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Disclosery

SYRE SPYRE THERAPEUTICS INC

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COM NEW (common), issuer CIK 1636282

128 managers (131 13F filers) reported a position in SYRE shares at 2025-06-30, 63,624,786 shares in all. 18 filers opened a position and 17 filers sold out during the quarter.

Managers
128
13F filers
131
New
18
Added
64
Reduced
25
Sold out
17
Shares held by filers
63,624,786

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

Each filer's latest stake. The shares are the aggregate the reporting persons state, which can include entities that file no 13F.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q2 2025

Filers in the available 13F reports with a share position at 2025-06-30, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
FMR LLCin group FMR LLC9,053,034$136M0.01%+14,48113F-HRTimelineGroup
Fairmount Funds Management LLCin group Fairmount Funds Management LLC4,018,101$60.2M7.79%013F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.4,007,296$60M<0.01%+434,62213F-HRTimelineGroup
RTW INVESTMENTS, LP3,621,996$54.2M0.77%013F-HRTimeline
TANG CAPITAL MANAGEMENT LLCin group TANG CAPITAL MANAGEMENT LLC3,200,000$47.9M2.42%+1,150,00013F-HRTimelineGroup
VANGUARD GROUP INCin group VANGUARD GROUP INC3,066,586$45.9M<0.01%+168,31913F-HRTimelineGroup
Venrock Adviser, LLC2,685,448$40.2M3.01%013F-HRTimeline
BRAIDWELL LP2,578,404$38.6M1.32%013F-HRTimeline
Capital International Investorsin group Capital International Investo…2,392,541$35.8M0.01%013F-HRTimelineGroup
Driehaus Capital Management LLC2,085,590$31.2M0.25%-631,72213F-HRTimeline
Commodore Capital LPin group Commodore Capital LP1,988,084$29.8M2.1%013F-HRTimelineGroup
Paradigm Biocapital Advisors LPin group Paradigm Biocapital Advisors …1,870,445$28M1.2%-256,76013F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP1,595,291$23.9M<0.01%-101,82413F-HRTimelineGroup
PERCEPTIVE ADVISORS LLCin group PERCEPTIVE ADVISORS LLC1,529,445$22.9M0.86%-783,82713F-HRTimelineGroup
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…1,513,478$22.7M<0.01%-80,20013F-HRTimelineGroup
Jefferies Financial Group Inc.in group Jefferies Financial Group Inc.1,388,854$20.8M0.34%+140,00013F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC1,227,232$18.4M<0.01%+167,66913F-HRTimelineGroup
Pictet Asset Management Holding SAin group Pictet Asset Management Holdi…1,079,443$16.2M0.02%+10,55113F-HRTimelineGroup
PRICE T ROWE ASSOCIATES INC /MD/930,481$13.9M<0.01%+681,93913F-HRTimeline
EMERALD ADVISERS, LLCgroup of 2 filers holding895,293$13.4M-41,956Timeline
FRANKLIN RESOURCES INCin group Franklin Resources795,275$11.9M<0.01%+34,64713F-HRTimelineGroup
Polar Capital Holdings Plcin group Polar Capital Holdings Plc745,000$11.2M0.06%-80,00013F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY671,044$10M<0.01%+335,57713F-HRTimelineGroup
BAKER BROS. ADVISORS LPin group BAKER BROS. ADVISORS LP626,703$9.38M0.09%new13F-HRTimelineGroup
DEERFIELD MANAGEMENT COMPANY, L.P.in group DEERFIELD MANAGEMENT COMPANY,…613,665$9.19M0.17%+163,66513F-HRTimelineGroup
ADAGE CAPITAL PARTNERS GP, L.L.C.in group ADAGE CAPITAL PARTNERS GP, L.…610,200$9.13M0.02%-193,00013F-HRTimelineGroup
Affinity Asset Advisors, LLC606,678$9.08M1.34%+125,00013F-HRTimeline
UBS Group AGgroup of 2 filers holding548,565$8.21M-55,816Timeline
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC523,416$7.84M<0.01%+326,34813F-HRTimelineGroup
Blackstone Inc.in group Blackstone Inc.489,248$7.32M0.03%013F-HRTimelineGroup
Woodline Partners LP465,152$6.96M0.04%+34413F-HRTimeline
NORTHERN TRUST CORPin group NORTHERN TRUST CORP436,947$6.54M<0.01%+57,07213F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co418,503$6.26M<0.01%+35,86713F-HRTimelineGroup
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/396,351$5.93M<0.01%-30,72413F-HRTimelineGroup
