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PERCEPTIVE ADVISORS LLC

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13F filer, CIK 1224962, NEW YORK, NY

PERCEPTIVE ADVISORS LLC reported $5,610,284,266 across 116 holdings for the quarter ended 2025-12-31, in a 13F-HR filed 2026-02-17. Its ten largest share positions make up 42.63% of the portfolio.

Filed (acceptance time not in the bulk data set), ingested 13F-HR 0001012975-26-000155

Period
2025-12-31
Reported value
$5.61B
Holdings
116
Top 10 weight
42.63%
New
39
Sold out
16

Part of the filer group PERCEPTIVE ADVISORS LLC

  • Joseph Edelman
  • Perceptive Capital Solutions Holdings LP
  • Perceptive Life Sciences Master Fund, Ltd.
How groups are built

Stakes and trades reported after 2025-12-31

13D, 13G and Form 4 filings by this filer's group, dated after the 13F period, on securities the quarter does not hold as shares.

  • KARD KARDIGAN INC: 13D/A 8,254,144 shares, 8.8% of the class, 13D/A filed 2026-10-01, 0001193125-26-410754Timeline
    Accepted , ingested

Largest buys vs the previous quarter

SecurityShares changeApprox. value
PRAXadded+431,432$127M
EXASadded+735,000$74.6M
APGEadded+978,662$73.9M
BSXadded+669,000$63.8M
SYREadded+1,839,780$60.3M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
MERUS N Vexited-1,353,093-$127M
INSMexited-702,130-$101M
ACLXreduced-1,002,282-$65.3M
VERONA PHARMA PLCexited-524,088-$55.9M
AKROexited-1,135,766-$53.9M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q4 2025

