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Disclosery

TYRA TYRA BIOSCIENCES INC

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COMMON STOCK (common), issuer CIK 1863127

119 managers (122 13F filers) reported a position in TYRA shares at 2025-06-30, 56,588,660 shares in all. 18 filers opened a position and 15 filers sold out during the quarter.

Managers
119
13F filers
122
New
18
Added
62
Reduced
20
Sold out
15
Shares held by filers
56,588,660

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q2 2025

Filers in the available 13F reports with a share position at 2025-06-30, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
RA CAPITAL MANAGEMENT, L.P.in group RA CAPITAL MANAGEMENT, L.P.12,198,625$117M1.97%+1,561,33513F-HRTimelineGroup
Alta Partners Management Company, L.P.4,080,296$39M93.82%013F-HRTimeline
Nextech Invest Ltd.4,055,861$38.8M7.35%013F-HRTimeline
BVF INC/ILin group BVF INC/IL3,944,194$37.7M1.35%013F-HRTimelineGroup
Canaan Partners XI LLC3,608,109$34.5M20.1%-536,48113F-HRTimeline
Commodore Capital LPin group Commodore Capital LP3,100,000$29.7M2.09%+2,150,00013F-HRTimelineGroup
TCG Crossover Management, LLC2,898,103$27.7M3.17%013F-HRTimeline
JANUS HENDERSON GROUP PLCin group Janus Henderson2,856,290$27.3M0.01%+163,05313F-HRTimelineGroup
Vestal Point Capital, LP2,655,000$25.4M1.34%-224,82913F-HRTimeline
Kynam Capital Management, LP2,329,998$22.3M2.4%-76,06913F-HRTimeline
BlackRock, Inc.in group BlackRock, Inc.1,893,328$18.1M<0.01%+197,41113F-HRTimelineGroup
VANGUARD GROUP INCin group VANGUARD GROUP INC1,401,693$13.4M<0.01%+183,32213F-HRTimelineGroup
FARALLON CAPITAL MANAGEMENT, L.L.C.1,143,818$10.9M0.05%013F-HRTimelineThe filing omitted confidential holdings, a later amendment may add them.
5AM Venture Management, LLC939,298$8.99M3.46%013F-HRTimeline
Sio Capital Management, LLC810,274$7.75M3.11%+393,65713F-HRTimeline
ORBIMED ADVISORS LLCin group ORBIMED ADVISORS LLC804,603$7.7M0.19%-948,22813F-HRTimelineGroup
Balyasny Asset Management L.P.in group Balyasny Asset Management583,386$5.58M0.01%+340,14213F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC567,126$5.43M<0.01%+50,83613F-HRTimelineGroup
MARSHALL WACE, LLPin group MARSHALL WACE, LLP428,108$4.1M<0.01%+47,40813F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP418,984$4.01M<0.01%+4,99613F-HRTimelineGroup
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC407,464$3.9M<0.01%+3,29913F-HRTimelineGroup
JACOBS LEVY EQUITY MANAGEMENT, INC395,299$3.78M0.01%+93,49813F-HRTimeline
MORGAN STANLEYin group MORGAN STANLEY378,402$3.62M<0.01%+197,81213F-HRTimelineGroup
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/372,967$3.57M<0.01%+289,44613F-HRTimelineGroup
Walleye Capital LLCin group Walleye Capital LLC370,408$3.54M0.03%+229,66613F-HRTimelineGroup
Point72 Asset Management, L.P.in group Point72 Asset Management, L.P.224,700$2.15M0.01%+175,10013F-HRTimelineGroup
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC216,136$2.07M<0.01%+119,85413F-HRTimelineGroup
NORTHERN TRUST CORPin group NORTHERN TRUST CORP205,308$1.96M<0.01%-11,13913F-HRTimelineGroup
TWO SIGMA INVESTMENTS, LPgroup of 2 filers holding192,825$1.85M+77,907Timeline
Caligan Partners LP189,950$1.82M0.35%+164,95013F-HRTimeline
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co178,104$1.7M<0.01%+13,99613F-HRTimelineGroup
