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Disclosery

TYRA TYRA BIOSCIENCES INC

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COMMON STOCK (common), issuer CIK 1863127

114 managers (116 13F filers) reported a position in TYRA shares at 2025-09-30, 55,638,641 shares in all. 8 filers opened a position and 14 filers sold out during the quarter.

Managers
114
13F filers
116
New
8
Added
40
Reduced
38
Sold out
14
Shares held by filers
55,638,641

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q3 2025

Filers in the available 13F reports with a share position at 2025-09-30, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
RA CAPITAL MANAGEMENT, L.P.in group RA CAPITAL MANAGEMENT, L.P.12,198,625$171M2.1%013F-HRTimelineGroup
Alta Partners Management Company, L.P.4,080,296$57.1M95.15%013F-HRTimeline
Nextech Invest Ltd.4,055,861$56.7M8.64%013F-HRTimeline
BVF INC/ILin group BVF INC/IL3,649,794$51.1M2.07%-294,40013F-HRTimelineGroup
Canaan Partners XI LLC3,608,109$50.5M49.07%013F-HRTimeline
Commodore Capital LPin group Commodore Capital LP3,375,000$47.2M2.3%+275,00013F-HRTimelineGroup
TCG Crossover Management, LLC2,898,103$40.5M1.99%013F-HRTimeline
JANUS HENDERSON GROUP PLCin group Janus Henderson2,874,804$40.2M0.02%+18,51413F-HRTimelineGroup
Vestal Point Capital, LP2,425,000$33.9M1.54%-230,00013F-HRTimeline
Kynam Capital Management, LP2,329,998$32.6M2.43%013F-HRTimeline
BlackRock, Inc.in group BlackRock, Inc.1,869,474$26.2M<0.01%-23,85413F-HRTimelineGroup
VANGUARD GROUP INCin group VANGUARD GROUP INC1,520,185$21.3M<0.01%+118,49213F-HRTimelineGroup
FARALLON CAPITAL MANAGEMENT, L.L.C.1,143,818$16M0.09%013F-HR/ATimeline
5AM Venture Management, LLC939,298$13.1M4.81%013F-HRTimeline
Balyasny Asset Management L.P.in group Balyasny Asset Management846,585$11.8M0.02%+263,19913F-HRTimelineGroup
Caligan Partners LP696,825$9.75M1.35%+506,87513F-HRTimeline
MARSHALL WACE, LLPin group MARSHALL WACE, LLP602,015$8.42M0.01%+173,90713F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC597,454$8.36M<0.01%+30,32813F-HRTimelineGroup
Sio Capital Management, LLC514,947$7.2M1.82%-295,32713F-HRTimeline
STATE STREET CORPin group STATE STREET CORP428,472$5.99M<0.01%+9,48813F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY322,143$4.51M<0.01%-56,25913F-HR/ATimelineGroup
TWO SIGMA INVESTMENTS, LPgroup of 2 filers holding312,638$4.37M+119,813Timeline
Walleye Capital LLCin group Walleye Capital LLC297,808$4.17M0.03%-72,60013F-HRTimelineGroup
Point72 Asset Management, L.P.in group Point72 Asset Management, L.P.282,032$3.95M0.01%+57,33213F-HRTimelineGroup
Eversept Partners, LP272,706$3.82M0.29%new13F-HRTimeline
JACOBS LEVY EQUITY MANAGEMENT, INC251,562$3.52M0.01%-143,73713F-HRTimeline
NORTHERN TRUST CORPin group NORTHERN TRUST CORP208,486$2.92M<0.01%+3,17813F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co201,587$2.82M<0.01%+23,48313F-HRTimelineGroup
BOOTHBAY FUND MANAGEMENT, LLC186,670$2.61M0.07%new13F-HRTimeline
RENAISSANCE TECHNOLOGIES LLC170,100$2.38M<0.01%+35,00013F-HRTimeline
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC144,016$2.01M<0.01%-263,44813F-HRTimelineGroup
