shares; 2024Q4: 543,277 shares; 2025Q1: 2,313,403 shares; 2025Q2: 2,247,390 shares; 2025Q3: 540,444 shares; 2025Q4: 3,478,944 shares; 2026Q1: 4,668,839 shares 4,668,839$84.6M1.67%+1,189,895Timeline
BCRXBIOCRYST PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 3,162,529 shares; 2026Q1: 7,434,033 shares 7,434,033$70.8M1.4%+4,271,504Timeline
ORKAORUKA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 1,235,187 shares; 2024Q4: 845,567 shares; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 1,268,021 shares; 2025Q4: 1,476,501 shares; 2026Q1: 1,395,501 shares 1,395,501$68.4M1.35%-81,000Timeline
AORTARTIVION INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 2,793,703 shares; 2024Q4: 2,793,703 shares; 2025Q1: 2,793,703 shares; 2025Q2: 2,793,703 shares; 2025Q3: 2,020,000 shares; 2025Q4: 1,722,290 shares; 2026Q1: 1,637,290 shares 1,637,290$60M1.18%-85,000Timeline
NRIXNURIX THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 330,614 shares; 2025Q1: 297,553 shares; 2025Q2: 1,096,985 shares; 2025Q3: 1,416,149 shares; 2025Q4: 3,555,877 shares; 2026Q1: 3,710,877 shares 3,710,877$57.5M1.14%+155,000Timeline
NAUTNAUTILUS BIOTECHNOLOGY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 12,594,211 shares; 2024Q4: 12,594,211 shares; 2025Q1: 12,594,211 shares; 2025Q2: 12,594,211 shares; 2025Q3: 12,594,211 shares; 2025Q4: 12,594,211 shares; 2026Q1: 12,594,211 shares 12,594,211$48.9M0.97%0Timeline
CTMXCYTOMX THERAPEUTICS INC.Quarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 6,993,646 shares; 2025Q3: 9,680,185 shares; 2025Q4: 9,680,185 shares; 2026Q1: 10,098,824 shares 10,098,824$47.5M0.94%+418,639Timeline
ANROALTO NEUROSCIENCE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 155,366 shares; 2025Q4: 1,784,393 shares; 2026Q1: 2,009,893 shares 2,009,893$45.2M0.89%+225,500Timeline
ENGNENGENE HOLDINGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 2,097,236 shares; 2025Q4: 5,869,076 shares; 2026Q1: 5,827,506 shares 5,827,506$39.7M0.78%-41,570Timeline
IMVTIMMUNOVANT INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 2,378,762 shares; 2024Q4: 2,139,199 shares; 2025Q1: 2,844,072 shares; 2025Q2: 2,137,890 shares; 2025Q3: 1,587,890 shares; 2025Q4: 1,994,890 shares; 2026Q1: 1,597,383 shares 1,597,383$39.7M0.78%-397,507Timeline
ISRGINTUITIVE SURGICAL INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 58,119 shares; 2024Q4: 63,119 shares; 2025Q1: 40,619 shares; 2025Q2: 45,119 shares; 2025Q3: 52,119 shares; 2025Q4: 87,919 shares; 2026Q1: 85,419 shares 85,419$39.4M0.78%-2,500Timeline
IONSIONIS PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 504,000 shares 504,000$37.8M0.75%newTimeline
DAWNDAY ONE BIOPHARMACEUTICALS IQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 1,755,799 shares 1,755,799$37.6M0.74%newTimeline
ABVXABIVAX SAQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 388,608 shares; 2025Q4: 458,343 shares; 2026Q1: 328,884 shares 328,884$36.6M0.72%-129,459Timeline
CRVSCORVUS PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 1,438,595 shares; 2025Q3: 1,438,595 shares; 2025Q4: 692,441 shares; 2026Q1: 2,292,441 shares 2,292,441$33.5M0.66%+1,600,000Timeline
RGENREPLIGEN CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 129,801 shares; 2025Q2: 166,000 shares; 2025Q3: 270,428 shares; 2025Q4: 315,541 shares; 2026Q1: 280,541 shares 280,541$33.1M0.65%-35,000Timeline
