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Disclosery

TYRA TYRA BIOSCIENCES INC

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COMMON STOCK (common), issuer CIK 1863127

116 managers (119 13F filers) reported a position in TYRA shares at 2025-03-31, 53,573,490 shares in all. 20 filers opened a position and 16 filers sold out during the quarter.

Managers
116
13F filers
119
New
20
Added
42
Reduced
31
Sold out
16
Shares held by filers
53,573,490

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q1 2025

Filers in the available 13F reports with a share position at 2025-03-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
RA CAPITAL MANAGEMENT, L.P.in group RA CAPITAL MANAGEMENT, L.P.10,637,290$98.9M1.65%013F-HRTimelineGroup
Canaan Partners XI LLC4,144,590$38.5M58.09%-35,26713F-HRTimeline
Alta Partners Management Company, L.P.4,080,296$37.9M90.83%013F-HRTimeline
Nextech Invest Ltd.4,055,861$37.7M8.77%13F-HRTimeline
BVF INC/ILin group BVF INC/IL3,944,194$36.7M1.5%013F-HRTimelineGroup
TCG Crossover Management, LLC2,898,103$27M3.68%+909,00013F-HRTimeline
Vestal Point Capital, LP2,879,829$26.8M1.91%+1,889,82913F-HRTimeline
JANUS HENDERSON GROUP PLCin group Janus Henderson2,693,237$26.3M0.01%+946,91713F-HRTimelineGroup
Kynam Capital Management, LP2,406,067$22.4M1.91%+1,875,58913F-HRTimeline
ORBIMED ADVISORS LLCin group ORBIMED ADVISORS LLC1,752,831$16.3M0.39%+282,74513F-HRTimelineGroup
FMR LLCin group FMR LLC1,707,148$15.9M<0.01%-1,400,82213F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.1,695,917$15.8M<0.01%-22,58713F-HRTimelineGroup
VANGUARD GROUP INCin group VANGUARD GROUP INC1,218,371$11.3M<0.01%+10,60613F-HRTimelineGroup
FARALLON CAPITAL MANAGEMENT, L.L.C.1,143,818$10.6M0.06%+142,83713F-HRTimelineThe filing omitted confidential holdings, a later amendment may add them.
Commodore Capital LPin group Commodore Capital LP950,000$8.84M0.65%new13F-HRTimelineGroup
5AM Venture Management, LLC939,298$8.74M3.3%013F-HRTimeline
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC516,290$4.8M<0.01%-1,28813F-HRTimelineGroup
Pictet Asset Management Holding SAin group Pictet Asset Management Holdi…459,113$4.27M<0.01%+105,10113F-HRTimelineGroup
Sio Capital Management, LLC416,617$3.87M1.17%+175,74713F-HRTimeline
STATE STREET CORPin group STATE STREET CORP413,988$3.85M<0.01%+6,41513F-HRTimelineGroup
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC404,165$3.76M<0.01%+89,02413F-HRTimelineGroup
MARSHALL WACE, LLPin group MARSHALL WACE, LLP380,700$3.54M<0.01%+326,62313F-HRTimelineGroup
JACOBS LEVY EQUITY MANAGEMENT, INC301,801$2.81M0.01%+57,55613F-HRTimeline
Balyasny Asset Management L.P.in group Balyasny Asset Management243,244$2.26M0.01%new13F-HRTimelineGroup
NORTHERN TRUST CORPin group NORTHERN TRUST CORP216,447$2.01M<0.01%-6,31713F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY180,590$1.68M<0.01%+106,44113F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co164,108$1.53M<0.01%-6,49213F-HR/ATimelineGroup
Polar Asset Management Partners Inc.141,241$1.31M0.04%+30,13413F-HRTimeline
Walleye Capital LLCin group Walleye Capital LLC140,742$1.31M0.01%+77,76213F-HRTimelineGroup
AXA S.A.in group AXA S.A.128,189$1.19M<0.01%new13F-HRTimelineGroup
TWO SIGMA INVESTMENTS, LPgroup of 2 filers holding114,918$1.07M+56,349Timeline
