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Disclosery

SYRE SPYRE THERAPEUTICS INC

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COM NEW (common), issuer CIK 1636282

135 managers (138 13F filers) reported a position in SYRE shares at 2025-09-30, 64,298,777 shares in all. 22 filers opened a position and 13 filers sold out during the quarter.

Managers
135
13F filers
138
New
22
Added
44
Reduced
43
Sold out
13
Shares held by filers
64,298,777

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

Each filer's latest stake. The shares are the aggregate the reporting persons state, which can include entities that file no 13F.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q3 2025

Filers in the available 13F reports with a share position at 2025-09-30, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
FMR LLCin group FMR LLC9,060,144$152M0.01%+7,11013F-HRTimelineGroup
Fairmount Funds Management LLCin group Fairmount Funds Management LLC4,018,101$67.3M6.06%013F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.3,982,744$66.8M<0.01%-24,55213F-HRTimelineGroup
RTW INVESTMENTS, LP3,621,996$60.7M0.75%013F-HRTimeline
TANG CAPITAL MANAGEMENT LLCin group TANG CAPITAL MANAGEMENT LLC3,200,000$53.6M2.06%013F-HRTimelineGroup
VANGUARD GROUP INCin group VANGUARD GROUP INC3,050,730$51.1M<0.01%-15,85613F-HRTimelineGroup
Venrock Adviser, LLC2,685,448$45M2.53%013F-HRTimeline
BRAIDWELL LP2,578,404$43.2M1.28%013F-HRTimeline
Capital International Investorsin group Capital International Investo…2,392,541$40.1M0.01%013F-HRTimelineGroup
Driehaus Capital Management LLC2,060,375$34.5M0.25%-25,21513F-HRTimeline
Commodore Capital LPin group Commodore Capital LP1,988,084$33.3M1.63%013F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP1,785,206$29.9M<0.01%+189,91513F-HRTimelineGroup
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…1,640,312$27.5M<0.01%+126,83413F-HRTimelineGroup
Paradigm Biocapital Advisors LPin group Paradigm Biocapital Advisors …1,467,266$24.6M0.73%-403,17913F-HRTimelineGroup
Affinity Asset Advisors, LLC1,419,299$23.8M2.21%+812,62113F-HRTimeline
Jefferies Financial Group Inc.in group Jefferies Financial Group Inc.1,388,854$23.3M0.21%013F-HRTimelineGroup
PERCEPTIVE ADVISORS LLCin group PERCEPTIVE ADVISORS LLC1,229,445$20.6M0.6%-300,00013F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC1,225,153$20.5M<0.01%-2,07913F-HRTimelineGroup
TCG Crossover Management, LLC1,100,582$18.4M0.91%new13F-HRTimeline
Pictet Asset Management Holding SAin group Pictet Asset Management Holdi…1,036,218$17.4M0.02%-43,22513F-HRTimelineGroup
BAKER BROS. ADVISORS LPin group BAKER BROS. ADVISORS LP1,000,000$16.8M0.12%+373,29713F-HRTimelineGroup
EMERALD ADVISERS, LLCgroup of 2 filers holding856,924$14.4M-38,369Timeline
FRANKLIN RESOURCES INCin group Franklin Resources795,275$13.3M<0.01%013F-HRTimelineGroup
Polar Capital Holdings Plcin group Polar Capital Holdings Plc788,788$13.2M0.06%+43,78813F-HRTimelineGroup
PRICE T ROWE ASSOCIATES INC /MD/620,620$10.4M<0.01%-309,86113F-HRTimeline
DEERFIELD MANAGEMENT COMPANY, L.P.in group DEERFIELD MANAGEMENT COMPANY,…613,665$10.3M0.16%013F-HRTimelineGroup
Blackstone Inc.in group Blackstone Inc.500,998$8.4M0.04%+11,75013F-HRTimelineGroupThe filing omitted confidential holdings, a later amendment may add them.
NORTHERN TRUST CORPin group NORTHERN TRUST CORP442,036$7.41M<0.01%+5,08913F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co425,345$7.13M<0.01%+6,84213F-HRTimelineGroup
UBS Group AGgroup of 2 filers holding425,087$7.12M-123,478Timeline
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC408,199$6.84M0.01%new13F-HRTimelineGroup
Candriam S.C.A.404,362$6.78M0.04%+158,33213F-HRTimeline
Siren, L.L.C.in group Siren, L.L.C.368,598$6.18M0.24%013F-HRTimelineGroup
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/344,803$5.78M<0.01%-51,54813F-HR/ATimelineGroup
MORGAN STANLEYin group MORGAN STANLEY334,722$5.61M<0.01%-336,32213F-HR/ATimelineGroup