Share positions as resolved from 13F-HR 0001012975-26-000155, largest first. % of portfolio is the value over $5,458,314,260, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
PRAXPRAXIS PRECISION MEDICINES IQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,164,035 shares; 2024Q4: 1,329,735 shares; 2025Q1: 980,894 shares; 2025Q2: 752,921 shares; 2025Q3: 1,564,554 shares; 2025Q4: 1,995,986 shares 1,995,986$588M10.78%+431,432Timeline
CELCCELCUITY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,362,279 shares; 2024Q4: 2,362,279 shares; 2025Q1: 2,362,279 shares; 2025Q2: 1,633,208 shares; 2025Q3: 2,956,319 shares; 2025Q4: 3,160,200 shares 3,160,200$315M5.77%+203,881Timeline
RYTMRHYTHM PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 3,560,214 shares; 2024Q4: 3,680,473 shares; 2025Q1: 2,548,445 shares; 2025Q2: 2,418,299 shares; 2025Q3: 2,438,969 shares; 2025Q4: 2,546,391 shares 2,546,391$273M4.99%+107,422Timeline
ASNDASCENDIS PHARMA A/SQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 963,886 shares; 2025Q3: 1,088,501 shares; 2025Q4: 1,081,421 shares 1,081,421$231M4.22%-7,080Timeline
APGEAPOGEE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,015,007 shares; 2024Q4: 1,047,232 shares; 2025Q1: 1,122,767 shares; 2025Q2: 1,182,148 shares; 2025Q3: 1,351,989 shares; 2025Q4: 2,330,651 shares 2,330,651$176M3.22%+978,662Timeline
ROIVROIVANT SCIENCES LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 847,745 shares; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 3,331,465 shares; 2025Q3: 7,368,461 shares; 2025Q4: 7,985,461 shares 7,985,461$173M3.17%+617,000Timeline
NUVLNUVALENT INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,979,235 shares; 2024Q4: 2,619,977 shares; 2025Q1: 1,633,968 shares; 2025Q2: 1,375,180 shares; 2025Q3: 1,562,336 shares; 2025Q4: 1,665,105 shares 1,665,105$167M3.07%+102,769Timeline
TVTXTRAVERE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 834,252 shares; 2025Q3: 3,794,615 shares; 2025Q4: 4,278,180 shares 4,278,180$163M2.99%+483,565Timeline
EXASEXACT SCIENCES CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 125,000 shares; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 465,487 shares; 2025Q4: 1,200,487 shares 1,200,487$122M2.23%+735,000Timeline
PTGXPROTAGONIST THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,374,563 shares; 2024Q4: 1,271,662 shares; 2025Q1: 1,091,271 shares; 2025Q2: 1,074,448 shares; 2025Q3: 1,030,134 shares; 2025Q4: 1,350,425 shares 1,350,425$118M2.16%+320,291Timeline
INBXINHIBRX BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,064,026 shares; 2024Q4: 1,064,026 shares; 2025Q1: 1,064,026 shares; 2025Q2: 977,892 shares; 2025Q3: 1,327,707 shares; 2025Q4: 1,452,707 shares 1,452,707$115M2.1%+125,000Timeline
EWTXEDGEWISE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,330,294 shares; 2024Q4: 2,685,537 shares; 2025Q1: 6,547,328 shares; 2025Q2: 4,639,949 shares; 2025Q3: 3,795,894 shares; 2025Q4: 4,457,974 shares 4,457,974$111M2.03%+662,080Timeline
IMTXIMMATICS N.VQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 8,086,159 shares; 2024Q4: 9,383,456 shares; 2025Q1: 9,383,456 shares; 2025Q2: 9,383,456 shares; 2025Q3: 9,383,456 shares; 2025Q4: 10,383,456 shares 10,383,456$109M2%+1,000,000Timeline
SYRESPYRE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,872,547 shares; 2024Q4: 2,574,723 shares; 2025Q1: 2,313,272 shares; 2025Q2: 1,529,445 shares; 2025Q3: 1,229,445 shares; 2025Q4: 3,069,225 shares 3,069,225$101M1.84%+1,839,780Timeline
AMLXAMYLYX PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,125,649 shares; 2024Q4: 6,774,348 shares; 2025Q1: 7,874,348 shares; 2025Q2: 7,902,365 shares; 2025Q3: 8,952,365 shares; 2025Q4: 8,284,882 shares 8,284,882$100M1.83%-667,483Timeline
ACLXARCELLX INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 3,888,669 shares; 2024Q4: 3,478,888 shares; 2025Q1: 2,926,478 shares; 2025Q2: 2,478,000 shares; 2025Q3: 2,468,353 shares; 2025Q4: 1,466,071 shares 1,466,071$95.6M1.75%-1,002,282Timeline
VRDNVIRIDIAN THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,812,665 shares; 2024Q4: 1,486,508 shares; 2025Q1: 659,662 shares; 2025Q2: 447,507 shares; 2025Q3: 1,462,400 shares; 2025Q4: 3,042,703 shares 3,042,703$94.7M1.73%+1,580,303Timeline