Ally Bridge Group (NY) LLC107,244$997K0.9%-67,81913F-HRTimeline
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…104,087$968K<0.01%+9,22813F-HRTimelineGroup
Woodline Partners LP100,108$931K0.01%new13F-HRTimeline
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC96,282$895K<0.01%+40,69513F-HRTimelineGroup
Cubist Systematic Strategies, LLC91,844$854K0.01%-17,90413F-HRTimeline
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO85,490$795K<0.01%-5,62513F-HRTimelineGroup
INVESTMENT COUNSEL CO OF NEVADA85,020$791K1.8%013F-HRTimeline
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/83,521$777K<0.01%+17,36413F-HRTimelineGroup
UBS Group AGgroup of 2 filers holding81,921$762K-1,565Timeline
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC78,006$725K<0.01%+13,89613F-HR/ATimelineGroup
OPPENHEIMER & CO INCin group OPPENHEIMER ASSET MANAGEMENT …74,805$696K0.01%-63413F-HRTimelineGroup
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS68,950$641K<0.01%+64,63213F-HRTimelineGroup
STATE OF WISCONSIN INVESTMENT BOARD58,712$546K<0.01%-6,32713F-HRTimeline
VICTORY CAPITAL MANAGEMENT INC56,150$522K<0.01%-49013F-HRTimeline
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC54,344$505K<0.01%-43913F-HRTimelineGroup
RENAISSANCE TECHNOLOGIES LLC51,400$478K<0.01%+22,30013F-HRTimeline
Nuveen, LLCin group TIAA49,998$465K<0.01%13F-HRTimelineGroup
Point72 Asset Management, L.P.in group Point72 Asset Management, L.P.49,600$461K<0.01%+36,81713F-HR/ATimelineGroup
Brevan Howard Capital Management LPin group Brevan Howard Capital Managem…46,371$431K0.01%new13F-HRTimelineGroup
BARCLAYS PLCin group BARCLAYS PLC42,511$395K<0.01%-55913F-HR/ATimelineGroup
Verition Fund Management LLC42,174$392K<0.01%new13F-HRTimeline
Bank of New York Mellon Corpin group Bank of New York Mellon Corp41,083$382K<0.01%-3,92413F-HRTimelineGroup
Ikarian Capital, LLCin group Ikarian Capital, LLC35,000$326K0.11%-25,00013F-HRTimelineGroup
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC34,813$324K<0.01%new13F-HR/ATimelineGroup
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP34,712$323K<0.01%-3,26913F-HRTimelineGroup
ExodusPoint Capital Management, LP30,235$281K<0.01%new13F-HRTimeline
AlphaQuest LLC29,622$275K0.03%+24,59913F-HRTimeline
Swiss National Bank29,400$273K<0.01%+8,70013F-HRTimeline
RHUMBLINE ADVISERS28,081$261K<0.01%+1,87913F-HR/ATimeline
Jump Financial, LLCin group Jump Financial, LLC27,949$260K<0.01%+12,78913F-HR/ATimelineGroup
Caligan Partners LP25,000$232K0.05%new13F-HRTimeline
HighVista Strategies LLC23,941$223K0.09%013F-HRTimeline
SUSQUEHANNA INTERNATIONAL GROUP, LLPgroup of 2 filers holding23,526$219K-15,567Timeline
AMERICAN CENTURY COMPANIES INCin group AMERICAN CENTURY COMPANIES INC23,431$218K<0.01%+1,28913F-HRTimelineGroup
Auour Investments LLC21,020$217K0.08%013F-HRTimeline
ALLIANCEBERNSTEIN L.P.17,570$163K<0.01%013F-HRTimeline
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\16,979$158K<0.01%-1,93013F-HRTimelineGroup
CITIGROUP INCin group CITIGROUP INC15,507$144K<0.01%-1,29613F-HRTimelineGroup
SG Americas Securities, LLC15,120$141K<0.01%+5,44913F-HRTimeline
EntryPoint Capital, LLC14,892$138K0.06%-3,31713F-HRTimeline
INTECH INVESTMENT MANAGEMENT LLC13,597$126K<0.01%new13F-HRTimeline
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding13,207$124K-120Timeline
