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Disclosery

TYRA TYRA BIOSCIENCES INC

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COMMON STOCK (common), issuer CIK 1863127

156 managers (164 13F filers) reported a position in TYRA shares at 2026-03-31, 65,938,356 shares in all. 40 filers opened a position and 14 filers sold out during the quarter.

Managers
156
13F filers
164
New
40
Added
59
Reduced
35
Sold out
14
Shares held by filers
65,938,356

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q1 2026

Filers in the available 13F reports with a share position at 2026-03-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
RA CAPITAL MANAGEMENT, L.P.in group RA CAPITAL MANAGEMENT, L.P.12,198,625$467M4.95%013F-HRTimelineGroup
FMR LLCin group FMR LLC7,747,648$297M0.02%+7,735,08513F-HRTimelineGroup
Nextech Invest Ltd.4,055,861$155M10.93%013F-HRTimeline
JANUS HENDERSON GROUP PLCin group Janus Henderson3,890,589$149M0.07%+955,14713F-HR/ATimelineGroup
Alta Partners Management Company, L.P.3,823,425$146M96.97%013F-HRTimeline
FARALLON CAPITAL MANAGEMENT, L.L.C.3,580,818$137M0.81%+1,514,00013F-HRTimelineThe filing omitted confidential holdings, a later amendment may add them.
TCG Crossover Management, LLC3,248,980$124M3.56%+350,87713F-HRTimeline
Commodore Capital LPin group Commodore Capital LP2,475,000$94.8M5.48%-900,00013F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.2,217,929$84.9M<0.01%+131,50613F-HRTimelineGroup
Paradigm Biocapital Advisors LPin group Paradigm Biocapital Advisors …2,054,991$78.7M1.61%new13F-HRTimelineGroup
BVF INC/ILin group BVF INC/IL1,976,196$75.7M2.41%-151,46913F-HRTimelineGroup
VANGUARD GROUP INCgroup of 6 filers holding1,558,430$59.7MnewTimeline
Caligan Partners LP1,276,968$48.9M3.46%+332,71113F-HRTimeline
STATE STREET CORPin group STATE STREET CORP1,216,078$46.6M<0.01%+466,61513F-HRTimelineGroup
5AM Venture Management, LLC1,029,298$39.4M10.94%013F-HRTimeline
PRICE T ROWE ASSOCIATES INC /MD/986,061$37.8M<0.01%+971,62913F-HRTimeline
Logos Global Management LP850,000$32.6M1.68%+640,00013F-HRTimeline
BARCLAYS PLCin group BARCLAYS PLC833,399$31.9M0.01%+757,09013F-HRTimelineGroup
Canaan Partners XI LLC750,000$28.7M37.76%-2,624,32913F-HRTimeline
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC658,482$25.2M<0.01%+72613F-HRTimelineGroup
JENNISON ASSOCIATES LLC632,432$24.2M0.02%new13F-HRTimeline
Sio Capital Management, LLC605,439$23.2M3.34%+79,43713F-HRTimeline
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC550,334$21.1M<0.01%+367,94713F-HRTimelineGroup
DEERFIELD MANAGEMENT COMPANY, L.P.in group DEERFIELD MANAGEMENT COMPANY,…549,000$21M0.25%new13F-HRTimelineGroup
Balyasny Asset Management L.P.in group Balyasny Asset Management351,479$13.5M0.03%-466,84713F-HRTimelineGroup
Elmind Capital, LP350,000$13.4M3.81%013F-HRTimeline
Woodline Partners LP301,040$11.5M0.04%new13F-HR/ATimeline
BOOTHBAY FUND MANAGEMENT, LLC273,274$10.5M0.24%+52,09713F-HRTimeline
Affinity Asset Advisors, LLC257,512$9.86M0.58%new13F-HRTimeline
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC247,098$9.46M<0.01%+77,06613F-HRTimelineGroup
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC221,581$8.49M0.01%+107,19313F-HRTimelineGroup