BSXBOSTON SCIENTIFIC CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 130,000 shares; 2025Q2: 280,000 shares; 2025Q3: 310,000 shares; 2025Q4: 979,000 shares 979,000$93.3M1.71%+669,000Timeline
FOLDAMICUS THERAPEUTICQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 28,057,456 shares; 2024Q4: 24,245,952 shares; 2025Q1: 21,464,527 shares; 2025Q2: 7,412,830 shares; 2025Q3: 6,370,851 shares; 2025Q4: 6,370,851 shares 6,370,851$90.7M1.66%0Timeline
ZYMEZYMEWORKS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,180,020 shares; 2024Q4: 2,130,020 shares; 2025Q1: 1,864,672 shares; 2025Q2: 1,275,274 shares; 2025Q3: 2,090,663 shares; 2025Q4: 3,261,850 shares 3,261,850$85.9M1.57%+1,171,187Timeline
ASTRIA THERAPEUTICS INCASTRIA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 6,485,420 shares; 2024Q4: 6,485,420 shares; 2025Q1: 6,485,420 shares; 2025Q2: 6,485,420 shares; 2025Q3: 6,485,420 shares; 2025Q4: 6,485,420 shares 6,485,420$84.9M1.56%0
MGTXMEIRAGTX HLDGS PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 12,581,103 shares; 2024Q4: 12,581,103 shares; 2025Q1: 12,581,103 shares; 2025Q2: 12,626,103 shares; 2025Q3: 12,626,103 shares; 2025Q4: 10,326,103 shares 10,326,103$82.1M1.5%-2,300,000Timeline
AORTARTIVION INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,793,703 shares; 2024Q4: 2,793,703 shares; 2025Q1: 2,793,703 shares; 2025Q2: 2,793,703 shares; 2025Q3: 2,020,000 shares; 2025Q4: 1,722,290 shares 1,722,290$78.6M1.44%-297,710Timeline
CNTACENTESSA PHARMACEUTICALS PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 6,282,290 shares; 2024Q4: 6,349,220 shares; 2025Q1: 3,040,395 shares; 2025Q2: 1,146,935 shares; 2025Q3: 3,100,902 shares; 2025Q4: 2,917,634 shares 2,917,634$73M1.34%-183,268Timeline
DYNDYNE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 718,144 shares; 2024Q4: 543,277 shares; 2025Q1: 2,313,403 shares; 2025Q2: 2,247,390 shares; 2025Q3: 540,444 shares; 2025Q4: 3,478,944 shares 3,478,944$68M1.25%+2,938,500Timeline
NRIXNURIX THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 330,614 shares; 2025Q1: 297,553 shares; 2025Q2: 1,096,985 shares; 2025Q3: 1,416,149 shares; 2025Q4: 3,555,877 shares 3,555,877$67.5M1.24%+2,139,728Timeline
SLDBSOLID BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 6,906,646 shares; 2024Q4: 6,906,646 shares; 2025Q1: 11,906,646 shares; 2025Q2: 11,906,646 shares; 2025Q3: 11,833,539 shares; 2025Q4: 11,833,539 shares 11,833,539$66.7M1.22%0Timeline
BLTEBELITE BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 49,788 shares; 2025Q4: 414,239 shares 414,239$66.3M1.21%+364,451Timeline
ABVXABIVAX SAQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 388,608 shares; 2025Q4: 458,343 shares 458,343$61.8M1.13%+69,735Timeline
IVVDINVIVYD INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 21,785,166 shares 21,785,166$53.8M0.99%newTimeline
ENGNENGENE HOLDINGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 2,097,236 shares; 2025Q4: 5,869,076 shares 5,869,076$53M0.97%+3,771,840Timeline
RGENREPLIGEN CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 129,801 shares; 2025Q2: 166,000 shares; 2025Q3: 270,428 shares; 2025Q4: 315,541 shares 315,541$51.7M0.95%+45,113Timeline
IMVTIMMUNOVANT INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,378,762 shares; 2024Q4: 2,139,199 shares; 2025Q1: 2,844,072 shares; 2025Q2: 2,137,890 shares; 2025Q3: 1,587,890 shares; 2025Q4: 1,994,890 shares 1,994,890$50.7M0.93%+407,000Timeline
ISRGINTUITIVE SURGICAL INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 58,119 shares; 2024Q4: 63,119 shares; 2025Q1: 40,619 shares; 2025Q2: 45,119 shares; 2025Q3: 52,119 shares; 2025Q4: 87,919 shares 87,919$49.8M0.91%+35,800Timeline
SIONSIONNA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 1,251,101 shares; 2025Q2: 1,216,045 shares; 2025Q3: 1,179,098 shares; 2025Q4: 1,179,098 shares 1,179,098$48.5M0.89%0Timeline
NBIXNEUROCRINE BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 212,228 shares; 2024Q4: 100,050 shares; 2025Q1: 100,050 shares; 2025Q2: 255,050 shares; 2025Q3: 450,050 shares; 2025Q4: 331,050 shares 331,050$47M0.86%-119,000Timeline
DHRDANAHER CORP DELQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 200,000 shares 200,000$45.8M0.84%newTimeline