JAZZJAZZ PHARMACEUTICALS PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 170,000 shares; 2026Q1: 170,000 shares 170,000$32.1M0.63%0Timeline
DMRADAMORA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 1,223,000 shares 1,223,000$31.7M0.63%newTimeline
XFORX4 PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 6,314,452 shares; 2026Q1: 6,737,648 shares 6,737,648$27.8M0.55%+423,196Timeline
GHGUARDANT HEALTH INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 160,000 shares; 2026Q1: 300,000 shares 300,000$27.7M0.55%+140,000Timeline
DRUGBRIGHT MINDS BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 403,649 shares; 2025Q1: 444,649 shares; 2025Q2: 420,690 shares; 2025Q3: 449,290 shares; 2025Q4: 449,290 shares; 2026Q1: 377,544 shares 377,544$27.5M0.54%-71,746Timeline
IVVDINVIVYD INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 21,785,166 shares; 2026Q1: 20,859,303 shares 20,859,303$27.1M0.54%-925,863Timeline
SIONSIONNA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 1,251,101 shares; 2025Q2: 1,216,045 shares; 2025Q3: 1,179,098 shares; 2025Q4: 1,179,098 shares; 2026Q1: 658,439 shares 658,439$26.4M0.52%-520,659Timeline
AXSMAXSOME THERAPEUTICS INC.Quarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 782,844 shares; 2024Q4: 664,074 shares; 2025Q1: 355,107 shares; 2025Q2: 198,534 shares; 2025Q3: 148,900 shares; 2025Q4: 148,900 shares; 2026Q1: 149,950 shares 149,950$25.3M0.5%+1,050Timeline
RVMDREVOLUTION MEDICINES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 258,600 shares 258,600$25.1M0.5%newTimeline
SABSSAB BIOTHERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 803,210 shares; 2026Q1: 6,431,743 shares 6,431,743$24.6M0.49%+5,628,533Timeline
BLTEBELITE BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 49,788 shares; 2025Q4: 414,239 shares; 2026Q1: 151,979 shares 151,979$24.2M0.48%-262,260Timeline
TENXTENAX THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 439,142 shares; 2026Q1: 1,447,782 shares 1,447,782$23.2M0.46%+1,008,640Timeline
AXGNAXOGEN INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 784,140 shares; 2026Q1: 697,312 shares 697,312$23.1M0.46%-86,828Timeline
VRDNVIRIDIAN THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 2,812,665 shares; 2024Q4: 1,486,508 shares; 2025Q1: 659,662 shares; 2025Q2: 447,507 shares; 2025Q3: 1,462,400 shares; 2025Q4: 3,042,703 shares; 2026Q1: 1,170,829 shares 1,170,829$22.9M0.45%-1,871,874Timeline
OBIOORCHESTRA BIOMED HLDGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 4,592,556 shares; 2024Q4: 4,592,556 shares; 2025Q1: 4,592,556 shares; 2025Q2: 4,592,556 shares; 2025Q3: 5,292,556 shares; 2025Q4: 5,127,256 shares; 2026Q1: 5,037,906 shares 5,037,906$21.4M0.42%-89,350Timeline
RAPPRAPPORT THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 748,183 shares; 2024Q4: 311,551 shares; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 403,923 shares; 2025Q4: 673,923 shares; 2026Q1: 673,923 shares 673,923$21.1M0.42%0Timeline
DBVTDBV TECHNOLOGIES S AQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 964,391 shares 964,391$20.1M0.4%newTimeline
LONALEONABIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 540,296 shares; 2025Q4: 1,859,322 shares; 2026Q1: 1,859,322 shares 1,859,322$19.1M0.38%0Timeline
AVRANTERIS TECHNOLOGIES GLOBALQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 2,140,000 shares; 2025Q1: 2,140,000 shares; 2025Q2: 1,705,130 shares; 2025Q3: 1,705,130 shares; 2025Q4: 1,675,476 shares; 2026Q1: 3,425,476 shares 3,425,476$19M0.38%+1,750,000Timeline