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC329,533$5.52M<0.01%-193,88313F-HRTimelineGroup
VICTORY CAPITAL MANAGEMENT INC326,081$5.47M<0.01%-28,03513F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS315,909$5.29M<0.01%+92,58913F-HRTimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO275,984$4.63M<0.01%+228,70513F-HR/ATimelineGroup
VOLORIDGE INVESTMENT MANAGEMENT, LLC264,317$4.43M0.01%-14,60313F-HRTimeline
HighVista Strategies LLC215,746$3.62M0.89%+102,94113F-HRTimeline
Parkman Healthcare Partners LLC200,753$3.36M0.37%new13F-HRTimeline
Capital World Investors200,172$3.35M<0.01%-150,60213F-HRTimeline
BARCLAYS PLCin group BARCLAYS PLC168,330$2.82M<0.01%-48,31613F-HR/ATimelineGroup
ARMISTICE CAPITAL, LLC156,000$2.61M0.08%-16,00013F-HRTimeline
Bank of New York Mellon Corpin group Bank of New York Mellon Corp135,960$2.28M<0.01%+3,81013F-HRTimelineGroup
Woodline Partners LP131,876$2.21M0.01%-333,27613F-HRTimeline
Universal- Beteiligungs- und Serviceges…in group Universal- Beteiligungs- und …110,456$1.85M<0.01%+1,17213F-HRTimelineGroup
MERCER GLOBAL ADVISORS INC /ADV106,664$1.79M<0.01%+52213F-HRTimeline
SCHRODER INVESTMENT MANAGEMENT GROUP107,738$1.76M<0.01%-21,82013F-HRTimeline
B Group, Inc.100,000$1.68M1.6%+20,00013F-HRTimeline
Nuveen, LLCin group TIAA96,172$1.61M<0.01%-38,89613F-HRTimelineGroup
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC96,057$1.61M<0.01%new13F-HRTimelineGroup
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP84,216$1.41M<0.01%new13F-HRTimelineGroup
Schonfeld Strategic Advisors LLC81,474$1.37M0.01%new13F-HRTimeline
TD Asset Management Inc72,368$1.21M<0.01%-41,60013F-HRTimeline
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …71,948$1.21M<0.01%-7,94813F-HRTimelineGroup
RHUMBLINE ADVISERS70,914$1.19M<0.01%-2,25413F-HRTimeline
Swiss National Bank70,200$1.18M<0.01%+1,60013F-HRTimeline
ExodusPoint Capital Management, LP68,563$1.15M0.02%-14,41413F-HRTimeline
AlphaQuest LLC66,163$1.11M0.07%+61,98913F-HRTimeline
Opaleye Management Inc.65,000$1.09M0.15%new13F-HRTimeline
Rafferty Asset Management, LLC59,667$1M<0.01%+8,71013F-HRTimeline
F/m Investments LLC54,893$920K0.04%+2,34713F-HRTimeline
Invesco Ltd.in group Invesco Ltd.50,702$850K<0.01%+16,02213F-HRTimelineGroup
Verition Fund Management LLC48,496$813K<0.01%-16,54613F-HRTimeline
Legal & General Group Plcin group Legal & General Group Plc46,841$785K<0.01%+11,87213F-HRTimelineGroup
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN39,319$659K<0.01%+4,91013F-HRTimelineGroup
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\38,543$646K<0.01%+4,60513F-HRTimelineGroup
ALLIANCEBERNSTEIN L.P.36,230$607K<0.01%013F-HRTimeline
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC34,051$571K0.06%013F-HRTimelineGroup
STATE OF WISCONSIN INVESTMENT BOARD33,546$562K<0.01%-1,50013F-HRTimeline
CALIFORNIA STATE TEACHERS RETIREMENT SY…33,203$556K<0.01%+213F-HRTimeline
CITIGROUP INCin group CITIGROUP INC32,896$551K<0.01%+3,63513F-HRTimelineGroup
DLD Asset Management, LP30,000$503K0.06%new13F-HR/ATimeline
MetLife Investment Management, LLCin group MetLife Investment Management…29,918$501K<0.01%013F-HRTimelineGroup
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding28,783$481K-3,360Timeline
Jump Financial, LLCin group Jump Financial, LLC27,100$454K0.01%new13F-HR/ATimelineGroup
Waverly Advisors, LLC25,953$435K<0.01%+6,50013F-HRTimeline
TEACHERS RETIREMENT SYSTEM OF THE STATE…25,799$432K<0.01%013F-HRTimeline
OPTIMIZE FINANCIAL INC.24,967$418K0.22%new13F-HRTimeline
Assenagon Asset Management S.A.22,136$371K<0.01%013F-HRTimeline
SUSQUEHANNA INTERNATIONAL GROUP, LLPgroup of 2 filers holding21,739$364K-38,077Timeline
INTECH INVESTMENT MANAGEMENT LLC20,360$341K<0.01%-4,58513F-HRTimeline
Squarepoint Ops LLCin group Squarepoint Ops LLC20,232$339K<0.01%-9,81413F-HRTimelineGroup
Quadrature Capital Ltdin group Quadrature Capital Ltd19,366$325K<0.01%new13F-HRTimelineGroup
VIRGINIA RETIREMENT SYSTEMS ET Al18,500$310K<0.01%new13F-HRTimeline
Global Endowment Management, LPin group Global Endowment Management, …18,184$305K0.04%013F-HRTimelineGroup