ORKAORUKA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,235,187 shares; 2024Q4: 845,567 shares; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 1,268,021 shares; 2025Q4: 1,476,501 shares 1,476,501$44.8M0.82%+208,480Timeline
CTMXCYTOMX THERAPEUTICS INC.Quarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 6,993,646 shares; 2025Q3: 9,680,185 shares; 2025Q4: 9,680,185 shares 9,680,185$41.2M0.76%0Timeline
OMDAOMADA HEALTH INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 2,426,330 shares; 2025Q3: 2,396,330 shares; 2025Q4: 2,396,330 shares 2,396,330$37.8M0.69%0Timeline
CDTXCIDARA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 165,131 shares 165,131$36.5M0.67%newTimeline
IRONDISC MEDICINE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 387,017 shares; 2024Q4: not reported; 2025Q1: 150,000 shares; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 450,743 shares 450,743$35.8M0.66%newTimeline
DRUGBRIGHT MINDS BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 403,649 shares; 2025Q1: 444,649 shares; 2025Q2: 420,690 shares; 2025Q3: 449,290 shares; 2025Q4: 449,290 shares 449,290$35.1M0.64%0Timeline
PENPENUMBRA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 73,338 shares; 2025Q1: not reported; 2025Q2: 32,797 shares; 2025Q3: 220,547 shares; 2025Q4: 110,529 shares 110,529$34.4M0.63%-110,018Timeline
ANROALTO NEUROSCIENCE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 155,366 shares; 2025Q4: 1,784,393 shares 1,784,393$31.8M0.58%+1,629,027Timeline
CAICARIS LIFE SCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 1,098,163 shares; 2025Q3: 1,098,163 shares; 2025Q4: 1,136,206 shares 1,136,206$30.7M0.56%+38,043Timeline
JAZZJAZZ PHARMACEUTICALS PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 170,000 shares 170,000$28.9M0.53%newTimeline
PALIPALISADE BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 12,050,000 shares 12,050,000$28.3M0.52%newTimeline
RAPTRAPT THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 183,890 shares; 2025Q3: 183,890 shares; 2025Q4: 825,890 shares 825,890$28M0.51%+642,000Timeline
PVLAPALVELLA THERAPEUTICS INC NEQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 395,093 shares; 2025Q4: 266,287 shares 266,287$27.9M0.51%-128,806Timeline
AXSMAXSOME THERAPEUTICS INC.Quarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 782,844 shares; 2024Q4: 664,074 shares; 2025Q1: 355,107 shares; 2025Q2: 198,534 shares; 2025Q3: 148,900 shares; 2025Q4: 148,900 shares 148,900$27.2M0.5%0Timeline
AXGNAXOGEN INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 784,140 shares 784,140$25.7M0.47%newTimeline
XFORX4 PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 6,314,452 shares 6,314,452$25.3M0.46%newTimeline
BCRXBIOCRYST PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 3,162,529 shares 3,162,529$24.7M0.45%newTimeline
NAUTNAUTILUS BIOTECHNOLOGY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 12,594,211 shares; 2024Q4: 12,594,211 shares; 2025Q1: 12,594,211 shares; 2025Q2: 12,594,211 shares; 2025Q3: 12,594,211 shares; 2025Q4: 12,594,211 shares 12,594,211$24.6M0.45%0Timeline
KODKODIAK SCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 634,577 shares; 2025Q4: 848,900 shares 848,900$23.7M0.43%+214,323Timeline
BIIBBIOGEN INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 124,000 shares 124,000$21.8M0.4%newTimeline
ALDXALDEYRA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 9,275,851 shares; 2024Q4: 9,275,851 shares; 2025Q1: 9,275,851 shares; 2025Q2: 4,051,631 shares; 2025Q3: 5,222,311 shares; 2025Q4: 4,185,632 shares 4,185,632$21.7M0.4%-1,036,679Timeline
OBIOORCHESTRA BIOMED HLDGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 4,592,556 shares; 2024Q4: 4,592,556 shares; 2025Q1: 4,592,556 shares; 2025Q2: 4,592,556 shares; 2025Q3: 5,292,556 shares; 2025Q4: 5,127,256 shares 5,127,256$21.3M0.39%-165,300Timeline
MIRMMIRUM PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 259,545 shares 259,545$20.5M0.38%newTimeline
RAPPRAPPORT THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 748,183 shares; 2024Q4: 311,551 shares; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 403,923 shares; 2025Q4: 673,923 shares 673,923$20.4M0.37%+270,000Timeline