Siren, L.L.C.in group Siren, L.L.C.368,598$5.52M0.29%013F-HRTimelineGroup
VICTORY CAPITAL MANAGEMENT INC354,116$5.3M<0.01%+102,27013F-HRTimeline
Capital World Investors350,774$5.25M<0.01%013F-HRTimeline
VOLORIDGE INVESTMENT MANAGEMENT, LLC278,920$4.18M0.02%+21,48813F-HRTimeline
Candriam S.C.A.246,030$3.68M0.02%013F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS223,320$3.34M<0.01%+167,48713F-HRTimelineGroup
Deep Track Capital, LP219,015$3.28M0.11%013F-HRTimeline
BARCLAYS PLCin group BARCLAYS PLC216,646$3.24M<0.01%+2,04013F-HR/ATimelineGroup
Capitolis Liquid Global Markets LLCin group CAPITOLIS LIQUID GLOBAL MARKE…183,000$2.74M0.02%new13F-HRTimelineGroup
ARMISTICE CAPITAL, LLC172,000$2.57M0.1%-28,00013F-HRTimeline
Nuveen, LLCin group TIAA135,068$2.02M<0.01%-5,06113F-HRTimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp132,150$1.98M<0.01%+17,91013F-HRTimelineGroup
SCHRODER INVESTMENT MANAGEMENT GROUP129,558$1.97M<0.01%+21,05413F-HRTimeline
TD Asset Management Inc113,968$1.71M<0.01%+91,60013F-HRTimeline
HighVista Strategies LLC112,805$1.69M0.62%+17,64613F-HRTimeline
Universal- Beteiligungs- und Serviceges…in group Universal- Beteiligungs- und …109,284$1.64M<0.01%-11,03713F-HRTimelineGroup
MERCER GLOBAL ADVISORS INC /ADV106,142$1.59M<0.01%new13F-HRTimeline
ExodusPoint Capital Management, LP82,977$1.24M0.02%+67,92213F-HRTimeline
B Group, Inc.80,000$1.2M1.03%+10,00013F-HRTimeline
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …79,896$1.2M<0.01%+25,99513F-HRTimelineGroup
RHUMBLINE ADVISERS73,168$1.1M<0.01%+17,14513F-HRTimeline
Foresite Capital Management VI LLCin group Foresite Capital Management V…70,000$1.05M0.59%new13F-HRTimelineGroup
Swiss National Bank68,600$1.03M<0.01%013F-HRTimeline
Verition Fund Management LLC65,042$974K0.01%new13F-HRTimeline
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…59,816$895K<0.01%+1,12013F-HRTimelineGroup
F/m Investments LLC52,546$787K0.03%+70213F-HRTimeline
Rafferty Asset Management, LLC50,957$763K<0.01%-19,36613F-HRTimeline
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO47,279$708K<0.01%+5,72313F-HRTimelineGroup
ALLIANCEBERNSTEIN L.P.36,230$542K<0.01%013F-HRTimeline
STATE OF WISCONSIN INVESTMENT BOARD35,046$525K<0.01%+14513F-HRTimeline
Legal & General Group Plcin group Legal & General Group Plc34,969$523K<0.01%-2,87513F-HRTimelineGroup
Invesco Ltd.in group Invesco Ltd.34,680$519K<0.01%+9,47313F-HRTimelineGroup
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN34,409$515K<0.01%+4,37413F-HRTimelineGroup
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC34,051$510K0.08%+19,01813F-HRTimelineGroup
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\33,938$508K<0.01%+5,45513F-HRTimelineGroup
CALIFORNIA STATE TEACHERS RETIREMENT SY…33,201$497K<0.01%+60313F-HRTimeline
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding32,143$482K+3,109Timeline
RENAISSANCE TECHNOLOGIES LLC30,936$463K<0.01%new13F-HRTimeline
Squarepoint Ops LLCin group Squarepoint Ops LLC30,046$450K<0.01%-41,96513F-HR/ATimelineGroup
MetLife Investment Management, LLCin group MetLife Investment Management…29,918$448K<0.01%+6,18513F-HRTimelineGroup
CITIGROUP INCin group CITIGROUP INC29,261$438K<0.01%-54,20313F-HRTimelineGroup
TEACHERS RETIREMENT SYSTEM OF THE STATE…25,799$386K<0.01%013F-HRTimeline
INTECH INVESTMENT MANAGEMENT LLC24,945$373K<0.01%+4,51713F-HRTimeline
Natixis Investment Managersgroup of 2 filers holding20,040$355K+3,639Timeline
Assenagon Asset Management S.A.22,136$331K<0.01%-59013F-HRTimeline
Waverly Advisors, LLC19,453$291K<0.01%+2313F-HRTimeline
NBW CAPITAL LLC19,430$291K0.06%013F-HRTimeline
Global Endowment Management, LPin group Global Endowment Management, …18,184$272K0.04%013F-HRTimelineGroup
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC17,973$269K<0.01%new13F-HRTimelineGroup