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/134,319$1.88M<0.01%-238,64813F-HR/ATimelineGroup
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS128,881$1.8M<0.01%+31,14513F-HRTimelineGroup
AXA Investment Managers S.A.128,789$1.8M<0.01%13F-HRTimeline
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC126,374$1.77M<0.01%+63,18713F-HRTimelineGroup
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC111,293$1.56M<0.01%-104,84313F-HRTimelineGroup
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC100,150$1.4M<0.01%-5,44513F-HRTimelineGroup
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC87,107$1.22M<0.01%+6,50513F-HRTimelineGroup
INVESTMENT COUNSEL CO OF NEVADA85,020$1.19M2.42%013F-HRTimeline
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…82,871$1.16M<0.01%-20,20713F-HRTimelineGroup
OPPENHEIMER & CO INCin group OPPENHEIMER ASSET MANAGEMENT …82,238$1.15M0.01%+8,20513F-HRTimelineGroup
Nuveen, LLCin group TIAA80,441$1.13M<0.01%013F-HRTimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO74,229$1.04M<0.01%-28,68813F-HR/ATimelineGroup
HighVista Strategies LLC65,812$921K0.23%+40,85013F-HRTimeline
Jump Financial, LLCin group Jump Financial, LLC62,000$867K0.01%-9,11913F-HR/ATimelineGroup
UBS Group AGin group UBS Group AG59,144$827K<0.01%+12,87613F-HRTimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp57,162$800K<0.01%+3,12313F-HRTimelineGroup
BARCLAYS PLCin group BARCLAYS PLC57,126$799K<0.01%-4,42913F-HR/ATimelineGroup
SUSQUEHANNA INTERNATIONAL GROUP, LLPgroup of 2 filers holding48,644$681K-37,782Timeline
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC44,680$625K<0.01%-13,48813F-HRTimelineGroup
PDT Partners, LLC43,310$606K0.04%013F-HRTimeline
RHUMBLINE ADVISERS40,636$568K<0.01%-4913F-HRTimeline
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP39,679$555K<0.01%-2,00213F-HRTimelineGroup
Cubist Systematic Strategies, LLC39,310$550K0.01%-82,72613F-HRTimeline
AMERICAN CENTURY COMPANIES INCin group AMERICAN CENTURY COMPANIES INC38,412$537K<0.01%+9,55813F-HRTimelineGroup
XTX Topco Ltdin group XTX Topco Ltd33,700$471K0.02%-90113F-HRTimelineGroup
ALLIANCEBERNSTEIN L.P.33,260$465K<0.01%-2,38013F-HRTimeline
Brevan Howard Capital Management LPin group Brevan Howard Capital Managem…31,101$435K0.01%-5,49313F-HRTimelineGroup
AlphaQuest LLC30,060$421K0.03%-43,01313F-HRTimeline
STATE OF WISCONSIN INVESTMENT BOARD29,648$415K<0.01%-46,80113F-HRTimeline
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC28,069$393K<0.01%-64313F-HRTimelineGroup
PUBLIC EMPLOYEES RETIREMENT SYSTEM OF O…24,962$349K<0.01%+6,45013F-HRTimeline
ALPS ADVISORS INCin group ALPS ADVISORS INC24,700$346K<0.01%-4,02913F-HRTimelineGroup
Auour Investments LLC21,020$294K0.1%013F-HRTimeline
VICTORY CAPITAL MANAGEMENT INC18,790$263K<0.01%-25,40013F-HRTimeline
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN18,470$258K<0.01%+3,01313F-HRTimelineGroup
Trexquant Investment LP15,758$220K<0.01%-28,92313F-HRTimeline
Invesco Ltd.in group Invesco Ltd.15,510$217K<0.01%new13F-HRTimelineGroup
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\15,483$217K<0.01%+2,18313F-HRTimelineGroup
MetLife Investment Management, LLCin group MetLife Investment Management…14,631$205K<0.01%013F-HRTimelineGroup