NORTHERN TRUST CORPin group NORTHERN TRUST CORP218,508$8.37M<0.01%+17,55213F-HRTimelineGroup
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/209,922$8.04M<0.01%+171,61213F-HRTimelineGroup
Sofinnova Investments, Inc.204,015$7.81M0.39%new13F-HRTimeline
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co199,111$7.63M<0.01%-31513F-HRTimelineGroup
MARSHALL WACE, LLPin group MARSHALL WACE, LLP197,748$7.57M0.01%-514,14313F-HRTimelineGroup
Seven Fleet Capital Management LP195,685$7.49M2.35%+116,12513F-HR/ATimeline
STEMPOINT CAPITAL LP193,177$7.4M1.42%new13F-HR/ATimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS190,039$7.28M<0.01%+69,76113F-HRTimelineGroup
ALGERT GLOBAL LLC188,010$7.2M0.11%+141,14013F-HR/ATimeline
JACOBS LEVY EQUITY MANAGEMENT, INC162,204$6.21M0.03%+32,45113F-HRTimeline
Trexquant Investment LP147,317$5.64M0.04%new13F-HRTimeline
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC144,900$5.55M<0.01%+90,27513F-HR/ATimelineGroup
HighVista Strategies LLC131,304$5.03M1.39%+96,21813F-HRTimeline
BNP PARIBAS ASSET MANAGEMENT Holding S.…in group BNP PARIBAS ASSET MANAGEMENT …128,860$4.94M0.01%-91913F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY120,485$4.61M<0.01%+1,58713F-HRTimelineGroup
Invesco Ltd.in group Invesco Ltd.109,052$4.18M<0.01%-20,38313F-HRTimelineGroup
TWO SIGMA INVESTMENTS, LPin group TWO SIGMA INVESTMENTS, LP101,618$3.89M<0.01%-5,40513F-HRTimelineGroup
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP91,826$3.52M<0.01%-3,81413F-HRTimelineGroup
OPPENHEIMER & CO INCin group OPPENHEIMER ASSET MANAGEMENT …84,192$3.22M0.04%-53413F-HRTimelineGroup
XTX Topco Ltdin group XTX Topco Ltd83,896$3.21M0.06%+53,48213F-HRTimelineGroup
Schonfeld Strategic Advisors LLC79,592$3.05M0.02%new13F-HRTimeline
Cinctive Capital Management LP78,018$2.99M0.2%new13F-HRTimeline
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…77,169$2.96M<0.01%-27,13613F-HRTimelineGroup
Kalehua Capital Management LLC74,465$2.85M2.02%013F-HR/ATimeline
Ensign Peak Advisors, Inc74,064$2.84M0.01%new13F-HR/ATimeline
Bank of New York Mellon Corpin group Bank of New York Mellon Corp72,213$2.77M<0.01%+11,31213F-HRTimelineGroup
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…70,422$2.7M<0.01%+57,42613F-HRTimelineGroup
UBS Group AGgroup of 2 filers holding69,393$2.66M+10,537Timeline
Catalio Capital Management, LP67,285$2.58M0.54%new13F-HRTimeline
SUSQUEHANNA INTERNATIONAL GROUP, LLPgroup of 2 filers holding62,568$2.4M-41,211Timeline
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO66,789$2.31M<0.01%-4,38613F-HR/ATimelineGroup
Vestal Point Capital, LP54,000$2.07M0.06%-2,371,00013F-HRTimeline
Nuveen, LLCin group TIAA50,840$1.95M<0.01%+3,49113F-HRTimelineGroup
TD Asset Management Inc50,000$1.92M<0.01%new13F-HRTimeline
AMERICAN CENTURY COMPANIES INCin group AMERICAN CENTURY COMPANIES INC47,929$1.84M<0.01%+1,70213F-HRTimelineGroup
Arkadios Wealth Advisors47,567$1.82M0.03%new13F-HRTimeline
ALPS ADVISORS INCin group ALPS ADVISORS INC43,856$1.68M0.01%+2913F-HRTimelineGroup
PDT Partners, LLC42,284$1.62M0.1%013F-HRTimeline
Jump Financial, LLCin group Jump Financial, LLC41,375$1.58M0.02%new13F-HRTimelineGroup