GRALGRAIL INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 237,342 shares 237,342$20.3M0.37%newTimeline
IRTCIRHYTHM HOLDINGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 22,591 shares; 2024Q4: 65,153 shares; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 123,000 shares; 2025Q4: 108,000 shares 108,000$19.2M0.35%-15,000Timeline
BBNXBETA BIONICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 1,593,608 shares; 2025Q2: 1,593,608 shares; 2025Q3: 277,944 shares; 2025Q4: 602,944 shares 602,944$18.4M0.34%+325,000Timeline
CVSCVS HEALTH CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 220,000 shares 220,000$17.5M0.32%newTimeline
CTNMCONTINEUM THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,516,668 shares; 2024Q4: 1,441,249 shares; 2025Q1: 1,441,249 shares; 2025Q2: 699,486 shares; 2025Q3: 714,592 shares; 2025Q4: 1,464,592 shares 1,464,592$16.7M0.31%+750,000Timeline
GHGUARDANT HEALTH INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 160,000 shares 160,000$16.3M0.3%newTimeline
ADMAADMA BIOLOGICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,060,200 shares; 2024Q4: 890,280 shares; 2025Q1: 1,373,233 shares; 2025Q2: 1,303,468 shares; 2025Q3: 1,153,468 shares; 2025Q4: 883,468 shares 883,468$16.1M0.3%-270,000Timeline
RLAYRELAY THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 1,903,245 shares 1,903,245$16.1M0.29%newTimeline
GKOSGLAUKOS CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 140,000 shares 140,000$15.8M0.29%newTimeline
DXCMDEXCOM INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 178,000 shares; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 225,758 shares 225,758$15M0.27%newTimeline
SVRASAVARA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 2,400,000 shares 2,400,000$14.5M0.27%newTimeline
LONALEONABIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 540,296 shares; 2025Q4: 1,859,322 shares 1,859,322$14.1M0.26%+1,319,026Timeline
SEPNSEPTERNA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 750,000 shares; 2025Q1: not reported; 2025Q2: 541,450 shares; 2025Q3: 541,450 shares; 2025Q4: 433,160 shares 433,160$12.1M0.22%-108,290Timeline
IKTINHIBIKASE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 5,925,000 shares; 2025Q1: 5,925,000 shares; 2025Q2: 5,432,293 shares; 2025Q3: 5,421,568 shares; 2025Q4: 5,421,568 shares 5,421,568$11.1M0.2%0Timeline
ADGMADAGIO MED HLDGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 9,812,419 shares; 2024Q4: 9,812,419 shares; 2025Q1: 9,812,419 shares; 2025Q2: 9,876,576 shares; 2025Q3: 9,876,576 shares; 2025Q4: 9,876,576 shares 9,876,576$10.3M0.19%0Timeline
OCSOCULIS HOLDING AGQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 493,827 shares 493,827$9.86M0.18%newTimeline
GOSSGOSSAMER BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 3,812,797 shares; 2025Q4: 3,139,669 shares 3,139,669$9.73M0.18%-673,128Timeline
MPLTMAPLIGHT THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 550,000 shares 550,000$9.66M0.18%newTimeline
XENEXENON PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 524,930 shares; 2024Q4: 325,324 shares; 2025Q1: 325,324 shares; 2025Q2: 200,791 shares; 2025Q3: 200,791 shares; 2025Q4: 200,791 shares 200,791$9M0.16%0Timeline
IRDOPUS GENETICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 4,325,000 shares; 2025Q2: 4,325,000 shares; 2025Q3: 4,325,000 shares; 2025Q4: 4,325,000 shares 4,325,000$8.69M0.16%0Timeline
AVRANTERIS TECHNOLOGIES GLOBALQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 2,140,000 shares; 2025Q1: 2,140,000 shares; 2025Q2: 1,705,130 shares; 2025Q3: 1,705,130 shares; 2025Q4: 1,675,476 shares 1,675,476$8.36M0.15%-29,654Timeline
KMTSKESTRA MED TECHNOLOGIES LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 200,000 shares; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 285,000 shares 285,000$7.56M0.14%newTimeline
BLLNBILLIONTOONE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 72,812 shares 72,812$5.96M0.11%newTimeline
KYMRKYMERA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 46,213 shares; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 210,106 shares; 2025Q3: 169,796 shares; 2025Q4: 69,935 shares 69,935$5.44M0.1%-99,861Timeline