RENAISSANCE TECHNOLOGIES LLC135,100$1.29M<0.01%+83,70013F-HRTimeline
AXA S.A.in group AXA S.A.128,400$1.23M<0.01%+21113F-HRTimelineGroup
Cubist Systematic Strategies, LLC122,036$1.17M0.01%+30,19213F-HRTimeline
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC105,595$1.01M<0.01%+27,58913F-HRTimelineGroup
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…103,078$986K<0.01%-1,00913F-HRTimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO102,917$985K<0.01%+17,42713F-HRTimelineGroup
Woodline Partners LP100,108$958K0.01%013F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS97,736$935K<0.01%+28,78613F-HRTimelineGroup
SUSQUEHANNA INTERNATIONAL GROUP, LLPgroup of 2 filers holding86,426$827K+62,900Timeline
INVESTMENT COUNSEL CO OF NEVADA85,020$814K1.67%013F-HRTimeline
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC80,602$771K<0.01%new13F-HRTimelineGroup
Nuveen, LLCin group TIAA80,441$770K<0.01%+30,44313F-HRTimelineGroup
STATE OF WISCONSIN INVESTMENT BOARD76,449$732K<0.01%+17,73713F-HRTimeline
OPPENHEIMER & CO INCin group OPPENHEIMER ASSET MANAGEMENT …74,033$708K0.01%-77213F-HRTimelineGroup
AlphaQuest LLC73,073$699K0.07%+43,45113F-HRTimeline
Jump Financial, LLCin group Jump Financial, LLC71,119$681K0.01%+43,17013F-HR/ATimelineGroup
ExodusPoint Capital Management, LP67,442$645K0.01%+37,20713F-HRTimeline
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC63,187$605K<0.01%+8,84313F-HRTimelineGroup
BARCLAYS PLCin group BARCLAYS PLC61,555$589K<0.01%+19,04413F-HR/ATimelineGroup
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC58,168$557K<0.01%+23,35513F-HRTimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp54,039$517K<0.01%+12,95613F-HRTimelineGroup
UBS Group AGgroup of 2 filers holding46,268$443K-35,653Timeline
Trexquant Investment LP44,681$428K<0.01%new13F-HRTimeline
VICTORY CAPITAL MANAGEMENT INC44,190$423K<0.01%-11,96013F-HRTimeline
PDT Partners, LLC43,310$414K0.02%new13F-HRTimeline
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP41,681$399K<0.01%+6,96913F-HRTimelineGroup
Verition Fund Management LLC40,939$392K<0.01%-1,23513F-HRTimeline
RHUMBLINE ADVISERS40,685$389K<0.01%+12,60413F-HRTimeline
Brevan Howard Capital Management LPin group Brevan Howard Capital Managem…36,594$350K<0.01%-9,77713F-HRTimelineGroup
ALLIANCEBERNSTEIN L.P.35,640$341K<0.01%+18,07013F-HRTimeline
XTX Topco Ltdin group XTX Topco Ltd34,601$331K0.01%new13F-HRTimelineGroup
Dynamic Technology Lab Private Ltd34,115$326K0.04%new13F-HRTimeline
Squarepoint Ops LLCin group Squarepoint Ops LLC31,408$301K<0.01%new13F-HR/ATimelineGroup
AMERICAN CENTURY COMPANIES INCin group AMERICAN CENTURY COMPANIES INC28,854$276K<0.01%+5,42313F-HRTimelineGroup
ALPS ADVISORS INCin group ALPS ADVISORS INC28,729$275K<0.01%new13F-HRTimelineGroup
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC28,712$275K<0.01%new13F-HRTimelineGroup
TUDOR INVESTMENT CORP ET AL26,265$251K<0.01%+14,17213F-HRTimeline
HighVista Strategies LLC24,962$239K0.09%+1,02113F-HRTimeline
Corton Capital Inc.24,346$233K0.27%new13F-HRTimeline
Auour Investments LLC21,020$201K0.07%013F-HRTimeline
INTECH INVESTMENT MANAGEMENT LLC19,919$191K<0.01%+6,32213F-HRTimeline
PUBLIC EMPLOYEES RETIREMENT SYSTEM OF O…18,512$177K<0.01%new13F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA16,213$156K<0.01%+15,53613F-HR/ATimelineGroup