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …40,224$1.54M<0.01%+31,86713F-HRTimelineGroup
RHUMBLINE ADVISERS39,660$1.52M<0.01%+87013F-HRTimeline
Point72 Asset Management, L.P.in group Point72 Asset Management, L.P.38,850$1.49M<0.01%-835,34213F-HRTimelineGroup
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC38,358$1.47M<0.01%+8,47113F-HRTimelineGroup
Brevan Howard Capital Management LPin group Brevan Howard Capital Managem…38,606$1.46M0.01%new13F-HRTimelineGroup
Rafferty Asset Management, LLC34,856$1.33M0.01%+19,40113F-HRTimeline
STATE OF WISCONSIN INVESTMENT BOARD33,258$1.27M<0.01%-5,76513F-HRTimeline
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC29,423$1.13M<0.01%+79213F-HRTimelineGroup
Fisher Asset Management, LLC28,800$1.1M<0.01%013F-HRTimeline
Eversept Partners, LP27,055$1.04M0.07%-251,50913F-HRTimeline
Swiss National Bank26,400$1.01M<0.01%new13F-HRTimeline
Creative Planningin group Creative Planning23,948$917K<0.01%+4,34513F-HRTimelineGroup
ALLIANCEBERNSTEIN L.P.31,990$841K<0.01%013F-HRTimeline
Auour Investments LLC21,020$805K0.25%013F-HRTimeline
PUBLIC EMPLOYEES RETIREMENT SYSTEM OF O…20,522$786K<0.01%+1,98013F-HRTimeline
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\20,495$785K<0.01%+4,11813F-HRTimelineGroup
Squarepoint Ops LLCin group Squarepoint Ops LLC20,494$785K<0.01%-33,93013F-HRTimelineGroup
Walleye Capital LLCin group Walleye Capital LLC18,715$717K<0.01%new13F-HR/ATimelineGroup
Quadrature Capital Ltdin group Quadrature Capital Ltd18,203$697K0.01%new13F-HRTimelineGroup
STRS OHIO18,100$693K<0.01%+17,40013F-HRTimeline
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding17,410$658K+1,908Timeline
TUDOR INVESTMENT CORP ET AL16,284$624K<0.01%new13F-HRTimeline
PSP Research LLC16,000$613K0.43%-5,85313F-HRTimeline
PROFUND ADVISORS LLC15,656$600K0.02%new13F-HRTimeline
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC15,396$590K<0.01%new13F-HRTimelineGroup
VICTORY CAPITAL MANAGEMENT INC15,230$583K<0.01%-3,56013F-HRTimeline
CANADA PENSION PLAN INVESTMENT BOARD14,300$548K<0.01%-14,60013F-HRTimeline
ExodusPoint Capital Management, LP14,066$539K0.01%-28,72513F-HRTimeline
MetLife Investment Management, LLCin group MetLife Investment Management…13,993$536K<0.01%-1,36313F-HRTimelineGroup
FRANKLIN RESOURCES INCin group Franklin Resources12,970$497K<0.01%013F-HRTimelineGroup
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…12,049$461K0.13%+29313F-HRTimelineGroup
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN11,672$447K<0.01%-17,37713F-HR/ATimelineGroup
BAKER BROS. ADVISORS LPin group BAKER BROS. ADVISORS LP10,607$406K<0.01%013F-HRTimelineGroup
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC10,169$389K<0.01%new13F-HRTimelineGroup
Soleus Capital Management, L.P.10,000$383K0.02%-115,00013F-HRTimeline
Legal & General Group Plcin group Legal & General Group Plc9,537$365K<0.01%+7,17013F-HRTimelineGroup
China Universal Asset Management Co., L…9,471$363K0.03%+77413F-HRTimeline
Arrowpoint Investment Partners (Singapo…in group Arrowpoint Investment Partner…8,075$309K0.45%new13F-HRTimelineGroup
Zurcher Kantonalbank (Zurich Cantonalba…8,038$308K<0.01%new13F-HRTimeline
Bridgefront Capital, LLC7,911$303K0.08%new13F-HRTimeline
