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Disclosery

SYRE SPYRE THERAPEUTICS INC

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COM NEW (common), issuer CIK 1636282

150 managers (154 13F filers) reported a position in SYRE shares at 2025-12-31, 80,976,884 shares in all. 27 filers opened a position and 14 filers sold out during the quarter.

Managers
150
13F filers
154
New
27
Added
76
Reduced
27
Sold out
14
Shares held by filers
80,976,884

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

Each filer's latest stake. The shares are the aggregate the reporting persons state, which can include entities that file no 13F.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q4 2025

Filers in the available 13F reports with a share position at 2025-12-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
FMR LLCin group FMR LLC11,638,819$381M0.02%+2,578,67513F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.5,522,101$181M<0.01%+1,539,35713F-HRTimelineGroup
RTW INVESTMENTS, LP4,171,996$137M1.37%+550,00013F-HRTimeline
VANGUARD GROUP INCin group VANGUARD GROUP INC4,035,074$132M<0.01%+984,34413F-HRTimelineGroup
Fairmount Funds Management LLCin group Fairmount Funds Management LLC4,018,101$132M10.02%013F-HRTimelineGroup
Venrock Adviser, LLC3,685,448$121M5.96%+1,000,00013F-HRTimeline
Capital International Investorsin group Capital International Investo…3,492,541$114M0.02%+1,100,00013F-HRTimelineGroup
PERCEPTIVE ADVISORS LLCin group PERCEPTIVE ADVISORS LLC3,069,225$101M1.84%+1,839,78013F-HRTimelineGroup
Driehaus Capital Management LLC2,882,420$94.4M0.64%+822,04513F-HRTimeline
Commodore Capital LPin group Commodore Capital LP2,388,245$78.2M5.21%+400,16113F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP2,262,839$74.1M<0.01%+477,63313F-HRTimelineGroup
TCG Crossover Management, LLC1,900,582$62.3M2.06%+800,00013F-HRTimeline
TANG CAPITAL MANAGEMENT LLCin group TANG CAPITAL MANAGEMENT LLC1,892,200$62M3.06%-1,307,80013F-HRTimelineGroup
JANUS HENDERSON GROUP PLCin group Janus Henderson1,829,009$59.9M0.03%+1,816,00913F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC1,659,140$54.4M<0.01%+433,98713F-HRTimelineGroup
BRAIDWELL LP1,634,615$53.5M1.71%-943,78913F-HRTimeline
RA CAPITAL MANAGEMENT, L.P.in group RA CAPITAL MANAGEMENT, L.P.1,621,620$53.1M0.54%new13F-HRTimelineGroup
PRICE T ROWE ASSOCIATES INC /MD/1,601,882$52.5M0.01%+981,26213F-HRTimeline
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…1,549,284$50.8M0.01%-91,02813F-HRTimelineGroup
Paradigm Biocapital Advisors LPin group Paradigm Biocapital Advisors …1,467,266$48.1M1.29%013F-HRTimelineGroup
Remedium Capital Partners, LLC1,456,231$47.7M28.03%13F-HRTimeline
Affinity Asset Advisors, LLC1,432,591$46.9M3.37%+13,29213F-HRTimeline
FRANKLIN RESOURCES INCin group Franklin Resources1,109,274$36.3M0.01%+313,99913F-HRTimelineGroup
EMERALD ADVISERS, LLCgroup of 2 filers holding1,048,480$34.3M+191,556Timeline
BAKER BROS. ADVISORS LPin group BAKER BROS. ADVISORS LP1,000,000$32.8M0.19%013F-HRTimelineGroup
Pictet Asset Management Holding SAin group Pictet Asset Management Holdi…913,960$29.9M0.03%-122,25813F-HRTimelineGroup
Siren, L.L.C.in group Siren, L.L.C.818,598$26.8M0.8%+450,00013F-HRTimelineGroup
UBS Group AGgroup of 2 filers holding742,782$24.3M+317,695Timeline
Polar Capital Holdings Plcin group Polar Capital Holdings Plc740,326$24.3M0.11%-48,46213F-HRTimelineGroup
