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Disclosery

TYRA TYRA BIOSCIENCES INC

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COMMON STOCK (common), issuer CIK 1863127

130 managers (133 13F filers) reported a position in TYRA shares at 2025-12-31, 56,827,618 shares in all. 23 filers opened a position and 10 filers sold out during the quarter.

Managers
130
13F filers
133
New
23
Added
43
Reduced
38
Sold out
10
Shares held by filers
56,827,618

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q4 2025

Filers in the available 13F reports with a share position at 2025-12-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
RA CAPITAL MANAGEMENT, L.P.in group RA CAPITAL MANAGEMENT, L.P.12,198,625$321M3.29%013F-HRTimelineGroup
Nextech Invest Ltd.4,055,861$107M10.31%013F-HRTimeline
Alta Partners Management Company, L.P.3,823,425$101M97.03%-256,87113F-HRTimeline
Commodore Capital LPin group Commodore Capital LP3,375,000$88.7M5.91%013F-HRTimelineGroup
Canaan Partners XI LLC3,374,329$88.7M64.85%-233,78013F-HRTimeline
JANUS HENDERSON GROUP PLCin group Janus Henderson2,935,442$77.1M0.03%+60,63813F-HRTimelineGroup
TCG Crossover Management, LLC2,898,103$76.2M2.52%013F-HRTimeline
Vestal Point Capital, LP2,425,000$63.8M2.34%013F-HRTimeline
BVF INC/ILin group BVF INC/IL2,127,665$55.9M1.88%-1,522,12913F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.2,086,423$54.9M<0.01%+216,94913F-HRTimelineGroup
FARALLON CAPITAL MANAGEMENT, L.L.C.2,066,818$54.3M0.28%+923,00013F-HRTimelineThe filing omitted confidential holdings, a later amendment may add them.
VANGUARD GROUP INCin group VANGUARD GROUP INC1,572,785$41.3M<0.01%+52,60013F-HRTimelineGroup
Kynam Capital Management, LP1,564,492$41.1M2.68%-765,50613F-HRTimeline
5AM Venture Management, LLC1,029,298$27.1M8.51%+90,00013F-HRTimeline
Caligan Partners LP944,257$24.8M2.27%+247,43213F-HRTimeline
Point72 Asset Management, L.P.in group Point72 Asset Management, L.P.874,192$23M0.04%+592,16013F-HRTimelineGroup
Balyasny Asset Management L.P.in group Balyasny Asset Management818,326$21.5M0.04%-28,25913F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP749,463$19.7M<0.01%+320,99113F-HRTimelineGroup
MARSHALL WACE, LLPin group MARSHALL WACE, LLP711,891$18.7M0.02%+109,87613F-HRTimelineGroup
Trails Edge Capital Partners, LP700,000$18.4M4.55%13F-HRTimeline
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC657,756$17.3M<0.01%+60,30213F-HRTimelineGroup
Sio Capital Management, LLC526,002$13.8M2.29%+11,05513F-HRTimeline
BOONE CAPITAL MANAGEMENT LLC398,482$10.5M3.29%new13F-HRTimeline
Elmind Capital, LP350,000$9.2M2.72%13F-HRTimeline
Eversept Partners, LP278,564$7.32M0.41%+5,85813F-HRTimeline
BOOTHBAY FUND MANAGEMENT, LLC221,177$5.81M0.15%+34,50713F-HRTimeline
Logos Global Management LP210,000$5.52M0.37%new13F-HRTimeline
NORTHERN TRUST CORPin group NORTHERN TRUST CORP200,956$5.28M<0.01%-7,53013F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co199,426$5.24M<0.01%-2,16113F-HRTimelineGroup
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC182,387$4.79M<0.01%+82,23713F-HR/ATimelineGroup
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC170,032$4.47M<0.01%+43,65813F-HRTimelineGroup
TWO SIGMA INVESTMENTS, LPgroup of 2 filers holding165,923$4.36M-146,715Timeline
BNP PARIBAS ASSET MANAGEMENT Holding S.…in group BNP PARIBAS ASSET MANAGEMENT …129,779$3.41M<0.01%new13F-HRTimelineGroup
JACOBS LEVY EQUITY MANAGEMENT, INC129,753$3.41M0.01%-121,80913F-HRTimeline
Invesco Ltd.in group Invesco Ltd.129,435$3.4M<0.01%+113,92513F-HRTimelineGroup