STROSUTRO BIOPHARMA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 715,307 shares 715,307$17.8M0.35%newTimeline
TNGXTANGO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 513,035 shares; 2026Q1: 808,153 shares 808,153$16.9M0.33%+295,118Timeline
CTNMCONTINEUM THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 1,516,668 shares; 2024Q4: 1,441,249 shares; 2025Q1: 1,441,249 shares; 2025Q2: 699,486 shares; 2025Q3: 714,592 shares; 2025Q4: 1,464,592 shares; 2026Q1: 1,255,592 shares 1,255,592$16.4M0.32%-209,000Timeline
PALIPALISADE BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 12,050,000 shares; 2026Q1: 8,928,149 shares 8,928,149$15.6M0.31%-3,121,851Timeline
OCSOCULIS HOLDING AGQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 493,827 shares; 2026Q1: 493,827 shares 493,827$13.1M0.26%0Timeline
IRTCIRHYTHM HOLDINGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 22,591 shares; 2024Q4: 65,153 shares; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 123,000 shares; 2025Q4: 108,000 shares; 2026Q1: 105,026 shares 105,026$12.4M0.24%-2,974Timeline
ADGMADAGIO MED HLDGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 9,812,419 shares; 2024Q4: 9,812,419 shares; 2025Q1: 9,812,419 shares; 2025Q2: 9,876,576 shares; 2025Q3: 9,876,576 shares; 2025Q4: 9,876,576 shares; 2026Q1: 9,876,576 shares 9,876,576$11M0.22%0Timeline
EVMNEVOMMUNE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 448,350 shares 448,350$10.3M0.2%newTimeline
PHATPHATHOM PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 925,000 shares 925,000$10.3M0.2%newTimeline
NMRANEUMORA THERAPEUTICS INC.Quarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 5,104,097 shares 5,104,097$9.95M0.2%newTimeline
OMDAOMADA HEALTH INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 2,426,330 shares; 2025Q3: 2,396,330 shares; 2025Q4: 2,396,330 shares; 2026Q1: 786,330 shares 786,330$9.88M0.2%-1,610,000Timeline
NBIXNEUROCRINE BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 212,228 shares; 2024Q4: 100,050 shares; 2025Q1: 100,050 shares; 2025Q2: 255,050 shares; 2025Q3: 450,050 shares; 2025Q4: 331,050 shares; 2026Q1: 65,050 shares 65,050$8.57M0.17%-266,000Timeline
BBNXBETA BIONICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 1,593,608 shares; 2025Q2: 1,593,608 shares; 2025Q3: 277,944 shares; 2025Q4: 602,944 shares; 2026Q1: 842,944 shares 842,944$8.45M0.17%+240,000Timeline
IRDOPUS GENETICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 4,325,000 shares; 2025Q2: 4,325,000 shares; 2025Q3: 4,325,000 shares; 2025Q4: 4,325,000 shares; 2026Q1: 1,835,842 shares 1,835,842$8.35M0.16%-2,489,158Timeline
BLLNBILLIONTOONE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 72,812 shares; 2026Q1: 91,812 shares 91,812$7.25M0.14%+19,000Timeline
TWSTTWIST BIOSCIENCE CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 150,000 shares 150,000$7.13M0.14%newTimeline
SRZNSURROZEN INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 229,393 shares 229,393$6.68M0.13%newTimeline
AGMBAGOMAB THERAPEUTICS NVQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 600,000 shares 600,000$6.29M0.12%newTimeline
EOLSEVOLUS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 5,356,622 shares; 2024Q4: 5,145,846 shares; 2025Q1: 4,129,142 shares; 2025Q2: 2,474,843 shares; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 1,286,862 shares 1,286,862$5.29M0.1%newTimeline
