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Disclosery

SYRE SPYRE THERAPEUTICS INC

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COM NEW (common), issuer CIK 1636282

130 managers (133 13F filers) reported a position in SYRE shares at 2024-12-31, 59,883,969 shares in all. 25 filers opened a position and 21 filers sold out during the quarter.

Managers
130
13F filers
133
New
25
Added
63
Reduced
20
Sold out
21
Shares held by filers
59,883,969

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

Each filer's latest stake. The shares are the aggregate the reporting persons state, which can include entities that file no 13F.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q4 2024

Filers in the available 13F reports with a share position at 2024-12-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
FMR LLCin group FMR LLC8,801,266$205M0.01%+1,177,38513F-HRTimelineGroup
Fairmount Funds Management LLCin group Fairmount Funds Management LLC4,018,101$93.5M9.3%013F-HRTimelineGroup
RTW INVESTMENTS, LP3,621,996$84.3M1.28%+363,63613F-HRTimeline
BlackRock, Inc.in group BlackRock, Inc.3,399,591$79.1M<0.01%+736,44413F-HRTimelineGroup
VANGUARD GROUP INCin group VANGUARD GROUP INC2,846,473$66.3M<0.01%+330,55313F-HRTimelineGroup
Driehaus Capital Management LLC2,803,655$65.3M0.54%+2,116,57513F-HRTimeline
Venrock Adviser, LLC2,685,448$62.5M4.29%013F-HRTimeline
BRAIDWELL LP2,578,404$60M1.78%+388,56813F-HRTimeline
PERCEPTIVE ADVISORS LLCin group PERCEPTIVE ADVISORS LLC2,574,723$59.9M1.67%-297,82413F-HRTimelineGroup
Commodore Capital LPin group Commodore Capital LP1,988,084$46.3M3.39%013F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP1,680,936$39.1M<0.01%+139,38113F-HRTimelineGroup
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…1,604,508$37.4M0.01%+97,30813F-HRTimelineGroup
Paradigm Biocapital Advisors LPin group Paradigm Biocapital Advisors …1,527,205$35.6M1.24%+259,62413F-HRTimelineGroup
JANUS HENDERSON GROUP PLCin group Janus Henderson1,456,740$33.9M0.02%+336,20913F-HRTimelineGroup
Jefferies Financial Group Inc.in group Jefferies Financial Group Inc.1,216,954$28.3M0.32%+762,14713F-HR/ATimelineGroup
Pictet Asset Management Holding SAin group Pictet Asset Management Holdi…1,092,124$25.4M0.03%+266,41813F-HRTimelineGroup
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC1,079,307$25.1M0.02%+371,72113F-HRTimelineGroup
ADAGE CAPITAL PARTNERS GP, L.L.C.in group ADAGE CAPITAL PARTNERS GP, L.…1,030,000$24M0.04%-25,00013F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC966,129$22.5M<0.01%+75,08113F-HRTimelineGroup
EMERALD ADVISERS, LLCgroup of 2 filers holding933,175$21.7M+387,056Timeline
Affinity Asset Advisors, LLC824,328$19.2M3%+325,90813F-HRTimeline
FRANKLIN RESOURCES INCin group Franklin Resources760,642$17.7M<0.01%-2413F-HRTimelineGroup
Polar Capital Holdings Plcin group Polar Capital Holdings Plc750,000$17.5M0.1%+250,00013F-HRTimelineGroup
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC747,552$17.4M<0.01%+578,23813F-HRTimelineGroup
PRICE T ROWE ASSOCIATES INC /MD/506,450$11.8M<0.01%+77,32313F-HRTimeline
Logos Global Management LP500,000$11.6M1.36%+300,00013F-HRTimeline
Boxer Capital Management, LLCin group Boxer Capital Management, LLC466,680$10.9M0.93%13F-HRTimelineGroup
DEERFIELD MANAGEMENT COMPANY, L.P.in group DEERFIELD MANAGEMENT COMPANY,…450,000$10.5M0.2%new13F-HRTimelineGroup
Blackstone Inc.in group Blackstone Inc.449,201$10.5M0.05%+156,20613F-HRTimelineGroup
UBS Group AGgroup of 2 filers holding441,178$10.3M+356,899Timeline
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co379,650$8.84M<0.01%+46,37513F-HRTimelineGroup
Capital World Investors378,573$8.81M<0.01%new13F-HRTimeline
Siren, L.L.C.in group Siren, L.L.C.374,000$8.71M0.38%new13F-HRTimelineGroup
Woodline Partners LP352,680$8.21M0.06%+88,42413F-HRTimeline
NORTHERN TRUST CORPin group NORTHERN TRUST CORP348,983$8.12M<0.01%+34,69313F-HRTimelineGroup