Soleus Capital Management, L.P.125,000$3.29M0.14%new13F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS120,278$3.16M<0.01%-8,60313F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY118,898$3.13M<0.01%-203,24513F-HR/ATimelineGroup
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC114,388$3.01M<0.01%-29,62813F-HRTimelineGroup
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…104,305$2.74M<0.01%+21,43413F-HRTimelineGroup
SUSQUEHANNA INTERNATIONAL GROUP, LLPgroup of 2 filers holding103,779$2.73M+55,135Timeline
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP95,640$2.51M<0.01%+55,96113F-HRTimelineGroup
INVESTMENT COUNSEL CO OF NEVADA85,020$2.24M4.8%013F-HRTimeline
OPPENHEIMER & CO INCin group OPPENHEIMER ASSET MANAGEMENT …84,726$2.23M0.03%+2,48813F-HRTimelineGroup
Seven Fleet Capital Management LP79,560$2.09M1.42%13F-HR/ATimeline
BARCLAYS PLCin group BARCLAYS PLC76,309$2.01M<0.01%+19,18313F-HRTimelineGroup
Kalehua Capital Management LLC74,465$1.96M1.94%13F-HRTimeline
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO71,175$1.87M<0.01%-3,05413F-HRTimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp60,901$1.6M<0.01%+3,73913F-HRTimelineGroup
UBS Group AGin group UBS Group AG58,856$1.55M<0.01%-28813F-HRTimelineGroup
SUPERSTRING CAPITAL MANAGEMENT LP58,677$1.54M0.83%new13F-HRTimeline
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC54,625$1.44M<0.01%-32,48213F-HRTimelineGroup
Squarepoint Ops LLCin group Squarepoint Ops LLC54,424$1.43M<0.01%+42,21013F-HRTimelineGroup
Nuveen, LLCin group TIAA47,349$1.24M<0.01%-33,09213F-HRTimelineGroup
ALGERT GLOBAL LLC46,870$1.23M0.02%new13F-HR/ATimeline
AMERICAN CENTURY COMPANIES INCin group AMERICAN CENTURY COMPANIES INC46,227$1.22M<0.01%+7,81513F-HRTimelineGroup
Y-Intercept (Hong Kong) Ltd45,942$1.21M0.03%new13F-HRTimeline
ALPS ADVISORS INCin group ALPS ADVISORS INC43,827$1.15M0.01%+19,12713F-HRTimelineGroup
ExodusPoint Capital Management, LP42,791$1.12M0.01%new13F-HRTimeline
PDT Partners, LLC42,284$1.11M0.07%-1,02613F-HRTimeline
STATE OF WISCONSIN INVESTMENT BOARD39,023$1.03M<0.01%+9,37513F-HRTimeline
RHUMBLINE ADVISERS38,790$1.02M<0.01%-1,84613F-HRTimeline
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/38,310$1.01M<0.01%-96,00913F-HRTimelineGroup
HighVista Strategies LLC35,086$922K0.24%-30,72613F-HRTimeline
ALLIANCEBERNSTEIN L.P.31,990$841K<0.01%-1,27013F-HRTimeline
XTX Topco Ltdin group XTX Topco Ltd30,414$800K0.02%-3,28613F-HRTimelineGroup
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC29,887$786K<0.01%new13F-HRTimelineGroup
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN29,049$764K<0.01%+10,57913F-HRTimelineGroup
CANADA PENSION PLAN INVESTMENT BOARD28,900$760K<0.01%new13F-HRTimeline
Fisher Asset Management, LLC28,800$757K<0.01%new13F-HRTimeline
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC28,631$753K<0.01%+56213F-HRTimelineGroup
PSP Research LLC21,853$575K0.5%13F-HRTimeline
Auour Investments LLC21,020$553K0.18%013F-HRTimeline
Creative Planningin group Creative Planning19,603$515K<0.01%new13F-HRTimelineGroup
VICTORY CAPITAL MANAGEMENT INC18,790$494K<0.01%013F-HRTimeline
PUBLIC EMPLOYEES RETIREMENT SYSTEM OF O…18,542$487K<0.01%-6,42013F-HRTimeline
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\16,377$431K<0.01%+89413F-HRTimelineGroup
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding15,502$407K+2,125Timeline
Rafferty Asset Management, LLC15,455$406K<0.01%new13F-HRTimeline
MetLife Investment Management, LLCin group MetLife Investment Management…15,356$404K<0.01%+72513F-HRTimelineGroup