PEPGPEPGEN INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,410,438 shares; 2024Q4: 829,536 shares; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 829,870 shares; 2025Q4: 829,870 shares 829,870$5.4M0.1%0Timeline
CBIOCRESCENT BIOPHARMA INC.Quarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 453,686 shares; 2025Q3: 453,686 shares; 2025Q4: 453,686 shares 453,686$5.38M0.1%0Timeline
TENXTENAX THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 439,142 shares 439,142$5.35M0.1%newTimeline
CRVSCORVUS PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 1,438,595 shares; 2025Q3: 1,438,595 shares; 2025Q4: 692,441 shares 692,441$5.33M0.1%-746,154Timeline
AQSTAQUESTIVE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 3,727,208 shares; 2025Q2: 2,190,420 shares; 2025Q3: 3,760,099 shares; 2025Q4: 747,193 shares 747,193$4.83M0.09%-3,012,906Timeline
TNGXTANGO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 513,035 shares 513,035$4.55M0.08%newTimeline
KRYSKRYSTAL BIOTECH INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 35,000 shares; 2025Q4: 17,500 shares 17,500$4.31M0.08%-17,500Timeline
COGTCOGENT BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 121,082 shares 121,082$4.3M0.08%newTimeline
OLMAOLEMA PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 165,713 shares 165,713$4.14M0.08%newTimeline
SDGRSCHRODINGER INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 202,400 shares 202,400$3.62M0.07%newTimeline
OMOUTSET MED INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 833,333 shares; 2025Q2: 833,333 shares; 2025Q3: 833,333 shares; 2025Q4: 833,333 shares 833,333$3.09M0.06%0Timeline
SABSSAB BIOTHERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 803,210 shares 803,210$3M0.06%newTimeline
AVTXAVALO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 520,000 shares; 2025Q2: 139,667 shares; 2025Q3: 139,667 shares; 2025Q4: 139,667 shares 139,667$2.54M0.05%0Timeline
CNTBCONNECT BIOPHARMA HLDGS LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 792,696 shares 792,696$2.24M0.04%newTimeline
IMMXIMMIX BIOPHARMA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 338,941 shares 338,941$1.77M0.03%newTimeline
LXEOLEXEO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 139,835 shares; 2024Q4: 139,835 shares; 2025Q1: 139,835 shares; 2025Q2: 139,835 shares; 2025Q3: 139,835 shares; 2025Q4: 139,835 shares 139,835$1.39M0.03%0Timeline
CPIXCUMBERLAND PHARMACEUTICALS IQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 341,087 shares 341,087$1.36M0.02%newTimeline
MDLNMEDLINE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 28,000 shares 28,000$1.18M0.02%newTimeline
PTNPALATIN TECHNOLOGIES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 70,000 shares 70,000$1.08M0.02%newTimeline
LENZLENZ THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 50,000 shares 50,000$800K0.01%newTimeline
BDSXBIODESIX INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 108,694 shares; 2025Q4: 108,694 shares 108,694$739K0.01%0Timeline
ENVVENO MEDICAL CORPORATIONENVVENO MEDICAL CORPORATIONQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 694,315 shares; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 1,284,966 shares; 2025Q3: 1,759,035 shares; 2025Q4: 1,759,035 shares 1,759,035$564K0.01%0
IOVAIOVANCE BIOTHERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 26,617,709 shares; 2024Q4: 22,112,266 shares; 2025Q1: 12,711,788 shares; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 152,714 shares 152,714$417K0.01%newTimeline
RVMDWREVOLUTION MEDICINES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 250,000 shares; 2024Q4: 250,000 shares; 2025Q1: 250,000 shares; 2025Q2: 250,000 shares; 2025Q3: 250,000 shares; 2025Q4: 250,000 shares 250,000$235K<0.01%0Timeline
ENSCENSYSCE BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 86,666 shares; 2025Q1: 86,666 shares; 2025Q2: 86,666 shares; 2025Q3: 86,666 shares; 2025Q4: 86,666 shares 86,666$79.7K<0.01%0Timeline
SRZNWSURROZEN INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 166,666 shares; 2024Q4: 166,666 shares; 2025Q1: 166,666 shares; 2025Q2: 166,666 shares; 2025Q3: 166,666 shares; 2025Q4: 166,666 shares 166,666$3.33K<0.01%0Timeline