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN15,457$148K<0.01%+6,10413F-HRTimelineGroup
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding15,236$146K+2,029Timeline
MetLife Investment Management, LLCin group MetLife Investment Management…14,631$140K<0.01%+2,42413F-HRTimelineGroup
Aquatic Capital Management LLC13,744$132K<0.01%+1,96313F-HRTimeline
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\13,300$127K<0.01%-3,67913F-HRTimelineGroup
AXQ CAPITAL, LP12,350$118K0.04%+2,04813F-HRTimeline
FMR LLCin group FMR LLC12,202$117K<0.01%-1,694,94613F-HRTimelineGroup
PRICE T ROWE ASSOCIATES INC /MD/12,022$116K<0.01%new13F-HRTimeline
China Universal Asset Management Co., L…10,681$102K0.01%+53113F-HRTimeline
BAKER BROS. ADVISORS LPin group BAKER BROS. ADVISORS LP10,607$102K<0.01%013F-HRTimelineGroup
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…9,975$95.5K<0.01%-26413F-HRTimelineGroup
CITIGROUP INCin group CITIGROUP INC9,497$90.9K<0.01%-6,01013F-HRTimelineGroup
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…9,103$87.1K0.03%-1,71513F-HRTimelineGroup
US BANCORP \DE\in group US BANCORP \DE\7,561$72.4K<0.01%+2,12613F-HRTimelineGroup
NEW YORK STATE COMMON RETIREMENT FUND7,423$71K<0.01%013F-HR/ATimeline
Police & Firemen's Retirement System of…5,049$48.3K<0.01%013F-HRTimeline
Point72 Asia (Singapore) Pte. Ltd.3,490$33.4K0.01%+2,69813F-HRTimeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…2,840$27.2K<0.01%+75713F-HRTimelineGroup
Point72 (DIFC) Ltd2,330$22.3K<0.01%+5713F-HRTimeline
Legal & General Group Plcin group Legal & General Group Plc2,192$21K<0.01%-7,06913F-HRTimelineGroup
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…1,991$19.1K<0.01%013F-HRTimelineGroup
CWM, LLCin group CWM, LLC1,541$15K<0.01%+1,15813F-HRTimelineGroup
CALIFORNIA STATE TEACHERS RETIREMENT SY…1,472$14.1K<0.01%-9,09813F-HRTimeline
GF FUND MANAGEMENT CO. LTD.1,296$12.4K<0.01%013F-HRTimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.1,009$9.65K<0.01%+17413F-HR/ATimelineGroup
Versant Capital Management, Inc819$7.84K<0.01%new13F-HRTimeline
AMALGAMATED BANK701$7K<0.01%013F-HRTimeline
STRS OHIO700$6.7K<0.01%013F-HRTimeline
Sterling Capital Management LLC650$6.22K<0.01%+62913F-HR/ATimeline
Caitong International Asset Management …569$5.45K<0.01%+6613F-HRTimeline
FEDERATED HERMES, INC.in group FEDERATED HERMES, INC.314$3K<0.01%-16113F-HRTimelineGroup
GAMMA Investing LLC215$2.06K<0.01%new13F-HRTimeline
Daiwa Securities Group Inc.in group Daiwa Securities Group Inc.173$2K<0.01%013F-HRTimelineGroup
True Wealth Design, LLC142$1.36K<0.01%new13F-HRTimeline
Clearstead Advisors, LLC125$1.2K<0.01%new13F-HRTimeline
Allworth Financial LP100$957<0.01%013F-HRTimeline
NISA INVESTMENT ADVISORS, LLC86$823<0.01%-6313F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…58$555<0.01%013F-HRTimelineGroup
ROTHSCHILD INVESTMENT LLC55$526<0.01%+5013F-HRTimeline
SIGNATUREFD, LLC43$412<0.01%new13F-HRTimeline
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…40$383<0.01%+3113F-HRTimelineGroup
Larson Financial Group LLC36$345<0.01%new13F-HRTimeline
SBI Securities Co., Ltd.4$38<0.01%013F-HRTimeline
Covestor Ltd6$00%013F-HRTimelineValue filed as zero, left out of ratios.
CONCOURSE FINANCIAL GROUP SECURITIES, I…0$0013F-HRTimelineValue filed as zero, left out of ratios. Amount filed as zero, left out of ratios.