DEERFIELD MANAGEMENT COMPANY, L.P.in group DEERFIELD MANAGEMENT COMPANY,…710,626$23.3M0.3%+96,96113F-HRTimelineGroup
Point72 Asset Management, L.P.in group Point72 Asset Management, L.P.662,351$21.7M0.03%new13F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co574,622$18.8M<0.01%+149,27713F-HRTimelineGroup
NORTHERN TRUST CORPin group NORTHERN TRUST CORP561,023$18.4M<0.01%+118,98713F-HRTimelineGroup
Blackstone Inc.in group Blackstone Inc.500,998$16.4M0.06%013F-HRTimelineGroupThe filing omitted confidential holdings, a later amendment may add them.
Candriam S.C.A.425,534$13.9M0.07%+21,17213F-HR/ATimeline
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/419,727$13.8M<0.01%+74,92413F-HRTimelineGroup
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC275,065$9.01M<0.01%-54,46813F-HR/ATimelineGroup
Woodline Partners LP265,892$8.71M0.03%+134,01613F-HRTimeline
Capital World Investors200,172$6.56M<0.01%013F-HRTimeline
ARMISTICE CAPITAL, LLC196,426$6.43M0.16%+40,42613F-HRTimeline
Bank of New York Mellon Corpin group Bank of New York Mellon Corp192,830$6.32M<0.01%+56,87013F-HRTimelineGroup
HighVista Strategies LLC188,206$6.17M1.59%-27,54013F-HRTimeline
SILVERARC CAPITAL MANAGEMENT, LLCin group SILVERARC CAPITAL MANAGEMENT,…187,737$6.15M0.89%new13F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY182,734$5.99M<0.01%-151,98813F-HR/ATimelineGroup
BARCLAYS PLCin group BARCLAYS PLC182,524$5.98M<0.01%+14,19413F-HRTimelineGroup
Universal- Beteiligungs- und Serviceges…in group Universal- Beteiligungs- und …171,211$5.61M0.01%+60,75513F-HRTimelineGroup
Nuveen, LLCin group TIAA150,980$4.95M<0.01%+54,80813F-HRTimelineGroup
Invesco Ltd.in group Invesco Ltd.150,934$4.94M<0.01%+100,23213F-HRTimelineGroup
Patient Square Capital LP150,000$4.91M1.05%new13F-HRTimeline
TD Asset Management Inc149,822$4.91M<0.01%+77,45413F-HRTimeline
VICTORY CAPITAL MANAGEMENT INC146,079$4.79M<0.01%-180,00213F-HRTimeline
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …129,013$4.14M<0.01%+57,06513F-HRTimelineGroup
Parkman Healthcare Partners LLC124,485$4.08M0.39%-76,26813F-HRTimeline
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\121,941$3.99M<0.01%+83,39813F-HRTimelineGroup
MERCER GLOBAL ADVISORS INC /ADV106,316$3.48M0.01%-34813F-HRTimeline
F/m Investments LLC103,718$3.4M0.13%+48,82513F-HRTimeline
CITIGROUP INCin group CITIGROUP INC100,058$3.28M<0.01%+67,16213F-HRTimelineGroup
SEVEN GRAND MANAGERS, LLC100,000$3.28M0.25%new13F-HRTimeline
B Group, Inc.100,000$3.28M2.43%013F-HRTimeline
Swiss National Bank96,500$3.16M<0.01%+26,30013F-HRTimeline
RHUMBLINE ADVISERS82,956$2.72M<0.01%+12,04213F-HRTimeline
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN82,416$2.7M<0.01%+43,09713F-HRTimelineGroup
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP77,290$2.53M<0.01%-6,92613F-HRTimelineGroup
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC76,194$2.5M<0.01%-332,00513F-HRTimelineGroup
Balyasny Asset Management L.P.in group Balyasny Asset Management73,465$2.41M<0.01%new13F-HRTimelineGroup
ALLIANCEBERNSTEIN L.P.67,500$2.21M<0.01%+31,27013F-HRTimeline
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC63,904$2.09M<0.01%new13F-HRTimelineGroup
ALPS ADVISORS INCin group ALPS ADVISORS INC63,708$2.09M0.01%new13F-HRTimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO62,951$2.06M<0.01%-213,03313F-HRTimelineGroup