MetLife Investment Management, LLCin group MetLife Investment Management…12,207$114K<0.01%013F-HRTimelineGroup
TUDOR INVESTMENT CORP ET AL12,093$112K<0.01%-3,48413F-HRTimeline
EXCHANGE TRADED CONCEPTS, LLC11,861$110K<0.01%+3,55013F-HRTimeline
Aquatic Capital Management LLC11,781$110K<0.01%+7,19513F-HRTimeline
Virtus Investment Advisers, LLCgroup of 2 filers holding10,818$101K+6,132Timeline
BAKER BROS. ADVISORS LPin group BAKER BROS. ADVISORS LP10,607$98.6K<0.01%013F-HRTimelineGroup
CALIFORNIA STATE TEACHERS RETIREMENT SY…10,570$98.3K<0.01%013F-HRTimeline
AXQ CAPITAL, LP10,302$95.8K0.04%new13F-HRTimeline
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…10,239$95.2K<0.01%-21613F-HRTimelineGroup
China Universal Asset Management Co., L…10,150$94.4K0.01%-58013F-HRTimeline
Corebridge Financial, Inc.in group Corebridge Financial, Inc.9,590$89.2K<0.01%-51213F-HRTimelineGroup
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN9,353$87K<0.01%-14013F-HRTimelineGroup
Legal & General Group Plcin group Legal & General Group Plc9,261$86.1K<0.01%-7913F-HRTimelineGroup
Zurcher Kantonalbank (Zurich Cantonalba…9,047$84.1K<0.01%new13F-HRTimeline
NEW YORK STATE COMMON RETIREMENT FUND7,423$69K<0.01%013F-HR/ATimeline
US BANCORP \DE\in group US BANCORP \DE\5,435$50.5K<0.01%+1,82313F-HRTimelineGroup
Police & Firemen's Retirement System of…5,049$47K<0.01%013F-HRTimeline
Point72 (DIFC) Ltd2,273$21.1K<0.01%+1,71213F-HRTimeline
KLP KAPITALFORVALTNING AS2,200$20.5K<0.01%013F-HRTimeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…2,083$19.4K<0.01%+66613F-HRTimelineGroup
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…1,991$18.5K<0.01%013F-HRTimelineGroup
GF FUND MANAGEMENT CO. LTD.1,296$12.1K<0.01%+23313F-HRTimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.835$7.76K<0.01%+81313F-HRTimelineGroup
Point72 Asia (Singapore) Pte. Ltd.792$7.37K<0.01%new13F-HRTimeline
AMALGAMATED BANK701$7K<0.01%+27713F-HRTimeline
STRS OHIO700$6.51K<0.01%013F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA677$6K<0.01%-9713F-HR/ATimelineGroup
Caitong International Asset Management …503$4.68K<0.01%new13F-HRTimeline
FEDERATED HERMES, INC.in group FEDERATED HERMES, INC.475$4.42K<0.01%-55313F-HRTimelineGroup
CWM, LLCin group CWM, LLC383$4K<0.01%+31213F-HRTimelineGroup
Daiwa Securities Group Inc.in group Daiwa Securities Group Inc.173$2K<0.01%new13F-HRTimelineGroup
NISA INVESTMENT ADVISORS, LLC149$1.39K<0.01%+12613F-HRTimeline
Allworth Financial LP100$1.01K<0.01%new13F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…58$539<0.01%013F-HRTimelineGroup
COLDSTREAM CAPITAL MANAGEMENT INC28$260<0.01%new13F-HRTimeline
Sterling Capital Management LLC21$195<0.01%013F-HRTimeline
CoreCap Advisors, LLC16$149<0.01%013F-HRTimeline
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…9$84<0.01%new13F-HRTimelineGroup
ROTHSCHILD INVESTMENT LLC5$47<0.01%013F-HRTimeline
SBI Securities Co., Ltd.4$37<0.01%-1513F-HRTimeline
Covestor Ltd6$00%013F-HRTimelineValue filed as zero, left out of ratios.
CONCOURSE FINANCIAL GROUP SECURITIES, I…0$0013F-HRTimelineValue filed as zero, left out of ratios. Amount filed as zero, left out of ratios.
NOMURA ASSET MANAGEMENT CO LTDin group NOMURA ASSET MANAGEMENT CO LTD0$00%013F-HRTimelineGroupValue filed as zero, left out of ratios. Amount filed as zero, left out of ratios.