Ikarian Capital, LLCin group Ikarian Capital, LLC282,159$6.57M1.88%-20,08813F-HRTimelineGroup
VICTORY CAPITAL MANAGEMENT INC268,076$6.24M0.01%new13F-HRTimeline
MORGAN STANLEYin group MORGAN STANLEY255,256$5.94M<0.01%+11,51413F-HR/ATimelineGroup
SOROS FUND MANAGEMENT LLCin group SOROS FUND MANAGEMENT LLC250,000$5.82M0.1%+105,00013F-HRTimelineGroup
Candriam S.C.A.247,591$5.76M0.03%+142,59113F-HRTimeline
Deep Track Capital, LP219,015$5.1M0.19%-780,98513F-HRTimeline
ARMISTICE CAPITAL, LLC200,000$4.66M0.11%+64,00013F-HRTimeline
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC167,804$3.91M<0.01%new13F-HRTimelineGroup
Nuveen Asset Management, LLCin group TIAA125,668$2.93M<0.01%+37813F-HRTimelineGroup
BARCLAYS PLCin group BARCLAYS PLC123,071$2.87M<0.01%+17,60413F-HR/ATimelineGroup
Universal- Beteiligungs- und Serviceges…in group Universal- Beteiligungs- und …122,153$2.84M0.01%13F-HRTimelineGroup
VOLORIDGE INVESTMENT MANAGEMENT, LLC115,470$2.69M0.01%-41,01113F-HRTimeline
SCHRODER INVESTMENT MANAGEMENT GROUP113,620$2.56M<0.01%new13F-HRTimeline
Bank of New York Mellon Corpin group Bank of New York Mellon Corp103,688$2.41M<0.01%-1,11813F-HRTimelineGroup
HighVista Strategies LLC95,159$2.22M0.82%-10,19213F-HRTimeline
BOOTHBAY FUND MANAGEMENT, LLC85,618$1.99M0.06%-6,15713F-HRTimeline
EFG Asset Management (North America) Co…82,818$1.93M0.26%+30,60813F-HRTimeline
Ensign Peak Advisors, Inc82,475$1.92M<0.01%013F-HRTimeline
Prosight Management, LP80,000$1.86M0.52%new13F-HRTimeline
Rafferty Asset Management, LLC76,740$1.79M0.01%+6,15413F-HRTimeline
CITIGROUP INCin group CITIGROUP INC73,752$1.72M<0.01%+48,56113F-HRTimelineGroup
Swiss National Bank68,600$1.6M<0.01%+19,00013F-HRTimeline
TD Asset Management Inc64,968$1.51M<0.01%+12,20013F-HRTimeline
RHUMBLINE ADVISERS57,657$1.34M<0.01%+3,72213F-HR/ATimeline
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …52,762$1.23M<0.01%+9,30213F-HRTimelineGroup
B Group, Inc.50,000$1.16M0.71%13F-HRTimeline
F/m Investments LLC48,806$1.14M0.04%new13F-HRTimeline
Legal & General Group Plcin group Legal & General Group Plc37,490$873K<0.01%+8,33513F-HRTimelineGroup
ALLIANCEBERNSTEIN L.P.36,230$843K<0.01%013F-HRTimeline
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO35,248$821K<0.01%+5,77513F-HRTimelineGroup
CALIFORNIA STATE TEACHERS RETIREMENT SY…32,598$759K<0.01%+7,92313F-HR/ATimeline
STATE OF WISCONSIN INVESTMENT BOARD31,484$733K<0.01%+13,16913F-HRTimeline
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\31,418$731K<0.01%+9,91013F-HR/ATimelineGroup
TEACHERS RETIREMENT SYSTEM OF THE STATE…25,799$601K0.01%+4,64513F-HRTimeline
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN24,718$575K<0.01%+6,90813F-HRTimelineGroup
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding24,696$573K+2,871Timeline
FIRST TRUST ADVISORS LPin group FIRST TRUST ADVISORS LP23,550$548K<0.01%new13F-HRTimelineGroup
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…23,089$538K<0.01%+9,89113F-HRTimelineGroup
Assenagon Asset Management S.A.22,652$527K<0.01%-1,120,11613F-HRTimeline
MetLife Investment Management, LLCin group MetLife Investment Management…21,382$498K<0.01%+1,25013F-HRTimelineGroup
Invesco Ltd.in group Invesco Ltd.19,663$458K<0.01%-118,19513F-HRTimelineGroup
Cinctive Capital Management LP19,567$456K0.02%-41,68913F-HRTimeline
NBW CAPITAL LLC19,430$452K0.08%-7,50013F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS18,784$437K<0.01%new13F-HRTimelineGroup
Global Endowment Management, LPin group Global Endowment Management, …18,184$423K0.05%013F-HRTimelineGroup
NATIXIS ADVISORS, LLCin group Natixis Investment Managers17,300$403K<0.01%new13F-HRTimelineGroup
Corebridge Financial, Inc.in group Corebridge Financial, Inc.17,213$401K<0.01%-1,29913F-HRTimelineGroup
Brevan Howard Capital Management LPin group Brevan Howard Capital Managem…16,899$393K0.01%new13F-HRTimelineGroup