SCHRODER INVESTMENT MANAGEMENT GROUP61,574$1.96M<0.01%-46,16413F-HRTimeline
SUSQUEHANNA INTERNATIONAL GROUP, LLPgroup of 2 filers holding59,212$1.94M+37,473Timeline
Legal & General Group Plcin group Legal & General Group Plc56,448$1.85M<0.01%+9,60713F-HRTimelineGroup
Rafferty Asset Management, LLC53,410$1.75M0.01%-6,25713F-HRTimeline
CALIFORNIA STATE TEACHERS RETIREMENT SY…48,038$1.57M<0.01%+14,83513F-HRTimeline
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding38,914$1.27M+10,131Timeline
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC38,256$1.25M<0.01%new13F-HRTimelineGroup
MetLife Investment Management, LLCin group MetLife Investment Management…38,011$1.25M0.01%+8,09313F-HRTimelineGroup
ExodusPoint Capital Management, LP37,871$1.24M0.01%-30,69213F-HRTimeline
Cinctive Capital Management LP35,935$1.18M0.07%new13F-HRTimeline
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC34,051$1.12M0.08%013F-HR/ATimelineGroup
STEMPOINT CAPITAL LP32,377$1.06M0.18%new13F-HRTimeline
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC27,277$894K<0.01%new13F-HRTimelineGroup
STATE OF WISCONSIN INVESTMENT BOARD27,252$893K<0.01%-6,29413F-HRTimeline
Waverly Advisors, LLC25,954$850K0.01%+113F-HRTimeline
TEACHERS RETIREMENT SYSTEM OF THE STATE…25,799$845K0.01%013F-HRTimeline
OPTIMIZE FINANCIAL INC.25,331$830K0.42%+36413F-HRTimeline
VIRGINIA RETIREMENT SYSTEMS ET Al24,950$817K<0.01%+6,45013F-HRTimeline
SG Americas Securities, LLC23,343$765K<0.01%new13F-HRTimeline
Assenagon Asset Management S.A.22,136$725K<0.01%013F-HRTimeline
PROFUND ADVISORS LLC20,593$675K0.02%+7,37013F-HRTimeline
NEW YORK STATE COMMON RETIREMENT FUND19,165$628K<0.01%+2,60013F-HRTimeline
Police & Firemen's Retirement System of…18,360$601K0.01%+4,55113F-HRTimeline
INTECH INVESTMENT MANAGEMENT LLC18,274$599K0.01%-2,08613F-HRTimeline
Neo Ivy Capital Management18,261$598K0.09%new13F-HRTimeline
Global Endowment Management, LPin group Global Endowment Management, …18,184$596K0.07%013F-HRTimelineGroup
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC17,820$584K<0.01%+77313F-HRTimelineGroup
State of New Jersey Common Pension Fund…in group State of New Jersey Common Pe…16,698$547K<0.01%new13F-HRTimelineGroup
ProShare Advisors LLC15,989$524K<0.01%+5,31113F-HRTimeline
PSP Research LLC15,840$519K0.45%13F-HRTimeline
ARIZONA STATE RETIREMENT SYSTEM13,797$452K<0.01%+3,10413F-HRTimeline
Arrowpoint Investment Partners (Singapo…in group Arrowpoint Investment Partner…13,724$450K0.07%new13F-HRTimelineGroup
China Universal Asset Management Co., L…12,644$414K0.03%+2,05713F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS11,844$388K<0.01%-304,06513F-HRTimelineGroup
Zurcher Kantonalbank (Zurich Cantonalba…11,164$366K<0.01%+29013F-HRTimeline
KLP KAPITALFORVALTNING AS10,400$341K<0.01%+2,60013F-HRTimeline
TUDOR INVESTMENT CORP ET AL10,127$332K<0.01%new13F-HRTimeline
Carlyle Group Inc.in group Carlyle Group Inc.9,620$315K<0.01%new13F-HRTimelineGroup
LOS ANGELES CAPITAL MANAGEMENT LLC12,882$313K<0.01%-5,29013F-HRTimeline
STATE BOARD OF ADMINISTRATION OF FLORID…9,030$296K<0.01%new13F-HRTimeline
CAXTON CORP8,919$292K6.83%new13F-HRTimelineThe filing omitted confidential holdings, a later amendment may add them.
VARCOV Co.8,008$262K0.1%13F-HRTimeline