LOS ANGELES CAPITAL MANAGEMENT LLC18,172$305K<0.01%new13F-HRTimeline
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC17,047$286K<0.01%-92613F-HRTimelineGroup
NEW YORK STATE COMMON RETIREMENT FUND16,565$278K<0.01%013F-HRTimeline
DARK FOREST CAPITAL MANAGEMENT LP14,733$247K0.01%new13F-HR/ATimeline
Police & Firemen's Retirement System of…13,809$231K<0.01%+2,28413F-HRTimeline
PROFUND ADVISORS LLC13,223$222K0.01%+2,18013F-HRTimeline
JANUS HENDERSON GROUP PLCin group Janus Henderson13,000$218K<0.01%013F-HRTimelineGroup
DRW Securities, LLC11,475$190K0.01%new13F-HRTimeline
Zurcher Kantonalbank (Zurich Cantonalba…10,874$182K<0.01%-1,99913F-HRTimeline
ARIZONA STATE RETIREMENT SYSTEM10,693$179K<0.01%+18113F-HRTimeline
ProShare Advisors LLC10,678$179K<0.01%-1,80113F-HRTimeline
China Universal Asset Management Co., L…10,587$177K0.01%-1,53513F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA7,883$132K<0.01%-59113F-HRTimelineGroup
KLP KAPITALFORVALTNING AS7,800$131K<0.01%013F-HRTimeline
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…6,425$108K0.03%+1,11513F-HRTimelineGroup
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…4,596$77K<0.01%-1,17313F-HRTimelineGroup
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…4,234$71K<0.01%+4,09213F-HRTimelineGroup
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…4,166$69.8K<0.01%-92513F-HRTimelineGroup
CWM, LLCin group CWM, LLC1,960$33K<0.01%+24813F-HRTimelineGroup
PUBLIC EMPLOYEES RETIREMENT ASSOCIATION…1,589$27K<0.01%013F-HRTimeline
HUNTINGTON NATIONAL BANKin group HUNTINGTON NATIONAL BANK1,470$24.6K<0.01%013F-HRTimelineGroup
AMALGAMATED BANK1,379$23K<0.01%013F-HRTimeline
GF FUND MANAGEMENT CO. LTD.1,299$21.8K<0.01%-20313F-HRTimeline
Sterling Capital Management LLC1,214$20.3K<0.01%+69013F-HRTimeline
NISA INVESTMENT ADVISORS, LLC705$11.8K<0.01%+15913F-HRTimeline
Optiver Holding B.V.in group Optiver Holding B.V.500$8.38K<0.01%new13F-HRTimelineGroup
Rockefeller Capital Management L.P.in group Rockefeller Capital Managemen…401$6.72K<0.01%new13F-HRTimelineGroup
BNP PARIBAS ASSET MANAGEMENT Holding S.…in group BNP PARIBAS ASSET MANAGEMENT …335$6K<0.01%-4213F-HRTimelineGroup
SBI Securities Co., Ltd.123$5.88K<0.01%+11213F-HRTimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.314$5.17K<0.01%+1413F-HRTimelineGroup
MEEDER ASSET MANAGEMENT INCin group Meeder Advisory Services, Inc.216$3.62K<0.01%+4613F-HRTimelineGroup
GAMMA Investing LLC208$3.49K<0.01%+3413F-HRTimeline
Daiwa Securities Group Inc.in group Daiwa Securities Group Inc.206$3K<0.01%013F-HRTimelineGroup
Arax Advisory Partners121$2.03K<0.01%new13F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…86$1.44K<0.01%new13F-HRTimelineGroup
ROTHSCHILD INVESTMENT LLC80$1.34K<0.01%-6013F-HRTimeline
SIGNATUREFD, LLC70$1.17K<0.01%-9513F-HRTimeline
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…65$1.09K<0.01%013F-HRTimelineGroup
Parkside Financial Bank & Trust35$587<0.01%013F-HRTimeline
Allworth Financial LP32$537<0.01%+213F-HRTimeline
IFP Advisors, Inc24$402<0.01%+113F-HR/ATimeline
Larson Financial Group LLC12$201<0.01%+613F-HRTimeline
US BANCORP \DE\in group US BANCORP \DE\10$168<0.01%013F-HRTimelineGroup
Farther Finance Advisors, LLC10$168<0.01%new13F-HRTimeline
COMERICA BANK5$84<0.01%new13F-HRTimeline
Covestor Ltd6$00%013F-HRTimelineValue filed as zero, left out of ratios.
NOMURA ASSET MANAGEMENT CO LTDin group NOMURA ASSET MANAGEMENT CO LTD0$00%013F-HRTimelineGroupValue filed as zero, left out of ratios. Amount filed as zero, left out of ratios.

Events

  • Fairmount Funds Management LLC and 3 other reporting persons reported 10,185,961 SYRE shares, 9.99% of the class, as of 2026-10-07, in a 13D/A filed 2026-10-09. 0001104659-26-115087

    Accepted , ingested

  • Paradigm Biocapital Advisors LP and 3 other reporting persons reported 4,457,450 SYRE shares, 5.1% of the class, as of 2026-09-24, in a 13G filed 2026-10-01. 0001104659-26-112828

    Accepted , ingested