ExodusPoint Capital Management, LP16,691$389K<0.01%+6,95813F-HRTimeline
Squarepoint Ops LLCin group Squarepoint Ops LLC15,231$355K<0.01%+6,75413F-HRTimelineGroup
PROFUND ADVISORS LLC14,862$346K0.01%+78713F-HRTimeline
INTECH INVESTMENT MANAGEMENT LLC14,043$327K<0.01%+5,67213F-HRTimeline
ProShare Advisors LLC12,531$292K<0.01%new13F-HRTimeline
China Universal Asset Management Co., L…12,440$290K0.03%new13F-HRTimeline
Aquatic Capital Management LLC11,767$274K0.01%new13F-HRTimeline
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC10,495$244K<0.01%-85613F-HR/ATimelineGroup
TEACHER RETIREMENT SYSTEM OF TEXAS10,383$242K<0.01%new13F-HRTimeline
NEW YORK STATE COMMON RETIREMENT FUND10,265$239K<0.01%013F-HR/ATimeline
ARIZONA STATE RETIREMENT SYSTEM10,115$235K<0.01%+2,80513F-HRTimeline
TWO SIGMA INVESTMENTS, LPin group TWO SIGMA INVESTMENTS, LP9,638$224K<0.01%-16513F-HRTimelineGroup
Carlyle Group Inc.in group Carlyle Group Inc.9,620$224K0.01%013F-HRTimelineGroup
STATE BOARD OF ADMINISTRATION OF FLORID…9,030$210K<0.01%013F-HRTimeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…8,574$200K<0.01%+8,05413F-HRTimelineGroup
KLP KAPITALFORVALTNING AS7,800$182K<0.01%13F-HRTimeline
Police & Firemen's Retirement System of…7,378$172K<0.01%13F-HRTimeline
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/7,142$166K<0.01%-250,65513F-HRTimelineGroup
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA4,022$94K<0.01%+23613F-HRTimelineGroup
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…3,392$79K<0.01%013F-HRTimelineGroup
VIRTUS ADVISERS, LLCin group Virtus Investment Advisers, L…2,972$69.2K0.03%+12413F-HRTimelineGroup
AlphaQuest LLC2,198$51.2K0.01%-3,45613F-HRTimeline
PUBLIC EMPLOYEES RETIREMENT ASSOCIATION…1,589$37K<0.01%013F-HRTimeline
HUNTINGTON NATIONAL BANKin group HUNTINGTON NATIONAL BANK1,470$34.2K<0.01%new13F-HRTimelineGroup
GF FUND MANAGEMENT CO. LTD.1,232$28.7K<0.01%13F-HRTimeline
AMALGAMATED BANK1,198$28K<0.01%013F-HRTimeline
Sterling Capital Management LLC1,009$23.5K<0.01%+89413F-HRTimeline
R Squared Ltd710$16.5K0.02%13F-HRTimeline
Venturi Wealth Management, LLC231$5.38K<0.01%new13F-HRTimeline
Sugar Maple Asset Management, LLC180$4.19K<0.01%new13F-HRTimeline
NISA INVESTMENT ADVISORS, LLC120$2.79K<0.01%+913F-HRTimeline
Brooklyn Investment Group120$2.79K<0.01%new13F-HRTimeline
IFP Advisors, Inc109$2.77K<0.01%-513F-HRTimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.105$2.44K<0.01%+2213F-HR/ATimelineGroup
SIGNATUREFD, LLC68$1.58K<0.01%new13F-HRTimeline
SIMPLEX TRADING, LLC55$1K<0.01%new13F-HRTimeline
ROTHSCHILD INVESTMENT LLC40$931<0.01%013F-HRTimeline
Amundiin group Amundi32$769<0.01%new13F-HRTimelineGroup
Caitong International Asset Management …14$326<0.01%13F-HR/ATimeline
Allworth Financial LP9$197<0.01%+213F-HRTimeline
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…8$186<0.01%new13F-HRTimelineGroup
Pacific Capital Wealth Advisors, Inc.8$186<0.01%013F-HRTimeline
SBI Securities Co., Ltd.5$116<0.01%13F-HRTimeline
CWM, LLCin group CWM, LLC8$00%-21913F-HRTimelineGroupValue filed as zero, left out of ratios.
Covestor Ltd4$00%+113F-HRTimelineValue filed as zero, left out of ratios.
CONCOURSE FINANCIAL GROUP SECURITIES, I…0$00%013F-HRTimelineValue filed as zero, left out of ratios. Amount filed as zero, left out of ratios.
NOMURA ASSET MANAGEMENT CO LTDin group NOMURA ASSET MANAGEMENT CO LTD0$00%013F-HRTimelineGroupValue filed as zero, left out of ratios. Amount filed as zero, left out of ratios.

Events

  • Fairmount Funds Management LLC and 3 other reporting persons reported 10,185,961 SYRE shares, 9.99% of the class, as of 2026-10-07, in a 13D/A filed 2026-10-09. 0001104659-26-115087

    Accepted , ingested

  • Paradigm Biocapital Advisors LP and 3 other reporting persons reported 4,457,450 SYRE shares, 5.1% of the class, as of 2026-09-24, in a 13G filed 2026-10-01. 0001104659-26-112828

    Accepted , ingested