COGTCOGENT BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 121,082 shares; 2026Q1: 121,082 shares 121,082$4.66M0.09%0Timeline
ADMAADMA BIOLOGICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 1,060,200 shares; 2024Q4: 890,280 shares; 2025Q1: 1,373,233 shares; 2025Q2: 1,303,468 shares; 2025Q3: 1,153,468 shares; 2025Q4: 883,468 shares; 2026Q1: 467,233 shares 467,233$4.21M0.08%-416,235Timeline
IKTINHIBIKASE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 5,925,000 shares; 2025Q1: 5,925,000 shares; 2025Q2: 5,432,293 shares; 2025Q3: 5,421,568 shares; 2025Q4: 5,421,568 shares; 2026Q1: 2,315,000 shares 2,315,000$3.89M0.08%-3,106,568Timeline
CBIOCRESCENT BIOPHARMA INC.Quarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 453,686 shares; 2025Q3: 453,686 shares; 2025Q4: 453,686 shares; 2026Q1: 206,942 shares 206,942$3.8M0.08%-246,744Timeline
APLSAPELLIS PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 80,956 shares 80,956$3.26M0.06%newTimeline
OMOUTSET MED INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 833,333 shares; 2025Q2: 833,333 shares; 2025Q3: 833,333 shares; 2025Q4: 833,333 shares; 2026Q1: 833,333 shares 833,333$3.2M0.06%0Timeline
EDSAEDESA BIOTECH INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 563,239 shares 563,239$2.95M0.06%newTimeline
ADPTADAPTIVE BIOTECHNOLOGIES CORQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 930,972 shares; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 152,500 shares 152,500$2.12M0.04%newTimeline
AVTXAVALO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 520,000 shares; 2025Q2: 139,667 shares; 2025Q3: 139,667 shares; 2025Q4: 139,667 shares; 2026Q1: 139,667 shares 139,667$2.09M0.04%0Timeline
CNTBCONNECT BIOPHARMA HLDGS LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 792,696 shares; 2026Q1: 792,696 shares 792,696$2.08M0.04%0Timeline
CORTCORCEPT THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 50,000 shares 50,000$2.02M0.04%newTimeline
MDLNMEDLINE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 28,000 shares; 2026Q1: 28,000 shares 28,000$1.25M0.02%0Timeline
PTNPALATIN TECHNOLOGIES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 70,000 shares; 2026Q1: 61,945 shares 61,945$1.08M0.02%-8,055Timeline
CPIXCUMBERLAND PHARMACEUTICALS IQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 341,087 shares; 2026Q1: 196,978 shares 196,978$640K0.01%-144,109Timeline
RVMDWREVOLUTION MEDICINES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 250,000 shares; 2024Q4: 250,000 shares; 2025Q1: 250,000 shares; 2025Q2: 250,000 shares; 2025Q3: 250,000 shares; 2025Q4: 250,000 shares; 2026Q1: 250,000 shares 250,000$448K0.01%0Timeline
XGNEXAGEN INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 114,893 shares 114,893$345K0.01%newTimeline
ENSCENSYSCE BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 86,666 shares; 2025Q1: 86,666 shares; 2025Q2: 86,666 shares; 2025Q3: 86,666 shares; 2025Q4: 86,666 shares; 2026Q1: 86,666 shares 86,666$46.7K<0.01%0Timeline
SRZNWSURROZEN INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 166,666 shares; 2024Q4: 166,666 shares; 2025Q1: 166,666 shares; 2025Q2: 166,666 shares; 2025Q3: 166,666 shares; 2025Q4: 166,666 shares; 2026Q1: 166,666 shares 166,666$2.67K<0.01%0Timeline