NEW YORK STATE COMMON RETIREMENT FUND16,565$248K<0.01%+6,30013F-HR/ATimeline
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC13,589$203K<0.01%+3,24113F-HRTimelineGroup
JANUS HENDERSON GROUP PLCin group Janus Henderson13,000$194K<0.01%-1,028,41013F-HRTimelineGroup
Zurcher Kantonalbank (Zurich Cantonalba…12,873$193K<0.01%new13F-HRTimeline
ProShare Advisors LLC12,479$187K<0.01%+1,10113F-HRTimeline
China Universal Asset Management Co., L…12,122$181K0.02%+3513F-HRTimeline
Police & Firemen's Retirement System of…11,525$173K<0.01%+2,75813F-HRTimeline
PROFUND ADVISORS LLC11,043$165K0.01%-3,61913F-HRTimeline
Man Group plcin group Man Group plc10,843$162K<0.01%new13F-HRTimelineGroup
ARIZONA STATE RETIREMENT SYSTEM10,512$157K<0.01%+49513F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA8,474$126K<0.01%+6,30213F-HR/ATimelineGroup
KLP KAPITALFORVALTNING AS7,800$117K<0.01%013F-HRTimeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…5,769$86.4K<0.01%+3,72513F-HRTimelineGroup
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…5,310$79.5K0.03%-1,55113F-HRTimelineGroup
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…5,091$76.2K<0.01%+1,04513F-HRTimelineGroup
AlphaQuest LLC4,174$62.5K0.01%+98313F-HRTimeline
CWM, LLCin group CWM, LLC1,712$26K<0.01%+1,33813F-HRTimelineGroup
PUBLIC EMPLOYEES RETIREMENT ASSOCIATION…1,589$24K<0.01%013F-HRTimeline
GF FUND MANAGEMENT CO. LTD.1,502$22.5K<0.01%013F-HRTimeline
HUNTINGTON NATIONAL BANKin group HUNTINGTON NATIONAL BANK1,470$22K<0.01%013F-HRTimelineGroup
AMALGAMATED BANK1,379$21K<0.01%013F-HRTimeline
NISA INVESTMENT ADVISORS, LLC546$8.17K<0.01%+36213F-HRTimeline
Sterling Capital Management LLC524$7.84K<0.01%-10513F-HR/ATimeline
Brooklyn Investment Group520$7.79K<0.01%new13F-HR/ATimeline
BNP PARIBAS ASSET MANAGEMENT Holding S.…in group BNP PARIBAS ASSET MANAGEMENT …377$6K<0.01%new13F-HRTimelineGroup
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.300$4.49K<0.01%+6213F-HR/ATimelineGroup
Daiwa Securities Group Inc.in group Daiwa Securities Group Inc.206$3K<0.01%013F-HRTimelineGroup
GAMMA Investing LLC174$2.6K<0.01%-9613F-HRTimeline
MEEDER ASSET MANAGEMENT INCin group Meeder Advisory Services, Inc.170$2.54K<0.01%new13F-HRTimelineGroup
SIGNATUREFD, LLC165$2.47K<0.01%new13F-HRTimeline
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…142$2.13K<0.01%new13F-HRTimelineGroup
ROTHSCHILD INVESTMENT LLC140$2.1K<0.01%+9013F-HRTimeline
SIMPLEX TRADING, LLC145$2K<0.01%new13F-HRTimeline
Caitong International Asset Management …102$1.53K<0.01%+7413F-HRTimeline
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…65$973<0.01%+4113F-HRTimelineGroup
Parkside Financial Bank & Trust35$524<0.01%new13F-HRTimeline
Allworth Financial LP30$450<0.01%+1713F-HRTimeline
IFP Advisors, Inc23$374<0.01%-8613F-HRTimeline
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC16$240<0.01%new13F-HRTimelineGroup
SBI Securities Co., Ltd.11$165<0.01%+613F-HRTimeline
US BANCORP \DE\in group US BANCORP \DE\10$150<0.01%+113F-HRTimelineGroup
Larson Financial Group LLC6$90<0.01%-3813F-HRTimeline
Covestor Ltd6$00%+213F-HRTimelineValue filed as zero, left out of ratios.
CONCOURSE FINANCIAL GROUP SECURITIES, I…0$0013F-HRTimelineValue filed as zero, left out of ratios. Amount filed as zero, left out of ratios.
NOMURA ASSET MANAGEMENT CO LTDin group NOMURA ASSET MANAGEMENT CO LTD0$00%013F-HRTimelineGroupValue filed as zero, left out of ratios. Amount filed as zero, left out of ratios.

Events

  • Fairmount Funds Management LLC and 3 other reporting persons reported 10,185,961 SYRE shares, 9.99% of the class, as of 2026-10-07, in a 13D/A filed 2026-10-09. 0001104659-26-115087

    Accepted , ingested

  • Paradigm Biocapital Advisors LP and 3 other reporting persons reported 4,457,450 SYRE shares, 5.1% of the class, as of 2026-09-24, in a 13G filed 2026-10-01. 0001104659-26-112828

    Accepted , ingested