Options

Puts and calls, as filed. The amount and value describe the underlying shares, not the option premium, so they stay out of % of portfolio (H5).

SecurityTypeAmountValueChange
XBISPDR SERIES TRUST S&P BIOTECHput1,100,000$134Mnew
CAPRCAPRICOR THERAPEUTICS INC COMMON STOCKcall242,100$6.99Mnew
BHVNBIOHAVEN LTD COMcall500,000$5.64Mnew
TECXTECTONIC THERAPEUTIC INC COMMON STOCKcall250,000$5.21Mnew

Principal amounts

Notes and convertibles filed as a face amount (PRN). A face amount is never added to a share count (H6).

SecurityTypeAmountValueChange
CELCUITY INCCELCUITY INC NOTE 2.750% 8/0principal6,500,000$14.1M0

Sold out in Q4 2025

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
MERUS N VMERUS N V1,353,093$127Mshares
INSMINSMED INC702,130$101Mshares
VERONA PHARMA PLCVERONA PHARMA PLC524,088$55.9Mshares
AKROAKERO THERAPEUTICS INC1,135,766$53.9Mshares
RYTMRHYTHM PHARMACEUTICALS INC416,666,000$42.1Mprincipal
JANXJANUX THERAPEUTICS INC292,686$7.15Mshares
TEMTEMPUS AI INC85,000$6.86Mshares
HTFLHEARTFLOW INC150,000$5.05Mshares
SCPHARMACEUTICALS INCSCPHARMACEUTICALS INC583,142$3.31Mshares
VKTXVIKING THERAPEUTICS INC105,597$2.78Mshares
PYXSPYXIS ONCOLOGY INC1,178,307$2.62Mshares
SPRYARS PHARMACEUTICALS INC200,000$2.01Mput
TRIBTRINITY BIOTECH INVT LTD1,790,000$1.86Mshares
LYRALYRA THERAPEUTICS INC COM NEW229,382$1.5Mshares
QUREUNIQURE NV20,000$1.17Mshares
APYXAPYX MEDICAL CORPORATION150,000$321Kshares

How Q4 2025 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0001012975-26-000155 base2026-02-17acceptance time not in the bulk data set