PRICE T ROWE ASSOCIATES INC /MD/14,432$380K<0.01%+1,63113F-HRTimeline
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…12,996$342K<0.01%+25513F-HRTimelineGroup
FRANKLIN RESOURCES INCin group Franklin Resources12,970$341K<0.01%new13F-HRTimelineGroup
FMR LLCin group FMR LLC12,563$330K<0.01%+3413F-HRTimelineGroup
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…11,756$309K0.08%+74113F-HRTimelineGroup
BANK OF NOVA SCOTIAin group BANK OF NOVA SCOTIA11,100$292K<0.01%new13F-HRTimelineGroup
BAKER BROS. ADVISORS LPin group BAKER BROS. ADVISORS LP10,607$279K<0.01%013F-HRTimelineGroup
INTECH INVESTMENT MANAGEMENT LLC9,801$258K<0.01%-1,60113F-HRTimeline
VARCOV Co.9,708$255K0.1%13F-HRTimeline
China Universal Asset Management Co., L…8,697$229K0.02%-64513F-HRTimeline
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …8,357$220K<0.01%new13F-HRTimelineGroup
NEW YORK STATE COMMON RETIREMENT FUND7,423$195K<0.01%013F-HRTimeline
Police & Firemen's Retirement System of…6,440$169K<0.01%013F-HRTimeline
CITIGROUP INCin group CITIGROUP INC3,817$100K<0.01%+2,11013F-HRTimelineGroup
Bellevue Group AGin group Bellevue Group AG3,143$82.6K<0.01%new13F-HRTimelineGroup
Caitong International Asset Management …2,997$78.8K0.02%new13F-HR/ATimeline
Legal & General Group Plcin group Legal & General Group Plc2,367$62.2K<0.01%+17513F-HRTimelineGroup
AlphaQuest LLC2,139$56.2K<0.01%-27,92113F-HRTimeline
Chung Wu Investment Group, LLC2,000$52.6K0.04%new13F-HRTimeline
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…1,991$52.3K<0.01%013F-HRTimelineGroup
CALIFORNIA STATE TEACHERS RETIREMENT SY…1,595$41.9K<0.01%+12213F-HRTimeline
CWM, LLCin group CWM, LLC1,546$41K<0.01%+1713F-HRTimelineGroup
Sterling Capital Management LLC1,488$39.1K<0.01%-17413F-HRTimeline
FEDERATED HERMES, INC.in group FEDERATED HERMES, INC.1,297$34.1K<0.01%-85813F-HRTimelineGroup
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.1,188$31.2K<0.01%-413F-HRTimelineGroup
GF FUND MANAGEMENT CO. LTD.1,048$27.6K<0.01%-9913F-HRTimeline
Versant Capital Management, Inc819$21.5K<0.01%013F-HRTimeline
AMALGAMATED BANK814$21K<0.01%+11313F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA742$19K<0.01%-41413F-HRTimelineGroup
STRS OHIO700$18.4K<0.01%013F-HRTimeline
GAMMA Investing LLC472$12.4K<0.01%+16113F-HRTimeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…331$8.7K<0.01%-54313F-HRTimelineGroup
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…208$5.47K<0.01%013F-HRTimelineGroup
Daiwa Securities Group Inc.in group Daiwa Securities Group Inc.173$5K<0.01%013F-HRTimelineGroup
Larson Financial Group LLC146$3.84K<0.01%+813F-HRTimeline
True Wealth Design, LLC142$3.73K<0.01%013F-HRTimeline
Optiver Holding B.V.in group Optiver Holding B.V.128$3.37K<0.01%-24013F-HRTimelineGroup
Smartleaf Asset Management LLC127$3.23K<0.01%new13F-HRTimeline
Allworth Financial LP100$2.63K<0.01%013F-HRTimeline
NISA INVESTMENT ADVISORS, LLC86$2.26K<0.01%013F-HRTimeline
Rockefeller Capital Management L.P.in group Rockefeller Capital Managemen…84$2.21K<0.01%new13F-HR/ATimelineGroup
Steward Partners Investment Advisory, L…77$2.02K<0.01%new13F-HRTimeline
Farther Finance Advisors, LLC60$1.58K<0.01%+4913F-HRTimeline
ROTHSCHILD INVESTMENT LLC55$1.45K<0.01%013F-HRTimeline
SIGNATUREFD, LLC43$1.13K<0.01%013F-HRTimeline
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…42$1.1K<0.01%-213F-HRTimelineGroup
Clearstead Advisors, LLC29$759<0.01%-9613F-HRTimeline
SBI Securities Co., Ltd.4$105<0.01%-113F-HRTimeline
Arax Advisory Partners3$79<0.01%-8213F-HRTimeline
Covestor Ltd6$00%013F-HRTimelineValue filed as zero, left out of ratios.