Options

Puts and calls, as filed. The amount and value describe the underlying shares, not the option premium, so they stay out of % of portfolio (H5).

SecurityTypeAmountValueChange
MRNAMODERNA INC COMput1,000,000$50.8Mnew
OCULOCULAR THERAPEUTIX INC COMcall500,000$4.24Mnew

Principal amounts

Notes and convertibles filed as a face amount (PRN). A face amount is never added to a share count (H6).

SecurityTypeAmountValueChange
CELCUITY INCCELCUITY INC NOTE 2.750% 8/0principal6,500,000$15.9M0

Sold out in Q1 2026

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
XBISPDR SERIES TRUST1,100,000$134Mput
EXASEXACT SCIENCES CORP1,200,487$122Mshares
ACLXARCELLX INC1,466,071$95.6Mshares
BSXBOSTON SCIENTIFIC CORP979,000$93.3Mshares
FOLDAMICUS THERAPEUTIC6,370,851$90.7Mshares
ASTRIA THERAPEUTICS INCASTRIA THERAPEUTICS INC6,485,420$84.9Mshares
DHRDANAHER CORP DEL200,000$45.8Mshares
CDTXCIDARA THERAPEUTICS INC165,131$36.5Mshares
IRONDISC MEDICINE INC450,743$35.8Mshares
PENPENUMBRA INC110,529$34.4Mshares
CAICARIS LIFE SCIENCES INC1,136,206$30.7Mshares
RAPTRAPT THERAPEUTICS INC825,890$28Mshares
PVLAPALVELLA THERAPEUTICS INC NE266,287$27.9Mshares
KODKODIAK SCIENCES INC848,900$23.7Mshares
BIIBBIOGEN INC124,000$21.8Mshares
ALDXALDEYRA THERAPEUTICS INC4,185,632$21.7Mshares
MIRMMIRUM PHARMACEUTICALS INC259,545$20.5Mshares
GRALGRAIL INC237,342$20.3Mshares
CVSCVS HEALTH CORP220,000$17.5Mshares
GKOSGLAUKOS CORP140,000$15.8Mshares
DXCMDEXCOM INC225,758$15Mshares
SVRASAVARA INC2,400,000$14.5Mshares
SEPNSEPTERNA INC433,160$12.1Mshares
GOSSGOSSAMER BIO INC3,139,669$9.73Mshares
MPLTMAPLIGHT THERAPEUTICS INC550,000$9.66Mshares
XENEXENON PHARMACEUTICALS INC200,791$9Mshares
KMTSKESTRA MED TECHNOLOGIES LTD285,000$7.56Mshares
CAPRCAPRICOR THERAPEUTICS INC242,100$6.99Mcall
BHVNBIOHAVEN LTD500,000$5.64Mcall
KYMRKYMERA THERAPEUTICS INC69,935$5.44Mshares
PEPGPEPGEN INC829,870$5.4Mshares
TECXTECTONIC THERAPEUTIC INC250,000$5.21Mcall
AQSTAQUESTIVE THERAPEUTICS INC747,193$4.83Mshares
KRYSKRYSTAL BIOTECH INC17,500$4.31Mshares
OLMAOLEMA PHARMACEUTICALS INC165,713$4.14Mshares
SDGRSCHRODINGER INC202,400$3.62Mshares
IMMXIMMIX BIOPHARMA INC338,941$1.77Mshares
LXEOLEXEO THERAPEUTICS INC139,835$1.39Mshares
LENZLENZ THERAPEUTICS INC50,000$800Kshares
BDSXBIODESIX INC108,694$739Kshares
ENVVENO MEDICAL CORPORATIONENVVENO MEDICAL CORPORATION1,759,035$564Kshares
IOVAIOVANCE BIOTHERAPEUTICS INC152,714$417Kshares

How Q1 2026 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0001012975-26-000443 superseded2026-05-15acceptance time not in the bulk data set
13F-HR/A 0001012975-26-000499 baserestatement2026-05-29acceptance time not in the bulk data set