NEW YORK STATE COMMON RETIREMENT FUND7,423$284K<0.01%013F-HRTimeline
SG Americas Securities, LLC7,215$276K<0.01%new13F-HRTimeline
Allianz Asset Management GmbHin group Allianz SE7,000$268K<0.01%new13F-HRTimelineGroup
Police & Firemen's Retirement System of…6,440$247K<0.01%013F-HRTimeline
INTECH INVESTMENT MANAGEMENT LLC6,345$243K<0.01%-3,45613F-HRTimeline
ProShare Advisors LLC6,142$235K<0.01%new13F-HRTimeline
CITIGROUP INCin group CITIGROUP INC5,991$229K<0.01%+2,17413F-HRTimelineGroup
Graham Capital Management, L.P.5,756$220K0.01%new13F-HRTimeline
Persistent Asset Partners Ltd4,518$173K0.07%new13F-HRTimeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…3,005$115K<0.01%+2,67413F-HRTimelineGroup
KLP KAPITALFORVALTNING AS2,900$111K<0.01%new13F-HRTimeline
Chung Wu Investment Group, LLC2,000$76.6K0.07%013F-HRTimeline
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…1,991$76.3K<0.01%013F-HRTimelineGroup
Caitong International Asset Management …1,891$72.4K0.01%-1,10613F-HRTimeline
Steward Partners Investment Advisory, L…1,577$60.4K<0.01%+1,50013F-HRTimeline
CWM, LLCin group CWM, LLC1,566$60K<0.01%+2013F-HRTimelineGroup
CALIFORNIA STATE TEACHERS RETIREMENT SY…1,402$53.7K<0.01%-19313F-HRTimeline
GF FUND MANAGEMENT CO. LTD.1,198$45.9K<0.01%+15013F-HRTimeline
Sterling Capital Management LLC858$32.9K<0.01%-63013F-HRTimeline
Versant Capital Management, Inc819$31.4K<0.01%013F-HRTimeline
Hilton Head Capital Partners, LLC772$29.6K0.02%new13F-HRTimeline
FEDERATED HERMES, INC.in group FEDERATED HERMES, INC.714$27.3K<0.01%-58313F-HRTimelineGroup
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.551$21.1K<0.01%-63713F-HRTimelineGroup
GAMMA Investing LLC506$19.4K<0.01%+3413F-HRTimeline
Rockefeller Capital Management L.P.in group Rockefeller Capital Managemen…421$16.1K<0.01%+33713F-HRTimelineGroup
Larson Financial Group LLC295$11.3K<0.01%+14913F-HRTimeline
Quantbot Technologies LP243$9.31K<0.01%new13F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…223$8.54K<0.01%+1513F-HRTimelineGroup
True Wealth Design, LLC142$5.44K<0.01%013F-HRTimeline
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…128$4.9K<0.01%+8613F-HR/ATimelineGroup
Smartleaf Asset Management LLC127$4.39K<0.01%013F-HRTimeline
Optiver Holding B.V.in group Optiver Holding B.V.106$4.06K<0.01%-2213F-HR/ATimelineGroup
Allworth Financial LP104$3.98K<0.01%+413F-HRTimeline
Atlantic Union Bankshares Corpin group Atlantic Union Bankshares Corp100$3.83K<0.01%new13F-HRTimelineGroup
NISA INVESTMENT ADVISORS, LLC88$3.37K<0.01%+213F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA88$3K<0.01%-65413F-HRTimelineGroup
ROTHSCHILD INVESTMENT LLC70$2.68K<0.01%+1513F-HRTimeline
Farther Finance Advisors, LLC60$2.3K<0.01%013F-HRTimeline
SIGNATUREFD, LLC43$1.65K<0.01%013F-HRTimeline
Clearstead Advisors, LLC29$1.1K<0.01%013F-HRTimeline
US BANCORP \DE\in group US BANCORP \DE\11$421<0.01%new13F-HRTimelineGroup
TWIN PEAKS WEALTH ADVISORS, LLC7$268<0.01%new13F-HRTimeline
MAI Capital Management4$154<0.01%new13F-HRTimeline
SBI Securities Co., Ltd.4$153<0.01%013F-HRTimeline
TFC Financial Management, Inc.1$39<0.01%new13F-HRTimeline
Covestor Ltd6$00%013F-HRTimelineValue filed as zero, left out of ratios.