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding13,377$187K-1,859Timeline
PRICE T ROWE ASSOCIATES INC /MD/12,801$180K<0.01%+77913F-HRTimeline
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…12,741$178K<0.01%+2,76613F-HRTimelineGroup
FMR LLCin group FMR LLC12,529$175K<0.01%+32713F-HRTimelineGroup
Squarepoint Ops LLCin group Squarepoint Ops LLC12,214$171K<0.01%-19,19413F-HRTimelineGroup
INTECH INVESTMENT MANAGEMENT LLC11,402$160K<0.01%-8,51713F-HRTimeline
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…11,015$154K0.04%+1,91213F-HRTimelineGroup
TUDOR INVESTMENT CORP ET AL10,761$151K<0.01%-15,50413F-HR/ATimeline
BAKER BROS. ADVISORS LPin group BAKER BROS. ADVISORS LP10,607$148K<0.01%013F-HRTimelineGroup
SG Americas Securities, LLC9,542$133K<0.01%new13F-HRTimeline
China Universal Asset Management Co., L…9,342$131K0.01%-1,33913F-HRTimeline
NEW YORK STATE COMMON RETIREMENT FUND7,423$104K<0.01%013F-HRTimeline
Police & Firemen's Retirement System of…6,440$90.1K<0.01%+1,39113F-HRTimeline
Legal & General Group Plcin group Legal & General Group Plc2,192$30.7K<0.01%013F-HRTimelineGroup
FEDERATED HERMES, INC.in group FEDERATED HERMES, INC.2,155$30.1K<0.01%+1,84113F-HRTimelineGroup
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…1,991$27.9K<0.01%013F-HRTimelineGroup
CITIGROUP INCin group CITIGROUP INC1,707$23.9K<0.01%-7,79013F-HRTimelineGroup
Sterling Capital Management LLC1,662$23.3K<0.01%+1,01213F-HRTimeline
CWM, LLCin group CWM, LLC1,529$21K<0.01%-1213F-HRTimelineGroup
CALIFORNIA STATE TEACHERS RETIREMENT SY…1,473$20.6K<0.01%+113F-HRTimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.1,192$16.1K<0.01%+18313F-HRTimelineGroup
GF FUND MANAGEMENT CO. LTD.1,147$16K<0.01%-14913F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA1,156$16K<0.01%-15,05713F-HRTimelineGroup
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…874$12.2K<0.01%-1,96613F-HRTimelineGroup
Versant Capital Management, Inc819$11.5K<0.01%013F-HRTimeline
AMALGAMATED BANK701$10K<0.01%013F-HRTimeline
STRS OHIO700$9.79K<0.01%013F-HRTimeline
Optiver Holding B.V.in group Optiver Holding B.V.368$5.15K<0.01%new13F-HRTimelineGroup
GAMMA Investing LLC311$4.35K<0.01%+9613F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…208$2.91K<0.01%+15013F-HRTimelineGroup
Daiwa Securities Group Inc.in group Daiwa Securities Group Inc.173$2K<0.01%013F-HRTimelineGroup
True Wealth Design, LLC142$1.99K<0.01%013F-HRTimeline
Larson Financial Group LLC138$1.93K<0.01%+10213F-HRTimeline
Clearstead Advisors, LLC125$1.75K<0.01%013F-HRTimeline
Allworth Financial LP100$1.4K<0.01%013F-HRTimeline
NISA INVESTMENT ADVISORS, LLC86$1.2K<0.01%013F-HRTimeline
Arax Advisory Partners85$1.19K<0.01%new13F-HRTimeline
ROTHSCHILD INVESTMENT LLC55$769<0.01%013F-HRTimeline
Rise Advisors, LLC49$686<0.01%new13F-HRTimeline
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…44$616<0.01%+413F-HRTimelineGroup
SIGNATUREFD, LLC43$602<0.01%013F-HRTimeline
Farther Finance Advisors, LLC11$154<0.01%new13F-HRTimeline
SBI Securities Co., Ltd.5$70<0.01%+113F-HRTimeline
Covestor Ltd6$00%013F-HRTimelineValue filed as zero, left out of ratios.