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…7,913$259K0.07%+1,48813F-HRTimelineGroup
TEACHER RETIREMENT SYSTEM OF TEXAS7,173$235K<0.01%new13F-HRTimeline
MARTINGALE ASSET MANAGEMENT L P6,930$227K0.01%new13F-HRTimeline
Brevan Howard Capital Management LPin group Brevan Howard Capital Managem…6,198$203K<0.01%new13F-HRTimelineGroup
SEI INVESTMENTS COin group SEI INVESTMENTS CO6,117$200K<0.01%new13F-HRTimelineGroup
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…5,593$183K0.01%+1,42713F-HRTimelineGroup
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…5,554$182K<0.01%+1,32013F-HRTimelineGroup
AlphaQuest LLC3,538$116K0.01%-62,62513F-HRTimeline
Persistent Asset Partners Ltd2,246$73.6K0.04%new13F-HRTimeline
AMALGAMATED BANK2,165$71K<0.01%+78613F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA1,988$65K<0.01%-5,89513F-HRTimelineGroup
CWM, LLCin group CWM, LLC1,970$65K<0.01%+1013F-HRTimelineGroup
Sterling Capital Management LLC1,610$52.7K<0.01%+39613F-HRTimeline
PUBLIC EMPLOYEES RETIREMENT ASSOCIATION…1,589$52K<0.01%013F-HRTimeline
GF FUND MANAGEMENT CO. LTD.1,523$49.9K<0.01%+22413F-HRTimeline
NISA INVESTMENT ADVISORS, LLC705$23.1K<0.01%013F-HRTimeline
BNP PARIBAS ASSET MANAGEMENT Holding S.…in group BNP PARIBAS ASSET MANAGEMENT …656$21K<0.01%+32113F-HRTimelineGroup
Rockefeller Capital Management L.P.in group Rockefeller Capital Managemen…549$18K<0.01%+14813F-HR/ATimelineGroup
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…425$13.9K<0.01%-4,17113F-HRTimelineGroup
GROUP ONE TRADING LLC400$13.1K<0.01%new13F-HRTimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.367$12K<0.01%+5313F-HRTimelineGroup
GAMMA Investing LLC330$10.8K<0.01%+12213F-HRTimeline
Daiwa Securities Group Inc.in group Daiwa Securities Group Inc.258$8K<0.01%+5213F-HRTimelineGroup
Optiver Holding B.V.in group Optiver Holding B.V.240$7.86K<0.01%-26013F-HRTimelineGroup
MEEDER ASSET MANAGEMENT INCin group Meeder Advisory Services, Inc.181$5.93K<0.01%-3513F-HRTimelineGroup
Larson Financial Group LLC144$4.72K<0.01%+13213F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…86$2.82K<0.01%013F-HRTimelineGroup
ROTHSCHILD INVESTMENT LLC82$2.69K<0.01%+213F-HRTimeline
SIGNATUREFD, LLC70$2.29K<0.01%013F-HRTimeline
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…65$2.13K<0.01%013F-HRTimelineGroup
Allworth Financial LP58$1.9K<0.01%+2613F-HRTimeline
Farther Finance Advisors, LLC37$1.21K<0.01%+2713F-HRTimeline
Parkside Financial Bank & Trust35$1.15K<0.01%013F-HRTimeline
IFP Advisors, Inc24$786<0.01%013F-HRTimeline
US BANCORP \DE\in group US BANCORP \DE\10$328<0.01%013F-HRTimelineGroup
COMERICA BANK5$164<0.01%013F-HRTimeline
SBI Securities Co., Ltd.5$164<0.01%-11813F-HRTimeline
Covestor Ltd6$00%013F-HRTimelineValue filed as zero, left out of ratios.
NOMURA ASSET MANAGEMENT CO LTDin group NOMURA ASSET MANAGEMENT CO LTD0$00%013F-HRTimelineGroupValue filed as zero, left out of ratios. Amount filed as zero, left out of ratios.

Events

  • Fairmount Funds Management LLC and 3 other reporting persons reported 10,185,961 SYRE shares, 9.99% of the class, as of 2026-10-07, in a 13D/A filed 2026-10-09. 0001104659-26-115087

    Accepted , ingested

  • Paradigm Biocapital Advisors LP and 3 other reporting persons reported 4,457,450 SYRE shares, 5.1% of the class, as of 2026-09-24, in a 13G filed 2026-10-01. 0001104659-26-112828

    Accepted , ingested